Digital Commons Network^™

Treatment Effect Heterogeneity Following Type 2 Diabetes Treatment With Glp1-Receptor Agonists And Sglt2-Inhibitors: A Systematic Review, Katherine G. Young, Eram Haider Mcinnes, Robert J. Massey, Anna R. Kahkoska, Scott J. Pilla, Sridharan Raghavan, Maggie A. Stanislawski, Deirdre K. Tobias, Andrew P. Mcgovern, Andrew P. Mcgovern, Adem Y. Dawed, Angus G. Jones, Ewan R. Pearson, Ewan R. Pearson, John M. Dennis, John M. Dennis, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng

Clinical Research Faculty Publications

Background: A precision medicine approach in type 2 diabetes requires the identification of clinical and biological features that are reproducibly associated with differences in clinical outcomes with specific anti-hyperglycaemic therapies. Robust evidence of such treatment effect heterogeneity could support more individualized clinical decisions on optimal type 2 diabetes therapy. Methods: We performed a pre-registered systematic review of meta-analysis studies, randomized control trials, and observational studies evaluating clinical and biological features associated with heterogenous treatment effects for SGLT2-inhibitor and GLP1-receptor agonist therapies, considering glycaemic, cardiovascular, and renal outcomes. After screening 5,686 studies, we included 101 studies of SGLT2-inhibitors and 75 studies …

Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman

Clinical Research Faculty Publications

Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a …

The Partner-An Underutilized Facilitator To Support Healthy Gestational Weight Gain, Joshua R. Sparks, Suzanne Phelan, Kimberly L. Drews, Leanne M. Redman

Clinical Research Faculty Publications

No abstract provided.

Author Correction: Predicting Alzheimer’S Disease Progression Using Multi-Modal Deep Learning Approach (Scientific Reports, (2019), 9, 1, (1952), 10.1038/S41598-018-37769-Z), Garam Lee, Kwangsik Nho, Byungkon Kang, Kyung Ah Sohn, Dokyoon Kim, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter

Clinical Research Faculty Publications

Correction to: Scientific Reports, published online 13 February 2019 This Article contains errors. A Supplementary Information file was omitted from the original version of this Article. The Supplementary Information file is now linked to this correction notice.

Prognostic Relevance Of Gait-Related Cognitive Functions For Dementia Conversion In Amnestic Mild Cognitive Impairment, Cosimo Tuena, Sara Maestri, Silvia Serino, Elisa Pedroli, Marco Stramba-Badiale, Giuseppe Riva, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Adam Fleisher, Helen Vanderswag, Jaimie Ziolkowski, Judith L. Heidebrink, Lisa Zbizek-Nulph, Joanne L. Lord, Colleen S. Albers, Ronald Petersen, Sara S. Mason, David Knopman, Kris Johnson, Javier Villanueva-Meyer, Valory Pavlik, Nathaniel Pacini

Clinical Research Faculty Publications

Background: Increasing research suggests that gait abnormalities can be a risk factor for Alzheimer’s Disease (AD). Notably, there is growing evidence highlighting this risk factor in individuals with amnestic Mild Cognitive Impairment (aMCI), however further studies are needed. The aim of this study is to analyze cognitive tests results and brain-related measures over time in aMCI and examine how the presence of gait abnormalities (neurological or orthopedic) or normal gait affects these trends. Additionally, we sought to assess the significance of gait and gait-related measures as prognostic indicators for the progression from aMCI to AD dementia, comparing those who converted …

Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo

Faculty Publications

Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased …

Painted Playgrounds For Preschoolers’ Physical Activity And Fundamental Motor Skill Improvement: A Randomized Controlled Pilot Trial Of Effectiveness, E. Kipling Webster, Maura M. Kepper, Sanjoy Saha, Robbie A. Beyl, Chelsea L. Kracht, Jessica St Romain, Amanda E. Staiano

Population and Public Health Science Faculty Publications

Background: Preschool children are not meeting recommended levels of physical activity (PA) nor are they proficient in fundamental motor skills (FMS), which are the foundation for PA. As such, interventions are needed to increase PA and FMS in young children. This trial examined the effects of an environmental (“painted playgrounds”) and capacity-building (written toolkit) intervention on child FMS, PA, and sedentary behavior at early childhood education (ECE) centers and examined feasibility. Methods: In a randomized controlled trial, four ECE centers were randomly assigned to an intervention group or wait-list control. For intervention centers, stencils were spray painted adjacent to playgrounds …

Labrad : Vol 48, Issue 2 - December 2023, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• Editorial
• Articles
• Navigating Lab Excellence in LARAD
• Lab Resilience in a Changing Climate: Sustainable Strategies for Future-Proof Clinical Laboratories
• Professional Insights from a Pioneer in Autoimmune Disease Testing: The Future of Antinuclear/Anticellular Antibody Testing
• Insights into CCHF and Other Viral Hemorrhagic Fevers
• Bombay Blood Group
• Role and Application of Cytogenetics in Multiple Myeloma
• Low-grade Nasopharyngeal Papillary Adenocarcinoma in a Deceivingly "blue" Biopsy
• Transplant Immunology – Diagnostics
• The Best of the Past
• Farewell Chronicles: Celebrating Dr Anila Rashid's Journey
• The Best of the Past
• Farewell Chronicles: Celebrating Dr Anila Rashid's Journey
• Polaroid
• Chemical Pathology
• Radiology
• Hematology
• Histopathology
• Microbiology
• Molecular Pathology
• Tests …

Environment And Sustainability: December 2023, Environment And Sustainability, Office Of The President

Environment and Sustainability Archives

• AKU’s Honourable Mention at the 2023 IHF Awards

• 7% energy savings at Stadium Road

• FMIC’s new solar water heater

• 2 Electric Shuttles for campus commuting

• AKU at COP28

• And much more…

A Study Of The Impact Of The Nation Builders Program On The Self-Perception Of African American Male Participants In The Fourth And Fifth Grades At Dunbar Elementary, Mason West

Masters Theses and Doctoral Dissertations

This study was designed to determine if there was a significant difference in the self-perception of fourth and fifth grade African American male participants in the Nation Builders Leadership Program and fourth and fifth grade African American male participants in traditional extracurricular programs offered at Paul Laurence Dunbar Elementary School. The availability sample included 30 African American males. Fifteen participants were randomly assigned to the Nation Builders Leadership Program and fifteen were randomly assigned to other programs by the school’s administration. The participants selected were given the self-perception profile family of assessments (SPPC) designed by Dr. Susan Harter. The SPPC …

Trends Of Autumn Phenology In Response To Environmental And Meteorological Variables, Meagan Renee Maguire

Masters Theses

Previous studies have identified that changes in plant phenology are most likely induced by climate variability. One such change is the end of season (EOS) for deciduous forests in the United States. In essence, the EOS represents the end of plant productivity for a given year; the phase in which plant dormancy is reached. However, our wealth of knowledge on plant phenology largely overlooks the phases that occur in autumn, especially the EOS, with many previous studies focusing on spring phenology. This study uses remote sensing MODIS aerial imagery data and historical meteorological data to analyze any relationships that may …

Super Parents: Preliminary Findings Of A Group-Based Parenting Intervention, Jens E. Jespersen, Cara D. Bosler, Ruth S. Slocum, Jennifer Hays-Grudo, Jerry Root, Laura Hubbs-Tait, Amanda Sheffield Morris

Journal of Human Sciences and Extension

Super Parents is a group-based, Extension-led parenting program developed to enhance the parent-child relationship. Implemented by trained Head Start staff using the train-the-trainer model, this effort is achieved by teaching positive parenting practices, increasing parents’ knowledge of child development, instructing parents in activities and exercises for enhancing their child’s executive function skills, and encouraging the use of mindfulness techniques in parenting. The specific aims of our study were to evaluate the program's effectiveness among parents of young children ages 0 to 5 by examining changes in parenting attitudes, mindfulness, executive function, parenting efficacy, stress, and child behavior. Through the use …

Impact Of Prolonged Professional Development On Teachers’ Confidence In Using Inquiry-Based Learning In The Classroom, Kasey Harmon, Taylor Ruth, Bryan Reiling, Nathan W. Conner, Christopher T. Stripling

Journal of Human Sciences and Extension

Professional development (PD) programs for science and agriculture teachers designed around the inquiry-based learning (IBL) teaching strategy could help to improve science proficiency amongst our high school students. PD that continues over a longer period of time is more effective than short-term workshops. The purpose of this study was to explore the impact of a prolonged PD program on teachers’ confidence in using IBL strategies for teaching animal sciences content. The following research questions guided this study: RQ1: What were participants’ perceptions of a prolonged PD program? and RQ2: How did the prolonged PD program influence the participants’ confidence in …

Educational Interests And Information-Seeking Behaviors Of Utah Residents, Amanda D. Ali, Lendel K. Narine

Journal of Human Sciences and Extension

With a limited body of literature examining residents’ preferences for Extension topic areas, this brief report examined the educational interests of Utah residents. It explores opportunities for future programming based on residents’ preferences for topic areas and their information-seeking behaviors. Data were gathered from Utah residents in May 2021 via an online Qualtrics survey (n = 668). Results showed the topics of highest interest to Utah residents were strengthening family relationships, emergency preparedness, mental health, food storage, and healthy couples’ relationships. Residents’ information-seeking behaviors were somewhat consistent with their interests; residents searched most frequently for information on mental health, strengthening …

Barriers To Policy, Systems, And Environment Work: Using Community Engagement As A Tool In Snap-Ed’S Multi-Level Comprehensive Programming, Cristian Meier, Casey Coombs, Amria Farnsworth, Lacee Jimenez, Heidi Leblanc

Journal of Human Sciences and Extension

Implementing policy, system, and environmental (PSE) changes has several well-known challenges that have been documented in Supplemental Nutrition Assistance Program Education’s (SNAP-Ed) comprehensive approach to obesity prevention and reduction. The purpose of the current study was to explore the use of community engagement (CE) as a strategy to address the common challenges experienced in implementing a multi-component community-based program. Phone interviews (N = 7) were conducted with SNAP-Ed educators in Utah using semi-structured interviews. Emergent themes were identified as transcripts were coded independently by two researchers until a high level of agreement was achieved. Four themes emerged from the interviews: …

Equipping Extension Professionals To Lead Volunteer Systems: An Evaluation Of An Online Course, Kandi O'Neil, Rachelle Vettern, Sarah Maass, Rebecca Harrington, Kari Robideau, Patricia Mcglaughlin, Josset Gauley

Journal of Human Sciences and Extension

Extension professionals enter their role with content-specific expertise; however, experience in volunteer leadership and management competencies is often limited. This study focused on the effectiveness of the Achieving the Extension Mission Through Volunteers (AEMTV) course in preparing professionals to use the Identification, Selection, Orientation, Training, Utilization, Recognition, Evaluation (ISOTURE) model to learn and apply volunteer systems concepts in a cohort-based online learning environment. We used quantitative and qualitative methods to assess how the course impacted participants and the programs they lead. Data from 127 participants indicated they increased their knowledge, improved volunteer systems, and influenced the quality of programming delivered …

Determining The Health Literacy Skills Of Extension Audiences In Maryland, Beverly Jackey, Heejung Song, Lisa Mccoy, Virginia Brown

Journal of Human Sciences and Extension

Strong health literacy skills empower people to make informed health decisions, especially those with chronic health conditions striving for positive health outcomes. Half of all people living in Maryland report having at least one chronic disease. Research examining the health literacy of Marylanders is limited. This paper reports how establishing a baseline for health literacy levels of Marylanders can identify major factors affecting the health literacy skills of Extension audiences and lays the important groundwork to develop Extension programs and explore the best delivery methods tailored to the needs of subpopulations. Using the Newest Vital Sign, a …

Self-Reflections Through A Screen: Self-Identity, Social Media, And Psychological Well-Being, Jeremy J. Serio

Undergraduate Honors Thesis Collection

Social media use among emerging adults is assumed to be related to a variety of negative psychological outcomes and has, in recent years, become a widely studied phenomenon (Kim, 2017, Pew Research Center, 2018). Despite the widespread assumption, the results from empirical studies of the effects of social media use on mental health in this population have been inconsistent and inconclusive (Keles et al., 2020, Yang et al., 2021). Several meta-analyses (e.g., Keles et al., 2020) demonstrate these inconsistent results across studies and point to the need to consider individual difference factors when researching this issue. Different self-identity styles have …

School Law Enforcement Officers’ Perspectives Of Youth In A Southern State, Shannon April Davenport

All Dissertations

The empirical literature has identified that school law enforcement officers respond to youth based on their training, personal feelings, emotions, and social-psychological reactions. Therefore, the perspectives that shape school law enforcement officers' feelings, emotions, and social-psychological reactions are vital to understanding their use of discretion as they interact with youth in a school setting. This study utilized an exploratory descriptive research design via survey to examine school law enforcement officers' perspectives of youth, the training received, their stress and emotional regulation.

School law enforcement officers were selected using systematic sampling after compiling a list of all the school districts in …

2023-12-01 Caudill Connection, Morehead State University. Caudill College Of Arts, Humanities And Social Sciences.

Caudill Connection

Caudill Connection newsletter for December of 2023.

Beyond The Plate: Leisure Studies As A Recipe For Food Justice, Julia M. Montano

Undergraduate Honors Theses

To address the issues that have been derived from the dominant forces in our food systems, movements such as food justice strive to find solutions through decolonization and addressing barriers to accessing healthy, affordable and culturally representative food. One group of individuals that are heavily involved in, and impacted by, food justice are college students. This study seeks to explore the extent to which college students’ involvement in food justice is shaped by their free time. With this research, I strive to bring in the voices of college students, while also bridging a gap in the field by bringing leisure …

Pacific Magazine 2023, University Of The Pacific

Pacific Magazine and Pacific Review

No abstract provided.

Application Of Arterial Infusion Ports In Hepatic Arterial Infusion Chemotherapy And Embolization For Advanced Hepatocellular Carcinoma, Xinqiang Han, Peng Zhao, Xuemin Wang, Xiaoyu Tan, Yongzhen Zhang

Saudi Medical Journal

Objectives: To investigate the safety and feasibility of subcutaneous implantable infusion ports in repeated hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma (HCC) in China. Methods: A total of 237 patients who were clinically diagnosed with advanced HCC (CNLC III a/III b) in our hospitals from December 2020 to October 2022 were retrospectively analyzed. The approaches of HAIC were divided into 2 groups: arterial infusion port implantation (group A) and one-time femoral artery catheterization (group B) based on the physicians’ suggestion and the patients’ intention. The comfort level (evaluated with the General Comfort Questionnaire), complications and average inpatient expenditure …

Impact Of Body Image Ideals On Form And Frequency Of Exercise In College Students, Isabella Dipippo

Honors Theses

Objective: Body image issues are very prevalent among college students and can cause a variety of physical and mental health problems as determined by previous research. The SUNY Cortland student population, which tends to have a higher active student population than other campuses, may have a unique correlation between exercise and body image. This study aims to examine the impact of body image ideals in SUNY Cortland students in relation to exercise habits.

Methods: This study was conducted through survey-based methodology and distributed to various classes and organizations of undergraduate SUNY Cortland students through Google Forms. A total sample of …

Evaluation Of Ambulatory Care Proton Pump Inhibitor Use, Jessica Offerle Pharmd, Shivani Bhakta Pharmd, Bcacp, Noah Budi Pharmd, Ashley Parrott Pharmd, Mba, Bcps, Bcacp, Sarah Pfaehler Pharmd, Mba, Bcps, Pacs

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

The objectives of this project were to assess appropriateness of PPI utilization and identify possible opportunities for alternative PPI or step-down therapy.

Evaluation Of Diabetic Ketoacidosis Management: Comparing The Effectiveness Of Computer Program-Directed Vs Physician-Directed Intravenous To Subcutaneous Insulin, Kendra Yarian Pharmd, Jennifer Sposito Pharmd, Bcps, Bcccp, Christina Ford Pharmd, Bcps, Zachary Crabill Pharmd, Bcps

Pharmacy Residency

Presented at the ASHP Midyear Clinical Meeting. December 2023.

This project compared effectiveness of computer-directed versus physician-directed intravenous (IV) to subcutaneous (SC) insulin transition in patients with diabetic ketoacidosis (DKA) by retrospectively reviewing blood glucose values and DKA recurrence.

Gig Work & College Students: An Analysis Of The Student Employment Experience, Lauren Andriaansen

Honors Projects in Politics, Law, and Society

Gig work has become increasingly popular with the prevalence of flexible and remote work opportunities. Despite this emerging trend, there is an overwhelming lack of research regarding undergraduate college students’ experience in that sector; the age group that is the most active in the gig economy. The majority of people partaking in alternative work arrangements do so in addition to their full-time jobs, and for young adults in college their full-time job is being a student. This research aims to understand the factors of gig work that contribute to students having a positive work experience during university. Additionally, this study …

Analysis Of The Potential Of Rice And Corn In Supporting Food Availability, Luh Pastiniasih, Ketut Sumantra, Ni Putu Pandawani, Putu Edi Yastika

The Philippine Agricultural Scientist

A region’s agricultural sector plays a strategic role in fulfilling its food needs with ideal nutrition. The potential of cereal commodities, specifically rice and corn, was identified based on the production level and competitiveness by district in Buleleng Regency, Indonesia. The regency’s potential to provide and support food security was also determined through a quantitative descriptive analysis of the Location Quotient (LQ), Shift Share Analysis (SSA), Localization Coefficients, and Levels of Food Availability by utilizing secondary data on cereal commodity production and population numbers over the course of 10 yr (2012–2021). Results showed that Sawan, Seririt, and Sukasada districts were …

Buoying Statehood: The Impact Of Rising Sea Levels On Statehood In International Law, Hayley Stancil

North Carolina Journal of International Law

No abstract provided.

Gene-Edited Crops And Food And The Bold Path Forward In U.S. Trade Agreements, Matthew Schaefer

North Carolina Journal of International Law

No abstract provided.