Digital Commons Network^™

Timigp: An R Package To Depict The Tumor Microenvironment From Bulk Transcriptomics, Chenyang Li, Jianjun Zhang, Chao Cheng

Faculty, Staff and Students Publications

Exploring the clinical relevance of diverse immune cell types within the tumor microenvironment is pivotal for unraveling cancer intricacies and developing treatments. Here, we present a protocol for using tumor immune microenvironment illustration based on gene pairs, an R package to deduce cell-cell interactions, unveiling the association between immune cell relative abundance and patient prognoses from bulk gene expression and survival data. We describe steps for harnessing cell-type markers derived from single-cell RNA sequencing data to map the tumor immune microenvironment across a spectrum of cancer types. For complete details on the use and execution of this protocol, please refer …

Monitoring Time Domain Characteristics Of Parkinson's Disease Using 3d Memristive Neuromorphic System, Md Abu Bakr Siddique, Yan Zhang, Hongyu An

Michigan Tech Publications

INTRODUCTION: Parkinson's disease (PD) is a neurodegenerative disorder affecting millions of patients. Closed-Loop Deep Brain Stimulation (CL-DBS) is a therapy that can alleviate the symptoms of PD. The CL-DBS system consists of an electrode sending electrical stimulation signals to a specific region of the brain and a battery-powered stimulator implanted in the chest. The electrical stimuli in CL-DBS systems need to be adjusted in real-time in accordance with the state of PD symptoms. Therefore, fast and precise monitoring of PD symptoms is a critical function for CL-DBS systems. However, the current CL-DBS techniques suffer from high computational demands for real-time …

Early Cellular And Molecular Signatures Correlate With Severity Of West Nile Virus Infection, Ho-Joon Lee, Yujiao Zhao, Ira Fleming, Sameet Mehta, Xiaomei Wang, Brent Vander Wyk, Shannon E Ronca, Heather Kang, Chih-Hung Chou, Benoit Fatou, Kinga K Smolen, Ofer Levy, Clary B Clish, Ramnik J Xavier, Hanno Steen, David A Hafler, J Christopher Love, Alex K Shalek, Leying Guan, Kristy O Murray, Steven H Kleinstein, Ruth R Montgomery

Faculty, Staff and Students Publications

Infection with West Nile virus (WNV) drives a wide range of responses, from asymptomatic to flu-like symptoms/fever or severe cases of encephalitis and death. To identify cellular and molecular signatures distinguishing WNV severity, we employed systems profiling of peripheral blood from asymptomatic and severely ill individuals infected with WNV. We interrogated immune responses longitudinally from acute infection through convalescence employing single-cell protein and transcriptional profiling complemented with matched serum proteomics and metabolomics as well as multi-omics analysis. At the acute time point, we detected both elevation of pro-inflammatory markers in innate immune cell types and reduction of regulatory T cell …

Gatekeeping At Bio, Daniel A Gorelick

Faculty, Staff and Students Publications

No abstract provided.

Galonsky V. East 17th Llc

All Decisions

No abstract provided.

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Li Ding, Feng Chen, Et Al.

2020-Current year OA Pubs

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …

Enniatin A Inhibits The Chaperone Hsp90 And Unleashes The Immune System Against Triple-Negative Breast Cancer, Nada H Eisa, Vincent M Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T F Tsai, Paulo C Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

Faculty, Staff and Students Publications

Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted in improved efficacy, even though induction of an extensive heat shock response (HSR) and less than optimal dosing of these inhibitors limited their clinical efficacy as monotherapies. We discovered that the natural product Enniatin A (EnnA) targets Hsp90 and destabilizes its client oncoproteins without inducing an HSR. EnnA triggers immunogenic cell death in triple-negative breast cancer (TNBC) syngeneic mouse models and exhibits superior antitumor activity compared to Hsp90 N-terminal inhibitors. …

A Single C-Terminal Residue Controls Sars-Cov-2 Spike Trafficking And Incorporation Into Vlps, Debajit Dey, Enya Qing, Yanan He, Yihong Chen, Benjamin Jennings, Whitaker Cohn, Suruchi Singh, Lokesh Gakhar, Nicholas J Schnicker, Brian G Pierce, Julian P Whitelegge, Balraj Doray, John Orban, Tom Gallagher, S Saif Hasan

2020-Current year OA Pubs

The spike (S) protein of SARS-CoV-2 is delivered to the virion assembly site in the ER-Golgi Intermediate Compartment (ERGIC) from both the ER and cis-Golgi in infected cells. However, the relevance and modulatory mechanism of this bidirectional trafficking are unclear. Here, using structure-function analyses, we show that S incorporation into virus-like particles (VLP) and VLP fusogenicity are determined by coatomer-dependent S delivery from the cis-Golgi and restricted by S-coatomer dissociation. Although S mimicry of the host coatomer-binding dibasic motif ensures retrograde trafficking to the ERGIC, avoidance of the host-like C-terminal acidic residue is critical for S-coatomer dissociation and therefore incorporation …

Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck

2020-Current year OA Pubs

Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites …

Advances In Diagnostic Tools And Therapeutic Approaches For Gliomas: A Comprehensive Review, Gayathree Thenuwara Nanolab Research Centre, James Curtin, Furong Tian Nanolab Research Centre

Articles

Gliomas, a prevalent category of primary malignant brain tumors, pose formidable clinical challenges due to their invasive nature and limited treatment options. The current therapeutic landscape for gliomas is constrained by a “one-size-fits-all” paradigm, significantly restricting treatment efficacy. Despite the implementation of multimodal therapeutic strategies, survival rates remain disheartening. The conventional treatment approach, involving surgical resection, radiation, and chemotherapy, grapples with substantial limitations, particularly in addressing the invasive nature of gliomas. Conventional diagnostic tools, including computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET), play pivotal roles in outlining tumor characteristics. However, they face limitations, such as …

Host-Microbiome Interactions In Distinct Subsets Of Preterm Labor And Birth, Jose Galaz, Roberto Romero, Jonathan M Greenberg, Kevin R Theis, Marcia Arenas-Hernandez, Yi Xu, Marcelo Farias-Jofre, Derek Miller, Tomi Kanninen, Valeria Garcia-Flores, Nardhy Gomez-Lopez

2020-Current year OA Pubs

Preterm birth, the leading cause of perinatal morbidity, often follows premature labor, a syndrome whose prevention remains a challenge. To better understand the relationship between premature labor and host-microbiome interactions, we conducted a mechanistic investigation using three preterm birth models. We report that intra-amniotic delivery of LPS triggers inflammatory responses in the amniotic cavity and cervico-vaginal microenvironment, causing vaginal microbiome changes and signs of active labor. Intra-amniotic IL-1α delivery causes a moderate inflammatory response in the amniotic cavity but increasing inflammation in the cervico-vaginal space, leading to vaginal microbiome disruption and signs of active labor. Conversely, progesterone action blockade by …

Cell-Free Rna Signatures Predict Alzheimer's Disease, Alejandro Cisterna-García, Aleksandra Beric, Muhammad Ali, Jose Adrian Pardo, Hsiang-Han Chen, Maria Victoria Fernandez, Joanne Norton, Jen Gentsch, Kristy Bergmann, John Budde, Joel S Perlmutter, John C Morris, Carlos Cruchaga, Juan A Botia, Laura Ibanez

2020-Current year OA Pubs

There is a need for affordable, scalable, and specific blood-based biomarkers for Alzheimer's disease that can be applied to a population level. We have developed and validated disease-specific cell-free transcriptomic blood-based biomarkers composed by a scalable number of transcripts that capture AD pathobiology even in the presymptomatic stages of the disease. Accuracies are in the range of the current CSF and plasma biomarkers, and specificities are high against other neurodegenerative diseases.

On The Selection Of Design Waves For Predicting Extreme Motions Of A Floating Offshore Wind Turbine, S. A. Brown, T. Tosdevin, S. Jin, M. Hann, D. Simmonds, D. M. Greaves

School of Engineering, Computing and Mathematics

Governments worldwide are setting ambitious targets for renewable energy sources as a response to the ongoing climate crisis, leading to increased investment in offshore wind. While fixed wind structures have restrictive water depth limitations, floating devices are being developed to harness the resource in deeper waters. As part of this development, accurate prediction of ultimate loads and platform motions is crucial for survivability and cost-competitiveness. Present design standards rely on time-consuming methodologies based on irregular sea state data to determine design loads. ‘Short design waves’ are a potential solution to speed up the process by simulating short wave profiles that …

Academic Adjustment Among The Desire-Oriented And Non-Desire-Oriented Students Of The First Year Of High School Students Afild Study In Some High School In The State Of Tizi-Ouzou -Algeria-, Hayat Khabet

Alustath Journal for Human and Social Sciences

Abstract :

This study aimed to find out the differences in academic adjustment between desire-oriented and non-desire-oriented students of the first year of high school studying in, some secondary schools in the state of TIZI-OUZOU- ALGERIA.

The sample of the study was (104) individuals, consisting of (68) with desire-oriented and (36) with non-desire-oriented registered in the academic year 2022/2023, they were rendomly selected by the stratified randomization method.

The result of the current study reached the following conclusion :

Keywords : academic adjustment, desire-oriented, non-desire-oriented, first year secondary students.

Leadership Skill And Its Relationship To Optimism Bias Among Educational Counselors, Fatima Karim Al Tamimi

Alustath Journal for Human and Social Sciences

The current research aims to identify the leadership skill and its relationship to the optimistic bias of educational counselors for both sexes. The sample of the current research included (200) male and female male and female counselors from the Directorate of Education of Baghdad / Al-Rusafa 1. The leadership skill scale was built and the optimism bias scale was adopted. After using the statistical bag (SPSS) to process the data, the results of the research showed that the educational counselors have the skill of leadership in their work. There is no statistically significant difference between males and females in their …

Geographical Distribution Of Fetal Deaths In Babylon Province And Its Spatial Analysis For The Year 2021, Naji Jawad Abbas

Alustath Journal for Human and Social Sciences

The research aims to reveal the magnitude of the phenomenon of fetal mortality and its spatial variation and spatial relationships causing it in Babylon Governorate for the year 2021, and to achieve this, the descriptive and analytical approach and the quantitative method were used, and the statistical bag (spss) was adopted. The research concluded that the phenomenon of fetal deaths in Babil Governorate for the year 2021 amounted to (1443) deaths, and their percentages varied at the level of administrative units, as the Hashemite District Center ranked first with a rate of (1.27%). While the Shomali district came in the …

Life Skills And Psychological Immunity Among University Students In The Southern Governorates In Palestine, Khaled Mahmoud Abu Nada, Ahmed Abdel Wahhab

Alustath Journal for Human and Social Sciences

This study aims to investigate the level of life skills and psychological immunity among university students in the Southern governorates in Palestine. Moreover, it checks the feasibility of predicting psychological immunity in the light of the life skills of students. Further, it explores the relationship between psychosocial skills and innate immunity. Furthermore, it examines the difference between university students based on demographic variables (gender, academic level, specialization. The study sample consists of 1116 male and female students from institution. This survey also uses study tool variables (tools the life skills scale and the psychological immunity scale). The findings demonstrate …

A Comparative Analysis Of The Baghdad And Babylon Universities Exploring Factors Affecting Their Competitiveness In World University Rankings, Ahmed Kanaan Suleiman

Alustath Journal for Human and Social Sciences

In recent years, global university rankings have gained popularity as a means of evaluating the quality of higher education institutions because they provide valuable insights into the best institutions around the globe; therefore, employers, academics, and students use this ranking to decide from where to hire new employees, where to pursue higher education, and where to conduct research. This holds true for Iraqi universities as well, as they strive to assess their standing and competitiveness on a global scale. In this study, the findings of Baghdad and Babylon universities in the Times Ranking are analyzed and compared. Additionally, the factors, …

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …

An Overview Of The Cut Flower Industry, Makaylie Langford, Kynda R. Curtis, Melanie Stock

All Current Publications

This fact sheet provides an overview of the cut flower industry. It provides information about traditional and specialty cut flowers, comparing flowers sourced locally in Utah and internationally.

State Insane Asylum, Jackson, Mississippi

Mississippi Capitol Region

This postcard features a black and white image of the State Insane Asylum in Jackson, Mississippi. The two story, multi-section building, has a cupola and white columns on the section in the foreground. The rest of the building is mostly obscured by a line of trees. The title of the card is printed along the bottom edge of the card. In 1900 the Mississippi State Lunatic Asylum changed its name to the Mississippi State Insane Hospital. In 1926 the word “Insane” was removed from the hospital’s name and by 1935 the hospital moved to Whitfield.

State Insane Asylum, Jackson, Mississippi

Mississippi Capitol Region

This postcard features a black and white image of the State Insane Asylum in Jackson, Mississippi. The two story, multi-section building, has a cupola and white columns on the section in the foreground. The rest of the building is mostly obscured by a line of trees. The title of the card is printed along the bottom edge of the card. In 1900 the Mississippi State Lunatic Asylum changed its name to the Mississippi State Insane Hospital. In 1926 the word “Insane” was removed from the hospital’s name and by 1935 the hospital moved to Whitfield.

State Insane Asylum, Jackson, Mississippi

Mississippi Capitol Region

This postcard features a black and white image of the State Insane Asylum in Jackson, Mississippi. The two story, multi-section building, has a cupola and white columns on the section in the foreground. The rest of the building is mostly obscured by a line of trees. The title of the card is printed along the bottom edge of the card. In 1900 the Mississippi State Lunatic Asylum changed its name to the Mississippi State Insane Hospital. In 1926 the word “Insane” was removed from the hospital’s name and by 1935 the hospital moved to Whitfield.

The Effect Of Covid-19 On Antibiotic Resistance, Debra A. Woo Dds, Ma, Karen A. Schulze Dds, Phd, Mali K. Mcguire Dds, Ms

Pacific Journal of Health

Over three years have passed since the beginning of the COVID-19 pandemic. During these times we have experienced significant changes in all areas of our life. In healthcare, more attention was focused on COVID-19 than other concerns. An unexpected consequence of the pandemic was a silent progression of an increased spread of multi-resistant pathogens. While antibiotic use during the pandemic varied across healthcare settings, antibiotics were prescribed for COVID-19 patients, even though antibiotics are known not to be effective against viruses.¹ In dentistry, antibiotics were prescribed to prevent potential dental infections, since many dental offices were not open. Antimicrobial …

Bear Creek Sanctuary: An Urban Grassland, Soheil Zendeh

Bird Observer

No abstract provided.

A New Peregrine Falcon Nest At Boston University Medical Campus, Jeffrey Boone Miller

Bird Observer

No abstract provided.

Respecting Birds, People, And History At Mount Auburn Cemetery, Dave Barnett, Regina Harrison

Bird Observer

No abstract provided.

Gleanings: Bugging The Birds - Tracking Individuals Through Migration, David M. Larson

Bird Observer

No abstract provided.

About Books: Looking Back And Planning Ahead, Mark Lynch

Bird Observer

No abstract provided.

Oceans Changing: Do Seabirds Tell Us Something About Ocean Changes?, Thomas Robben, Stephen Broker, Shoon N. Robben

Bird Observer

No abstract provided.