Digital Commons Network^™

Baseline Extracellular Vesicle Mirna-30c And Autophagic Ctcs Predict Chemoradiotherapy Resistance And Outcomes In Patients With Lung Cancer, Diego De Miguel-Perez, Francisco Gabriel Ortega, Rosario Guerrero Tejada, Antonio Martínez-Única, Christine B Peterson, Muthukumar Gunasekaran, Victor Amezcua, Jose Antonio Lorente, Jose Expósito Hernández, Christian Rolfo, Maria Jose Serrano

Faculty, Staff and Student Publications

Concurrent chemoradiotherapy (cCRT) is the mainstay of treatment for patients diagnosed with locally advanced non-small cell lung cancer (NSCLC). One significant challenge in the effectiveness of this therapy is the potential development of resistance mechanisms, where autophagy up-regulation has been proposed as a key contributing factor. However, there is a lack of reliable biomarkers to predict outcomes on these patients. Interestingly, for addressing this gap, extracellular vesicles (EVs) and circulating tumor cells (CTCs) have emerged as potential sources of such biomarkers. In this study, we investigated EV-associated miRNAs and presence of autophagic CTCs in prospectively collected serial samples from 38 …

Dissociable Effects Of Alzheimer's Disease-Related Cognitive Dysfunction And Aging On Functional Brain Network Segregation, Ziwei Zhang, Micaela Y Chan, Liang Han, Claudia A Carreno, Ezra Winter-Nelson

Faculty, Staff and Student Publications

Alzheimer's disease (AD) is associated with changes in large-scale functional brain network organization. Individuals with AD exhibit less segregated resting-state brain networks compared with individuals without dementia. However, declines in brain network segregation are also evident as adult individuals grow older. Determining whether these observations reflect unique or overlapping alterations on the functional connectome of the brain is essential for understanding the impact of AD on network organization and incorporating measures of functional brain network organization toward AD characterization. Relationships between AD dementia severity and participant's age on resting-state brain system segregation were examined in 326 cognitively healthy and 275 …

Indices Of Narrative Language Associated With Disability

Faculty, Staff and Student Publications

Narratives skills are associated with long-term academic and social benefits. While students with disabilities often struggle to produce complete and complex narratives, it remains unclear which aspects of narrative language are most indicative of disability. In this study, we examined the association between a variety of narrative contents and form indices and disability. Methodology involved drawing 50 K-3 students with Individual Education Programs (IEP) and reported language concerns from a large diverse sample (n = 1074). Fifty typically developing (TD) students were matched to the former group using propensity score matching based on their age, gender, grade, mother’s education, …

Relationship Between Parental Attachment Styles And Suicide In Adolescents And Adults Admitted To An Inpatient Psychiatric Hospital, Julia T Myerson, Jillian K Thomas, Katrina A Rufino, Nausheen Noor, Michelle A Patriquin

Staff and Researcher Publications

Background: Suicide is among one of the leading causes of death in the United States affecting individuals of all ages.

Methods: We examined the relationship between suicide risk and parental attachment among an inpatient psychiatric sample of 690 adolescents and 1000 adults. Participants completed self-report measures of suicide risk and attachment.

Results: We found that both adolescents and adults with insecure (i.e., preoccupied, dismissive, fearful) maternal and paternal attachment are at a significantly higher risk of suicide compared to those with secure maternal and paternal attachment. Adolescents who endorsed a previous suicide attempt (27.2 %) were less likely to have …

A Multi-Institutional Phase 2 Trial Of Ablative 5-Fraction Stereotactic Magnetic Resonance-Guided On-Table Adaptive Radiation Therapy For Borderline Resectable And Locally Advanced Pancreatic Cancer, Parag Jitendra Parikh, Hyun Kim, Lauren E Henke, Alex T Price, Et Al.

2020-Current year OA Pubs

PURPOSE: Magnetic resonance (MR) image guidance may facilitate safe ultrahypofractionated radiation dose escalation for inoperable pancreatic ductal adenocarcinoma. We conducted a prospective study evaluating the safety of 5-fraction Stereotactic MR-guided on-table Adaptive Radiation Therapy (SMART) for locally advanced (LAPC) and borderline resectable pancreatic cancer (BRPC).

METHODS AND MATERIALS: Patients with LAPC or BRPC were eligible for this multi-institutional, single-arm, phase 2 trial after ≥3 months of systemic therapy without evidence of distant progression. Fifty gray in 5 fractions was prescribed on a 0.35T MR-guided radiation delivery system. The primary endpoint was acute grade ≥3 gastrointestinal (GI) toxicity definitely attributed to …

Retrieval Of Large Balloon Fragments During Transcatheter Pulmonary Valve Implantation Using A Novel Retrieval System, Srinath T Gowda, Flora Nunez-Gallegos, Lynn F Peng, Jamil A Aboulhosn, Daniel S Levi, Doff B Mcelhinney, Athar M Qureshi

Faculty, Staff and Students Publications

The removal of balloon fragments from the pulmonary artery without damaging the pulmonary and tricuspid valves can be difficult. Four cases during transcatheter pulmonary valve replacement are described in which a novel retrieval system was used to facilitate safe removal. (Level of Difficulty: Advanced.)

Nad+ Rescues Aging-Induced Blood-Brain Barrier Damage Via The Cx43-Parp1 Axis, Jie Xu, Hongtu Cui, Jialei Yang, Yangkai Xu, Mingming Shi, Jing Xue, Weiwei Yu, Gaofei Hu, Ke Li, Xiaoxiao Ge, Qi Zhang, Mingming Zhao, Jianyong Du, Xin Guo, Wenli Xu, Yang Gao, Changyu Yao, Fan Chen, Yue Chen, Wenxin Shan, Yujie Zhu, Liang Ji, Bing Pan, Yan Yu, Wenguang Li, Xuyang Zhao, Qihua He, Xiaohui Liu, Yue Huang, Shengyou Liao, Bin Zhou, Dehua Chui, Y Eugene Chen, Zheng Sun, Erdan Dong, Yongjun Wang, Lemin Zheng

Faculty, Staff and Students Publications

Blood-brain barrier (BBB) function deteriorates during aging, contributing to cognitive impairment and neurodegeneration. It is unclear what drives BBB leakage in aging and how it can be prevented. Using single-nucleus transcriptomics, we identified decreased connexin 43 (CX43) expression in cadherin-5

The Role Of Noncoding Rnas In Pancreatic Birth Defects

Faculty, Staff and Students Publications

Congenital defects in the pancreas can cause severe health issues such as pancreatic cancer and diabetes which require lifelong treatment. Regenerating healthy pancreatic cells to replace malfunctioning cells has been considered a promising cure for pancreatic diseases including birth defects. However, such therapies are currently unavailable in the clinic. The developmental gene regulatory network underlying pancreatic development must be reactivated for in vivo regeneration and recapitulated in vitro for cell replacement therapy. Thus, understanding the mechanisms driving pancreatic development will pave the way for regenerative therapies. Pancreatic progenitor cells are the precursors of all pancreatic cells which use epigenetic changes …

Differential Contribution Of Cardiac And Peripheral Blood Flow To Metaboreceptor-Mediated Pressor Responses In Autism Spectrum Disorder, Matthew Pizano Gomez, Gabriel B. Carlota, Stephanie S. Wang, Areum K. Jensen

International Journal of Exercise Science: Conference Proceedings

Young adults with Autism Spectrum Disorder (ASD) experience a higher prevalence of hypertension than the general population. Abnormal blood pressure (BP) response to acute exercise is seen in hypertension. BP response evoked during exercise is the outcome of a central interaction between neural inputs such as the exercise pressor reflex. However, it is unclear if this neurocardiovascular interaction is altered differently to regulate BP during exercise in ASD. PURPOSE: To determine whether contributions of cardiac and peripheral blood flow to metaboreceptor-mediated pressor responses are different during exercise in ASD. METHODS: 21 young adults with and without ASD completed the study. …

Does Neuromuscular Fatigue Occur From One Doubles Pickleball Match?, Matthew Ritchey, Margaret Falknor, George Beckham, Eric Martin

International Journal of Exercise Science: Conference Proceedings

Pickleball is an emerging sport that is continuing to gain popularity among people of all ages. Little research has been completed on the performance aspects of the game. PURPOSE: Lower body force production is an important aspect of any sport. A countermovement jump is a useful way to test that characteristic. Acute decreases in force production are an indicator of fatigue. No previous research of force production and fatigue has been completed on pickleball. Therefore the purpose of this study was to test countermovement jump performance before and after a match of doubles pickleball to determine if neuromuscular fatigue …

Teaching Current And Future Professionals Techniques For Lay Communication: Validation Study Of Published Training Material, Jafra Thomas, Jasmine C. Wong, Solana R. Martin, Yi Sheng Wu

International Journal of Exercise Science: Conference Proceedings

Thomas et al. (2023), developed two mock physical activity promotion (PAP) material, which university students (and others) could practice critiquing and revising using the suitability assessment of materials (SAM) protocol. Their objective, however, was to produce mock material at two reading grade levels (11th & 8th RGL), meaning they did not compute suitability scores for other sub/main areas (eg, font size, literacy demand, respectively). PURPOSE: The purpose of the present study was to (1) establish trustworthy baseline data in other SAM sub/main areas for students to compare their own scores to (2) compare mock material SAM scores to one …

Walking With Blood Flow Restriction Elicits Postexercise Hypotension In Prehypertensive Individuals, Dae Sik Song, Geoffrey Dorsett, Justine Wills, Iridian Valdivia, Isaac Sumaran, Jong-Kyung Kim

International Journal of Exercise Science: Conference Proceedings

It is well documented that prehypertension is associated with increased risk of developing into the future hypertension and cardiovascular events. Exercise is well known as one of the best nonpharmacological treatments for prehypertension to prevent future hypertension development. Blood flow restriction (BFR) training have been known to improve health-related components of physical fitness such as body composition, muscular strength and endurance, and aerobic capacity. However, there is still paucity of research that BFR exercise induces postexercise hypotension. PURPOSE: accordingly, the goal of this study was to assess that BFR exercise is more effective in reducing blood pressure (BP) compared to …

Handgrip Strength, Pinch Grip Strength, And Screen Time In College-Age Adults And Older Adults, Zarmina Amin, Galilea Gutierrez, Larissa True

International Journal of Exercise Science: Conference Proceedings

Smartphones have become an essential part of daily life for people of all ages, serving as a vital tool for communication, information, and entertainment. However, excessive smartphone use can lead to addiction-like behavior and musculoskeletal issues, with the extent and characteristics of problematic usage varying by age. PURPOSE: The purpose was two-fold: (1) Investigate the differences in handgrip strength (HGS), pinch grip strength (PGS), and total screen time between college-age individuals (18-to-25 years old; n = 50) and older adults (50+ years old; n = 50); (2) Explore correlations between HGS, PGS, and total screen time in college-age individuals …

Investigation Into Lower Extremity Accommodation During Lbppt Submaximal Running, Ciya Clyde, Miles Mercer, Julia Freedman Silvernail

International Journal of Exercise Science: Conference Proceedings

Running is a popular sport but often leads to overuse injuries due to repetitive ground reaction forces (GRF) impacting the lower extremities. Lower Body Positive Pressure Treadmills (LBPPT) have gained popularity in clinical and research environments for their ability to reduce the runners’ bodyweight, consequently lowering the GRFs. PURPOSE: To investigate whether there is an accommodation period present during LBPPT submaximal running for lower body GRFs. METHODS: Participants (n =3; 1 male, 2 females; age: 26 ± 1.63 years; mass: 63.73 ± 7.77kg; height: 1.64 ± 0.11m) were recruited to complete three 15-minute bodyweight support (BWS) conditions at …

A Novel Waveform To Extract Exercise Gas Exchange Response Dynamics: The Chirp Waveform, Michele Girardi, Michael A. Roman, Janos Porszasz, William W. Stringer, Carrie Ferguson, Harry B. Rossiter, Richard Casaburi

International Journal of Exercise Science: Conference Proceedings

Characterizing exercise gas exchange response dynamics reveals important information about physiological control processes and cardiopulmonary dysfunction. However, current methods for extracting exercise response dynamics typically use multiple step-wise transitions, limiting applicability of this technique. PURPOSE: We designed a new protocol (chirp waveform) to extract exercise gas exchange response dynamics in a single visit. We tested the hypothesis that gas exchange response dynamics extracted from chirp forcing would be similar to those extracted from step-wise transitions. METHODS: Thirty-one participants (14 young healthy, 7 older healthy, and 10 patients with chronic obstructive pulmonary disease) visited the laboratory on three occasions. …

Low Back Demand Of Equipment Carriage Tasks In Golf, Guanrong Cai, Jacob Cho, Yunsheng Zou, Jordan Cannon, George Salem

International Journal of Exercise Science: Conference Proceedings

Low back injury is a common concern in golfers and caddies. The literature often points to the biomechanics of the golf swing as the major contributing factor; however, golfers and caddies can regularly walk upward of 10,000 steps on uneven terrain while carrying equipment, which can contribute to the cumulative load on the low back. PURPOSE: To examine the low back biomechanical demands during golf equipment carriage and pick-up tasks. METHODS: Sixteen golfers (11M/5F, 27.4±3.5yrs) participated in 3D motion capture of a golf bag pick-up task and 3 walking tasks (1. unloaded walking [UW], 2. unilateral carrying on …

The Effect Of Aicar-Induced Ampk Activation On Gene Expression In Sarcopenic Muscle, Daniel M. Rasch, Steven D. Dray, Jouber Dos Santos, Shalene E. Wilcox, David M. Thomson

International Journal of Exercise Science: Conference Proceedings

The loss of muscle mass and function (sarcopenia) afflicts 11-74% of all aging adults, with prevalence increasing with age. Exercise training is clearly effective in preventing or attenuating sarcopenia. The cellular mechanisms of exercise’s protective effects are not entirely clear, but AMP-activated protein kinase (AMPK) is thought to play an important role, in part by regulating gene expression. PURPOSE: To determine the effect of chronic pharmacological AMPK activation on skeletal muscle gene expression in sarcopenic muscle. METHODS: 24-month-old C57Bl/6J mice received either one acute injection or chronic daily saline injections of the AMPK-activating drug AICAR for 31 days. …

Effects Of Chronic Grape Seed Extract Supplementation On Muscle Metaboreflex In Young Prehypertensive Individuals, Dongnyeuck Seo, Carmen Wardwell, Dae Sik Song, Joslyn Leage, Isaac Sumaran, Jong-Kyung Kim

International Journal of Exercise Science: Conference Proceedings

Previously, our laboratory demonstrated that acute grape seed extract (GSE) substantially reduced mean arterial pressure (MAP) in response to static exercise (SE) and post exercise muscular ischemia (PEMI) in normotensive young adults. However, limited evidence has reported regarding the potential beneficial effects of this extract on blood pressure (BP) induced by the muscle metaboreflex (MMR) activation in prehypertensive individuals. PURPOSE: The aim of this study was to compare effects of 7 days of GSE supplementation and placebo (PL) on hemodynamic response to SE and PEMI. METHODS: Subjects were randomly assigned via a double-blind, cross-over design to receive either GSE (600 …

Comparing Knee Kinetics And Muscular Activity Between The Barbell Squat And Flywheel Squat In Recreationally Trained Females, Justin Lam, Janice Ko, Sean Yonemori, Jenny Nguyen, Kevin Valenzuela, Kurt A. Escobar, Joshua A. Cotter

International Journal of Exercise Science: Conference Proceedings

Previous literature has supported flywheel (FW) training with inducing muscular size and strength comparable to resistance training with free weights. However, it remains unclear how the biomechanical demands of these two training methods differ regarding reducing the risk of load-dependent injuries. PURPOSE: With the growing population of female astronauts, this study aimed to compare knee joint kinetics and muscle activation when squatting to full depth on the barbell back (BB) squat and a gravity-independent FW device utilizing technology to be deployed in future long-term space missions. METHODS: Twenty recreationally trained females (22.3 ± 2.7 yrs, 1.6 ± 0.1 m, 59.8 …

Effects Of 7 Days Of Grape Seed Extract Supplementation On Heart Rate Recovery In Young Prehypertensive Individuals, Isaac Sumaran, Dongnyeuck Seo, Carmen Wardwell, Dae Sik Song, Joslyn Leage, Jong-Kyung Kim

International Journal of Exercise Science: Conference Proceedings

Evidence suggested heart rate recovery (HRR) is a useful maker to evaluate cardiac sympathetic function. Prehypertension is characterized by overactive sympathetic output and dysfunction of cardiac parasympathetic activity and associated with delayed HRR. Even though dietary supplementation with grape seed extract (GSE) elicits the production of nitric oxide, limited evidence has reported regarding the potential beneficial effects of this extract on HRR. Purpose: The aim of this study was to compare effects of 7 days of GSE supplementation and placebo (PL) on HRR for 5 min after graded exercise. Methods: Subjects were randomly assigned via a double-blind, cross-over design to …

Frontal Plane Range Of Motion Differences In Unilateral And Bilateral Battle Rope Sets: A Pilot Study, Janice Ko, Sean Yonemori, Kevin Valenzuela

International Journal of Exercise Science: Conference Proceedings

Battle rope exercises are commonly used among cross-fitters to build overall muscular strength and cardiorespiratory endurance. Although this training method is physically demanding, no studies have examined the frontal plane movements in the lower extremities when performing battle ropes exercises in their different variations. PURPOSE: The objective of this research was to compare the frontal plane range of motion (ROM) along with the peak joint angles of the ankle, knee, and hip when performing bilateral and unilateral battle ropes exercises. METHODS: Participants with at least six months of resistance training experience performed four sets of bilateral and unilateral battle ropes …

Multiple Stress Fractures And Low Energy Availability In Female Recreational Runners, Malorie Wilwand, Marissa Miles, Kelly Pritchett, Robert Pritchett, Abigail Larson

International Journal of Exercise Science: Conference Proceedings

Low energy availability (LEA) is the underlying factor for Relative Energy Deficiency in Sport which includes a facet of bone health. Stress fractures (SF) are common injuries among runners. The prevalence of coexisting LEA and multiple SF in recreational runners is unknown. PURPOSE: The purpose is 1) to assess the prevalence of multiple SF and risk of LEA among recreational female runners 2) to compare current eating disorders, body weight dissatisfaction, and restrictive eating behaviors between females with a history of SF and those with ≤ 1 SF. METHODS: Female noncompetitive, recreational runners (running > 10 miles/week, 18-25 years …

The Effects Of Unilateral And Bilateral Battle Rope Exercise On The Lower Extremity Joint Force: A Pilot Study, Sean A. Yonemori, Janice Ko, Kevin Valenzuela

International Journal of Exercise Science: Conference Proceedings

The battle rope exercise recently has increased its popularity due to cross fit gyms implementing it into the workout programs. Individuals use this workout to strengthen their upper body, however it is unknown how different modalities of using the battle ropes affects the lower extremity joint force required to stabilize the body. PURPOSE: To examine the effects of unilateral and bilateral battle ropes exercises on lower extremity joint force. METHODS: Subjects performed four bilateral battle rope trials and four unilateral battle rope trials. The trials consisted of twenty seconds of continuous activity with three minutes of rest in between …

The Effects Of Fatigue On Center Of Pressure Measures During Front Lunges, Logan C. Randall, Michele Leblanc

International Journal of Exercise Science: Conference Proceedings

Front lunges are a common exercise in strength and conditioning programs. Extensive research on front lunge biomechanical movement exists previously, however, the existing research lacks information regarding fatigue or center of pressure (COP). PURPOSE: The aim of this study was to determine the effect of fatigue on COP behavior in front lunges. METHODS: Participants were ages 18 to 30 and recreationally active. Participants were guided through sufficient warm up and practiced the lunge movement, barefoot, at the cadence of 15 repetitions/minute. Step length was assigned as the length from their greater trochanter to lateral malleolus. Participants completed front lunges …

Effects Of Biodensity Training On Lipid Profile In Young Women: A Pilot Study, Tristan R. Issa, Rosalinda Escobar-Prado, Auguste Torres, Maurice Cruz, Carolina Garcia, Braulio Cazarez, Nathaniel Bodell, Zhaojing Chen

International Journal of Exercise Science: Conference Proceedings

bioDensity training is a novel type of resistance exercise, which includes four basic isometric exercises in a subsequent fashion: chest press, leg press, core pull, and vertical lift. Although it’s primarily targeted on bone strength, a previous study showed that it improved HbA1C, fasting glucose, HDL, LDL and total cholesterol in elderly patients with Type 2 diabetes (Zheng et al. 2019). To date, the research on bioDensity training is limited, and its effects on a healthy population are unknown. PURPOSE: We are looking to examine the effects of 12-week bioDensity training on lipid profiles in young women. METHODS: …

Vascular Alteration With Postural Change As Observed Using The Anterior Tibial Artery: A Pilot Study, Camille L. Nguyen, Kassity D. Clay, Pat R. Vehrs Facsm, Aaron W. Johnson

International Journal of Exercise Science: Conference Proceedings

Plantar fasciopathy and plantar fasciosis are common lower extremity conditions. Vascular health is an important aspect of plantar fascia health. Footwear choices are thought to influence lower extremity vascular flow, but how the anterior tibial artery is affected by purely postural changes over time is unknown. PURPOSE: To observe the anterior tibial artery vascular alterations over a ten-minute period after transitioning from a sitting to a standing position while barefoot. METHODS: Nine participants (age= 23.8yrs ±2.5, height= 176.0cm ±8.0, weight= 69.8kg ±10.2) were recruited from Brigham Young University for a single 30-minute visit. The participants had no previous …

Examining Stroke Volume Changes During Exercise In Healthy Young Adults, Thomas Clark, Anthony Ciccone, Zane Evans, Keslee Stephenson, Chandler Rose, Carlos Goff, Shane Draper, Nicolas Clark

International Journal of Exercise Science: Conference Proceedings

Cardiac output is determined by the combination of heart rate and stroke volume. While heart rate is primarily influenced by cardiac autonomic input, stroke volume's behavior is more intricate due to the interplay between myocardial response to stretch (Frank-Starling law) and adrenergic changes in contractility. No consensus exist on its behavior during exercise despite extensive data. PURPOSE: The aim of this study was to assess how normalized stroke volume scores (SV) change in young, healthy adult males during a graded exercise test to exhaustion (GXT). METHODS: Participants (n=20; age=22.9±2.4; BMI=23.7±2.4) were instructed to abstain from engaging in vigorous …

Validation Of The Work Capacity Test For Wildland Firefighters, Cassandra Mcfarland, Zachary Hofheins, Janna Thompson, Lexi Sorensen, Andrew Creer, Shane Draper

International Journal of Exercise Science: Conference Proceedings

Much of the reported Wildland Firefighter (WLFF) data use prediction equations which tend to underestimate oxygen consumption (VO2) during load carriage. As a result, the reported metabolic and oxygen consumption data values may actually be higher creating a larger gap between the US Forest Service arduous pack test (APT) and true occupational demand. The reported data regarding the energy cost upon which the APT has been based (22.5 mL/kg/min of oxygen) has overwhelmingly been tested in current WLFF with few participants. However, no studies have recently examined the current energy expenditure of men and women who want to qualify to …

Health & Wellness Team- Esports At Csudh, Dr. Monique Turner, Alyse Freeman

International Journal of Exercise Science: Conference Proceedings

The goal of the Health and Wellness Team within Esports at California State University, Dominguez Hills (CSUDH) is to share the skill sets we have learned in our professional careers and apply them to our student eAthletes, so they are equipped with the mental, physical, nutritional, and socio-emotional resources, education, and support they need to thrive. PURPOSE: The Health and Wellness Team (HWT) within Esports at CSUDH and the student club organization aligns with the five pillars of the academy: Academics & Research, Career Development, Community, Competition, and Entertainment. The HWT can reach our student population through mental, …

The Effects Of Initiating A Fast With A High Fat Or A High Carbohydrate Shake On Mcp-1, Tnf-Alpha, And Il-6 Levels, Gage Jensen, Bruce Bailey

International Journal of Exercise Science: Conference Proceedings

Alzheimer’s disease, stroke, heart disease, and diabetes all rank among the leading causes of death in the United States, particularly among the elderly. While many behavioral and pharmacological strategies have been employed to reduce the incidence of these conditions, increasing evidence indicates that entering a mild to moderate state of ketosis through fasting or a very low carbohydrate diet can improve the prognosis for these conditions. PURPOSE: The purpose of this study was to evaluate the extent to which a high carbohydrate low fat (HC/LF) pre-fast meal altered MCP-1, TNF-alpha and IL-6 compared to a low carbohydrate high-fat pre-fast …