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2023

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2023 December, Morehead State University. Office Of Communications & Marketing. Dec 2023

2023 December, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for December of 2023.


Pee Wee Herman Is Dead, Josh Matthews Dec 2023

Pee Wee Herman Is Dead, Josh Matthews

Pro Rege

This article was previously published at https://learningaboutmovies.substack.com/


Prediction Of Unplanned 30-Day Readmission Of Heart Failure Patients Using Lstm, Jesdin Raphael Dec 2023

Prediction Of Unplanned 30-Day Readmission Of Heart Failure Patients Using Lstm, Jesdin Raphael

Theses

In the context of heart failure, a leading cause of hospitalization in the United States, approximately 15\% of patients discharged within 30 days face readmission, contributing to escalated healthcare costs and compromised clinical outcomes. This study leverages a wealth of personal information extracted from Emergency Health Records (EHRs) spanning two decades. This research aims to enhance the predictive capabilities of re-hospitalization for cardiac patients by creating a two-stage LSTM model while incorporating features into regression and time series datasets. A critical aspect of this study involves ensuring the integration of all relevant features across both datasets. Including constant data elements, …


Transfer Pathways: Ensuring Transfer Student Success, Jonathan Vega Martinez, Fabián Torres-Ardila, Lorna Rivera, Michelle Sunday Dec 2023

Transfer Pathways: Ensuring Transfer Student Success, Jonathan Vega Martinez, Fabián Torres-Ardila, Lorna Rivera, Michelle Sunday

Gastón Institute Publications

This report reflects the partnership between the University of Massachusetts Boston’s Gastón Institute and Bunker Hill Community College’s Center for Equity and Cultural Wealth to build cultural inclusivity in curricular and co-curricular practices with the diverse student bodies served by both postsecondary institutions.

The partnership was created with the aim to develop activities and create data, including data sharing and joint data collection, to explore and create common research questions that will help close diversity gaps across the two institutions. This report is part of a study that seeks to improve the partners’ understanding of student transfer pathways between these …


Attitudes About Inclusivity Among Preservice Educators: A Mixed Methods Approach, Kathleen M. Quinn Dec 2023

Attitudes About Inclusivity Among Preservice Educators: A Mixed Methods Approach, Kathleen M. Quinn

Theses & Dissertations

In 1975, the Education for All Handicapped Children Act (EHA) became the first enacted policy that led the fight against ableism, providing students with disabilities the right to public education. In 2004, this policy became known as the Individuals with Disabilities Act (IDEA), which included these major components supporting the policy of inclusion: Free and Appropriate Public Education (FAPE), Individual Education Plans (IEP), and Least Restrictive Environment (LRE). This study highlights how teacher preparation programs are pivotal in preservice teachers' attitudes toward inclusion. The data for this study was collected and analyzed based on quantitative surveys and qualitative interviews with …


Evaluation Of Caring Behaviors In High-Fidelity Simulation Following A Caring Concept Educational Intervention, Debra Ann Mcwilliams Dec 2023

Evaluation Of Caring Behaviors In High-Fidelity Simulation Following A Caring Concept Educational Intervention, Debra Ann Mcwilliams

Theses & Dissertations

Background.

Simulation has created a new paradigm in nursing education. Behaviors that demonstrate caring are important aspects of quality nursing practice. Nursing education needs to integrate opportunities to teach caring, and simulation is an ideal environment to do this. Faculty must assist nursing students to establish competence in psychomotor, cognitive, and the affective domains of learning. Many of the widely used, standardized scenarios in simulation predominantly focus on critical-thinking skills while marginalizing the demonstration of caring behaviors.

Purpose.

The purpose of this quantitative study was to examine the effect of a caring concept educational intervention (CCEI) in students’ self-reported confidence …


Elementary English Language Learners' Perceptions Of Teacher Care In The Classroom, Carol Boodram-Wright Dec 2023

Elementary English Language Learners' Perceptions Of Teacher Care In The Classroom, Carol Boodram-Wright

Theses & Dissertations

English Language Learners (ELLs) experience care in the classroom based on prior experiences, teacher and student relationships, academic support, health support, and safety. The purpose of this study was to understand how ELLs experience care in the classroom with their classroom teacher as described by six ELL participants. A positive teacher-student relationship rooted in care, comfort, safety, and trust enhanced ELLs' engagement with their classroom teacher. The findings of this qualitative narrative study revealed that unconditional support and individualized quality time contributed to ELLs’ well-being in the classroom. Interpretations of care from the ELLs’ narratives depicted how experiences in the …


The Cluster Analysis By Using Nonparametric Cubic B-Spline Modeling For Longitudinal Data, Noor Nawzat Ahmed, Suhail Najm Abdulla Dec 2023

The Cluster Analysis By Using Nonparametric Cubic B-Spline Modeling For Longitudinal Data, Noor Nawzat Ahmed, Suhail Najm Abdulla

Journal of Economics and Administrative Sciences

Longitudinal data is becoming increasingly common, especially in the medical and economic fields, and various methods have been analyzed and developed to analyze this type of data. In this research, the focus was on compiling and analyzing this data, as cluster analysis plays an important role in identifying and grouping co-expressed subfiles over time and employing them on the nonparametric smoothing cubic B-spline model, which is characterized by providing continuous first and second derivatives, resulting in a smoother curve with fewer abrupt changes in slope. It is also more flexible and can pick up on more complex patterns and fluctuations …


The Role Of Quality Of Work Life In Reinforcing Core Competencies: A Descriptive And Analytical Research In The Ministry Of Health, Ali Adnan Hasan, Haider Fadhel Kadhem, Alaulddin B. Jawad Dec 2023

The Role Of Quality Of Work Life In Reinforcing Core Competencies: A Descriptive And Analytical Research In The Ministry Of Health, Ali Adnan Hasan, Haider Fadhel Kadhem, Alaulddin B. Jawad

Journal of Economics and Administrative Sciences

The research aims to diagnose the shortcomings and weaknesses in applying the dimensions of the quality of work life and the extent of their impact on employees’ attitudes and behaviors, and thus their relationship to enhancing their core competencies. The scientific value of the research stems from highlighting the importance of the dimensions of the quality of professional life in improving the productive efficiency of workers in the public sector and raising the level of organizational performance. Because the quality of working life plays an important role in enhancing the core competencies of employees in the public sector, it can …


A Holistic Approach To Creating Cultures Of Quality Excellence Within Higher Education Institutions In North Carolina, Natalie Aman Dec 2023

A Holistic Approach To Creating Cultures Of Quality Excellence Within Higher Education Institutions In North Carolina, Natalie Aman

All-Inclusive List of Electronic Theses and Dissertations

This paper first seeks to identify cultural factors of faculty, staff, and students within Higher Education Intuitions (HEI) and then understand how those factors affect the individual as well as the overall larger population of all studied groups to create cultures of quality excellence. Secondary data collected from government databases was used for the research. The independent variables included cultural factors for each stakeholder and the dependent variables included satisfaction levels of each stakeholder. Faculty and staff independent cultural variables included Performance Management, Supervisor/Department Chair Effectiveness, Communication & Collaboration, Diversity, Inclusion & Belonging, and Mission and Pride. The dependent variable …


The Psychological Science Accelerator's Covid-19 Rapid-Response Dataset, Erin M. Buchanan, Andree Hartanto Dec 2023

The Psychological Science Accelerator's Covid-19 Rapid-Response Dataset, Erin M. Buchanan, Andree Hartanto

Research Collection School of Social Sciences

In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with …


How Does Parents’ Social Support Impact Children’S Health Practice? Examining A Mediating Role Of Health Knowledge, Paulin Tay Straughan, Chengwei Xu Dec 2023

How Does Parents’ Social Support Impact Children’S Health Practice? Examining A Mediating Role Of Health Knowledge, Paulin Tay Straughan, Chengwei Xu

Research Collection School of Social Sciences

Background: Family environmental factors play a vital role in shaping children’s health practices (e.g., obesity prevention). It is still unclear how parents’ social support affects children’s obesity-related health practices. The present study argues that whether parents’ social support positively associates with children’s obesity-related health practice depends on if it could promote parents’ obesity-related health knowledge. Thus, we hypothesize that health knowledge mediates the relationship between parents’ social support and children’s health practice regarding weight management. Methods: To test the hypothesis, we conducted a questionnaire survey and collected a nationally representative sample of 1488 household responses in Singapore. The survey included …


Greater Traditionalism Predicts Covid-19 Precautionary Behaviors Across 27 Societies, Theodore Samore, D. M. T. Fessler, A. M. Sparks, C. Holbrook, L. Aaroe, Norman P. Li, Kai Lin Lynn Tan, Et Al Dec 2023

Greater Traditionalism Predicts Covid-19 Precautionary Behaviors Across 27 Societies, Theodore Samore, D. M. T. Fessler, A. M. Sparks, C. Holbrook, L. Aaroe, Norman P. Li, Kai Lin Lynn Tan, Et Al

Research Collection School of Social Sciences

People vary both in their embrace of their society’s traditions, and in their perception of hazards as salient and necessitating a response. Over evolutionary time, traditions have offered avenues for addressing hazards, plausibly resulting in linkages between orientations toward tradition and orientations toward danger. Emerging research documents connections between traditionalism and threat responsivity, including pathogen-avoidance motivations. Additionally, because hazard-mitigating behaviors can conflict with competing priorities, associations between traditionalism and pathogen avoidance may hinge on contextually contingent tradeoffs. The COVID-19 pandemic provides a real-world test of the posited relationship between traditionalism and hazard avoidance. Across 27 societies (N = 7844), we …


Prevalence Of Anxiety In College And University Students: An Umbrella Review, Gabriel Xing Da Tan, Xun Ci Soh, Andree Hartanto, Adalia Yin Hui Goh, Nadyanna M. Majeed Dec 2023

Prevalence Of Anxiety In College And University Students: An Umbrella Review, Gabriel Xing Da Tan, Xun Ci Soh, Andree Hartanto, Adalia Yin Hui Goh, Nadyanna M. Majeed

Research Collection School of Social Sciences

The pervasiveness of anxiety has been increasing progressively over the years, becoming one of the most critical concerns among colleges and universities. With implications extending towards poorer academic performance and overall student mental health, there is an urgent need to address this growing concern. As such, we conducted an umbrella review of systematic reviews and meta-analyses to summarize data in the literature on the overall prevalence of anxiety among college and university students. Moreover, this umbrella review also considered the impact of the COVID-19 pandemic and assessed potential moderators through distinct subgroup analyses. A systematic search was carried out across …


Relationship Status And Psychological Well-Being: Initial Evidence For The Moderating Effects Of Commitment Readiness, Kenneth Tan, Daniel Ho, Christopher R. Agnew Dec 2023

Relationship Status And Psychological Well-Being: Initial Evidence For The Moderating Effects Of Commitment Readiness, Kenneth Tan, Daniel Ho, Christopher R. Agnew

Research Collection School of Social Sciences

Past research has suggested that the association between romantic relationship status (i.e., single vs. coupled) and well-being can be dependent on different aspects of an individual's personal life. In the current research, we examined whether commitment readiness (i.e., the subjective sense that the current time is "right" to be in a committed romantic relationship) moderates the link between current relationship status and psychological well-being. With correlational data obtained from three independent samples (two from Singapore, one cross-cultural comparison between Singapore and USA), we found a significant moderating effect of commitment readiness. Coupled individuals higher in readiness reported greater levels of …


When Social Status Gets In The Way Of Mating: The Incompatibility Between Social Status And Reproductive Goals In Modern Contexts, Jose C. Yong, Amy J. Y. Lim, Norman P. Li Dec 2023

When Social Status Gets In The Way Of Mating: The Incompatibility Between Social Status And Reproductive Goals In Modern Contexts, Jose C. Yong, Amy J. Y. Lim, Norman P. Li

Research Collection School of Social Sciences

Low fertility is a growing concern in modern societies. While economic and structural explanations of reproductive hindrances have been informative to some extent, they do not address the fundamental motives that underlie reproductive decisions and are inadequate to explain why East Asian countries, in particular, have such low fertility rates. The current paper advances a novel account of low fertility in modern contexts by describing how modern environments produce a mismatch between our evolved mechanisms and the inputs they were designed to process, leading to preoccupations with social status that get in the way of mating and reproductive outcomes. We …


Becoming A Father, Staying A Father: An Examination Of The Cumulative Fatherhood Wage Premium To U.S. Residential Fathers, Ohjae Gowen Dec 2023

Becoming A Father, Staying A Father: An Examination Of The Cumulative Fatherhood Wage Premium To U.S. Residential Fathers, Ohjae Gowen

Research Collection School of Social Sciences

The instability of fathers’ co-residence with children has become an increasingly prevalent experience for U.S. families. Despite long-standing scholarship examining the relationship between fatherhood and wage advantages, few studies have investigated how variation in fathers’ stable co-residence with a child may produce temporal changes in the wage premium over the life course. Building on prior explanations of the fatherhood wage premium, I test if the wage premium grows with time since the birth of a resident child and if the premium depends on fathers’ co-residence with a child. I use marginal structural models with repeated outcome measures and data from …


China’S Changing Perspective On The Wto: From Aspiration, Assimilation To Alienation, Henry S. Gao Dec 2023

China’S Changing Perspective On The Wto: From Aspiration, Assimilation To Alienation, Henry S. Gao

Research Collection Yong Pung How School Of Law

Since its accession to the WTO twenty years ago, China’s image has shifted from a good student aspiring to assimilate itself into the multilateral trading system to one that is increasingly alienated from key WTO principles. How has China’s perspective on WTO been evolving? What are the reasons behind China’s changing perspective? This chapter addresses these questions from the Chinese perspective with a comprehensive analysis of the key moments in China’s first two decades in the WTO, followed by practical suggestions on how to engage China more constructively in the WTO and beyond.


Fy24 Usability Program Test #3: Assessing Awareness Of I-Share And Usability Of I-Share Request Form, Lindsey Skaggs Dec 2023

Fy24 Usability Program Test #3: Assessing Awareness Of I-Share And Usability Of I-Share Request Form, Lindsey Skaggs

Faculty and Staff Publications – Milner Library

The FY24 Usability Testing Program was designed to iteratively assess user experience at Milner Library. The program gathers data through usability testing of the library's website and discovery layer, as well as survey questions about users' experiences with library services. Test #3 focuses on library users' awareness of I-share and the usability of the I-Share request form embedded in Primo VE. Takeaways and recommendations are included in the report.


In-Person And Remote Employees And Information Security Policy Compliance, Joyce Mui Dec 2023

In-Person And Remote Employees And Information Security Policy Compliance, Joyce Mui

All-Inclusive List of Electronic Theses and Dissertations

Many workers have changed their working status from in-person to remote, in the past several years, with a large increase in the number of employees working remotely during and after the COVID-19 pandemic. In parallel, the increasing costs of data breaches and number of security incidents continue to be a concern to organizations seeking to protect their organization, systems, and data. This study’s research questions were formed using a theoretical framework of the Theory of Planned Behavior (TPB) to discover influences on employee behavior and the Social Bonds Theory (SBT) to address strength of relationships and impact to compliance. This …


Quality & Patient Safety Gazette : Volume 2, Issue 4 - 2023, The Aga Khan University Hospital, Karachi Dec 2023

Quality & Patient Safety Gazette : Volume 2, Issue 4 - 2023, The Aga Khan University Hospital, Karachi

Quality and Patient Safety Archives

• World Quality Day 2023
• Workshop on How to conduct a Root Cause Analysis
• Blast from the Past
• Learn with Fun!
• Stay Tuned with Us…..


A Case Report: Kikuchi Disease Associated With A Positive Auto-Immune Panel Triggered By Covid-19 Infection., Andrew Graef, Aimee Willett, Andrew-Huy Dang, Jayalakshmi Balakrishna, Charles Nicely, Robert Baiocchi Dec 2023

A Case Report: Kikuchi Disease Associated With A Positive Auto-Immune Panel Triggered By Covid-19 Infection., Andrew Graef, Aimee Willett, Andrew-Huy Dang, Jayalakshmi Balakrishna, Charles Nicely, Robert Baiocchi

Ambulatory and Primary Care Articles

Kikuchi disease (KD) is a rare, benign inflammatory condition characterized by fever and cervical lymphadenopathy. While the pathogenesis is largely unknown, Kikuchi disease onset has strong associations with various infections and autoimmune conditions. There are few reported cases of Kikuchi disease triggered by coronavirus disease 2019 (COVID-19) infection or vaccination. A 43-year-old Filipina female with a history of anemia and recent uncomplicated COVID-19 infection one month prior presented with a one-month history of progressive weakness, fatigue, anorexia with 30-pound weight loss, fevers, odynophagia, and new-onset hematemesis. Initial laboratory findings were most significant for a markedly elevated ferritin level prompting initial …


A Case Report: Kikuchi Disease Associated With A Positive Auto-Immune Panel Triggered By Covid-19 Infection., Andrew Graef, Aimee Willett, Andrew-Huy Dang, Jayalakshmi Balakrishna, Charles Nicely, Robert Baiocchi Dec 2023

A Case Report: Kikuchi Disease Associated With A Positive Auto-Immune Panel Triggered By Covid-19 Infection., Andrew Graef, Aimee Willett, Andrew-Huy Dang, Jayalakshmi Balakrishna, Charles Nicely, Robert Baiocchi

Ambulatory and Primary Care Articles

Kikuchi disease (KD) is a rare, benign inflammatory condition characterized by fever and cervical lymphadenopathy. While the pathogenesis is largely unknown, Kikuchi disease onset has strong associations with various infections and autoimmune conditions. There are few reported cases of Kikuchi disease triggered by coronavirus disease 2019 (COVID-19) infection or vaccination. A 43-year-old Filipina female with a history of anemia and recent uncomplicated COVID-19 infection one month prior presented with a one-month history of progressive weakness, fatigue, anorexia with 30-pound weight loss, fevers, odynophagia, and new-onset hematemesis. Initial laboratory findings were most significant for a markedly elevated ferritin level prompting initial …


Systematic Review And Meta-Analysis Of The Association Between Radiation Therapy Treatment Volume And Patient Outcomes, Jerry Ye Aung Kyaw, Alice Rendall, Erin F Gillespie, Tom Roques, Laurence Court, Yolande Lievens, Alison C Tree, Chris Frampton, Ajay Aggarwal Dec 2023

Systematic Review And Meta-Analysis Of The Association Between Radiation Therapy Treatment Volume And Patient Outcomes, Jerry Ye Aung Kyaw, Alice Rendall, Erin F Gillespie, Tom Roques, Laurence Court, Yolande Lievens, Alison C Tree, Chris Frampton, Ajay Aggarwal

Faculty, Staff and Student Publications

Purpose: Evidence of a volume-outcome association in cancer surgery has shaped the centralization of cancer services; however, it is unknown whether a similar association exists for radiation therapy. The objective of this study was to determine the association between radiation therapy treatment volume and patient outcomes.

Methods and materials: This systematic review and meta-analysis included studies that compared outcomes of patients who underwent definitive radiation therapy at high-volume radiation therapy facilities (HVRFs) versus low-volume facilities (LVRFs). The systematic review used Ovid MEDLINE and Embase. For the meta-analysis, a random effects model was used. Absolute effects and hazard ratios (HRs) were …


An Analysis Of Community Health Workers And Its Prospect As A Profession, Medea Sanabria Dec 2023

An Analysis Of Community Health Workers And Its Prospect As A Profession, Medea Sanabria

Undergraduate Theses and Capstone Projects

This literature paper reviews the purpose of community health workers, how they impact community access to health systems and services, and the professional prospects for this career path. In this paper, I discuss how community health workers integrate the main pillars of liberation psychology, specifically the concepts of problematization, acompañamiento, and praxis into their day-to-day responsibilities. The goal of community health workers is to help people navigate complex health systems, raise awareness about health-related topics, organize interventions, and advocate for patients to receive health services. Throughout this literature paper, I analyzed the position of community health workers and contemplated …


What Role Do Parents And Acculturation Play In Chinese Female International High School Students’ Mental Health?, You Wu Dec 2023

What Role Do Parents And Acculturation Play In Chinese Female International High School Students’ Mental Health?, You Wu

Doctoral Dissertations

This study examines the challenges and mental health issues faced by Chinese female international students in private Catholic female high schools in the U.S. It explores three main areas: the types of acculturation challenges students face, the impact of these challenges on their mental health, and the role of parental communication in shaping students' and parents' perceptions of acculturation and mental health. Using qualitative methods, the research involved interviews with nine students and five parents from a girls' Catholic high school in California. Data were collected via narrative-inspired Zoom interviews, and analyzed using phenomenological principles, focusing on understanding the lived …


Radiation-Induced Innate Neutrophil Response In Tumor Is Mediated By The Cxcls/Cxcr2 Axis, Faya Zhang, Oscar Mulvaney, Erica Salcedo, Subrata Manna, James Z Zhu, Tao Wang, Chul Ahn, Laurentiu M Pop, Raquibul Hannan Dec 2023

Radiation-Induced Innate Neutrophil Response In Tumor Is Mediated By The Cxcls/Cxcr2 Axis, Faya Zhang, Oscar Mulvaney, Erica Salcedo, Subrata Manna, James Z Zhu, Tao Wang, Chul Ahn, Laurentiu M Pop, Raquibul Hannan

Faculty, Staff and Student Publications

The early events that lead to the inflammatory and immune-modulatory effects of radiation therapy (RT) in the tumor microenvironment (TME) after its DNA damage response activating the innate DNA-sensing pathways are largely unknown. Neutrophilic infiltration into the TME in response to RT is an early innate inflammatory response that occurs within 24-48 h. Using two different syngeneic murine tumor models (RM-9 and MC-38), we demonstrated that CXCR2 blockade significantly reduced RT-induced neutrophilic infiltration. CXCR2 blockade showed the same effects on RT-induced tumor inhibition and host survival as direct neutrophil depletion. Neutrophils highly and preferentially expressed CXCR2 compared to other immune …


The Risk Index As A Basis For Risk/Benefit Analyses And Protocol Optimization In Diagnostic Nuclear Imaging, Juan C Ocampo Ramos, Lukas M Carter, Justin L Brown, Harry Marquis, Carlos F Uribe, Pat B Zanzonico, Wesley E Bolch, Adam L Kesner Dec 2023

The Risk Index As A Basis For Risk/Benefit Analyses And Protocol Optimization In Diagnostic Nuclear Imaging, Juan C Ocampo Ramos, Lukas M Carter, Justin L Brown, Harry Marquis, Carlos F Uribe, Pat B Zanzonico, Wesley E Bolch, Adam L Kesner

Faculty, Staff and Student Publications

Background: Potential risk associated with low-dose radiation exposures is often expressed using the effective dose (E) quantity. Other risk-related quantities have been proposed as alternatives. The recently introduced risk index (RI) shares similarities with E but expands the metric to incorporate medical imaging-appropriate risks factors including patient-specific size, age, and sex.

Purpose: The aim of this work is to examine the RI metric for quantifying stochastic radiation risk and demonstrate its applications in nuclear imaging. The advantages in this improved metric may help the field progress toward stratified risk consideration in the course of patient management, improve efforts for procedure …


Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan Dec 2023

Droid: Dose-Ranging Approach To Optimizing Dose In Oncology Drug Development, Beibei Guo, Ying Yuan

Faculty, Staff and Student Publications

In the era of targeted therapy, there has been increasing concern about the development of oncology drugs based on the "more is better" paradigm, developed decades ago for chemotherapy. Recently, the US Food and Drug Administration (FDA) initiated Project Optimus to reform the dose optimization and dose selection paradigm in oncology drug development. To accommodate this paradigm shifting, we propose a dose-ranging approach to optimizing dose (DROID) for oncology trials with targeted drugs. DROID leverages the well-established dose-ranging study framework, which has been routinely used to develop non-oncology drugs for decades, and bridges it with established oncology dose-finding designs to …


An Update On The Management Of Advanced Phase Chronic Myeloid Leukemia, Nicholas J Short, Jayastu Senapati, Elias Jabbour Dec 2023

An Update On The Management Of Advanced Phase Chronic Myeloid Leukemia, Nicholas J Short, Jayastu Senapati, Elias Jabbour

Faculty, Staff and Student Publications

Purpose of review: While most patients with chronic myeloid leukemia (CML) present in a chronic phase and are expected to have a normal life expectancy, some patients present with or progress to a more aggressive accelerated phase (AP) or blast phase (BP) of CML. Herein, we discuss the diagnostic considerations of advanced phase CML and review its contemporary management.

Recent findings: Later-generation, more potent BCR::ABL1 tyrosine kinase inhibitors (TKIs) such as ponatinib may result in superior outcomes in patients with advanced phase CML. For CML-BP, combination approaches directed against the blast immunophenotype appear superior to TKI monotherapy. The role of …