De Novo, Jagadish Chandrabose Sundaramurthi, Anita M Bagley, Hannah Blau, Leigh Carmody, Amy Crandall, Daniel Danis, Michael Gargano, Anxhela Gjyshi Gustafson, Ellen M Raney, Mallory Shingle, Jon R Davids, Peter N Robinson

Faculty Research 2024

We identified a de novo heterozygous transient receptor potential cation channel subfamily M (melastatin) member 3 (TRPM3) missense variant, p.(Asn1126Asp), in a patient with developmental delay and manifestations of cerebral palsy (CP) using phenotype-driven prioritization analysis of whole-genome sequencing data with Exomiser. The variant is local- ized in the functionally important ion transport domain of the TRPM3 protein and predicted to impact the protein structure. Our report adds TRPM3 to the list of Mendelian disease– associated genes that can be associated with CP and provides further evidence for the path- ogenicity of the variant p.(Asn1126Asp).

Aging And Urinary Control: Alterations In The Brain-Bladder Axis., Cara C Hardy, Ron Korstanje

Faculty Research 2023

Age-associated alterations in bladder control affect millions of older adults, with a heavy burden added to families both economically and in quality of life. Therapeutic options are limited with poor efficacy in older adults, lending to a growing need to address the gaps in our current understanding of urinary tract aging. This review summarizes the current knowledge of age-associated alterations in the structure and function of the brain-bladder axis and identifies important gaps in the field that have yet to be addressed. Urinary aging is associated with decreased tissue responsiveness, decreased control over the voiding reflex, signaling dysfunction along the …

Bridging The Gap: Analyzing The Relationship Between Environmental Justice Awareness On Twitter And Socio-Environmental Factors Using Remote Sensing And Big Data, Charles Knoble, Danlin Yu

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

Mounting awareness of the discriminatory distribution of environmental factors has increasingly placed environmental justice at the forefront of discussions on sustainable development, but responses to these disparities are often too little, too late. Remote sensing has emerged as a potential solution to this problem, capitalizing on the ability to capture high-resolution, spatially explicit data in near-real time. However, a conventional reliance on physical measurements and surface-level analyses risks overlooking the experiences and perceptions of affected communities. It is against this backdrop that the potential integration of remote sensing imagery and socially sensed big data such as social media data assumes …

Sembrando Semillas, Sowing Seeds: Reflections On Latinx Representations In Us Community Psychology's Ajcp, Jesica S. Fernandez, Ireri Bernal, Bianca L. Guzmán

Ethnic Studies

Latinx have contributed to the foundation and formation of the United States, and as this demographic increases, overlooking their unique experiences and lived conditions can limit community psychology's potential to better support them in their wellbeing. Thus, in alignment with the call for a virtual special issue highlighting critical themes in the American Journal of Community Psychology (AJCP), we take an exemplar approach to reviewing 15 articles published between 1979 and 2023. We highlight these articles for their unique contributions in laying the foundation or shifting the discourses of Latinx in the United States. We organize each article under one …

Fostering Self-Advocacy In Primary School-Aged Children With Cerebral Palsy, Meagan Ellner

Occupational Therapy Doctoral Capstones

Developing self-advocacy skills in individuals with disabilities promotes lifelong independence and disability awareness. Introducing and implementing opportunities to engage in self-advocacy at an early age allows children to understand their diagnosis, strengths, and needs. Early self-advocacy equips children to determine and request accommodations that may benefit them. Children with cerebral palsy often face challenges in communication, ambulation, and social participation, making the need for self-advocacy prominent in encouraging their success in the school setting. In implementing a tool built during school-based occupational therapy services, children with cerebral palsy learned to recognize and voice their academic and social needs while informing …

Clinical Practice Skills For Incorporating Animal-Assisted Therapy In Occupational Therapy, Erin Wilhelm

Occupational Therapy Doctoral Capstones

The aim of my capstone project was to advance the field of animal-assisted therapy (AAT) and promote the incorporation of AAT within occupational therapy (OT) services. Existing research notably supports the implementation of AAT in OT practice in many settings and for a wide variety of diagnoses to promote occupational performance, build therapeutic rapport, and encourage motivation and engagement in therapy, but stronger evidence is needed to promote the incorporation of AAT (Andreason et al., 2017; Fine et al., 2019b). Despite the growth of AAT over the past two decades, there are few resources tailored specifically to the implementation of …

Applications Of Causal Inference Methods For The Estimation Of Effects Of Bone Marrow Transplant And Prescription Drugs On Survival Of Aplastic Anemia Patients, Yesha M. Patel

Computational and Data Sciences (PhD) Dissertations

This dissertation provides an in-depth exploration into the treatment effectiveness for aplastic anemia using causal inference methods, structured around three pivotal research papers. Each paper contributes to a nuanced understanding of treatment impacts, specifically focusing on bone marrow transplantation (BMT) and prescription drugs, and the identification of optimal treatment strategies.

The first paper, "Causal Inference Analysis for Assessing the Effect of Bone Marrow Transplantation on the One-Year Survival of Adult and Pediatric Aplastic Anemia Patients," sets the foundation. It examines the short-term effectiveness of BMT in both adult and pediatric patients, providing crucial insights into how this treatment affects survival …

Novel Implementation Of Additive Manufacturing To Visualize The Human Brain Connectome, Greg Tyler

Computational and Data Sciences (MS) Theses

Additive manufacturing (AM) is an emerging technology with diverse areas of application. In this paper we explore a new application of AM that uses a subset of AM known as 3D printing, to create real life models of the human connectome. The human connectome is a color coded map of the connections in the human brain where directions are indicated by colors and the density of connections are indicated by color intensity.

There are several different algorithms for mapping the connections and describing the output. The Neu- roImaging Tools and Resource Collaboratory (NITRC) provides one such algorithm. It uses probabilistic …

Disinfection Of Foodborne Bacteria Using The Contamination Sanitization Inspection And Disinfection (Csi-D) Device, Jennifer Mccoy Sanders

Food Science (MS) Theses

Foodborne pathogens, including Escherichia coli, Salmonella enterica, and Listeria monocytogenes, are major causes of gastrointestinal disease globally. The Contamination Sanitization Inspection and Disinfection (CSI-D) device is a new handheld fluorescence-based imaging system designed to disinfect food contact surfaces contaminated with microorganisms using ultraviolet-C (UVC) illumination. This study aimed to determine the optimal parameters for the disinfection of foodborne bacteria using the CSI-D device. The following bacterial strains were tested: generic E. coli; enterohemorrhagic E. coli (EHEC) O157:H7; enterotoxigenic E. coli (ETEC) O78:H11; S. enterica serotypes Enteritidis, Newport, Typhimurium, and Javiana; and L. monocytogenes serotypes 1/2a, 1/2b, and 4b …

Adaptation And Coping Mechanisms To Financial Constraints Among Socially Disadvantaged Farmers In South Carolina: A Qualitative Study, Akanksha Rathi

All Theses

Abstract

Throughout American history, Socially Disadvantaged Farmers and Ranchers (SDFRs) have faced systemic discrimination, often leading to their intentional exclusion from federal programs. This has contributed to a decline in the number of farms operated by SDFRs. Even though certain policies led to a gradual increase in their numbers, the average acreage of SDFR-owned farms has diminished over time. Recognizing the impact of racial disadvantages on the diminished participation of SDFRs, the United States Department of Agriculture (USDA) has instituted programs specifically tailored for minority farmers, offering financial aid and outreach initiatives. However, persistent and emerging barriers continue to impede …

Pulse: The Monthly Newsletter Of Nnlm Region 2, December 2023, Network Of The National Library Of Medicine, Regional Medical Library 2

NNLM Region 2 Newsletters

No abstract provided.

Scholarships, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Notes From The Director, The Mcnair Team

McNair Scholars Research Journal

No abstract provided.

Breaking Barriers: Latinas And Business In The United States, Jacqueline Vidales

McNair Scholars Research Journal

No abstract provided.

Tiktok: Effects On Anxiety, Depression, And Physical Activity, Lazar L. Ismail

McNair Scholars Research Journal

No abstract provided.

Iron Promotes Glycolysis To Drive Colon Tumorigenesis., Zhaoli Liu, Luke Villareal, Lavanya Goodla, Hyeoncheol Kim, Daniel M. Falcon, Mohammad Haneef, David R. Martin, Li Zhang, Ho-Joon Lee, Daniel Kremer, Costas A. Lyssiotis, Yatrik M. Shah, Henry C. Lin, Hui-Kuan Lin, Xiang Xue

Pathology Research and Scholarship

Colorectal cancer (CRC) is the third most common cancer and is also the third leading cause of cancer-related death in the USA. Understanding the mechanisms of growth and progression of CRC is essential to improve treatment. Macronutrients such as glucose are energy source for a cell. Many tumor cells exhibit increased aerobic glycolysis. Increased tissue micronutrient iron levels in both mice and humans are also associated with increased colon tumorigenesis. However, if iron drives colon carcinogenesis via affecting glucose metabolism is still not clear. Here we found the intracellular glucose levels in tumor colonoids were significantly increased after iron treatment.

Monitoring The Competitiveness Of The Australia Awards, Debbie Wong, Yung Nietschke

Global education monitoring

The Australia Awards are prestigious international scholarships and short courses funded by the Australian Government to contribute to the achievement of development outcomes and the promotion of prosperity, resilience and stability in partner countries. The closure of Australia’s borders during COVID-19 caused a decline in international student numbers and prompted concerns about Australia’s competitiveness in the global scholarship market. This paper provides a framework and proposed methodology for systematic monitoring of Australia Awards competitiveness to provide DFAT’s Global Education and Scholarships section with data to inform ongoing policy and programming decisions. This paper uses theories of capital as a conceptual …

Can The Vegetation Structure And Composition In Urban Green Spaces Determine Diversity Of Green Lacewings (Neuroptera: Chrysopidae)?, Jose I. Martinez, Raiza J. Castillo, Adrián Ardila-Camacho, Charles V. Covell, José Isabel López-Arroyo, Francisco Javier Nava-Guízar

Insecta Mundi

Green spaces represent the only natural areas in several cities around the world, providing good shelters for the local fauna. Based on this premise, many ecological studies have been conducted focused on these areas. Most of these works are about insects, particularly butterflies and beetles. Our study is centered on a different group: green lacewings (Neuroptera: Chrysopidae). These insects exhibit a similar feeding behavior to some other groups, such as beetles. We estimated diversity, richness, distribution, abundance and similarity employing two methods: sweep netting and suction trapping. Also, oviposition hosts were identified in 20 different green spaces. Approximately 740 specimens …

Exploring The Utilization Of Digital Twins In Facilities Management, Veronica Brems

Discovery Undergraduate Interdisciplinary Research Internship

Digital twin is often referred to as a realistic digital replica of any asset. Depending on the level and details of the digital twin, it comprises real-time data and analytics that would be utilized to identify any potential issues in building systems and components. Considering the increasing attention and applications of digital twins in the architecture, engineering, construction, and operations (AECO) industry, this project aims to identify the utilization of digital twins in facility management and building operations/maintenance. The project focuses on current literature to reveal the use, challenges, barriers, and benefits of the digital twin in facilities management with …

Reforma December Retreat, Network Of The National Library Of Medicine, Regional Medical Library 2

All NNLM R2 Presentations

No abstract provided.

The Discovery Of Diverse Picophytoplankton Populations In The Columbia And Willamette Rivers Using Flow Cytometry, Kylee M. Lamberson

Chemistry Undergraduate Departmental Honors Theses

As important primary producers, picophytoplankton determine the flow of carbon and energy in aquatic ecosystems. Picocyanobacteria are one picophytoplankton group known to be dominant in oceans and lakes, but they are still poorly understood in river systems. This project examined picophytoplankton communities in two distinct river systems: the Columbia and Willamette Rivers in Portland, Oregon. I aimed to characterize and quantify the picophytoplankton populations in the context of the environmental conditions of the two rivers. I used flow cytometry to detect cells based on their relative size and pigment fluorescence. I sampled nearly weekly for ten months to capture population …

“The Debt Is Suffocating To Be Honest”: Student Loan Debt, Prospective Sensemaking, And The Social Psychology Of Precarity In An Allopathic Medical School, William Burr, Judson G. Everitt, James Johnson

Sociology: Faculty Publications and Other Works

Confronted with soaring medical school costs and intensifying disparities in physician compensation by specialty, medical students are forced to make sense of medical education debt during the nascent stages of their careers in medicine. Few studies, however, have examined exactly how medical students make sense of these constraints or how this process might influence decisions about which specialty to pursue or affect doctors’ wellbeing. Leveraging qualitative data collected from current students across all four years of medical education at a Midwestern allopathic medical school, we document how medical students collectively engage in prospective sensemaking about their debt and how it …

The Radical Power Of Education—Brief, Arindam Nandi, Nicole Haberland, Thoai Ngo

Gender, Education, Justice, and Equity (GEJE)

This research brief summarizes the findings of GEJE’s recent report on the impact of education across society.

A Qualitative Analysis Of Catholic Mental Health Services In Texas For School-Age Children And Adolescents, Dylan R. Benson

Social Work Theses - Archive

Introduction: This study’s purpose was to provide a snapshot of what mental health services are available to school-age children and adolescents in the state of Texas that are provided by the Catholic Church and Catholics, and to provide feasible recommendations for improvements concerning said services. This study also aims to dispel the stigma against mental healthcare provision by licensed professionals that still exists in some areas of the Catholic Church by displaying the intersection between having faith and the ability to provide care to everyone regardless of faith or lack thereof. Methods: This study used a qualitative research method due …

Preparing Students For Social Work Practice With Grieving Clients, Lisa Battle

Social Work Theses - Archive

Social workers will encounter grief, death, and dying in their professional careers. Whether or not it is integral to the practice setting, it is integral to life, and clients in all settings will be impacted by grief and death. Rapidly increasing research in this area has uncovered grief and death as an important competency that new social workers are lacking (Pomeroy et al., 2019). This shortfall impacts social workers through increased risk of vicarious grief and trauma, and their clients through decreased level of care provided (Richmond et al., 2021). Extricating social workers and clients from this burden is a …

Former And Present Military Service Members' Perceptions Of The Use Of Psychedelic Substances For The Treatment Of Mental Health Conditions, Chloe Seay

Social Work Theses - Archive

Now more than ever, Americans are experiencing a serious mental health crisis. However, it can be asserted that veterans are even more in need of effective interventions to address mental health concerns. Veterans experience disproportionally high rates of anxiety, depression, substance abuse disorders, PTSD, and death by suicide. They often do not find significant symptom reduction from traditional mental health intervention methods. Psychedelics are re-emerging as an option for mental health treatment, however our knowledge of veterans’ attitudes toward the use of psychedelics for treatment for various mental health conditions is currently limited. This work presents the results of an …

Health Care Quality And Health Care Access Disparities Among Racial And Ethnic Populations With Comorbid Mental And Physical Health Conditions, Amanda Lee Ryan

Social Work Dissertations - Archive

This study reports the individual and county-level factors associated with racial and ethnic disparities in the ED and inpatient utilization rates and discharge status for adult individuals with chronic mental illness (CMI) and comorbid medical conditions. Social determinants at the individual and county levels associated with rates of higher risk discharge statuses, and the extent to which these account for heterogeneity in acute care utilization and post-acute care plans were also assessed. Despite the significant literature in racial and ethnic disparities, and emergency department and inpatient admission utilization, there remains gaps in the literature regarding individuals with chronic mental illness …

Molecular Mechanisms Underlying Meropenem Tolerance In Acinetobacter Baumannii, Nowrosh Islam

Biology Dissertations - Archive

The emergence and proliferation of Gram-negative bacterial infections has become a serious public health concern due to their rapid rise of resistant to all the clinically available antibiotics. The increasing incidence of bacterial infections has prioritized the invention of new therapeutics to prevent the antibiotic treatment failure. Typically, Gram-negative bacteria use several defensive strategies such as modification of the cell envelope to escape the lethal effects of bactericidal antibiotics. Carbapenem beta-lactam considered last resort antibiotic to treat Gram-negative bacteria infections, while they are considered first line prescription against nosocomial pathogen Acinetobacter baumannii (denoted as Ab). Beside resistance, the susceptible populations …

The Role Of Leaders In Implementing Effective Leadership Strategies Towards The Educational Barriers Of Us-Based Refugee Students: A Qualitative Case Study Of Congolese Refugee Students, Faustin Busane

Masters Theses & Specialist Projects

This qualitative research study explored the experiences of three families of refugee school students, two school officials (a Superintendent and a Principal), three teachers, and one humanitarian agent all living in a Southeastern U.S. city. The results of the study revealed that the language barrier is the main academic challenge that refugee students encounter when they enroll in U.S. schools. The study also found that educators conceptualize their responsibilities toward refugee children by emphasizing the importance of high-quality teaching, and establishing through establishing strong relationships between parents, school officials, and exercising patience in the process. This study poses important implications …

Block Charting For Hemodynamic Unstable Patients, Tasha Walker

Student Scholarly Projects

Practice Problem: The intensive care unit poses many challenges for nurses. Nurses are placed in a position to decide on dosing and administration, which could conflict with their scope of practice, and documentation needs to coincide with orders. The accuracy of nursing documentation plays a vital role in measuring the outcomes, and failure to document accurately could result in noncompliance with scope of practice or a medication error.

PICOT: For intensive care nurses (P), how does block charting of vasoactive medications (I) compared to current documentation practices (C) affect the accuracy of nurses' documentation (O) within 4 weeks?

Evidence: Nursing …