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2023

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Characterizing A Unique Oprm1 Expressing Neuronal Population In The Rat Nucleus Accumbens, Emma Andraka Jan 2023

Characterizing A Unique Oprm1 Expressing Neuronal Population In The Rat Nucleus Accumbens, Emma Andraka

All ETDs from UAB

Opioid-related overdose deaths have increased drastically in the past three decades, and especially since the beginning of the COVID-19 pandemic, due to the addictive, analgesic, and euphoric properties of the drugs. To produce these effects, opioids bind to the mu opioid receptor (MOR) in GABAergic neurons. The MOR is encoded by the Oprm1 gene and is expressed in multiple brain regions that regulate reward and motivation, such as the nucleus accumbens (NAc). Previous studies of Oprm1 knockdown in medium spiny neurons (MSNs) of the mouse NAc have shown that these neuronal populations are involved in reinforcing reward-context pairing as well …

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Short Root Anomaly: Prevalence, Genetics, And Its Effect In Orthodontic Treatment, Lauren Sharp Jan 2023

Short Root Anomaly: Prevalence, Genetics, And Its Effect In Orthodontic Treatment, Lauren Sharp

All ETDs from UAB

Short root anomaly (SRA) is a poorly understood developmental defect of root formation. Patients with this condition have short roots with rounded apexes and significantly reduced root to crown (R/C) ratios1, which can compromise dental care and may increase the risk of root resorption during tooth movement. SRA prevalence ranges from 1-10% but has not been studied in many ethnic populations. Furthermore, its genetic basis is undetermined. Our goals were to determine the prevalence of SRA among various ethnicities, identify genetic variations contributing to its phenotype, and evaluate how SRA can affect the outcome of orthodontic treatment. This study found …

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Nasal Septum Deviation In Patients With Or Without Impacted Canines, Naurine Shah Jan 2023

Nasal Septum Deviation In Patients With Or Without Impacted Canines, Naurine Shah

All ETDs from UAB

There has been a recent rise in interest for studying the relationship between orthodontic treatment and the airway. Most studies have focused on measuring the oropharyngeal airway and how it is affected by growth with or without orthodontic treatment. The Nasal Septum, a midline structure is an integral part of the anatomy of the nasopharynx. Nasal Septum Deviations (NSD) can be caused by mechanical injuries, nasal polyps, neoplasia, infections, genetic influences as well as congenital malformations. The proximity of the septum can be correlated to changes in the housing of dentition in the naso maxillary complex. Objective: We aim to …

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Examination Of The Bidirectional Relationship Between Anhedonia And Vaporized Cannabis Use In Adolescents: A Longitudinal Cohort Analysis, Cynthia Estrella Ortiz Jan 2023

Examination Of The Bidirectional Relationship Between Anhedonia And Vaporized Cannabis Use In Adolescents: A Longitudinal Cohort Analysis, Cynthia Estrella Ortiz

All ETDs from UAB

Cannabis is the most commonly used illicit substance in the United States, and the prevalence of cannabis use has increased in recent years following changes in. One method that has become increasingly popular among adolescents is vaporized cannabis. Current research appears to be contradictory, whereas some studies indicate that vaporized cannabis use can boost mood, other investigations have indicated that vaporized cannabis use is associated with an increase in depressive symptoms. A limited number of research studies have also identified a relationship between cannabis use and anhedonia, however, this relationship is unclear, particularly among adolescents. Due to the reported adverse …

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Comparing The Efficiency Of Molar Protraction Using Herbsts And Temporary Anchorage Devices, Ishita Zem Taneja Jan 2023

Comparing The Efficiency Of Molar Protraction Using Herbsts And Temporary Anchorage Devices, Ishita Zem Taneja

All ETDs from UAB

Objective: The purpose of this study is twofold. First, to assess the utilization of the Herbst device in mandibular molar protraction. Second, to compare the effectiveness of the protraction Herbst and TADs in patients with congenitally missing mandibular second premolars. Methods: This project was designed as a retrospective study. Orthodontic patients with unilateral or bilateral congenitally missing mandibular premolars, who received the protraction Herbst appliance or TADs as part of their treatment were included in the study. We excluded patients treated with maxillary counterbalancing extractions. Our final patient sample included a total of 33 patients (22 females and 11 males). …

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Strategic Balance In Healthcare Organizations, Corey Spraberry Jan 2023

Strategic Balance In Healthcare Organizations, Corey Spraberry

All ETDs from UAB

The purpose of this dissertation was to assess the relationship between service mix offerings relative to competitors and firm performance. Specifically, this study explores if an optimal point of service offerings in the competitive market is associated with financial performance. This study is important to both researchers and healthcare leaders as it helps understand the relationship between optimal service mix and firm performance. The results find a relationship that suggests a differentiated service mix compared to a generalized service mix is associated with financial performance. Additionally, hospital characteristics are associated with service duplication and differentiation. The findings of this research …

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Increasing Naloxone Access For Persons Who Use Opioids: An Online Recruitment And Training Approach To Opioid Overdose Education And Naloxone Distribution, Michelle L. Sisson Jan 2023

Increasing Naloxone Access For Persons Who Use Opioids: An Online Recruitment And Training Approach To Opioid Overdose Education And Naloxone Distribution, Michelle L. Sisson

All ETDs from UAB

Drug overdose is the primary cause of accidental death in the United States, with a majority of those fatalities involving opioids. Annual rates of fatal opioid overdoses have exponentially increased over the past two decades, leading to the declaration of the current opioid epidemic. The severity of the epidemic has increased due to an upsurge in the use of heroin, synthetic opioids (e.g., fentanyl), and the lacing of other substances with synthetic opioids. As such, federal agencies have made recommendations aimed at combating fatal opioid overdose including the enhancement of naloxone distribution. Administration of naloxone has been expanded from emergency …

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Uncovering The Mental World Of Children: Attachment Quality, Mentalization, And Children’S Drawings, Holly Rosen Jan 2023

Uncovering The Mental World Of Children: Attachment Quality, Mentalization, And Children’S Drawings, Holly Rosen

Selected Full Text Dissertations, 2011-

Although we have long been aware of the widespread benefits of drawing for children (Goodenough, 1926), there is much to learn from a clinical perspective about children’s attachment patterns and mentalization capacities in analyzing their drawings. The present study utilized archival data to uncover trends associated with children’s drawing characteristics, attachment qualities, and mentalization capacities. This study further explored the extent to which mentalization mediates the relationship between attachment quality and Formal Elements (FE) scores as well as the relationship between attachment quality and Content scores of children’s drawings. Two samples of 5–12-year-old children and their caregivers were recruited: one …

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Is The Relationship Between Adverse Childhood Experiences And Adult Belief In Paranormality Moderated By Locus Of Control?, Michelle Alessia Cardone M.S., M.A. Jan 2023

Is The Relationship Between Adverse Childhood Experiences And Adult Belief In Paranormality Moderated By Locus Of Control?, Michelle Alessia Cardone M.S., M.A.

Selected Full Text Dissertations, 2011-

Research has established a relationship between adverse childhood experiences (ACEs) and belief in paranormal phenomena (Lawrence et al., 1994). In the present study, I sought to replicate this finding in more detail by examining seven dimensions of paranormality. Further, the current study investigated whether locus of control moderated the relationship between ACEs and paranormal belief. I hypothesized that ACEs positively correlated with paranormal belief. Further, I hypothesized that the relationship between ACEs and paranormal belief would be moderated by locus of control, such that, the stronger the internal locus of control, the weaker the relationship between ACEs and paranormal belief. …

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Minority Parents And School Choice: A Multiple Case Study, Jeannette M. Boursiquot Jan 2023

Minority Parents And School Choice: A Multiple Case Study, Jeannette M. Boursiquot

Selected Full Text Dissertations, 2011-

Low levels of academic achievement among minority students in U.S. schools continues to be problematic. Although school choice, via enrollment in public charter or private schools, is one strategy that may improve academic achievement among minorities, little is known about how parents of minority students understand and exercise school choice. The purpose of this multiple case study was to explore understandings of school choice among parents with students enrolled in three types of schools: (a) public charter, (b) private, and (c) traditional public. The framework consisted of three theories: bounded rationality, the economic theory of school choice, and critical race …

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Shared Screens: A Qualitative Study Of Therapist Self-Disclosure Over Telehealth, Nathan Fordsham M.S. Jan 2023

Shared Screens: A Qualitative Study Of Therapist Self-Disclosure Over Telehealth, Nathan Fordsham M.S.

Selected Full Text Dissertations, 2011-

The following qualitative study explored how psychodynamic clinicians approach and use self-disclosure with patients over telehealth platforms. There is an abundance of research on therapist self-disclosure, with discussion of this topic dating back as early as Freud (1912) and Ferenczi (1933), and since spanning the spectrum of theoretical orientation and practice. There is some literature on psychotherapy over telehealth, with a recent surge in research as a response to the COVID-19 pandemic. There is less research on psychodynamic therapy or psychoanalysis over telehealth (Wolson, 2021), and to the author’s knowledge, no research on therapist self-disclosure and telehealth. This study aimed …

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The Perceptions Of Teachers Regarding Mindfulness Training As A Means To Foster Growth And Academic Success In The Classroom, Brian T. Nolan Jan 2023

The Perceptions Of Teachers Regarding Mindfulness Training As A Means To Foster Growth And Academic Success In The Classroom, Brian T. Nolan

Selected Full Text Dissertations, 2011-

Mindfulness-based training of educators in our schools is a necessary skill for the success of young children. As a professional educator and a parent of three children, my interest is in exploring this topic and uncovering the why behind student executive functioning skills and the mindfulness-based strategies incorporated into their learning capabilities. As a necessity to learning, students benefit from having self-regulatory abilities in order to tackle the inherent stressors and adversities of their evolving lives. Our schools have steadily become centers of learning in which students are taught fundamental strategies to benefit their scholastic journey. Teachers and school staff …

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Guidance And Support For One-To-One Paraprofessionals: A Multiple Regression Analysis, Amanda A. Agurkis Jan 2023

Guidance And Support For One-To-One Paraprofessionals: A Multiple Regression Analysis, Amanda A. Agurkis

Selected Full Text Dissertations, 2011-

Research has focused on methods to support, train, and prepare one-to-one paraprofessionals from perspectives of administrators and teachers. This quantitative study extended research by investigating perspectives of one-to-one paraprofessionals on preparation, support, communication, feedback, and involvement in planning. These variables were investigated using 20 statements on a Likert-scale survey. Demographic information of participants include age, gender, age level of student, passage of the Assessment of Teaching Assistant Skills (ATAS), years of experience in education, type of class student is in, and professional preparation were surveyed as well. A convenience sample of 50 participants responded to the survey. Pearson’s correlation coefficients …

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Does Perceived Emotional Invalidation Moderate The Relation Between Occupational Stress And Mental Health Outcomes In Law Enforcement Officers?, Sahar Jaafar M.S.; M.A. Jan 2023

Does Perceived Emotional Invalidation Moderate The Relation Between Occupational Stress And Mental Health Outcomes In Law Enforcement Officers?, Sahar Jaafar M.S.; M.A.

Selected Full Text Dissertations, 2011-

Police officers are exposed to operational stressors while on duty, including child abuse, domestic violence, car crashes, and homicides (Jetelina et al., 2020). Repeated exposure to these stressors is associated with the development of mental illness (Jetelina et al., 2020). Organizational stressors, including lack of support/validation, demand, job pressure, administrative/organizational pressure, and long working hours, may be an even greater source of stress for police officers (Purba & Demou, 2019). Exposure to such organizational stressors can result in psychological distress, burnout, and suicidal ideation (Purba & Demou, 2019). However, there is a dearth of research on invalidation and the role …

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Psychologists' Experiences Providing Cognitive-Behavioral Therapy (Cbt) To Children Via Telehealth, Carly Apar M.S. Jan 2023

Psychologists' Experiences Providing Cognitive-Behavioral Therapy (Cbt) To Children Via Telehealth, Carly Apar M.S.

Selected Full Text Dissertations, 2011-

Due to COVID-19, psychologists were forced to rapidly transition to telehealth. While about 1% of American Psychological Association (APA) clinicians used telehealth for most clients pre-pandemic, 92% used telehealth post-pandemic onset (APA, 2020). However, research has not yet thoroughly assessed psychologists’ experiences providing child teletherapy. This study fills that gap by exploring psychologists’ experiences providing virtual child cognitive-behavioral therapy (CBT). This study is important for teletherapy’s potential use for children lacking access to care. Eighteen clinical psychologists who provided CBT to children (ages 7-12) were recruited by sending a flyer to the researcher’s graduate program’s alumni and training sites, child …

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Transgender Family Transitions: A Sibling Perspective, Mariessa Robles M.S. Jan 2023

Transgender Family Transitions: A Sibling Perspective, Mariessa Robles M.S.

Selected Full Text Dissertations, 2011-

As more families are seeking professional help to navigate issues surrounding gender, there is a growing need for clinicians who can assist in the family transition that accompanies an individual’s gender transition process (Coolhart, Ritenour, & Grodzinski, 2018). While family therapy literature is currently expanding to address families with a transgender member, existing psychological thought mostly centers therapeutic focus on the identified transgender individuals and their parents, neglecting the roles and experiences of siblings in this process (Blumer, Green, Knowles, & Williams, 2012). The purpose of this qualitative study was to explore the experiences of those who had a sibling …

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Faculty Perceptions And Beliefs About Utilizing Social Media As A Teaching Tool In Higher Education: A Q Methodology Study, April Robinson Jan 2023

Faculty Perceptions And Beliefs About Utilizing Social Media As A Teaching Tool In Higher Education: A Q Methodology Study, April Robinson

Selected Full Text Dissertations, 2011-

The purpose of this study was to examine college faculty’s perceptions, beliefs, and attitudes concerning the use of social media as a teaching and learning tool, and to determine possible factors that may influence their perceptions, beliefs, and attitudes about social media use in the classroom. For this purpose, Q Methodology which is a mixed-methods approach was used to study the subjectivity of the participant’s perceptions and beliefs objectively. Q methodology systematically can reveal the shared perceptions and beliefs of college faculty. Data were analyzed from 19 teaching faculty in Long Island, New York. This study identified and examined the …

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Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring Jan 2023

Molecular Influences Of Racial Disparities In Pancreatic Neuroendocrine Tumors, Brendon Herring

All ETDs from UAB

Pancreatic Neuroendocrine Tumors (PNETs) are highly heterogeneous neoplasms arising from the hormone-secreting cells of the endocrine pancreas. PNETs are broadly categorized as functional and non-functional based on the presence of symptoms associated with hormone secretion, which occurs in approximately 30% of cases. While functional tumors are all considered for resection because of these symptoms and their associated sequelae, non-functional tumors > 2cm are currently resected based on increased risk of developing metastatic disease. However, this criterion is based on data from predominantly White patients. Recent studies have shown that Black patients have much higher rates of lymph node metastatic disease at …

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Spilling The Tea, Memoir Of A Future's Past: A Scholarly Personal Narrative, Dominique Jerome Hector Jan 2023

Spilling The Tea, Memoir Of A Future's Past: A Scholarly Personal Narrative, Dominique Jerome Hector

All ETDs from UAB

Lesbian, Gay, Bisexual, Transgender, and Questioning (LGBTQ) individuals and topics have been at the precipice of media coverage and policy decisions for decades. With the passage of same sex marriage by the Supreme Court in 2015, this ushered in a new era of unearthing narratives that are unique to LGBTQ+ identities. Although this is a huge advancement for this population here within the United States, scholars have posited how these identities intersecting with other social constructs such as race, gender, socioeconomic status, and social justice have reimaged how LGBTQ+ identities are viewed and treated in the country. Although there is …

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Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap Jan 2023

Optimization Of Progranulin Gene Therapy, A Potential Treatment For Frontotemporal Dementia, Shreya Natesh Kashyap

All ETDs from UAB

Heterozygous loss of function mutations in the progranulin gene cause frontotemporal dementia, characterized by deficits in social behavior, language comprehension and motor function. Almost every frontotemporal dementia-related progranulin mutation is loss of function and results in progranulin haploinsufficiency. For this reason, progranulin replacement is a conceptually straightforward therapeutic strategy for patients with frontotemporal dementia caused by progranulin mutations. Here, we outline progranulin biology, progranulin deficient mouse models of frontotemporal dementia and preclinical interventions centered around increasing brain progranulin levels. We have demonstrated that blocking the progranulin C-terminus, which harbors the sortilin binding site, improves the cross-correctional capacity of neurotropic progranulin …

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Physical Activity And Related Social Cognitive Theory Constructs By Major Depression Status In Persons With Multiple Sclerosis, Catherine Danielle Jones Jan 2023

Physical Activity And Related Social Cognitive Theory Constructs By Major Depression Status In Persons With Multiple Sclerosis, Catherine Danielle Jones

All ETDs from UAB

Major depressive disorder (MDD) is highly prevalent among the 1 million per-sons living with multiple sclerosis (MS) in the United States. The prevalence of MDD is nearly 1.7 times higher in persons with MS than in the general population. MDD is associated with negative outcomes in MS, including worse neuropsychological functioning, lower quality of life (QOL), and worse disability. Higher levels of physical activity (PA) are associated with lower depressive symptoms in MS and participation in moderate to vigorous physical activity (MVPA) has been recommended for managing depression se-verity in the general population. However, the rates, patterns, and behavioral correlates …

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Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones Jan 2023

Genetic And Epigenetic Risk Scores For Chronic Kidney Disease In African Americans, Alana C. Jones

All ETDs from UAB

Kidney disease is the tenth-leading cause of death in the United States (US). There are significant racial disparities within kidney disease: African Americans (AAs) have the highest rates of CKD and carry a four-fold higher risk of developing end-stage renal disease (ESRD). They are also less likely to undergo kidney transplants, and among those who do, are more likely to experience graft rejection. Additionally, until 2021, kidney function equations were shown to underestimate the severity of kidney disease in AA due to the use of race coefficients. Among all populations, genetic and epigenetic factors contribute to kidney disease. However, AAs …

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Understanding Molecular Mechanisms Of Glioblastoama Resistance To Design Novel Combinatorial Therapies, Amber B. Jones Jan 2023

Understanding Molecular Mechanisms Of Glioblastoama Resistance To Design Novel Combinatorial Therapies, Amber B. Jones

All ETDs from UAB

Treatment options for the universally lethal brain tumor, glioblastoma (GBM), are severely limited and often unsuccessful in fully eradicating the disease. Extremely aggressive in nature, GBM cells often implore suppressive mechanisms to evade therapeutic detection which aids in the dismal 15-month median survival rate. Facilitating disease severity and more importantly, disease recurrence, are the immunosuppressive and chemoresistant phenotypes of GBM cells. Specifically, the DNA alkylating agent, temozolomide (TMZ) possesses lymphodepleting properties shunting robust immune cell infiltration into an immunologically cold tumor microenvironment. Additionally, through inherent or acquired mechanisms, GBM tumors commonly become resistant to the DNA damaging effects of TMZ …

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Respiratory Symptoms And Psychological Distress In Farmers Living With Copd, Prasert Kham-Ai Jan 2023

Respiratory Symptoms And Psychological Distress In Farmers Living With Copd, Prasert Kham-Ai

All ETDs from UAB

Farmers are susceptible to both Chronic Obstructive Pulmonary Disease (COPD) and psychological distress. It is known that psychological distress is associated with increased respiratory symptoms and triggers COPD exacerbation. Therefore, farmers who have COPD may experience worsening respiratory symptoms as a result of psychological distress. Since no known studies revealed the association between the frequency of respiratory symptoms and the level of psychological distress among farmers with COPD, this study aimed to explore (1) the frequency of respiratory symptoms and the level of psychological distress, (2) the factors related to increased respiratory symptoms and psychological distress, and (3) the association …

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A Prospective Randomized Clinical Trial To Compare Side Access Mucosal Releasing Incision (Samri) And Sulcular Tunnel Access And Root Coverage Procedures With Coronally Advanced Flap And Acellular Dermal Matrix (Adm) To Treat Teeth With Gingival Recession And Lack Of Adequate Keratinized Tissue. A Pilot Study, Wangsoo Lee Jan 2023

A Prospective Randomized Clinical Trial To Compare Side Access Mucosal Releasing Incision (Samri) And Sulcular Tunnel Access And Root Coverage Procedures With Coronally Advanced Flap And Acellular Dermal Matrix (Adm) To Treat Teeth With Gingival Recession And Lack Of Adequate Keratinized Tissue. A Pilot Study, Wangsoo Lee

All ETDs from UAB

Aims. The aim of this prospective, randomized, blinded, controlled clinical trial was to compare clinical and patient-centered outcomes of Cairo recession type 1 (RT1) gingival recession defects treated with acellular dermal matrix (ADM) grafts and either Side Access Mucosal Releasing Incision (SAMRI) or Sulcular Tunnel Access (STA) techniques with coronal flap advancement (CAF). Methods. 11 patients, 22 surgical procedures and 81 gingival recession defect sites with Cairo RT1 gingival recession and £ 2mm of keratinized tissue at each site were randomly divided into two groups (A: SAMRI, B: STA) and were treated and evaluated for 12 months post-surgically. Clinical measurements …

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The Long Non-Coding Rna Neat1 Mediates Astrocyte Gene Expression And Hippocampus-Dependent Memory In Aging And Alzheimer's Disease, Ashleigh Burns Irwin Jan 2023

The Long Non-Coding Rna Neat1 Mediates Astrocyte Gene Expression And Hippocampus-Dependent Memory In Aging And Alzheimer's Disease, Ashleigh Burns Irwin

All ETDs from UAB

Dysregulation of long non-coding RNAs (lncRNAs) is increasingly associated with cognitive dysfunction and neurodegenerative disorders such as Alzheimer’s disease (AD). The highly evolutionarily conserved lncRNA Nuclear-Enriched Abundant Transcript 1 (NEAT1) is expressed not only in a tissue- and temporally-specific manner, but also celltype specific manner. Despite the predominance of NEAT1 in glial populations, and the significant role astrocytes play in memory, relatively little is known about Neat1 regulation of astrocyte transcriptomics during age-related memory. Here, we report a crucial role of the lncRNA Neat1 in astrocyte dysfunction and memory deficits associated with both normal aging and AD. Expression of Neat1 …

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Unveiling The Molecular Features Of Cancer Health Differences Through Multi-Omics Data Analysis, Fengyuan Huang Jan 2023

Unveiling The Molecular Features Of Cancer Health Differences Through Multi-Omics Data Analysis, Fengyuan Huang

All ETDs from UAB

Understanding the molecular features underlying cancer health differences is crucial for developing effective therapeutic strategies. Multi-omics data analysis, integrating various molecular layers such as genomics, transcriptomics, epigenomics, proteomics, and metabolomics, provides a comprehensive approach to characterize the molecular landscape of cancer differences. By integrating diverse omics data, researchers can identify genetic variations, gene expression patterns, epigenetic modifications, and protein alterations that contribute to differences in cancer progression, and treatment response. These molecular features can serve as potential biomarkers for predicting patient outcomes and guiding personalized treatment strategies. Furthermore, multi-omics data analysis enables the identification of molecular subtypes specific to different …

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Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis Jan 2023

Investigating Scientific Self-Concept In The General Chemistry Laboratory While Performing Course-Based Undergraduate Research Throughout A Pandemic, Josh Forakis

All ETDs from UAB

Climate change, waste management crises, and global pandemics emphasize the need for a thriving science, technology, engineering, and mathematics (STEM) workforce, and one of the jobs of STEM educators is to provide meaningful educational experiences that engage STEM students in scientific practices, broaden their worldview, and prepare them for a future career in the scientific field. Undergraduate research experiences have been shown to benefit STEM students, but few students can participate, especially at early stages in their undergraduate studies. To broaden participation in undergraduate research, an honors general chemistry laboratory course was converted into a course-based undergraduate research experience (CURE) …

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Physical Activity Promotion In Persons Newly Diagnosed With Multiple Sclerosis, Le Thao Trinh Huynh Jan 2023

Physical Activity Promotion In Persons Newly Diagnosed With Multiple Sclerosis, Le Thao Trinh Huynh

All ETDs from UAB

Multiple sclerosis (MS) is a prevalent immune-mediated, neurodegenerative disorder, affecting approximately 1 million people in the United States. MS onset is commonly between 20 and 40 years of age, and persons with MS often live a long life with the disease resulting from the early initiation of disease-modifying therapies and comorbidity-managing approaches. Notably, physical activity is promising for disease modification and symptoms and comorbidity management in MS. Yet, physical activity has been initiated quite late during the disease course. Further, early MS could be a “window of opportunity” for initiating physical activity to maximize its health benefits for symptom management …

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Application Of Machine Learning And Network Approaches To Prioritize Safe And Efficacious Drug Repurposing Candidates, Jennifer L. Fisher Jan 2023

Application Of Machine Learning And Network Approaches To Prioritize Safe And Efficacious Drug Repurposing Candidates, Jennifer L. Fisher

All ETDs from UAB

Only ten percent of drugs in clinical trials are ultimately approved by the Food and Drug Administration (FDA). With many diseases and disorders needing therapeutic options, computational drug repurposing methodologies are great alternatives to some drug discovery methods due to quicker FDA approval and lower cost. We sought to gain insights to improve the identification of drug repurposing candidates that will be safe and effective to increase the success of computational drug repurposing approaches. In regards to identifying safe drug candidates, pharmacovigilance studies of adverse event case reports identified that women are more likely to experience an adverse event, and …

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