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Residual Pulmonary Vascular Obstruction Following Mechanical Thrombectomy For Submassive Pulmonary Embolism: A Single-Center Analysis, Brian Stegman, Thom G. Dahle, Wade Schmidt, Jacob R. Dutcher, Tanya Glenz

Articles

Background:

Residual pulmonary vascular obstruction (RPVO) following pulmonary embolism (PE) is associated with residual dyspnea, recurrent venous thromboembolism, and chronic thromboembolic pulmonary hypertension. Historically, acute PE treated with anticoagulation alone results in high rates of significant RPVO. Contemporary treatment of submassive PE often involves catheter-based interventions, including mechanical thrombectomy (MT), although their relation to RPVO is not characterized. In this study, we aimed to evaluate the rate of greater than or equal to 10% RPVO in patients treated with MT.

Methods:

Twenty consecutive patients with submassive PE in a single center underwent MT and subsequent planar ventilation/perfusion scintigraphy scan at …

Project Silverlight: Community Based And Participant-Led Initiatives To Increase Civic Engagement Among Older Adults, Paulin T. Straughan, William Tov, Wensi Lim, Rachel Ngu, Yan Er Tan, Mindy Eiko Tadai

ROSA Research Briefs

Project Silverlight was a year-long project aimed at redefining social engagement and participation of older adults in the community. In this report, we share our findings from the project and key recommendations to community partners who are looking to adopt a similar model of participant-led programs. Our study found that by engaging student volunteers as a key partner in this initiative, participants showed a significant improvement in their perceptions of youth, and that participants derived a great sense of satisfaction from being involved in the curation of their activities.

To Ban Ransomeware Payments Or Not To Ban Ransomware Payments: The Problems Drafting Legislation In Reponse To Ransomware, Sean O'Connell

Journal of International Business and Law

No abstract provided.

Clinic Bulletin H2 - 2023, Outpatient Services

AKUH Outpatient Services Archives

• Special Message By Dr. Asim Belgaumi
• Clinical Statistics
• Outpatient Packages
• New Initiatives
• Wch Clinic Commissioning
• Insight Updates Activities And Celebrations
• Department Participations
• New Appointments And Farwell
• Way Forward And Core Team Insights

Assessing The Effectiveness Of Nuclear Security Training And Education In Ghana, Michael Nii Sanka Ansah, Boris Stepanov Pavlovich, Paul Atta Amoah, David Okoh Kpeglo, Simon Adu, Bright Kwame Afornu

International Journal of Nuclear Security

Growing attention is being given to nuclear power across several African countries, including in Ghana. The world is depending on nuclear energy as a reliable and efficient means of energy generation. Ghana as a country is developing nuclear energy; thus, equal attention must be directed toward nuclear safety and security. Ghana is gradually developing interest in and is devoting substantial required resources to educating and training on nuclear security to meet the standards required by international bodies. Institutions such as the Nuclear Safety and Security Centre and the School of Nuclear and Allied Sciences of the Ghana Atomic Energy Commission …

Exploring Underserved Communities’ Perspectives On Wilderness Character In Everglades National Park, Elena R. Thomas, Jaclyn F. Rushing, William L. Rice, Jennifer M. Thomsen, Christopher A. Armatas

Society and Conservation Faculty Publications

Issues related to diversity, equity, and inclusion are becoming increasingly important to park and protected area managers. Recently, several Executive Orders have established policies and priorities for steering public lands to better serve the diversity of the US public. Certain groups, compared to the US population at large, are underrepresented as visitors to parks and protected areas in the US, including BIPOC communities (Black, Indigenous, and other People of Color), women, people with disabilities, veterans, people with lower socioeconomic status, and the elderly. This disparity in visitation may be even more pronounced in federally designated wilderness areas. We present a …

Anthropogenic Effects On Global Soil Nitrogen Pools, Shih Chieh Chien, Jennifer Adams Krumins

Department of Biology Faculty Scholarship and Creative Works

The amount of nitrogen stored in terrestrial soils, its “nitrogen pool”, moderates biogeochemical cycling affecting primary productivity, nitrogen pollution and even carbon budgets. The soil nitrogen pools and the transformation of nitrogen forms within them are heavily influenced by environmental factors including anthropogenic activities. However, our understanding of the global distribution of soil nitrogen with respect to anthropogenic activity and human land use remains unclear. We constructed a meta-analysis from a global sampling, in which we compare soil total nitrogen pools and the driving mechanisms affecting each pool across three major classifications of human land use: natural, agricultural, and urban. …

The Future Of Terrorist Use Of Improvised Explosive Devices: Getting In Front Of An Evolving Threat, Austin C. Doctor, Samuel Hunter

Psychology Faculty Publications

Because of their outsized impact—as well as the wide availability of device components—violent extremists in the United States consider improvised explosive devices a valuable part of their arsenal. They are easy to make, difficult to combat, and cause significant harm and disruption. Yet this threat is not static. Violent extremists continue to innovate, drawing on emerging technologies and creative problem solving. The onus of initiative requires that the counterterrorism mission community looks over the horizon to identify emerging threats. In support of this need, the authors offer a forward-leaning taxonomy of emerging threats related to terrorist use of IEDs in …

2023-December-01-Why I Teach- Dr. Joshua Reid, University Marketing And Communication, East Tennessee State University

ETSU News

In this episode, Dr. Josh Reid, Associate Professor of English, talks about how he engages his students with classical and early modern literature. He also shares his favorite books of the year.

Early Emergency Department Experience With 7-Day Extended-Release Injectable Buprenorphine For Opioid Use Disorder., Gail D'Onofrio, Jeanmarie Perrone, Kathryn F. Hawk, Ethan Cowan, Ryan Mccormack, Edouard Coupet, Patricia H. Owens, Shara H. Martel, Kristen Huntley, Sharon L. Walsh, Michelle R. Lofwall, Andrew Herring, The Ed-Innovation Investigators

Center on Drug and Alcohol Research Faculty Publications

As the opioid overdose epidemic escalates, there is an urgent need for treatment innovations to address both patient and clinician barriers when initiating buprenorphine in the emergency department (ED). These include insurance status, logistical challenges such as the ability to fill a prescription and transportation, concerns regarding diversion, and availability of urgent referral sites. Extended-release buprenorphine (XR-BUP) preparations such as a new 7-day injectable could potentially solve some of these issues. We describe the pharmacokinetics of a new 7-day XR-BUP formulation and the feasibility of its use in the ED setting. We report our early experiences with this medication (investigational …

A Wearable Fluorescence Imaging Device For Intraoperative Identification Of Human Brain Tumors, Mehrana Mohtasebi, Chong Huang, Mingjun Zhao, Siavash Mazdeyasna, Xuhui Liu, Samaneh Rabienia Haratbar, Faraneh Fathi, Jinghong Sun, Thomas A. Pittman, Guoqiang Yu

Biomedical Engineering Faculty Publications

Malignant glioma (MG) is the most common type of primary malignant brain tumors. Surgical resection of MG remains the cornerstone of therapy and the extent of resection correlates with patient survival. A limiting factor for resection, however, is the difficulty in differentiating the tumor from normal tissue during surgery. Fluorescence imaging is an emerging technique for real-time intraoperative visualization of MGs and their boundaries. However, most clinical grade neurosurgical operative microscopes with fluorescence imaging ability are hampered by low adoption rates due to high cost, limited portability, limited operation flexibility, and lack of skilled professionals with technical knowledge. To overcome …

Epistemic (In)Justice: Whose Voices Count? Listening To Migrants And Students, Anne Carr, Gabriela B. Bonilla, Athena Alchazidu, William A. Booth, Kateřina Chudová, Patricia E. Tineo, Pilar Constanzo

Journal of Comparative & International Higher Education

Special Issue

Medication Use Evaluation Of Neonatal Starter Total Parenteral Nutrition, Allexa Buckingham Pharmd, Heather Kistler Rd, Csp, Ldn, Ophira Silbert Md, Nisha Vyas Rph, Sharyn Jones Rph, Laura Hayn Pharmd

Department of Pharmacy

No abstract provided.

Early Screening Of Oral Premalignant And Malignant Lesions Using Salivary Biomarkers, Sara Abdelwahed, Mohamed Shamel, Mahmoud Al Ankily, Mohamed Mansy, Myra De Guzman Angeles

Dentistry

No abstract provided.

Root And Canal Morphology Of Mandibular Second Molars In An Egyptian Subpopulation: A Cone-Beam Computed Tomography Study, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Background: This study was using Cone beam computed tomography (CBCT) to examine the anatomical variations in mandibular second molars in an Egyptian sub-population. Methods: A total of 350 CBCT images (215 females and 135 males, aged 15–65 years) of mandibular second molars were evaluated. Samples were evaluated in terms of: number of roots, number of root canals, roots’ cross section as well as prevalence and configurations of C-shaped canals. Statistical analysis was done to highlight differences between different categories and their prevalence among genders (significance level was set at p < 0.05). Data were presented as frequency and percentage values and were analyzed using chi square test followed by pairwise comparisons utilizing multiple Fisher’s exact tests with Bonferroni correction. The significance level was set at p < 0.05 within all tests. Results: Of the 350 mandibular second molars evaluated, 87.2% were non-C-shaped while 12.8% were C-shaped with no gender-based statistically significant differences (χ2 = 0.19, p = 0.656). Most samples had three root canals (80%) followed by two (16%), then one (3.2%), and finally four (0.8%) root canals. Among the non-C-shaped molars, presence of two roots was most common (83.4%) followed by presence of a single root (16.2%), and only one sample (0.2%) had three roots, and this had no correlation with gender (χ2 = 1.86, p = 0.431). In the mesial roots Type IV Vertucci was the most common configuration found (68.8%), while Type I was the most prevalent in the distal roots (91.8%). The long oval configuration was the most commonly found cross section in mesial roots while “oval” was the most prevalent in distal roots. Conclusion: Egyptian sub-population shows highly variable morphological features in mandibular second molars, hence, CBCT is highly recommended on case-to-case conditions.

Root And Canal Morphology Of Mandibular Second Molars In An Egyptian Subpopulation: A Cone-Beam Computed Tomography Study, Shehabeldin Mohamed Saber Prof.Dr.

Dentistry

Background: This study was using Cone beam computed tomography (CBCT) to examine the anatomical variations in mandibular second molars in an Egyptian sub-population. Methods: A total of 350 CBCT images (215 females and 135 males, aged 15–65 years) of mandibular second molars were evaluated. Samples were evaluated in terms of: number of roots, number of root canals, roots’ cross section as well as prevalence and configurations of C-shaped canals. Statistical analysis was done to highlight differences between different categories and their prevalence among genders (significance level was set at p < 0.05). Data were presented as frequency and percentage values and were analyzed using chi square test followed by pairwise comparisons utilizing multiple Fisher’s exact tests with Bonferroni correction. The significance level was set at p < 0.05 within all tests. Results: Of the 350 mandibular second molars evaluated, 87.2% were non-C-shaped while 12.8% were C-shaped with no gender-based statistically significant differences (χ2 = 0.19, p = 0.656). Most samples had three root canals (80%) followed by two (16%), then one (3.2%), and finally four (0.8%) root canals. Among the non-C-shaped molars, presence of two roots was most common (83.4%) followed by presence of a single root (16.2%), and only one sample (0.2%) had three roots, and this had no correlation with gender (χ2 = 1.86, p = 0.431). In the mesial roots Type IV Vertucci was the most common configuration found (68.8%), while Type I was the most prevalent in the distal roots (91.8%). The long oval configuration was the most commonly found cross section in mesial roots while “oval” was the most prevalent in distal roots. Conclusion: Egyptian sub-population shows highly variable morphological features in mandibular second molars, hence, CBCT is highly recommended on case-to-case conditions

Translational Research Targeting Biliary Tract Cancer, Yan Zhu

Dissertations and Theses (Open Access)

Biliary tract cancer (BTC) is malignant tumor that originates from the biliary tract, including cholangiocarcinoma (CCA) and gallbladder cancer (GBC). In this translational research program targeting BTC, we focus on three aspects: the development of a combination treatment against CCA, the exploration of the immune background of GBC, and the establishment of a CCA mouse model mimicking mutation profiles of CCA patients.

Patients with cholangiocarcinoma have poor clinical outcomes due to late diagnoses, poor prognoses, and limited treatment strategies. To identify novel drug combinations for this disease, we have conducted a genome wide CRISPR screen anchored on the bromodomain and …

Special Education Teachers’ Emotional Well-Being And Work-Related Stressors In The School Environment, Mallory J. Laravie

Electronic Theses and Dissertations

There is little to no research regarding novice elementary special education teachers (SETs) and their emotional well-being while in the school environment. The goal of this work is to illuminate special education teacher’s voices missing in previous research. Additionally, this research examines the impact of work-related stressors on novice elementary SETs' emotional well-being in the school environment. The theoretical perspective of heuristics is used to illuminate a problem or answer a question about the lived experience of the researcher. Lazarus and Folkman’s (1984) transactional theory of stress and coping framework guided the research question development, data analysis, and presentation of …

Selecting Patient-Reported Outcome Measures For A Patient-Facing Technology, Priyank Raj, Youmin Cho, Yun Jiang, Yang Gong

Faculty, Staff and Student Publications

OBJECTIVE: This article provides insight into our process and considerations for selecting patient-reported outcome measures (PROMs) designed for self-reporting symptoms and quality-of-life among breast cancer (BCA) patients undergoing oral anticancer agent treatment via a patient-facing technology (PFT) platform.

METHODS: Following established guidelines, we conducted a thorough assessment of a specific set of PROMs, comparing their content to identify the most suitable options for studying BCA patients.

RESULTS: We recommend utilizing the combination of EORTC QLQ-C30 + EORTC QLQ-BR45 as the preferred instrument, especially when developing a dedicated "breast cancer-only" application.

DISCUSSION: When developing and maintaining a dashboard for a PFT …

Discovery Of Novel 2-Aminopyridine Derivatives As Ros1 And Alk Dual Inhibitors To Combat Drug-Resistant Mutants Including Ros1g2032r And Alkg1202r, Siming Liu, Chuan Huang, Chunhui Huang, Yaqi Huang, Yonghuan Yu, Guowu Wu, Fengqiu Guo, Ying Jiang, Shanhe Wan, Zhengguang Zhu, Yuanxin Tian, Jianghua Zhu, Jiajie Zhang

Faculty, Staff and Student Publications

Clinical treatment by FDA-approved ROS1/ALK inhibitor Crizotinib significantly improved the therapeutic outcomes. However, the emergence of drug resistance, especially driven by acquired mutations, have become an inevitable problem and worsened the clinical effects of Crizotinib. To combat drug resistance, some novel 2-aminopyridine derivatives were designed rationally based on molecular simulation, then synthesised and subjected to biological test. The preferred spiro derivative C01 exhibited remarkable activity against CD74-ROS1G2032R cell with an IC50 value of 42.3 nM, which was about 30-fold more potent than Crizotinib. Moreover, C01 also potently inhibited enzymatic activity against clinically Crizotinib-resistant ALKG1202R, harbouring a 10-fold potency superior to …

Value Added By Using Joint Displays In Mixed Methods Research, Elizabeth Svoboda

College of Education and Human Sciences: Dissertations, Theses, and Student Research

Mixed methods research collects, analyzes, and integrates rigorous qualitative and quantitative methods to gain a deeper understanding of a phenomenon than would be gained by using either method alone. Integration is one of the key features of mixed methods research and consists of mixing qualitative and quantitative research in a systematic way to generate new inferences or follow-up studies. However, the process of integration can be challenging to draw on expertise in both qualitative and quantitative methods, decide when and how to integrate qualitative and quantitative research, and combine multiple data sources in a coherent way to generate new inferences. …

Ecological Impacts Of Restoring Fire-Grazing Interaction In Sandhills Prairie Through Patch-Burn Grazing, Nolan P. Sipe

School of Natural Resources: Dissertations, Theses, and Student Research

A Collaborative Adaptive Management (CAM) Project was started at the University of Nebraska in 2020 to address some of the key uncertainties related to the management of grasslands in the Nebraska Sandhills through stakeholder driven experiments and the adaptive management cycle. Patch-burn grazing was selected by CAM as a management tool to generate heterogeneity across the landscape and promote biodiversity while balancing economic and ecological trade-offs. The patch-burn grazing system was implemented with controlled burns in May of 2022 and March of 2023. Other parties in CAM will be examining the impact that patch-burn grazing has on forage and livestock …

Population Demography Of A Glacial-Relict Stream Fish Mediated Via Anthropogenic Alteration, Joseph M. Spooner

School of Natural Resources: Dissertations, Theses, and Student Research

Northern Pearl Dace Margariscus nachtriebi are a small-bodied glacial-relict fish species of greatest conservation need (SGCN) found throughout Canada and the northern United Sates. Their distribution within the Nebraska Sandhills Ecoregion is isolated from the northern core distribution of the species following the last glaciation period approximately 18,000 years ago. Headwater streams within the Nebraska Sandhills Ecoregion are predominately groundwater fed and provide the cool water temperatures needed to support Northern Pearl Dace and other glacial-relict SGCN. Headwater streams within the Nebraska Sandhills Ecoregion have been geomorphically altered through anthropogenic processes such as channelization whereby habitat homogenization has occurred. Evidence …

Habitat Heterogeneity In Nebraska Streams And Distribution Prediction For Tier-1 Cyprinids Using Multi-Scale Modeling Of Fluvial And Landscape Features, Connor P. Hart

School of Natural Resources: Dissertations, Theses, and Student Research

Multiscale environmental processes determine in-stream habitat conditions which drive species distributions. Habitat constitutes the physical template upon which ecological processes occur and species conduct life stage activities. Habitat heterogeneity promotes biodiversity of aquatic systems. Stream classification informs freshwater conservation by providing a useful framework to account for habitat heterogeneity, often based on landscape regions of similar environmental processes. A greater understanding of landscape-based classification frameworks as means to classify stream systems may improve understanding of drivers of biodiversity. Using Nebraska as a case study, on a statewide scale, objectives were 1) to characterize habitat availability for several at-risk fish species, …

Understanding Avidities Of Recreational Activities For People Possessing Fishing Licenses And Residing In Urban Environments, Kyle F. Hansen

School of Natural Resources: Dissertations, Theses, and Student Research

Recreational fishing is one of the world's most popular pastimes, wherein participation is associated with sociodemographic factors. Even so, fishing license sales are declining in the USA in conjunction with a reduction in rural populations as people move to urban areas. Thus, urban areas are constantly growing in population size, population diversity, and geographic size suggesting a need to understand fishing participation in these growing areas. Natural resource managers often use participation to understand recreationists, yet avidity could provide a new way to understand recreationists. The goal of our study is to understand what sociodemographic factors influence the fishing avidity …

Development Of A Machine Learning System For Irrigation Decision Support With Disparate Data Streams, Eric Wilkening

Department of Agricultural and Biological Systems Engineering: Dissertations, Theses, and Student Research

In recent years, advancements in irrigation technologies have led to increased efficiency in irrigation applications, encompassing the adoption of practices that utilize data-driven irrigation scheduling and leveraging variable rate irrigation (VRI). These technological improvements have the potential to reduce water withdrawals and diversions from both groundwater and surface water sources. However, it is vital to recognize that improved application efficiency does not necessarily equate to increased water availability for future or downstream use. This is particularly crucial in the context of consumptive water use, which refers to water consumed and not returned to the local or sub-regional watershed, representing a …

Teaching Literacy By Modeling Language, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

The Bombeck Family Learning Center is participating in a four-year grant to study the development of language and literacy in children aged 0 to 3.

Fostering Youth-Led Innovations To Accelerate Progress On The United Nations Sustainable Development Goals: A Guide For Policy Makers At Cop28, Brock Dickinson, Issa Gonzalez-Peltier Leogal, Radhika Iyengar, Nicholas Palaschuk, Haein Shin, Iveta Silova, Sumie Song, Hana Sahatqija, Valeria Soto, Deepak Sridhar, Wen-Wen Tung, Matthew A. Witenstein, Shriya Iyer, Eshan Akula, Suvid Bordia, Eshaan Jain, Aaryan Jain, Vidya Bindal

Educational Leadership Faculty Publications

In today’s world, to address the most pressing global challenges, education must equip all learners with the values, skills, and knowledge that nurture cooperation, resilience, respect for diversity, gender justice, and human rights. This concept is called Global Citizenship Education which is a target of the Sustainable Development Goal 4 – Quality Education.

I commend the Mission 4.7 initiative facilitated by Columbia University’s Center for Sustainable Development, UNESCO, UN SDSN and the Ban Ki-moon Centre for Global Citizens, for playing a pivotal role in addressing SDG Target 4.7 and on the release of the “Fostering Youth-led Innovations to Accelerate Progress …

Nevada Workforce Diversity, Equity, And Inclusion Study 2023, Becky Harris, Andrea Dassopoulos

International Gaming Institute Faculty Research

Diversity, Equity, and Inclusion (DEI) metrics enable organizations to set concrete goals and self-monitor their performance. In 2021, Nevada’s legislature passed Senate Bill No. 267 (SB267), authorizing the University Nevada, Las Vegas (UNLV) to study DEI benchmarks in the State. The study is designed to produce actionable results capable of informing policy and employer best practices in Nevada. Workforce Study data was collected for the 2022 calendar year with study participation taking place between January 2-April 30, 2023.

The questions in the study were crafted based on DEI public policy considerations as well as metrics for gauging the scope of …

Evaluation Of Efferent Unmasking Using Cortical Auditory-Evoked Potentials, Donguk Lee

Theses and Dissertations (ETD)

Purpose. All human beings, regardless of whether they have hearing impairments or not, face difficulties in detecting signals in the presence of background noise. To cope with such situations, people can enhance their performance by either increasing the signal levels or reducing the noise levels, which in turn increases the signal-to-noise ratios (SNRs). SNRs play a crucial role in determining one's speech perception abilities. For instance, if the noise levels are high, individuals may raise their voices or decrease their distance from the source to amplify the signal levels, thereby increasing the SNR. However, in real-life situations, individuals may not …