Digital Commons Network^™

Isolated Vaginal Recurrence In Women With Stage I Endometrial Cancer, Eric Rios-Doria, Han T Cun, Olga T Filippova, Jennifer J Mueller, Kaled M Alektiar, Lora H Ellenson, Vicky Makker, Yulia Lakhman, Mario M Leitao, Anuja Jhingran, Pamela T Soliman, Nadeem R Abu-Rustum

Faculty, Staff and Student Publications

Objective: To compare clinical and pathologic characteristics of women with surgical stage I endometrial carcinoma by location of first recurrence and describe characteristics of isolated vaginal recurrence.

Methods: Patients with 2009 International Federation of Obstetrics and Gynecology (FIGO) stage I endometrial carcinoma treated at two large cancer centers from 1/1/2009-12/31/2017 were identified. Sarcoma histology was excluded. Recurrences were grouped into isolated vaginal or extravaginal. Isolated vaginal recurrences were localized by anatomic location within the vaginal vault. Clinical and pathologic variables were compared with chi-square analysis, and Kaplan-Meier curves with log-rank tests.

Results: Of 2815 women identified, 278 (10%) experienced a …

Skin Cancers In Medicare Beneficiaries With Actinic Keratoses, Cassandra Mohr, Yao Li, Lucy J Navsaria, Candice L Hinkston, Sanjay S Shete, David J Margolis, Mackenzie R Wehner

Faculty, Staff and Student Publications

Importance: Actinic keratoses (AK) are common premalignant skin lesions with a small risk of progressing to cutaneous squamous cell carcinoma (SCC). There is some evidence that patients with AKs also have increased risks of other skin cancers beyond SCC. However, the absolute risks of skin cancer in patients with AKs are unknown.

Objective: To calculate the absolute and relative risks of future skin cancer in Medicare beneficiaries with AKs.

Design, setting, and participants: This retrospective cohort study was performed using a deidentified, random sample of 4 999 999 fee-for-service Medicare beneficiaries from 2009 through 2018. Patients with treated AKs were …

Angiotensin Ii Type 2 Receptor Signalling As A Pain Target: Bench, Bedside And Back-Translation, Andrew J Shepherd, Andrew Sc Rice, Maree T Smith

Faculty, Staff and Student Publications

Translating promising preclinical pain relief data for novel molecules from drug discovery to positive clinical trial outcomes is challenging. The angiotensin II type 2 (AT2) receptor is a clinically-validated target based upon positive proof-of-concept clinical trial data in patients with post-herpetic neuralgia. This trial was conducted because AT2 receptor antagonists evoked pain relief in rodent models of neuropathic pain. EMA401 was selected as the drug candidate based upon its suitable preclinical toxicity and safety profile and good pharmacokinetics. Herein, we provide an overview of the discovery, preclinical and clinical development of EMA401, for the alleviation of peripheral neuropathic pain.

Alpha Particle-Emitting Radiopharmaceuticals As Cancer Therapy: Biological Basis, Current Status, And Future Outlook For Therapeutics Discovery, Ryan P Coll, Scott J Bright, David K J Martinus, Dimitra K Georgiou, Gabriel O Sawakuchi, H Charles Manning

Faculty, Staff and Student Publications

Critical advances in radionuclide therapy have led to encouraging new options for cancer treatment through the pairing of clinically useful radiation-emitting radionuclides and innovative pharmaceutical discovery. Of the various subatomic particles used in therapeutic radiopharmaceuticals, alpha (α) particles show great promise owing to their relatively large size, delivered energy, finite pathlength, and resulting ionization density. This review discusses the therapeutic benefits of α-emitting radiopharmaceuticals and their pairing with appropriate diagnostics, resulting in innovative "theranostic" platforms. Herein, the current landscape of α particle-emitting radionuclides is described with an emphasis on their use in theranostic development for cancer treatment. Commonly studied radionuclides …

Synthesis And Characterization Of Silver-Coated Polyester Dendrimers With Potential Antimicorbial Properties, Che’Darria Lacey

All Theses

As bacterial cell lines continue to develop resistance to conventional antibiotic medications, the threat of untreatable bacterial infections continues to grow. The limited manufacture of new pharmaceuticals further exacerbates this severe health risk. This risk has facilitated numerous investigations to counter microbial species’ antibiotic resistance. The use of silver, a well-known natural remedy, has grown significant attraction through its use in the nanoparticle form or even as silver ions.

This thesis project involves the synthesis of branched polymers that were suitably functionalized to enable the complexation of silver ions to develop antimicrobial materials. Polyester dendrimers were synthesized utilizing divergent dendronization. …

Structural Health Monitoring: The Use Of Acoustic Emission To Optimize The Fdm Additive Manufacturing Process, Ethan Phillips

All Theses

Fused Deposition Modeling (FDM) has gained widespread popularity as an affordable, versatile, and user-friendly additive manufacturing technique. However, ensuring consistent and high-quality prints remains a significant challenge. This study investigated the potential use of Nondestructive Evaluation (NDE) in the form of Acoustic Emission (AE) to optimize the FDM 3D printing process, including filament defects and the selection of print parameters. AE monitoring involves the detection and analysis of acoustic waves generated during the printing post-process, providing valuable insights into the dynamic behavior of a specimen with respect to the selected print parameters and integrity of the system. Specific acoustic patterns …

An Ecological Assessment Of An Endangered Lichen From Central California: Sulcaria Isidiifera, The Splitting Yarn Lichen, Elijah C. Balderas

Master's Theses

Lichens are an underrepresented group of organisms when it comes to both research and conservation efforts. At the same time, lichens face increasing threats from anthropogenic sources including wildfires, climate change and urbanization. With this thesis, I seek to ascertain and publish ecological data on a critically endangered lichen to inform future conservation designations and efforts to preserve and protect the species in perpetuity.

In Chapter 1, I provide an ecological overview of the known range of Sulcaria isidiifera and assess the status of Sulcaria isidiifera via a population count. Sulcaria isidiifera occurs in maritime chaparral habitat in the Los …

The Tidal Prism, Viable Eelgrass Habitat, And The Effects Of Sea Level Rise In Morro Bay, Kaden A. Caliendo

Master's Theses

The tidal prism, or the volume of water exchanged from the sea to an estuary from mean low to mean high tide, influences system hydrodynamics and ecological functioning. Since 1884, the tidal prism in Morro Bay, California has been estimated to be decreasing over time due to sedimentation from upstream practices. What is the current tidal prism in Morro Bay and how will that change with sea level rise? How will eelgrass respond to rising sea levels?

For this study, inexpensive tidal gauges were deployed at four locations in Morro Bay from March to August 2023 to measure spatially varying …

The Biological, Physical And Chemical Response Of The Little Creek Watershed To The 2020 Czu Lighting Complex Fire, Natalie Fontana

Master's Theses

This post-fire study was conducted to characterize and observe fire induced changes in physical habitat parameters, water-quality conditions and macroinvertebrate assemblages in the Little Creek watershed, a tributary to Scotts Creek located in Cal Poly’s Swanton Pacific Ranch in Davenport, California. Pre-fire data was collected by a Cal Poly student, John Hardy, for his 2017 thesis. Post-burn bioassessment surveys for this study were repeated at four of the same study sites used by Hardy to provide comparisons to the California Stream Condition Index via a modified version of the State of California’s Surface Water Ambient Monitoring Program protocol. Macroinvertebrates were …

Diet Induced Metabolic Alterations In The Brain Tissues Of Juvenile Pigs With Non-Alcoholic Fatty Liver Disease, Rhesa Lacanienta

Master's Theses

The objective of this study was to investigate the diet-induced metabolic changes that affect the brain tissue of juvenile pigs with NAFLD. This study explored the liver- brain axis and metabolic markers in the frontal cortex (FC) affected by liver damage. 18 male (M) and 20 female (F) Iberian pigs were randomly allocated to 1 of 3 high-fructose high-fat liquid diets (lard, olive oil, and coconut oil) and fed for 10 consecutive weeks. “Healthy” Iberian pigs were fed a eucaloric diet to establish a physiological baseline. Protein precipitation extraction using ultra-performance liquid chromatography-tandem quadrupole mass spectrometry was performed for primary …

Evaluating Physical Activity Resources To Support Health Equity In Arizona, Kathryn M. Orzech, Theresa A. Legros, Laurel Jacobs, Gregory Goodman, Ryan Lang

Journal of Extension

We evaluated physical activity (PA) resources in lower-income Arizona communities to support the Supplemental Nutrition Assistance Program – Education (SNAP-Ed) in pursuing equitable policy, systems, and environment (PSE) interventions. In 2017, 71 PA resources across 10 counties (65% parks) were rated using the Physical Activity Resource Assessment (PARA) tool. Accessibility was high, but condition scores and attractiveness varied across resources, with no rural/urban differences. Results suggest that Extension SNAP-Ed staff can be agents of change by assessing resource condition where physical activity health inequities may exist and then convening partners to begin to address needed changes.

2023 Rc Ac, Greg Jordan

Advisory Council

No abstract provided.

We Want It That Way: Post-Traditional Transfer Student Advising Expectations As They Transition To The Four-Year University, Jessica Davis

Electronic Theses, Projects, and Dissertations

Post-traditional students (typically defined as individuals who are at least 25 years of age, have experienced a gap in their educational journey, care for dependents, and who generally work full time [American Council on Education, 2022]), represented 35% of the post-secondary undergraduate population enrolled full time at four-year universities in the United States during the Fall 2019 term (NCES, 2020). The purpose of this phenomenological study was to understand the lived experiences of post-traditional transfer students and how their community college advising experience may have shaped/informed their advising expectations at their current university. Data was collected from six participants who …

Post-Wildfire Effects On A Headwater Stream In The San Bernardino National Forest, Kelley Giron

Electronic Theses, Projects, and Dissertations

Southern California has experienced prolonged drought conditions that have supported frequent wildfires that adversely impact ecosystems, natural resources, and human development. A primary consequence of these events is the impact on water quality and quantity. Of equal concern is evaluating how diverse land use configurations within a watershed can alter the physio-chemical properties of headwater reaches where drought and wildfire conditions are prevalent. To better understand the extent to which wildfires impact water quality and quantity across a headwater watershed, this study investigates wildfire impacts from the 2021 South Fire to Lytle Creek, a headwater stream of the Santa Ana …

Education As A Solution To Combat Rising Cybercrime Rates Against Children And Teenagers, Christian Javier Solis-Diaz

Electronic Theses, Projects, and Dissertations

Ninety seven percent (97%) of people between the ages of 3 and 18 are found to be users of technology and internet services daily. This number also correlates with rising cyber crime rates against people in this age bracket. It is found that people between 3 and 18 years old are found to be technologically savvy but often lack the knowledge of how to protect themselves in online environments. Researchers have suggested that cybersecurity awareness training is an effective method at combating common forms of cyberattack such as social engineering. Social engineering attacks are found to make up 98% of …

Hypothyroid Disease Analysis By Using Machine Learning, Sanjana Seelam

Electronic Theses, Projects, and Dissertations

Thyroid illness frequently manifests as hypothyroidism. It is evident that people with hypothyroidism are primarily female. Because the majority of people are unaware of the illness, it is quickly becoming more serious. It is crucial to catch it early on so that medical professionals can treat it more effectively and prevent it from getting worse. Machine learning illness prediction is a challenging task. Disease prediction is aided greatly by machine learning. Once more, unique feature selection strategies have made the process of disease assumption and prediction easier. To properly monitor and cure this illness, accurate detection is essential. In order …

Early-Warning Prediction For Machine Failures In Automated Industries Using Advanced Machine Learning Techniques, Satnam Singh

Electronic Theses, Projects, and Dissertations

This Culminating Experience Project explores the use of machine learning algorithms to detect machine failure. The research questions are: Q1) How does the quality of input data, including issues such as outliers, and noise, impact the accuracy and reliability of machine failure prediction models in industrial settings? Q2) How does the integration of SMOTE with feature engineering techniques influence the overall performance of machine learning models in detecting and preventing machine failures? Q3) What is the performance of different machine learning algorithms in predicting machine failures, and which algorithm is the most effective? The research findings are: Q1) Effective outlier …

Classification Of Thorax Diseases From Chest X-Ray Images, Sharad Jayusukhbhai Dobariya

Electronic Theses, Projects, and Dissertations

Chest X-ray images are crucial for medical decisions and patient care. However, their manual interpretation is time-consuming and prone to human error. This project aims to create an automated system that uses deep learning techniques to classify thorax disease from chest X-ray images. We are using the NIH Chest X-Ray Dataset, which contains many annotated images, as input data for this project. This approach uses UNet architecture as its classification layer. UNet architecture is well-known for its efficiency in image segmentation. Adding residual blocks enhances this approach's ability to classify images. The goal of this project is to create a …

Administrative Browbeating And Insurance Markets, George A. Mocsary

Villanova Law Review (1956 - )

No abstract provided.

Exploration Of Privilege And Preschool Teachers’ Demographics Associated With Teachers’ Self-Efficacy In Culturally Responsive Classroom Management, Katherine Madison

Electronic Theses and Dissertations

Every child in America is entitled to a free public education; however, racial disparities in academics and discipline continue to grow in America’s school system (Glock et al., 2019; Muñiz, 2019). These racial disparities begin in preschool, following the students throughout their school years. African American students, specifically African American males, are three times more likely than their Caucasian peers to be suspended in preschool (CRDC, 2016; Musu-Gillette et al., 2016). Suspension at an early age correlates with students entering juvenile detentions, prisons and incompletion of schooling (Love, 2014; Meek & Gilliam,2016; Muñiz, 2019). Culturally responsive teaching and classroom management …

Chemistry Instructors’ Perspectives On Incorporating Climate Change Instruction In Undergraduate Chemistry Courses, Patrick Wilson

Dissertations

Education plays an important role in preparing current and future generations for the challenges ahead caused by climate change. The purpose of this dissertation was to examine the educational influence textbooks and undergraduate instructors have on their students. Three studies were carried out to explore these influences on climate change instruction. The first study looked at the extent, type, and location of climate change topics across 24 undergraduate general chemistry textbooks. Gas chemistry concepts were the most prevalent topic connected to climate change. However, the distribution of climate change related material varied considerably across books. The majority of climate change …

“Just Go For The Lie”: A Critical Autoethenographic Study Of A White Female Elementary School Principal, Christie Michelle Toliver

Dissertations

The purpose of this study was to analyze my own leadership experiences as a White cisgender female elementary school principal and how my white privilege contributed to maintaining white supremacy and systemic racism. The purpose was also to explore the impact of the evolution of my white racial frame and intentionally break my silence about white supremacy and systemic racism over the 2018–2019 school year. Critical Race Theory (CRT) and Critical White Studies (CWS) provided the framework of analysis using a narrative structure to develop four critical vignettes at the micro level of education. Qualitative data were drawn from personal …

Establishing Guidelines For Achieving Optimal Individual Posture In Hornists, Daniel Alan Nebel

Dissertations

Potentially debilitating performance-related pain (PRP) is common among professional and aspiring instrumentalists, can lead to significant loss of income, and sometimes end a career. Postural misalignments that lead to PRP can develop early in students’ training and is often successfully addressed by a music teacher recommending a change in technique. The nature of a musician’s PRP is dependent on how their instrument is held; there has never been an in-depth study of PRP specifically for hornists. This dissertation summarizes the current relevant research of PRP in musicians and hornists, conducts and analyzes a comprehensive hornist-specific health survey, seeks to identify …

Resiliency In Families Of Children With Low Vision, Deborah Lynn Mendoza

Dissertations

Resiliency is comprised of a complex interplay of risk and protective factors that change and develop over time. In the past, research focused on characteristics that allowed individuals to remain untouched by negative events around them; however, over time, this has morphed into investigating not only the characteristics individuals possess but those present within families as well. Families of children who have either a congenital or an acquired disability could face a unique set of risk factors over time that might require different protective factors to ensure they emerged from their adversity positively changed. As professionals, we have a responsibility …

A Mixed-Methods Approach To Investigating Core Self-Evaluations, Ethnicity, And Perceived Discrimination Among Undergraduate Students, Rosa I. Law

Dissertations

This research, guided by Yosso’s (2005) social capital theory, delved deep into the lived experiences of individuals navigating spaces where they encountered perceived discrimination and how their core self-evaluations played a pivotal role in shaping their responses to such experiences. Through a meticulous process involving qualitative data analysis strategies such as coding and thematic analysis, the study unveiled larger themes and narratives that moved away from a deficit perspective, focusing instead on assets the individuals brought to the table including their aspirations, goals, and familial and social capital. In the discussion section, focus group settings facilitated rich dialogues where participants …

Resilience In High-Achieving Music Ensemble Directors, Stacey Lynn Larson Dolan

Dissertations

Understanding the professional, relational, and personal traits and characteristics of those who remain and excel in the profession is paramount in helping to retain quality music teachers. Past research has established the complex nature of teacher resilience as a social construct that is unique to an individual’s context, past experiences, and personal and professional values (Day & Gu, 2007; Gu, 2014; Mansfield et al., 2016; Smith, 2020). This case study and photo elicitation sought to better understand resilience in high-achieving music ensemble directors by analyzing the attributes, professional lifestyle traits, and school cultures of teachers who excelled in their role …

Effects Of The Good Behavior Game On Preschoolers’ Self-Regulation, Megan Blythe Baxter

Dissertations

The purpose of this study was to evaluate whether after participation in the classroom management intervention (GBG), students would perform better in a behavioral measure of selfregulation than those who did not receive the intervention (business-as-usual group). In total, 48 preschool students across four classrooms were either assigned to a treatment or control group. The treatment groups completed a one-day behavioral intervention during circle time, whereas classes in the control groups were conducted business-as-usual. All participants completed a preand posttest measure of self-regulation (head toes knees shoulders). The analysis method was two-pronged, consisting of a two-way, mixed methods ANOVA performed …

The Effect Of A Patient-Centered Fall Prevention Tool On Reducing Falls, Maria Gracia Skallet

Master's Projects and Capstones

Problem: Maintaining patient safety is of utmost importance in healthcare. Healthcare organizations develop policies and protocols to minimize preventable harm and deliver care safely. However, hospital falls continue to occur, and preventing falls remains challenging. Falls and fall-related injuries can significantly impact the patient’s quality of life, cause prolonged hospital stays, and higher hospital expenses. Implementing an effective fall prevention program is imperative.

Context: There has been an increased incidence of falls within two medical-surgical units (5C and 5D) at Hospital J in Northern California despite using fall prevention measures such as hourly rounding, wearing yellow skid socks and yellow …

Reflections Of Elementary Principals Leading Through Disruption And Crisis: An Exploration Of Pandemic Leadership, Nicole Renee Peterson

Dissertations

COVID-19 had a tremendous impact on schools across the globe. Educational leaders had to respond to executive orders quickly. Centers for Disease Control and Prevention (CDC) guidelines focused on mandates regarding students’ and staff’s educational, health, and social-emotional needs. This study explored and described the experience and reflections of elementary principals and their staff members during this disruptive time in history.

This qualitative multiple case study involved the interviews of five elementary principals and staff focus groups from each of their buildings. The overarching research questions were: (a) How do principals describe, metacognitively process, and make meaning of their response …

Evaluation Of A Balloon Implant For Simultaneous Magnetic Nanoparticle Hyperthermia And High-Dose-Rate Brachytherapy Of Brain Tumor Resection Cavities, Shuying Wan, Dario Rodrigues, Janet Kwiatkowski, Omaditya Khanna, Kevin Judy, Robert Goldstein, Marty Overbeek Bloem, Yan Yu, Sophia Rooks, Wenyin Shi, Mark Hurwitz, Paul Stauffer

Department of Radiation Oncology Faculty Papers

Previous work has reported the design of a novel thermobrachytherapy (TBT) balloon implant to deliver magnetic nanoparticle (MNP) hyperthermia and high-dose-rate (HDR) brachytherapy simultaneously after brain tumor resection, thereby maximizing their synergistic effect. This paper presents an evaluation of the robustness of the balloon device, compatibility of its heat and radiation delivery components, as well as thermal and radiation dosimetry of the TBT balloon. TBT balloon devices with 1 and 3 cm diameter were evaluated when placed in an external magnetic field with a maximal strength of 8.1 kA/m at 133 kHz. The MNP solution (nanofluid) in the balloon absorbs …