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International Tuberculum Sellae Meningioma Study: Surgical Outcomes And Management Trends, Michael Mcdermott

All Publications

Background and objectives: Tuberculum sellae meningiomas (TSMs) can be resected through transcranial (TCA) or expanded endonasal approach (EEA). The objective of this study was to report TSM management trends and outcomes in a large multicenter cohort.

Methods: This is a 40-site retrospective study using standard statistical methods.

Results: In 947 cases, TCA was used 66.4% and EEA 33.6%. The median maximum diameter was 2.5 cm for TCA and 2.1 cm for EEA ( P < .0001). The median follow-up was 26 months. Gross total resection (GTR) was achieved in 70.2% and did not differ between EEA and TCA ( P = .5395). Vision was the same or better in 87.5%. Vision improved in 73.0% of EEA patients with preoperative visual deficits compared with 57.1% of TCA patients ( P < .0001). On multivariate analysis, a TCA (odds ratio [OR] 1.78, P = .0258) was associated with vision worsening, while GTR was protective (OR 0.37, P < .0001). GTR decreased with increased diameter (OR: 0.80 per cm, P = .0036) and preoperative visual deficits (OR 0.56, P = .0075). Mortality was 0.5%. Complications occurred in 23.9%. New unilateral or bilateral blindness occurred in 3.3% and 0.4%, respectively. The cerebrospinal fluid leak rate was 17.3% for EEA and 2.2% for TCA (OR 9.1, P < .0001). The recurrence rate was 10.9% (n = 103). Longer follow-up (OR 1.01 per month, P < .0001), World Health Organization II/III (OR 2.20, P = .0262), and GTR (OR: 0.33, P < .0001) were associated with recurrence. The recurrence rate after GTR was lower after EEA compared with TCA (OR 0.33, P = .0027).

Conclusion: EEA for appropriately selected TSM may lead to better visual outcomes and decreased recurrence rates after GTR, but cerebrospinal fluid leak rates are high, and …

A New Method To Evaluate Pressure Distribution Using A 3d-Printed C2-C3 Cervical Spine Model With An Embedded Sensor Array, Frank Vrionis

All Publications

Cervical degenerative disc diseases such as myelopathy and radiculopathy often require conventional treatments like artificial cervical disc replacement or anterior cervical discectomy and fusion (ACDF). When designing a medical device, like the stand-alone cage, there are many design inputs to consider. However, the precise biomechanics of the force between the vertebrae and implanted devices under certain conditions require further investigation. In this study, a new method was developed to evaluate the pressure between the vertebrae and implanted devices by embedding a sensor array into a 3D-printed C2-C3 cervical spine. The 3D-printed cervical spine model was subjected to a range of …

Preoperative Serum Albumin And Other Risk Factors Related To 30-Day Postoperative Complications In Total Ankle Arthroplasty, Jeffrey T. Bowcutt, Naohiro Shibuya, Daniel C. Jupiter

School of Podiatric Medicine Publications

This study investigates effects of preoperative albumin on 30-day TAA outcomes. Additionally, other preoperative risk factors are addressed, including American Anesthesia Society (ASA) class, functional status, chronic obstructive pulmonary disease (COPD), diabetes, smoking status, time of operation, and age. Outcomes assessed were readmission, return to operating room, surgical site infection, wound dehiscence, and total length of stay (TLOS). Data was extracted from the National Surgical Quality Improvement Program database. Bivariate comparisons were analyzed using correlation coefficients, t tests, or chi-squared tests; multivariate comparisons used linear or logistic regression. Our data showed no significant correlation between serum albumin and patients with …

A Model Of Immediate Implant Placement To Evaluate Early Osseointegration In 129/Sv Diabetic Mice, Cláudia Cristina Biguetti, Alexandra Arteaga, Bhuvana Lakkasetter Chandrashekar, Evelin Rios, Ryan Margolis, Danieli C. Rodrigues

School of Podiatric Medicine Publications

Purpose: To analyze the process of early oral osseointegration of titanium (Ti) implants in diabetic 129/Sv mice through microCT and histologic and immunohistochemical analysis.

Materials and methods: A group of 30 male 129/Sv mice was equally subdivided into two groups: (1) nondiabetic (ND), in which mice did not undergo systemic alterations and received a standard diet, and (2) diabetic (D), in which mice were provided a high-fat diet from the age of 6 weeks until the conclusion of the study and received two intraperitoneal (IP) injections of streptozotocin (STZ) at a concentration of 100 mg/Kg each. Each mouse underwent extraction …

Análisis De La Violencia Crónica Desde Una Perspectiva De Género (Estudio De Caso: Jamaica), Elena B. Stavrevska, Nattecia Nerene Bohardsingh, María Dolores Hernández Montoya, Tania Cecilia Martínez, Briana Mawby, Aliza Carns

Kroc IPJ Research and Resources

Tradicionalmente, la violencia se ha considerado a través del prisma de los conflictos armados o de incidentes violentos concretos y específicos. Sin embargo, es necesario comprender que la violencia puede ser un fenómeno crónico, una agresión persistente y profundamente arraigada que afecta a la vida cotidiana.

El informe aboga por una reconceptualización de la violencia en los ámbitos de la Mujer, la Paz y la Seguridad (WPS) y la igualdad de género, basándose en las concepciones feministas del continuo de la violencia para reconocer que las estructuras sociales, la discriminación sistémica e incluso las normas culturales dominantes pueden ser fuentes …

The Evolution Of The Role Of Speech-Language Pathologists In The Nicu: Are Educational Programs Supporting The Change?, Melanie Spinnie

Honors College Theses

The purpose of this thesis was to determine the progressive roles of speech-language pathologists (SLP) in performing feeding and swallowing interventions in preterm infants in the neonatal intensive care unit (NICU) and evaluate the education SLPs receive regarding this topic, as well as how this can affect their work in the NICU and what changes in curriculum and experience should be made for SLPs to best serve this fragile population. SLPs have not always been the primary providers in this field, so it is crucial to understand these established roles and how they have changed and will continue to change. …

The Relationship Of Insufficient Resources To Leadership Burnout In Rural Nonprofit Organizations, Keilee Webb

Honors College Theses

The purpose of this thesis is to describe and analyze the relationship between the lack of resources in nonprofit organizations and burnout. In this literature review, the aim is to explore various resources affecting nonprofit entities as they relate to organizational capacity. These specific resources will be reviewed and discussed to understand how closely related those resources are to burnout. Additionally, the implications of nonprofit employee and volunteer burnout will be analyzed. Within the literature review, the research indicates nonprofits in rural United States are more likely to encounter a deficit in connections to resources than their urban counterparts. This …

A Revisionist History Of Products Liability, Alexandra D. Lahav

Michigan Law Review

Increasingly courts, including the Supreme Court, rely on ossified versions of the common law to decide cases. This Article demonstrates the risks of this use of the common law. The main contribution of the Article is to demonstrate that the traditional narrative about early products law—that manufacturers were not liable for injuries caused by their products because the doctrine of privity granted producers immunity from suit by the ultimate consumers of their goods—is incorrect. Instead, the doctrinal rule was negligence liability for producers of injurious goods across the United States in the nineteenth century. Courts routinely ignored or rejected privity …

Is There Anything Left In The Fight Against Partisan Gerrymandering? Congressional Redistricting Commissions And The “Independent State Legislature Theory”, Derek A. Zeigler, Jose Urteaga

Michigan Law Review

Partisan gerrymandering is a scourge on our democracy. Instead of voters choosing their representatives, representatives choose their voters. Historically, individuals and states could pursue multiple paths to challenge partisan gerrymandering. One way was to bring claims in federal court. The Supreme Court shut this door in Rucho v. Common Cause. States can also resist partisan gerrymandering by establishing congressional redistricting commissions. However, the power of these commissions to draw congressional districts is at risk. In Moore v. Harper, a case decided in the Supreme Court’s 2022-2023 Term, the petitioners asked the Court to embrace the “Independent State Legislature …

Gut Microbiota Induces Weight Gain And Inflammation In The Gut And Adipose Tissue Independent Of Manipulations In Diet, Genetics, And Immune Development, Devesha H Kulkarni, Brigida Rusconi, Alexandria N Floyd, Elisabeth L Joyce, Khushi B Talati, Hrishi Kousik, Dereck Alleyne, Dalia L Harris, Lorena Garnica, Ryan Mcdonough, Shay S Bidani, Hrishikesh S Kulkarni, Elizabeth P Newberry, Keely G Mcdonald, Rodney D Newberry

2020-Current year OA Pubs

Obesity and the metabolic syndrome are complex disorders resulting from multiple factors including genetics, diet, activity, inflammation, and gut microbes. Animal studies have identified roles for each of these, however the contribution(s) specifically attributed to the gut microbiota remain unclear, as studies have used combinations of genetically altered mice, high fat diet, and/or colonization of germ-free mice, which have an underdeveloped immune system. We investigated the role(s) of the gut microbiota driving obesity and inflammation independent of manipulations in diet and genetics in mice with fully developed immune systems. We demonstrate that the human obese gut microbiota alone was sufficient …

Identification Of New 4-(6-Oxopyridazin-1-Yl)Benzenesulfonamides As Multi-Target Anti-Inflammatory Agents Targeting Carbonic Anhydrase, Cox-2 And 5-Lox Enzymes: Synthesis, Biological Evaluations And Modelling Insights, Waleed A Badawi, Mahmoud Rashed, Alessio Nocentini, Alessandro Bonardi, Mohammad M Abd-Alhaseeb, Sara T Al-Rashood, Giri Babu Veerakanellore, Taghreed A Majrashi, Eslam B Elkaeed, Bahaa Elgendy, Paola Gratteri, Claudiu T Supuran, Wagdy M Eldehna, Mohamed Elagawany

2020-Current year OA Pubs

Multiple inhibitions of CA, COX-2 and 5-LOX enzymes has been recognised as a useful strategy for the development of anti-inflammatory drugs that can avoid the disadvantages of using NSAIDs alone. Here, we report new pyridazine-based sulphonamides (

Sex Trafficking: Saudi Arabian Women's Perspectives, Jennifer O. Rowland

Walden Dissertations and Doctoral Studies

No abstract provided.

Cerebellar Eeg Source Localization Reveals Age-Related Compensatory Activity Moderated By Genetic Risk For Alzheimer’S Disease, Elizabeth Paitel, Kristy A. Nielson

Psychology Faculty Research and Publications

The apolipoprotein-E (APOE) ε4 allele is the greatest genetic risk factor for late-onset Alzheimer's disease (AD), but alone it is not sufficiently predictive. Because neuropathological changes associated with AD begin decades before cognitive symptoms, neuroimaging of healthy, cognitively intact ε4 carriers (ε4+) may enable early characterization of patterns associated with risk for future decline. Research in the cerebral cortex highlights a period of compensatory recruitment in elders and ε4+, which serves to maintain cognitive functioning. Yet, AD-related changes may occur even earlier in the cerebellum. Advances in electroencephalography (EEG) source localization now allow effective modeling of cerebellar activity. Importantly, healthy …

Neuroimaging-Based Classification Of Ptsd Using Data-Driven Computational Approaches: A Multisite Big Data Study From The Enigma-Pgc Ptsd Consortium, Jacklynn M. Fitzgerald

Psychology Faculty Research and Publications

Background

Recent advances in data-driven computational approaches have been helpful in devising tools to objectively diagnose psychiatric disorders. However, current machine learning studies limited to small homogeneous samples, different methodologies, and different imaging collection protocols, limit the ability to directly compare and generalize their results. Here we aimed to classify individuals with PTSD versus controls and assess the generalizability using a large heterogeneous brain datasets from the ENIGMA-PGC PTSD Working group.

Methods

We analyzed brain MRI data from 3,477 structural-MRI; 2,495 resting state-fMRI; and 1,952 diffusion-MRI. First, we identified the brain features that best distinguish individuals with PTSD from controls …

No Bullying Allowed Here: Adopting A Misuse Doctrine To Defeat Trademark Bullies, Jessica Shechtman

Cardozo Law Review

In order to maintain trademark rights, trademark owners are encouraged to enforce and police their trademarks through civil actions. Enforcing trademark rights is encouraged and incentivized by the Lanham Act because failure to do so may result in harsh consequences for trademark owners. Some of these consequences include weakening of strength or abandonment of the mark, which may result in loss of trademark rights. However, large companies go above and beyond to police and protect their trademarks. At times, this overenforcement is unethical and crosses a fine line between following the law and abusing the law, causing a number of …

The Roddey Mcmillan Record - December 2023, Winthrop University

The RMR 2020-2029

The Roddey McMillan Record (RMR) is Winthrop’s monthly multicultural student publication. The RMR has been a significant voice of the minority population of the Winthrop community since its creation by Gail Harris in April 1986. It promotes awareness and understanding of issues concerning minorities for the prosperity of the entire Winthrop community. The purpose of the RMR is to shine light on the many diverse cultures at Winthrop, focusing on issues, concerns and happenings of those who represent the multicultural community on campus. The Roddey McMillan Record is named after Dr. Cynthia Roddey and Atty, Sheila McMillan. Cynthia Roddey was …

Loco-Regional Irradiation In Patients With Biopsy-Proven Axillary Node Involvement At Presentation Who Become Pathologically Node-Negative After Neoadjuvant Chemotherapy: Primary Outcomes Of Nrg Oncology/Nsabp B-51/Rtog 1304, E Mamounas, H Bandos, J White, T Julian, A Khan, S Shaitelman, M Torres, Frank Vicini, P Ganz, Andrew Muskovitz

Conference Presentation Abstracts

No abstract provided.

Sequence Analysis Of Cardiometabolic Multimorbidity And Association With Subsequent Dementia, Corey Nagel, Heather Allore, Anda Botoseneanu, Jeffrey Kaye, Jason Newsom, Nicholas Bishop, Ana Quinones

Psychology Faculty Publications and Presentations

Sequence analysis is used in the social sciences to examine patterns of events occurring across the life course, but there are few examples of its use in multimorbidity research among older adults. We used sequence analysis to identify longitudinal patterns of cardiometabolic multimorbidity over a five-year period among participants in the National Health and Aging Trends Study (N=5,218). Multimorbidity sequences were constructed using self-reported diagnosis of diabetes, heart disease, stroke, and myocardial infarction (MI) assessed annually. Death was included as an absorbing state, yielding a total of 281 distinct sequences. We calculated sequence dissimilarity using optimal matching then used hierarchical …

The Effects Of Agroecological Farming Systems On Human Health, Olivia Kathryn Mason

All Graduate Theses and Dissertations, Fall 2023 to Present

There is a growing concern that the current farming techniques are producing less-nutrient dense soils and foods impacting human health. To improve the health of soils, people, and the plant, a growing number of farmers are using regenerative, or agroecological, farming practices. Some of these methods include multi-cropping (growing various plants on the same plot of land), ley systems (alternating between crops and livestock), and rotational grazing of livestock. Previous studies have found that regenerative farming systems have various benefits for the lands, crops, and animals, as well as increasing the nutrient density of foods.

The purpose of this study …

Linking Microbial Community Assembly In Flowers With Function Under Diverse Environmental Conditions: A Case Study Involving Erwinia Amylovora, Christopher Skylar Mcdaniel

All Graduate Theses and Dissertations, Fall 2023 to Present

Fire blight, a devastating disease of pome fruit trees caused by the bacterium Erwinia amylovora, can cause millions of dollars in losses for producers each year around the globe. Management approaches that involve use of antibiotics, such as streptomycin, can be effective; although concerns exist over pollinator and crop health when using them regularly. Recently, there have been developments that allow for biological agents such as microbes to curtail fire blight infection. These agents work by competing with Erwinia for resources or space, producing antibacterial compounds, or even killing Erwinia cells on contact. Unfortunately, these agents do not yet …

Characterization Of Enterovirus D68 In A Mouse Model And Evaluation Of Antiviral Therapies, Zoe K. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Enterovirus D68 (EV-D68) is a virus that causes respiratory disease. Children are most commonly affected by EV-D68 but immunocompromised adults can also get infected and develop severe disease signs. In 2014, the United States experienced an unprecedented outbreak of EV-D68. Similar outbreaks were also observed in 2016, 2018 and 2022. Interestingly, few EV-D68 infections were observed in 2020, likely due to public health measures put in place to reduce the spread of another respiratory disease, coronavirus disease 2019 (COVID-19). EV-D68 is in the same virus family as polio, and one of the most concerning findings from these outbreaks is that …

Geographic Variation In Blue Orchard Bee (Osmia Lignaria) Development And Performance As A Managed Pollinator In The Western United States, Morgan B. Scalici

All Graduate Theses and Dissertations, Fall 2023 to Present

Most flowering plants, including many cultivated food crops, will only produce well-developed fruits and seeds if pollen is transferred from one flower to another with the help of an animal pollinator. Honey bees are the most well-known and ubiquitous but are poor pollinators of some commercially important crops, or are in poor supply during crop bloom. In such cases, farmers will employ other managed pollinators such as bumble bees or solitary bees like mason and leafcutting bees. The blue orchard bee is North America's most agriculturally important native mason bee as effective pollinators of spring-blooming fruit crops. Differences in developmental …

Integrated Behavioral-Health Supports: Combining Pbis And Sel At Tier 2, Thomas K. Franzmann

All Graduate Theses and Dissertations, Fall 2023 to Present

Childhood behavior problems present many challenges for youth, families, and schools. To assist in preventing and reducing such problems, schools have adopted various strategies to assist with such concerns. Two widely used strategies for addressing problem behavior in schools are Positive Behavioral Interventions and Supports (PBIS) and Social-Emotional Learning (SEL). While both have a plethora of evidence of their effectiveness independently, less is known as to whether than can compliment one another for even better outcomes. The current study examined the effectiveness of an integrated approach (PBIS + SEL) to classroom intervention for elementary school students exhibiting behavior problems. This …

Incorporating Sustainability Into Utah High School's Textiles And Apparel Curriculum, Michelle Clouse

All Graduate Theses and Dissertations, Fall 2023 to Present

The purpose of this study was to propose sustainability-based curriculum changes to Utah's textiles and apparel (TA) curriculum. This study's specific curriculum change proposals are limited to Sewing Construction and Textiles (SCT) 1 and Sports and Outdoor Design (SOD) 1 courses. The proposed changes were made with the input of 24 Utah FCS TA educators via a research-developed survey on Qualtrics. FCS TA educators were asked to give their input on sustainability topics already taught in their classroom, teaching methods of sustainable topics, potential barriers to incorporating sustainability into the curriculum, and their receptiveness to curriculum change.

The Teacher Attitudes …

Beyond ‘Bisexual’: Toward A New Conceptualization Of Bi+ Experience, Brook Hutchinson

All Graduate Theses and Dissertations, Fall 2023 to Present

Scholars have begun to explore sexual identity development and the impact of sexuality binaries on well-being for bi+ individuals. However, extant research has not yet fully analyzed the experiences of bi+ individuals in heterosexual relationships, particularly those who have never experienced a non-heterosexual relationship. This community remains relatively invisible in research and theory on sexuality and within LGBTQIA+ communities. The unique experiences of these individuals can provide valuable insights to the field of bi+ research by furthering our understanding of sexual identity development and queer inclusion and by underscoring the need for more inclusive research, policy, and practice. The current …

Impacts Of Area-Wide Air Pollution On Multimodal Traffic: Comparing Pedestrian, Motor Vehicle, And Transit Volumes In Utah, Prachanda Tiwari

All Graduate Theses and Dissertations, Fall 2023 to Present

The impact of area-wide air pollution on multimodal traffic volumes has been underexplored. Thus, this research investigates the effect of area-wide air pollution on pedestrian volumes, motor volumes, and transit ridership across two urban areas in Utah for two years (2018 and 2019). The research employed multilevel modeling to study this effect. The model results showed an overall decrease in pedestrian volumes in both study areas, while driving volumes saw both increases and decreases in different locations. Transit ridership saw an increase during days with moderate air quality in one particular study area. Median income, vehicle ownership, and higher street …

Bells Of Mindfulness: An Online Mindfulness Meditation Course To Promote Mindfulness Meditation For Phd Students, Michael Folland

All Graduate Theses and Dissertations, Fall 2023 to Present

Over the last 20 years, there has been growing evidence of mental health issues in doctoral candidates worldwide (Zhang et al., 2022; Barry et al., 2019; Gewin, 2012; Radison & DiGeronimo, 2005). Practicing mindfulness meditation, which is one way to cope with stress and anxiety (Kabat-Zinn, 1991), could be a useful practice for these PhD students. However, despite all the evidence that suggests the health benefits of having a regular meditation routine, motivating graduate students to practice meditation can be challenging (Franco, 2020). This study addresses this challenge by assessing a 5-week mindfulness meditation course designed to support graduate students …

Evaluating The Effects Of Ketamine On Cognitive Flexibility In Rats Using A Probabilistic Reversal Learning Task, Anthony N. Nist

All Graduate Theses and Dissertations, Fall 2023 to Present

Depression is one of the most debilitating and widespread mental health conditions in the world today. Drugs that are traditionally prescribed to combat depression are flawed in several ways, and because of this, new treatments are needed. One drug that seems capable of overcoming the limitations of traditional antidepressants is ketamine. In clinical research, a single dose of ketamine can significantly reduce symptoms of depression quickly, its effects may last for weeks to months, and its side effects appear to be limited and relatively harmless. However, clinical research is ongoing, and more research is needed to fully understand ketamine's beneficial …

Specialized Recreation, Spatial Behavior, And Ecological Implications In The Nature Reserve Of Orange County, Ca, Jake Van Deursen

All Graduate Theses and Dissertations, Fall 2023 to Present

A widespread surge in park and protected area (PPA) visitation strikes managers with the imminent challenge of preserving ecological conditions and maintaining accessibility in the open spaces that are a fundamental component to the health and wellness needs of society. In the field of recreation resource management, recreation specialization, the selective channeling of interests and abilities into a specific recreational activity, has contributed to comprehensive understandings of recreation behavior, site preference, management perceptions and conservation support. Contributing to historical understandings of specialization can inform recreation planning on the diversity of uses occurring in urban-proximate PPAs. Survey data providing information on …

Investigating K-3 Spanish Dual Language Immersion Teachers' Conceptions Of Mathematics-Focused Content-Based Language Teaching, Rachel C. Reeder

All Graduate Theses and Dissertations, Fall 2023 to Present

Classroom instruction is influenced by and reflects teachers’ conceptions about their teaching. In elementary Dual Language Immersion (DLI) classrooms, teachers deliver mathematics and target-language instruction with the expectation that both can be developed concurrently. This qualitative study investigated K-3 Spanish DLI teachers’ conceptions about Mathematics-Focused Content-Based Language Teaching (MF-CBLT), which emphasizes the instructional parameters guiding teachers’ integration of content (mathematics), language (Spanish), and teaching (pedagogy).

The study examined 11 teachers’ statements and teaching samples to investigate their knowledge, beliefs, and preferences (i.e., conceptions) about MF-CBLT. A survey and individual teacher interviews provided access to what teachers had to say while …