Digital Commons Network^™

Investigating The Role Of Bhlhe40 In Host Responses To Mycobacterium Tuberculosis Infection And Myeloid Cell Development, Skyler Hendrix

Arts & Sciences Graduate Student Theses and Dissertations

Infections with Mycobacterium tuberculosis (Mtb), the causative agent of the disease tuberculosis (TB), remain a prominent global health threat that affects millions of people annually. While antibiotic treatments for Mtb infections are available, the increased prevalence of drug-resistant Mtb cases has highlighted the urgent need to develop additional therapeutic options such as host-directed therapies. Development of host-directed therapies, however, first requires a better understanding of the protective immune responses required to control Mtb infection. Such responses must strike a precise balance between pro-inflammatory and anti-inflammatory responses that promote bacterial clearance while also minimizing tissue damage. Here we show that the …

Topical Gabapentin Solution For The Management Of Burning Mouth Syndrome: A Retrospective Study, Alessandro Villa

All Publications

Objective: The aim of this retrospective study was to evaluate the effectiveness and safety of topical gabapentin solution (250 mg/mL) for the management of burning mouth syndrome (BMS).

Study design: A retrospective chart review was conducted of all patients diagnosed with BMS and managed with gabapentin 250 mg/mL solution (swish and spit) between January 2021 and October 2022. Patient-reported outcomes included changes in burning score ranked on a 10-point numeric rating scale (NRS) and reported adverse drug reactions (ADR). Wilcoxon signed-rank test was used to assess differences in the oral burning score ranked on a NRS (0-10) between the baseline …

Understanding And Combating The Spread Of Antibiotic-Resistant Organisms, Bejan Mahmud

Arts & Sciences Graduate Student Theses and Dissertations

The introduction of antibiotics in the 20th century stands as one of our greatest scientific achievements, profoundly transforming human health and global well-being. Over the past century, antibiotics have ensured that infectious diseases are no longer the most common causes of death worldwide. In further enabling a vast array of invasive medical procedures (e.g., surgeries, organ transplants), antibiotics have effectively added decades to the average human lifespan. In agriculture, antibiotics have been heavily relied upon to meet the nutritional demands of the growing human population. Thus, ever since the introduction of penicillin, antibiotics have been the “miracle drugs” they were …

The Experiences Of Black Women Direct Care Workers In Long-Term Care, Nakeshia Knight-Coyle

Dissertations and Theses

This study expands understanding about the experiences of Black women direct care workers (DCWs) experiences with racism, discrimination, and economic exploitation in the long-term care (LTC) sector. It comes at a critical time when COVID-19 has demonstrated the important and essential nature of long-term care work. COVID-19 has also elucidated the challenges of an insufficient workforce and its detrimental impact on the long-term care system’s ability to meet the care needs of those accessing long-term care services. Finally, workforce needs are projected to increase with the impending influx of baby boomers into retirement, making this study a timely effort at …

2023-December-14-Etsu Trio Celebrates First-Generation Students.Pdf, University Marketing And Communication, East Tennessee State University

ETSU News

“The fact that I got into college was just a dream come true.”

This statement is true for East Tennessee State University senior Chloe Salyer and resonates with many other first-generation college students.

The journey of a first-generation student may not be the same journey that their peers encounter, but certainly displays the resilience and perseverance of those working toward a college degree.

“In a lot of cases, first-generation students have overcome so many obstacles to be in college, and we are just so fortunate that they are here,” said Dr. Erin Messmer, assistant director for TRIO Student Support Services …

Resilience Small Group: A Small Group For Upper Elementary Students, Devyn Stenzel

Dissertations, Theses, and Projects

Resilience is important for a child’s ability to persevere, as well as their physical health. Parental influence, connection, cultural identity and coping skills are some factors that can help build resilience within a child. Teaching and surrounding the child with positive connections can help children overcome and persevere when faced with stressful and traumatic events. Children need opportunities to learn skills to reduce the impact of severe stress on their bodies (Sciaraffa, et al, 2018). The resilience small group will help children receive the chance to practice these skills in a group of 4-6 of their peers. Children will be …

Recognizing Teacher Burnout: Utilizing Teacher Retention Strategies To Help Work Life Balance Of Educators, Meghann Downer

Dissertations, Theses, and Projects

The ongoing shortage of special education teachers coupled with an increasing attrition rate has prompted many researchers to investigate why teachers are choosing to leave the field. Multiple studies (Lehmann 2008, et al Cheng 2022, et al Bryant 2023) have been conducted to determine the rates of attrition at multiple levels in education. Results of studies (Hughes 2012, et al Robinson 2019, et al Ogakwu 2022) indicate that there has been a statistically significant relationship between job satisfaction and burnout among special education teachers. This project provides a literature review focused on special education teacher burnout and attrition along with …

World Aids Day, University Of Dayton. School Of Education And Health Sciences

School of Education and Health Sciences Blog Archive

Junior Kassidy McGlone used her practicum experience to bring education and awareness about HIV/AIDS to UD. She reached 1,099 students over the course of one week of events.

Embodying Compassion: Striving Towards Sensitivity, Inclusion And Synergy, Arva N. Anees

Student Theses and Dissertations

Inspired by the author's experience as the sole Muslim woman in a company of over 100 employees, the capstone project addresses the observed lack of prioritization for minority inclusion in the workplace. The capstone project outlined aims to address this issue by developing a cultural sensitivity and inclusion workshop that surpasses superficial efforts and encourages participants to internally reflect on their daily workplace interactions. The workshop, designed with an experiential approach lasting 1.5-2 hours, seeks to foster practical knowledge and instigate changes towards a more inclusive, equitable, and diverse working environment. Emphasizing increased awareness, engagement in reflective and collaborative activities, …

Feminist Ethnographic Case Study: Financial/Emotional Stressors Of Parenting Trans-Children, Kay Siebler

English Faculty Publications

When a child resists gender socialization, many parents struggle to understand the path forward. Even supportive parents trying to help a gender-nonconforming child navigate a gendered world experience stress. These stressors are extended to the family. Through their attempts to navigate support for their gender-nonconforming children, parents are often without support or assistance when faced with systems of institutional power such as education, medicine, and government. This case study examines the complexities of being a supportive parent of a trans-identified child and the emotional, physical, and financial stress on the parent/family, using a feminist ethnographic approach. This case study of …

Board Of Trustees Meeting Minutes, December 14, 2023

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 14, 2023.

Wmu Board Of Trustees Formal Session December 14, 2023, Wmu Board Of Trustees

WMU Board of Trustees Meetings

• Acceptance of the Agenda
• Remarks by the Chair
• Remarks by the President
• Public Comments Regarding Action Items

Action Items

• International Alliance of Theatrical Stage Employees Labor Agreement
• Professional Instructors Organization Labor Agreement (Wage Re opener)
• General Public Comments

Verification And Validation Of Robot Manipulator Adaptive Control With Actuator Deficiency, Sebastian Comeaux

Doctoral Dissertations and Master's Theses

This work addresses the joint tracking problem of robotic manipulators with uncertain dynamical parameters and actuator deficiencies, in the form of an uncertain control effectiveness matrix, through adaptive control design, simulation, and experimentation. Specifically, two novel adaptive controller formulations are implemented and tested via simulation and experimentation. The proposed adaptive control formulations are designed to compensate for uncertainties in the dynamical system parameters as well as uncertainties in the control effectiveness matrix that pre-multiplies the control input. The uncertainty compensation of the dynamical parameters is achieved via the use of the desired model compensation–based adaptation, while the uncertainties related to …

Deep-Learning Based Multiple-Model Bayesian Architecture For Spacecraft Fault Estimation, Rocio Jado Puente

Doctoral Dissertations and Master's Theses

This thesis presents recent findings regarding the performance of an intelligent architecture designed for spacecraft fault estimation. The approach incorporates a collection of systematically organized autoencoders within a Bayesian framework, enabling early detection and classification of various spacecraft faults such as reaction-wheel damage, sensor faults, and power system degradation.

To assess the effectiveness of this architecture, a range of performance metrics is employed. Through extensive numerical simulations and in-lab experimental testing utilizing a dedicated spacecraft testbed, the capabilities and accuracy of the proposed intelligent architecture are analyzed. These evaluations provide valuable insights into the architecture's ability to detect and classify …

Utilizing Multitask Transfer Learning For Sonographic Rheumatoid Arthritis Synovitis Grading, Jordan Marie Claire Sanders

Doctoral Dissertations and Master's Theses

Classifying the four sonographic Rheumatoid Arthritis (RA) synovitis grades (Grade 0, Grade 1, Grade 2, and Grade 3) is a difficult problem due to the complexity of the relevant markers. Therefore, the current research proposes a Multitask Transfer Learning (MTL) framework for sonographic RA synovitis grading of Ultrasound (US) images in Brightness mode (B-Mode) and Power Doppler mode.

In the medical community, the lack of reliability of scoring these images has been an issue and reason for concern for doctors and other medical practitioners. The human/machine variability across the acquisition procedure of these US images creates an additional challenge that …

A Review Of Slipping Rib Syndrome: Diagnostic And Treatment Updates To A Rare And Challenging Problem, Isheeta Madeka, Sneha Alaparthi, Marisa Moreta, Shawn Peterson, Jeffrey Mojica, Johanes Roedl, Olugbenga Okusanya

Department of Surgery Faculty Papers

Slipping rib syndrome (SRS) is a disorder that occurs when one or more of the eighth through tenth ribs become abnormally mobile. SRS is a poorly understood condition leading to a significant delay in diagnosis and therapeutic management. History and a physical exam are usually sufficient for a diagnosis of SRS. The utility of dynamic ultrasounds has also been studied as a useful diagnostic tool. Multiple surgical techniques for SRS have been described within the literature. Cartilage rib excision (CRE) has been the most common technique utilized. However, the literature has shown a high rate of recurrence and associated risks …

Resting-State Eeg Power Differences In Autism Spectrum Disorder: A Systematic Review And Meta-Analysis, Weisi Siong Neo, Dan Foti, Brandon Keehn, Bridgette Kelleher

Purdue University Libraries Open Access Publishing Fund

Narrative reviews have described various resting-state EEG power differences in autism across all five canonical frequency bands, with increased power for low and high frequencies and reduced power for middle frequencies. However, these differences have yet to be quantified using effect sizes and probed robustly for consistency, which are critical next steps for clinical translation. Following PRISMA guidelines, we conducted a systematic review of published and gray literature on resting-state EEG power in autism. We performed 10 meta-analyses to synthesize and quantify differences in absolute and relative resting-state delta, theta, alpha, beta, and gamma EEG power in autism. We also …

Analysis Of Self, Peace Peter

Dissertations, Theses, and Projects

Abstract

This self-analysis paper explores the author's personal growth and development over a specific period. The paper begins with an overview of the author's background and experiences of immigration that have shaped their identity. Next, the author reflects on their personal relationships with family and friends, discussing areas in which they have made progress and areas in which they still need improvement. The paper also explores the author's theoretical orientation and aspirations, outlining the steps they are taking to achieve them. Through this self-analysis, the author gains a deeper understanding of themselves, their motivations, and their potential for growth. Overall, …

Body Positivity: A School Counseling Group For Adolescents, Zoe Justine Hess

Dissertations, Theses, and Projects

An eating disorder is a mental illness characterized by severe, unhealthy changes in appetite and dysphoric body image. One main indicator that an eating disorder is likely to occur is the person having a perfectionistic personality type. Another major factor is having an intense consciousness of body image, often with this being very skewed and negative. Both, when brought to extremes, have dangerous consequences for the person’s mental and physical health. Eating disorders typically first appear in adolescence or young adulthood, most markedly for females; thus, it is pertinent that school counselors are aware of the signs of an eating …

P-12 Teachers' Perceptions And Knowledge About Students' Mental Health And Their Willingness To Provide Mental Health Supports Within Their Classroom, Tamara Engel

Dissertations, Theses, and Projects

P-12 students are experiencing higher rates of mental health needs, which generates a growing concern among teachers, parents, and educational leaders. Students with mental health challenges may struggle socially, emotionally, behaviorally, and academically and become at a risk for lower academic achievement, reduced graduation rates, and increased school suspensions and expulsions. While most of the literature is qualitative and has consistently identified schools as the ideal location to provide targeted mental health supports to students, teachers have reported having insufficient knowledge, skills, and resources to provide these supports to students. This correlational study aimed to move forward the quantitative methodology …

The Impact Of Mindfulness On Perceived Stress And Academic Performance Among English Language Students In Central Asia, Laurie Wolfe

Dissertations, Theses, and Projects

The current study investigated the effectiveness of mindfulness training in reducing stress and increasing academic performance among Uzbek English language students. The researcher partnered with four English faculty at Tashkent State Pedagogical University (TSPU) to conduct a quasi-experimental study using a convenience sample of sixty 2^nd year students studying English as a foreign language. One group of students (n = 30) received mindfulness training while the acted as an active control group (n = 30) and received study skills training. Both groups received 20-minutes training in their English classes, four days a week, for 4-weeks. All participants …

Enhancing Inclusion: Neurodiversity In The Workplace, Micah Cox

Dissertations, Theses, and Projects

Neurodiverse individuals have long been viewed negatively, particularly in the workplace. Many recruiters or hiring managers have never considered the benefits that hiring a neurodiverse candidate could bring to their organization, rather looking at the additional costs of accommodation. The results of analyzing several case studies show that companies who incorporate neurodiverse candidates into their labor pool have seen increased productivity, creativity, process innovation, and cost reductions. This paper reviews several case studies combined with data obtained from interviews with a neurodiverse individual and a direct support care professional to develop a list of methods to be used in the …

Exploring The Coverage Of Cyberchondria Addiction In Newspapers: A Perspective From The Usa, Rifat Afrin, Mumtahina Obaid, Gayle Prybutok, Ahasan Harun, Victor R. Prybutok

Information Systems Faculty Publications

Objectives: The purpose of this study is to investigate how US newspapers reported cyberchondria from 2009 to 2021. Cyberchondria shares similarities with addiction, making it imperative to delve into its representation in media. Cyberchondria refers to an issue of excessive and repetitive internet searches for health information often accompanied by obsessive-compulsive behavior. The goal of this research is locate the frames that appear in cyberchondria coverage, look at how the frames have changed over the given time span, and assess the emotions that the news frames portray.

Method: After collecting the relevant news items, the study applies correspondence analysis, sentiment …

Deep Learning-Based Phenotyping Reclassifies Combined Hepatocellular-Cholangiocarcinoma, Julien Calderaro, Pooja Navale, Et Al.

2020-Current year OA Pubs

Primary liver cancer arises either from hepatocytic or biliary lineage cells, giving rise to hepatocellular carcinoma (HCC) or intrahepatic cholangiocarcinoma (ICCA). Combined hepatocellular- cholangiocarcinomas (cHCC-CCA) exhibit equivocal or mixed features of both, causing diagnostic uncertainty and difficulty in determining proper management. Here, we perform a comprehensive deep learning-based phenotyping of multiple cohorts of patients. We show that deep learning can reproduce the diagnosis of HCC vs. CCA with a high performance. We analyze a series of 405 cHCC-CCA patients and demonstrate that the model can reclassify the tumors as HCC or ICCA, and that the predictions are consistent with clinical …

Iron Oxide-Coupled Crispr-Ncas9-Based Genome Editing Assessment In Mucopolysaccharidosis Iva Mice, Andrés Leal, Betul Celik, Nidhi Fnu, Shaukat Khan, Shunji Tomatsu

Department of Pediatrics Faculty Papers

Mucopolysaccharidosis (MPS) IVA is a lysosomal storage disorder caused by mutations in the GALNS gene that leads to the lysosomal accumulation of keratan sulfate (KS) and chondroitin 6-sulfate, causing skeletal dysplasia and cardiopulmonary complications. Current enzyme replacement therapy does not impact the bone manifestation of the disease, supporting that new therapeutic alternatives are required. We previously demonstrated the suitability of the CRISPR-nCas9 system to rescue the phenotype of human MPS IVA fibroblasts using iron oxide nanoparticles (IONPs) as non-viral vectors. Here, we have extended this strategy to an MPS IVA mouse model by inserting the human GALNS cDNA into the …

Re-Thinking Education For Sustainable Development: Key Learning Insights From The Sdsn Usa Transformative Education Summit 2023, Radhika Iyengar, Sumie Song, Deepak Sridhar, Wendy M. Purcell, Ann Nielsen, Iveta Silova, Matthew A. Witenstein, Wen-Wen Tung

Journal of Contemplative and Holistic Education

This paper summarizes key learning insights from the 2023 U.S. Summit on Transformative Education organized by the Sustainable Development Solutions Network USA. Over 400 members from higher education institutions, non-governmental organizations, think tanks, students, and teachers, joined the online event held February 23-25. The Summit created a bridge between social justice issues with an historical lens and sustainable development. Learning insights include those shared by session speakers, dialogue among participants during thematic conversations and regional networking forums, comments made by attendees on session Jamboards and the Zoom Chat function, and post-Summit feedback. A high-level thematic review was undertaken to cluster …

Staying Home” And Domestic Student (Im)Mobilities: Thinking Through “Stuckness” Beyond Covid-19, M Holton, K Finn

School of Geography, Earth and Environmental Sciences

No abstract provided.

Illyrian Props. Inc. V Department Of Hous. Preserv. & Dev.

All Decisions

No abstract provided.

Pwv Acquisition Owner, Llc V Lerner

All Decisions

No abstract provided.

Implementation Of Positive Behavior Interventions And Supports (Pbis) And Its Impact On Middle School Students’ Academic Success And Problem Behaviors, Brittanie Watson

Dissertations, Theses, and Projects

Positive Behavior Interventions and Supports (PBIS) has been implemented across the United States in the effort to help diminish problem behaviors and increase academic success. Schools across the country are reporting an increase in numbers and intensity of problem behaviors. In addition, academic success after the COVID-19 pandemic has decreased in some school districts across the United States. Therefore, districts are looking for an intervention to help increase academics and decrease problem behaviors. With school districts already implementing PBIS, research studies and analyses are needed to ensure that the outcomes expected of PBIS are occurring. In addition, with the little …