Digital Commons Network^™

Telomere Maintenance In African Trypanosomes, Bibo Li Ph.D.

Biological, Geological, and Environmental Faculty Publications

Telomere maintenance is essential for genome integrity and chromosome stability in eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to mask the natural chromosome ends from DNA damage repair machineries and to prevent nucleolytic degradation of the telomeric DNA. In Trypanosoma brucei and several other microbial pathogens, virulence genes involved in antigenic variation, a key pathogenesis mechanism essential for host immune evasion and long-term infections, are located at subtelomeres, and expression and switching of these major surface antigens are regulated by telomere proteins and the telomere structure. Therefore, understanding telomere maintenance mechanisms and how these pathogens achieve …

Biogeochemistry Of Upland To Wetland Soils, Sediments, And Surface Waters Across Mid-Atlantic And Great Lakes Coastal Interfaces, Allison N. Myers-Pigg, Stephanie C. Pennington, Khadijah K. Homolka, Allison M. Lewis, Opal Otenburg, Kaizad F. Patel, Erin K. Eberhard, Amy Marcarelli, Et Al.

Michigan Tech Publications

Transferable and mechanistic understanding of cross-scale interactions is necessary to predict how coastal systems respond to global change. Cohesive datasets across geographically distributed sites can be used to examine how transferable a mechanistic understanding of coastal ecosystem control points is. To address the above research objectives, data were collected by the EXploration of Coastal Hydrobiogeochemistry Across a Network of Gradients and Experiments (EXCHANGE) Consortium – a regionally distributed network of researchers that collaborated on experimental design, methodology, collection, analysis, and publication. The EXCHANGE Consortium collected samples from 52 coastal terrestrial-aquatic interfaces (TAIs) during Fall of 2021. At each TAI, samples …

Occlusive Membranes For Guided Regeneration Of Inflamed Tissue Defects., Woojin Choi, Utkarsh Mangal, Jin-Young Park, Ji-Yeong Kim, Taesuk Jun, Ju Won Jung, Moonhyun Choi, Sungwon Jung, Milae Lee, Ji-Yeong Na, Du Yeol Ryu, Jin Man Kim, Jae-Sung Kwon, Won-Gun Koh, Sangmin Lee, Patrick T J Hwang, Kee-Joon Lee, Ui-Won Jung, Jae-Kook Cha, Sung-Hwan Choi, Jinkee Hong

Henry M. Rowan College of Engineering Departmental Research

Guided bone regeneration aided by the application of occlusive membranes is a promising therapy for diverse inflammatory periodontal diseases. Symbiosis, homeostasis between the host microbiome and cells, occurs in the oral environment under normal, but not pathologic, conditions. Here, we develop a symbiotically integrating occlusive membrane by mimicking the tooth enamel growth or multiple nucleation biomineralization processes. We perform human saliva and in vivo canine experiments to confirm that the symbiotically integrating occlusive membrane induces a symbiotic healing environment. Moreover, we show that the membrane exhibits tractability and enzymatic stability, maintaining the healing space during the entire guided bone regeneration …

Effect Of Menstrual Cycle And Contraceptive Pill Phase On Aspects Of Exercise Physiology And Athletic Performance In Female Athletes: Protocol For The, Kirsty J Elliott Sale, Tessa R Flood, Shawn M Arent, Eimear Dolan, Bryan Saunders, Mette Hansen, Johanna K Ihalainen, Ritva S Mikkonen, Clare Minahan, Jane S Thornton, Kathryn E Ackerman, Constance M Lebrun, Craig Sale, Trent Stellingwerff, Paul A Swinton, Anthony C Hackney

Family Medicine Publications

The idiom 'more high-quality research is needed' has become the slogan for sport and exercise physiology-based research in female athletes. However, in most instances, it is challenging to address this gap of high-quality research in elite female athletes at a single study site due to challenges in recruiting enough participants with numerous menstrual cycle and contraceptive pill permutations. Accordingly, we have assembled an international multisite team to undertake an innovative project for female athletes, which investigates the effects of changes in endogenous and exogenous oestrogen and progesterone/progestins across the menstrual cycle and in response to second-generation combined monophasic contraceptive …

Performance Analysis Of Emg Signal Classification Methods For Hand Gesture Recognition In Stroke Rehabilitation, Anggun Winursito, Fatchul Arifin, Muslikhin Muslikhin, Herjuna Artanto, Femilia Hardina Caryn

Elinvo (Electronics, Informatics, and Vocational Education)

This study evaluates the performance of different classification methods in classifying healthy individuals and stroke patients. The hand gesture variations of the subjects were also analyzed based on electromyography (EMG) signals. Several classification methods were tested in this analysis to find out which method had the most suitable performance. The results showed that Decision Tree and Naive Bayes classifiers achieved the highest performance in classifying EMG signals from healthy individuals and stroke patients, with both methods showing high accuracy, precision, recall, and F1 score. Specifically, Decision Tree excelled in overall accuracy and recall, while Naive Bayes showed superior precision. For …

Innovation Process And Industrial System Of Us Food And Drug Administration-Approved Software As A Medical Device: Review And Content Analysis, Jiakan Yu, Jiajie Zhang, Shintaro Sengoku

Faculty, Staff and Student Publications

BACKGROUND: There has been a surge in academic and business interest in software as a medical device (SaMD). SaMD enables medical professionals to streamline existing medical practices and make innovative medical processes such as digital therapeutics a reality. Furthermore, SaMD is a billion-dollar market. However, SaMD is not clearly understood as a technological change and emerging industry.

OBJECTIVE: This study aims to review the landscape of SaMD in response to increasing interest in SaMD within health systems and regulation. The objectives of the study are to (1) clarify the innovation process of SaMD, (2) identify the prevailing typology of such …

Adverse Childhood Experiences And Sports Participation Among Lesbian, Gay, And Bisexual Adolescents, Robert John O'Brien

Walden Dissertations and Doctoral Studies

No abstract provided.

Barriers To Mental Health Services For Immigrant Latinx Clients, Cristin Rene Martinez

Walden Dissertations and Doctoral Studies

No abstract provided.

Evaluating 17 Methods Incorporating Biological Function With Gwas Summary Statistics To Accelerate Discovery Demonstrates A Tradeoff Between High Sensitivity And High Positive Predictive Value, Amy Moore, Jesse A Marks, Bryan C Quach, Yuelong Guo, Laura J Bierut, Nathan C Gaddis, Dana B Hancock, Grier P Page, Eric O Johnson

2020-Current year OA Pubs

Where sufficiently large genome-wide association study (GWAS) samples are not currently available or feasible, methods that leverage increasing knowledge of the biological function of variants may illuminate discoveries without increasing sample size. We comprehensively evaluated 17 functional weighting methods for identifying novel associations. We assessed the performance of these methods using published results from multiple GWAS waves across each of five complex traits. Although no method achieved both high sensitivity and positive predictive value (PPV) for any trait, a subset of methods utilizing pleiotropy and expression quantitative trait loci nominated variants with high PPV (>75%) for multiple traits. Application …

Dynamical Control Enables The Formation Of Demixed Biomolecular Condensates, Andrew Z Lin, Kiersten M Ruff, Furqan Dar, Ameya Jalihal, Matthew R King, Jared M Lalmansingh, Ammon E Posey, Nadia A Erkamp, Ian Seim, Amy S Gladfelter, Rohit V Pappu

2020-Current year OA Pubs

Cellular matter can be organized into compositionally distinct biomolecular condensates. For example, in Ashbya gossypii, the RNA-binding protein Whi3 forms distinct condensates with different RNA molecules. Using criteria derived from a physical framework for explaining how compositionally distinct condensates can form spontaneously via thermodynamic considerations, we find that condensates in vitro form mainly via heterotypic interactions in binary mixtures of Whi3 and RNA. However, within these condensates, RNA molecules become dynamically arrested. As a result, in ternary systems, simultaneous additions of Whi3 and pairs of distinct RNA molecules lead to well-mixed condensates, whereas delayed addition of an RNA component results …

Genetic Separation Of Brca1 Functions Reveal Mutation-Dependent Polθ Vulnerabilities, John J Krais, Et Al.

2020-Current year OA Pubs

Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be synthetic lethal with Polθ, but whether distinct HR gene mutations give rise to equivalent Polθ-dependence, and the events that drive lethality, are unclear. In this study, we utilized mouse models with separate Brca1 functional defects to mechanistically define Brca1-Polθ synthetic lethality. Surprisingly, homozygous Brca1 mutant, Polq

Association Between The Introduction Of A National Targeted Intervention Program And The Incidence Of Surgical Site Infections In Swiss Acute Care Hospitals, Marcus Eder, Rami Sommerstein, Arlette Szelecsenyi, Alexander Schweiger, Matthias Schlegel, Andrew Atkinson, Stefan P Kuster, Danielle Vuichard-Gysin, Nicolas Troillet, Andreas F Widmer, For Swissnoso

2020-Current year OA Pubs

BACKGROUND: In Switzerland, the national surgical site infection (SSI) surveillance program showed a modest decrease in SSI rates for different procedures over the last decade. The study aimed to determine whether a multimodal, targeted intervention program in addition to existing SSI surveillance is associated with decreased SSI rates in the participating hospitals.

METHODS: Prospective multicenter pre- and postintervention study conducted in eight Swiss acute care hospitals between 2013 and 2020. All consecutive patients > 18 years undergoing cardiac, colon, or hip/knee replacement surgery were included. The follow-up period was 30 days and one year for implant-related surgery. Patients with at least …

Echo Brings Joy To Over 200 Children At Christmas, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

A partnership with Giving Angels allows University of Dayton staff members to help families in need put presents under the Christmas tree this time of year.

Teaching Chinese Politics In The “New Cold War”: A Survey Of Faculty, Sara A. Newland

Government: Faculty Publications

How have worsening US-China relations affected faculty teaching Chinese politics in the US? This paper presents results from a 2022 survey of political science faculty. While student interest in Chinese politics remains high, faculty report a range of new challenges arising from increasingly nationalistic sentiments among both Chinese and American students, negative effects of both US and Chinese government policies, and an increase in anti-Asian bias. This article documents faculty experiences teaching Chinese politics, and offers recommendations for addressing common challenges.

Effect Of Menstrual Cycle And Contraceptive Pill Phase On Aspects Of Exercise Physiology And Athletic Performance In Female Athletes: Protocol For The Feminae International Multisite Innovative Project, Kirsty J. Elliott Sale, Tessa R. Flood, Shawn M. Arent Ph.D., Cscs*D, Fissn, Facsm, Fnak, Eimear Dolan, Bryan Saunders, Mette Hansen, Johanna K. Ihalainen, Ritva S. Mikkonen, Clare Minahan, Jane S. Thornton, Kathryn E. Ackerman, Constance M. Lebrun, Craig Sale, Trent Stellingwerff, Paul A. Swinton, Anthony C. Hackney

Faculty Publications

The idiom € more high-quality research is needed' has become the slogan for sport and exercise physiology-based research in female athletes. However, in most instances, it is challenging to address this gap of high-quality research in elite female athletes at a single study site due to challenges in recruiting enough participants with numerous menstrual cycle and contraceptive pill permutations. Accordingly, we have assembled an international multisite team to undertake an innovative project for female athletes, which investigates the effects of changes in endogenous and exogenous oestrogen and progesterone/progestins across the menstrual cycle and in response to second-generation combined monophasic contraceptive …

2023-November-24-Yao Named Quillen College Of Medicine’S Dishner Chair Of Excellence.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

Dr. Zhi Q. Yao, division chief of research and director of East Tennessee State University’s Center of Excellence in HIV/AIDS in the Quillen College of Medicine, has been named the college’s Paul Dishner Chair of Excellence in Medicine.

Established in 1989, the primary focus of the Dishner Chair of Excellence in Medicine is to enhance research efforts in the Quillen College of Medicine.

He is well-suited for the task.

During his time at ETSU, Yao has brought more than $10 million in grant funding for his research either as the principal or co-principal investigator on numerous research projects and …

An Experimental Approach To Identify Lifestyle Indicators In Diabetic Patients’ Daily Episodic Notes Using Umls And Nlp With Reduced Ambiguity, Adib Ahmed Anik

Master's Theses (2009 -)

The objective of this master’s thesis is to utilize daily episode notes obtained from users in order to develop a lifestyle indicator through the application of natural language processing (NLP) techniques. The primary objective is to enhance the precision of this indicator by reducing its level of ambiguity. In order to achieve this objective, the present work undertakes a comprehensive examination of conversational agents, specifically focusing on social media data that has been annotated with content pertaining to diabetes. The study uses a variety of NLP methodologies to establish a correlation between the subject matter of these discussions and medical …

Tracking Formation Changes And Its Effects On Soccer Using Position Data, Jinho Kim

Master's Theses (2009 -)

This study investigated the application of advanced machine learning methods, specifically k-means clustering, k-Nearest Neighbors (kNN), and Support Vector Machines (SVM), to analyze player tracking data in soccer. The primary hypothesis posits that such data can yield a standalone, in-depth understanding of soccer matches. The study revealed that while k-means and spatial analysis are promising in analyzing player positions, kNN and SVM show limitations without additional variables. Spatial analysis examined each team’s convex hull and studied the correlation between team length, width, and surface area. Results showed team length and surface area have a strong positive correlation with a value …

Improving Self-Management In Patients With Diabetes: A Staff Education Project, Tanja Ganues

Walden Dissertations and Doctoral Studies

No abstract provided.

Atherogenic Index Of Plasma’S Association With Cardiovascular Disease Risk Factors Among Postmenopausal Pakistani Women, Amad Wafa Khan

Walden Dissertations and Doctoral Studies

No abstract provided.

The Effect Of Caregiver Communication On Self-Care Outcomes For African Americans With Heart Failure, Adrienne Michelle Johnson

Walden Dissertations and Doctoral Studies

No abstract provided.

The Effect Of A Disaster Medical Assistance Team On The Medical Surge Objectives For Hospitals Affected By A Mass Casualty Incident, Gary White

Walden Dissertations and Doctoral Studies

No abstract provided.

Family Members' Perceptions Of Elder Abuse At U.S. Nursing Homes, Philomena Nkem Onoyona

Walden Dissertations and Doctoral Studies

No abstract provided.

Introduction To The Symposium: China And The Campus, Sara A. Newland

Government: Faculty Publications

The US-China relationship has worsened dramatically in recent years. After decades of pro-engagement policies toward China, a bipartisan consensus began to emerge around 2016 that engagement had neither accomplished US policy goals (such as encouraging China to liberalize politically) nor served US citizens well.1 At the same time, political changes within China have pointed to a declining appetite for engagement with the United States and sidelined the domestic constituencies who remained interested in cooperation and exchange. Further restrictions have shrunk the already limited space for media, civil society groups, and academic exchange in China. Pandemic-related border closures eliminated in-person exchanges …

Imprisoned By Algorithms: Risk Assessment Instruments And Predictive Sentencing In The Criminal Legal System, Thomas Johnson

Master's Theses (2009 -)

Tools for predicting an individual’s risk of recidivism are implemented throughout the criminal legal system, from informing decisions about release pretrial to identifying appropriate treatment plans for successful reentry. Data-driven risk assessment is increasingly being incorporated during sentencing proceedings across the United States. There is significant variation across jurisdictions in how these tools are constructed and what they aim to predict. The use of algorithmic risk assessment at sentencing is hotly contested due to concerns over the opacity of algorithms developed by private corporations, the potential for perpetuating disparities present in the criminal legal system, and violations of the constitutional …

Genetic Separation Of Brca1 Functions Reveal Mutation-Dependent Polθ Vulnerabilities, John J. Krais, David J. Glass, Ilse Chudoba, Yifan Wang, Wanjuan Feng, Dennis Simpson, Pooja Patel, Zemin Liu, Ryan Neumann-Domer, Robert G. Betsch, Andrea J. Bernhardy, Alice M. Bradbury, Jason Conger, Wei-Ting Yueh, Joseph Nacson, Richard T. Pomerantz, Gaorav P. Gupta, Joseph R. Testa, Neil Johnson

Department of Biochemistry and Molecular Biology Faculty Papers

Homologous recombination (HR)-deficiency induces a dependency on DNA polymerase theta (Polθ/Polq)-mediated end joining, and Polθ inhibitors (Polθi) are in development for cancer therapy. BRCA1 and BRCA2 deficient cells are thought to be synthetic lethal with Polθ, but whether distinct HR gene mutations give rise to equivalent Polθ-dependence, and the events that drive lethality, are unclear. In this study, we utilized mouse models with separate Brca1 functional defects to mechanistically define Brca1-Polθ synthetic lethality. Surprisingly, homozygous Brca1 mutant, Polq−/− cells were viable, but grew slowly and had chromosomal instability. Brca1 mutant cells proficient in DNA end resection were …

321 Bay Ridge Company Inc. V. Cordova

All Decisions

This holdover proceeding, settled in February 2023, involved allegations of substantial breaches of the rent-stabilized tenancy. The settlement stipulation outlined payment agreements, including sums owed and deadlines. However, an amount provisionally approved for payment by ERAP was not accepted by the landlord, resulting in waiver. The court, guided by principles of strict construction, denied the landlord's motion to restore the case to the calendar, as the settlement stipulation did not specify any relief upon restoration.

Exploring Alternative Treatment Choices For Multidrug-Resistant Clinical Strains Of Helicobacter Pylori In Mongolia, Ayush Khangai, Batsaikhan Saruuljavkhlan, Dashdorj Azzaya, Boldbaatar Gantuya, Khasag Oyuntsetseg, Junko Akada, Takashi Matsumoto, Yoshio Yamaoka

Faculty, Staff and Students Publications

Helicobacter pylori is a pathogen related to severe diseases such as gastric cancer; because of rising antimicrobial-resistant strains, failure to eradicate H. pylori with antibiotics has increased worldwide. Multidrug-resistant H. pylori and gastric cancer is common in Mongolia; therefore, we aimed to explore alternative antimicrobial treatments and the genomes of resistant strains in this country. A total of 361 H. pylori strains isolated from patients in Mongolia were considered. Minimal inhibitory concentrations for two fluoroquinolones (ciprofloxacin and moxifloxacin), rifabutin, and furazolidone were determined via two-fold agar dilution. Genomic mutations in antibiotic-resistant strains were identified by next-generation sequencing using the Illumina …

Top Tips On Staying Up To Date In Primary Care, L Burns, E Mccoll

Peninsula Dental School

No abstract provided.

Assessing Medication Self-Management Challenges And Self-Efficacy During Emergency Department Medication Reconciliation: An Evidence-Based Quality Improvement Project, Mitchel Erickson, Jyu-Lin Chen, Yoonmee Joo, Stephanie Rogers, Thomas Hoffman, Claire Bainbridge

Journal of Geriatric Emergency Medicine

Abstract

Background

Older adult patients (≥65) accessing emergency departments (ED) represent a significant demographic. Recidivism secondary to adverse drug events (ADE) ranges between 6-24% and levels of prescribed medication non-adherence is common among older adults. The ED pharmacist medication reconciliation workflow may mitigate self-management challenges in real time and reduce medication-related harm while potentially impacting recidivism, medication adherence, and patient self-efficacy. The purposes of this evidence-based project were to (1) evaluate the impact of a modified Medication Management for Deficiencies in the Elderly (MedMalDE) intervention on Self-Efficacy for Appropriate Medication Use (SEAMS) and 30-day return to care and (2) identify …