Digital Commons Network^™

How Covid-19 And Racial Justice Protests Influenced Social Workers’ Perceptions Of Policy And Political Participation, Amy Krings, Maria V. Wathen, Teresa Kilbane

Social Work: School of Social Work Faculty Publications and Other Works

Drawing on political opportunity theory, this study examined how the political context created by the COVID-19 pandemic and Black Lives Matter protests influenced social workers’ perceptions about social welfare policy and political participation in the summer of 2020. Authors conducted a thematic analysis of the open-ended survey responses of 120 social work practitioners. Regarding perceptions of policy, respondents reported that they experienced new awareness about the breadth and depth of structural racism in the United States; that they held pessimistic views of the government’s ability to mitigate harm associated with the pandemic or racial injustice; and that structural change, including …

Targeted Gene Expression Profiling Predicts Meningioma Outcomes And Radiotherapy Responses, William C Chen, Abrar Choudhury, Mark W Youngblood, Mei-Yin C Polley, Calixto-Hope G Lucas, Kanish Mirchia, Sybren L N Maas, Abigail K Suwala, Minhee Won, James C Bayley, Akdes S Harmanci, Arif O Harmanci, Tiemo J Klisch, Minh P Nguyen, Harish N Vasudevan, Kathleen Mccortney, Theresa J Yu, Varun Bhave, Tai-Chung Lam, Jenny Kan-Suen Pu, Lai-Fung Li, Gilberto Ka-Kit Leung, Jason W Chan, Haley K Perlow, Joshua D Palmer, Christine Haberler, Anna S Berghoff, Matthias Preusser, Theodore P Nicolaides, Christian Mawrin, Sameer Agnihotri, Adam Resnick, Brian R Rood, Jessica Chew, Jacob S Young, Lauren Boreta, Steve E Braunstein, Jessica Schulte, Nicholas Butowski, Sandro Santagata, David Spetzler, Nancy Ann Oberheim Bush, Javier E Villanueva-Meyer, James P Chandler, David A Solomon, C Leland Rogers, Stephanie L Pugh, Minesh P Mehta, Penny K Sneed, Mitchel S Berger, Craig M Horbinski, Michael W Mcdermott, Arie Perry, Wenya Linda Bi, Akash J Patel, Felix Sahm, Stephen T Magill, David R Raleigh

Faculty, Staff and Student Publications

Surgery is the mainstay of treatment for meningioma, the most common primary intracranial tumor, but improvements in meningioma risk stratification are needed and indications for postoperative radiotherapy are controversial. Here we develop a targeted gene expression biomarker that predicts meningioma outcomes and radiotherapy responses. Using a discovery cohort of 173 meningiomas, we developed a 34-gene expression risk score and performed clinical and analytical validation of this biomarker on independent meningiomas from 12 institutions across 3 continents (N = 1,856), including 103 meningiomas from a prospective clinical trial. The gene expression biomarker improved discrimination of outcomes compared with all other systems …

Encapsulating Holistic Intercultural Competence Development In Higher Education: A Literature Review On Assessments And Competencies, Constantina Rokos, Svetlana N. Khapova, Marcus Laumann

Journal of Comparative & International Higher Education

No abstract provided.

Greening The Cement Industry In Egypt: Exploring Decarbonisation Policies For The Cement Industry, Saleh Elghamrawi

Theses and Dissertations

The cement industry is a major contributor to global greenhouse gas emissions, accounting for approximately 7% of carbon dioxide (CO2) emissions. Cement is the most consumed material on earth, second only to water, and its demand is fueled by continuous urbanization and the lack of alternative materials. In Egypt, the cement sector is responsible for 14% of CO2 emissions, emitting over 800 kilograms of CO2 per ton of cement, surpassing the global average of 600. In 2016, Egypt ratified the Paris agreement to address climate change and has committed in its National Determined Contributions (NDC) to reduce CO2 emissions. However, …

Examining The Conditions Affecting The Success Of Income-Generating Activities By Refugees: A Focus On Programs Provided By Ingos In Egypt., Wesal Elkorashy

Theses and Dissertations

With the global decline in resettlement opportunities for refugees in the so-called Global North, many displaced populations are hosted in the Global South. The shift towards first asylum and transit countries often places them in environments where economic stability is often elusive, coupled with legal, social, and cultural barriers. In this challenging situation, addressing refugees' economic lives resilience, and their contribution in the overall economy of host countries becomes increasingly urgent. This is intrinsically linked to the support provided by humanitarian organizations, particularly INGOs, which play a pivotal role in implementing economic programs aimed at increasing refugees’ engagement in the …

Eeg Classification While Listening To Murottal Al-Quran And Classical Music Using Random Forest Method, Heni Sumarti, Fahira Septiani, Agus Sudarmanto, Wahyu Caesarendra, Rizki Edmi Edison

Knowledge Engineering and Data Science

This study is aimed to classify the brain activity of adolescents associated with audio stimuli; murottal Al-Quran and classical music. The raw data were filtered using Independent Component Analisys (ICA) and followed by band-pass filter in Python on the Google Colab Extraction was processed with Power Spectral Density (PSD) and the Random Forest Method in Weka Machine Learning was used for classification. The research results showed the same results between the two types of stimulation, namely the order of brain waves from highest to lowest were delta, alpha, theta and beta. The average brain waves of teenagers when given murottal …

Social Costs Of Dobbs' Pro-Adoption Agenda, Malinda L. Seymore

Faculty Scholarship

Abortion opponents have long claimed that women denied access to abortion can simply give their children up for adoption. Justice Alito repeated this argument in Dobbs v. Jackson Women’s Health. Of course, this claim assumes away the burdens of the pregnancy itself, which can result in economic strife, domestic violence, health risks, and potentially death in childbirth. But even on its own terms, the argument that adoption is an adequate substitute for abortion access makes normative assumptions about adoption as a social good in and of itself, ignoring the social costs of adoption for birth parents and adoptees. Idealizing adoption …

A Public Technology Option, Hannah Bloch-Wehba

Faculty Scholarship

Private technology increasingly underpins public governance. But the state’s growing reliance on private firms to provide a variety of complex technological products and services for public purposes brings significant costs for transparency: new forms of governance are becoming less visible and less amenable to democratic control. Transparency obligations initially designed for public agencies are a poor fit for private vendors that adhere to a very different set of expectations.

Aligning the use of technology in public governance with democratic values calls for rethinking, and in some cases abandoning, the legal structures and doctrinal commitments that insulate private vendors from meaningful …

Swimming Together Upstream: How To Align Mlp Services With U.S. Healthcare Delivery, William M. Sage, Keegan D. Warren

Faculty Scholarship

Medical-legal partnership (MLP) embeds attorneys and paralegals into care delivery to help clinicians address root causes of health inequities. Notwithstanding decades of favorable outcomes, MLP is not as well-known as might be expected. In this essay, the authors explore ways in which strategic alignment of legal services with healthcare services in terms of professionalism, information collection and sharing, and financing might help the MLP movement become a more widespread, sustainable model for holistic care delivery.

Demystifying The Panorama Of Electoral Violence In Nigeria: Exploring Education And E-Library Resources As Antidotes, Grace Ogechukwu Ugwonna, Phd, Chizoba Jovita Akudike, Josephine Ngozi Morah, Anthony Chikadibia Ugwonna

Library Philosophy and Practice (e-journal)

The incidence of electoral violence in Nigeria and the involvement of youth, has remained a threat to the survival of Democracy. Given the damaging impact it has on the socioeconomic, cultural, religious, and political lives of the people and its threat to human existence, scholars have continued to explore ways of dealing with the enigma. This study therefore sought to ascertain the extent to which Civic education and voter education are relevant in curbing electoral violence among the youth and the extent of using e-library resources by the youth to access political information. This research effort was driven by the …

Severe Group A Streptococcus Infections Among Pediatric Patients In The Lehigh Valley, Pennsylvania Following The Covid-19 Pandemic, Stormie Gough Do, Jonathan T. Berback Mph, Cic, Tibisay Villalobos Md

Department of Pediatrics

No abstract provided.

Initial Experience Of Smartphone-Based Ai-Generated Uroflowmetry In Post-Holep Patients, James Johannes Md, Alexis R. Brown Pa-C, Jaylon Hartley Pa-C

Department of Medicine

No abstract provided.

Sensory Stimulation Protocol For The Complex Acute Cva Patient: A Case Report, Caitlin Costanzo Pt, Dpt, Aubrey Schmidt Ms Otr/L, Csrs, Chelsea Shade Otd, Otr/L, Cns, Cbis

Department of Medicine

No abstract provided.

A Project To Decrease Blood Utilization In A Hospital Network, Matthew D. Painter Md, Warren Behr Mba, Timothy J. Harrison Do, Ms, Elsie S. Lee Md, Mark Cipolle Md

Department of Surgery

No abstract provided.

Admission Guideline For Acute Tbi Patients At A Level Iii Trauma Center Without Neurosurgery Who Would Have Otherwise Been Transferred To A Level I Or Ii Trauma Center, Alexandra Evans Bsn, Rn, Tcrn, Daniel Roesler Md, Kimberlee Hettel Bsn, Mary Ann Devine Md, Mark Cipolle Md

Department of Surgery

No abstract provided.

Under Pressure: Medsurg Initiatives For Pressure Ulcer Reduction, Julia Cheng, Joseph J. Stirparo Md, Kathryn L Wheel Md, Bree A. Harrison Bsn, Rn, Tcrn, Emily Bear Bsn, Rn, Ccrn, Tcrn, Jaclyn Sharkazy Pa-C, Mspas, Heather Faust Msn, Rn, Cmsrn

Department of Surgery

No abstract provided.

Surviving A Mass Casualty Event In A Rural Trauma Center, Carol Fox Rn, Bsn, Ccrn, Melanie Bowman Msn, Rn Tcrn

Department of Surgery

No abstract provided.

One Team: Integrating Quality, Registry And Clinical Care Through The Electronic Health Medical Record, Julia Cheng, Joseph J. Stirparo Md, Kathryn L Wheel Md, Bree A. Harrison Bsn, Rn, Tcrn, Emily Bear Bsn, Rn, Ccrn, Tcrn, Jaclyn Sharkazy Pa-C, Mspas, Jacquelynn Knight Emt-B

Department of Surgery

No abstract provided.

To Transfer Or Not To Transfer: A Cost And Resource Savings Plan, Kristin Oller Do, Nathan Miller Ms, Rovinder S. Sandhu Md, Mark Cipolle Md, Michael Steven Farrell Md, Ms

Department of Surgery

No abstract provided.

Characteristics Of Breast Cancer In Carriers Of Pathogenic Variant In Atm In A Large Academic Health Center, Ujjwal Karki, Tara Rangarajan, Dana Zakalik

Conference Presentation Abstracts

Background: Pathogenic variants (PVs) in ATM are associated with an increased risk of breast, pancreas, and other cancers. The clinical and pathological characteristics of ATM-associated breast cancers have not been well defined. Methods: Patients who underwent multigene panel testing between December 2012 and May 2023 and were identified to harbor ATM PVs were included in the study. We analyzed demographics, germline findings, histopathology, genomic recurrence score, and management of ATM PV carriers with breast cancer. Results: A total of 222 individuals were identified to have PVs in ATM, of whom 184 (83%) were female. The majority were Caucasian (n = …

Circulating Pre-Treatment T-Cell Receptor Repertoire As A Predictive Biomarker In Advanced Or Metastatic Non-Small-Cell Lung Cancer Patients Treated With Pembrolizumab Alone Or In Combination With Chemotherapy, A. Abed, Aaron B. Beasley, Anna L. Reid, N. Law, L. Calapre, M. Millward, Johnny Lo, Elin S. Gray

Research outputs 2022 to 2026

Background: The circulating T-cell receptor (TCR) repertoire is a dynamic representation of overall immune responses in an individual. Materials and methods: We prospectively collected baseline blood from patients treated with first-line pembrolizumab monotherapy or in combination with chemotherapy. TCR repertoire metrics were correlated with clinical benefit rate (CBR), progression-free survival (PFS), overall survival (OS) and immune-related adverse events (irAEs). We built a logistic regression classifier by fitting all four TCR- repertoire metrics to the immune checkpoint inhibitor (ICI) CBR data. In the subsequent receiver operating characteristic (ROC) analysis of the resulting logistic regression model probabilities, the best cut-off value was …

Quality Assessment Of Hydroquinone, Mercury, And Arsenic In Skin-Lightening Cosmetics Marketed In Ilorin, Nigeria, Olasunkanmi David Bamidele, Blessing A. Kayode, Oluwasegun I. Eniayewu, Adebanjo J. Adegbola, Raphael S. Olatoye, Ngaitad S. Njinga, Sa’Ad T. Abdullahi, Moji T. Bakare-Odunola

Research outputs 2022 to 2026

Hydroquinone, Mercury (Hg), and Arsenic (As) are hazardous to health upon long-term exposure. Hydroquinone, Hg, and As were analysed in skin-lightening cosmetics randomly purchased from different cosmetic outlets within the Ilorin metropolis, Nigeria. The amount of hydroquinone in the samples was determined using a UV-spectrophotometry method at 290 nm. Hg and As were quantified using atomic absorption spectrophotometry (AAS). UV-spectrophotometry method validation showed excellent linearity (r2 = 0.9993), with limits of detection (0.75 g/mL), limits of quantification (2.28 g/mL), relative standard deviation (0.01–0.35%), and recovery (95.85–103.56%) in the concentration range of 5–50 g/mL. Similarly, r2, LOD, and LOQ for Hg …

Leveraging Igg N-Glycosylation To Infer The Causality Between T2d And Hypertension, Haotian Wang, Yuan Li, Weijie Cao, Jie Zhang, Mingyang Cao, Xiaoni Meng, Di Liu, Youxin Wang

Research outputs 2022 to 2026

Background: Observational studies demonstrated a bidirectional association between type 2 diabetes (T2D) and hypertension, whereas Mendelian randomization (MR) analyses supported the causality from T2D to hypertension but not causal from hypertension to T2D. We previously found that IgG N-glycosylation is associated with both T2D and hypertension, and thus IgG N-glycosylation might link the causality between them. Methods: We carried out a genome-wide association study (GWAS) to identify IgG N-glycosylation-quantitative-trait loci (QTLs) integrating GWAS for T2D and hypertension and then performed bidirectional univariable and multivariable MR analyses to infer the causal association among them. The inverse-variance-weighted (IVW) analysis was performed as …

Effects Of Exercise Training On Muscle Quality In Older Individuals: A Systematic Scoping Review With Meta-Analyses, Tibor Hortobágyi, Tomas Vetrovsky, Jennifer S. Brach, Martijn Van Haren, Krystof Volesky, Regis Radaelli, Pedro Lopez, Urs Granacher

Research outputs 2022 to 2026

Background: The quantity and quality of skeletal muscle are important determinants of daily function and metabolic health. Various forms of physical exercise can improve muscle function, but this effect can be inconsistent and has not been systematically examined across the health-neurological disease continuum. The purpose of this systematic scoping review with meta-analyses was to determine the effects and potential moderators of exercise training on morphological and neuromuscular muscle quality (MMQ, NMQ) in healthy older individuals. In addition and in the form of a scoping review, we examined the effects of exercise training on NMQ and MMQ in individuals with neurological …

Frailty And Pain In An Acute Private Hospital: An Observational Point Prevalence Study, Rosemary Saunders, Kate Crookes, Karla Seaman, Seng Giap Marcus Ang, Caroline Bulsara, Max K. Bulsara, Beverley Ewens, Olivia Gallagher, Renée Graham, Karen Gullick, Sue Haydon, Jeff Hughes, Kim-Huong Nguyen, Bev O’Connell, Debra Scaini, Christopher Etherton-Beer

Research outputs 2022 to 2026

Frailty and pain in hospitalised patients are associated with adverse clinical outcomes. However, there is limited data on the associations between frailty and pain in this group of patients. Understanding the prevalence, distribution and interaction of frailty and pain in hospitals will help to determine the magnitude of this association and assist health care professionals to target interventions and develop resources to improve patient outcomes. This study reports the point prevalence concurrence of frailty and pain in adult patients in an acute hospital. A point prevalence, observational study of frailty and pain was conducted. All adult inpatients (excluding high dependency …

Type 2 Diabetes Modifies The Association Of Cad Genomic Risk Variants With Subclinical Atherosclerosis, Natalie R Hasbani, Kenneth E Westerman, Soo Heon Kwak, Han Chen, Xihao Li, Daniel Di Corpo, Jennifer Wessel, Joshua C Bis, Chloè Sarnowski, Peitao Wu, Lawrence F Bielak, Xiuqing Guo, Nancy Heard-Costa, Gregory L Kinney, Michael C Mahaney, May E Montasser, Nicholette D Palmer, Laura M Raffield, James G Terry, Lisa R Yanek, Jessica Bon, Donald W Bowden, Jennifer A Brody, Ravindranath Duggirala, David R Jacobs, Rita R Kalyani, Leslie A Lange, Braxton D Mitchell, Jennifer A Smith, Kent D Taylor, April P Carson, Joanne E Curran, Myriam Fornage, Barry I Freedman, Stacey Gabriel, Richard A Gibbs, Namrata Gupta, Sharon L R Kardia, Brian G Kral, Zeineen Momin, Anne B Newman, Wendy S Post, Karine A Viaud-Martinez, Kendra A Young, Lewis C Becker, Alain G Bertoni, John Blangero, John J Carr, Katherine Pratte, Bruce M Psaty, Stephen S Rich, Joseph C Wu, Rajeev Malhotra, Patricia A Peyser, Alanna C Morrison, Ramachandran S Vasan, Xihong Lin, Jerome I Rotter, James B Meigs, Alisa K Manning, Paul S De Vries

Faculty, Staff and Student Publications

BACKGROUND: Individuals with type 2 diabetes (T2D) have an increased risk of coronary artery disease (CAD), but questions remain about the underlying pathology. Identifying which CAD loci are modified by T2D in the development of subclinical atherosclerosis (coronary artery calcification [CAC], carotid intima-media thickness, or carotid plaque) may improve our understanding of the mechanisms leading to the increased CAD in T2D.

METHODS: We compared the common and rare variant associations of known CAD loci from the literature on CAC, carotid intima-media thickness, and carotid plaque in up to 29 670 participants, including up to 24 157 normoglycemic controls and 5513 …

What Can The Plasma Proteome Tell Us About Platelets And (Vice Versa)?, Steven Bruzek, Marisol Betensky, Jorge Di Paola, Thomas Diacovo, Neil Goldenberg, Vera Ignjatovic

2020-Current year OA Pubs

Multi-omics approaches are being used increasingly to study physiological and pathophysiologic processes. Proteomics specifically focuses on the study of proteins as functional elements and key contributors to, and markers of the phenotype, as well as targets for diagnostic and therapeutic approaches. Depending on the condition, the plasma proteome can mirror the platelet proteome, and hence play an important role in elucidating both physiologic and pathologic processes. In fact, both plasma and platelet protein signatures have been shown to be important in the setting of thrombosis-prone disease states such as atherosclerosis and cancer. Plasma and platelet proteomes are increasingly being studied …

Normalization Of Drug And Therapeutic Concepts With Thera-Py, Matthew Cannon, James Stevenson, Kori Kuzma, Susanna Kiwala, Jeremy L Warner, Obi L Griffith, Malachi Griffith, Alex H Wagner

2020-Current year OA Pubs

OBJECTIVE: The diversity of nomenclature and naming strategies makes therapeutic terminology difficult to manage and harmonize. As the number and complexity of available therapeutic ontologies continues to increase, the need for harmonized cross-resource mappings is becoming increasingly apparent. This study creates harmonized concept mappings that enable the linking together of like-concepts despite source-dependent differences in data structure or semantic representation.

MATERIALS AND METHODS: For this study, we created Thera-Py, a Python package and web API that constructs searchable concepts for drugs and therapeutic terminologies using 9 public resources and thesauri. By using a directed graph approach, Thera-Py captures commonly used …

Diroximel Fumarate In Patients With Relapsing-Remitting Multiple Sclerosis: Final Safety And Efficacy Results From The Phase 3 Evolve-Ms-1 Study, Barry A Singer, Robert T Naismith, Et Al.

2020-Current year OA Pubs

BACKGROUND: Diroximel fumarate (DRF) is approved for adults with relapsing-remitting multiple sclerosis (RRMS) in Europe and for relapsing forms of MS in the United States. DRF and dimethyl fumarate (DMF) yield bioequivalent exposure of the active metabolite monomethyl fumarate. Prior studies indicated fewer gastrointestinal (GI)-related adverse events (AEs) with DRF compared with DMF.

OBJECTIVE: To report final outcomes from EVOLVE-MS-1.

METHODS: EVOLVE-MS-1 was an open-label, 96-week, phase 3 study assessing DRF safety, tolerability, and efficacy in patients with RRMS. The primary endpoint was safety and tolerability; efficacy endpoints were exploratory.

RESULTS: Overall, 75.7% (800/1057) of patients completed the study; median …

Continuous Subcutaneous Foslevodopa/Foscarbidopa In Parkinson's Disease: Safety And Efficacy Results From A 12-Month, Single-Arm, Open-Label, Phase 3 Study, Jason Aldred, Susan R Criswell, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Foslevodopa/foscarbidopa, a soluble formulation of levodopa/carbidopa (LD/CD) prodrugs for the treatment of Parkinson's disease (PD), is administered as a 24-hour/day continuous subcutaneous infusion (CSCI) with a single infusion site. The efficacy and safety of foslevodopa/foscarbidopa versus oral immediate-release LD/CD was previously demonstrated in patients with PD in a 12-week, randomized, double-blind, phase 3 trial (NCT04380142). We report the results of a separate 52-week, open-label, phase 3 registrational trial (NCT03781167) that evaluated the safety/tolerability and efficacy of 24-hour/day foslevodopa/foscarbidopa CSCI in patients with advanced PD.

METHODS: Male and female patients with levodopa-responsive PD and ≥ 2.5 hours of "Off" time/day …