Digital Commons Network^™

Myod-Skp2 Axis Boosts Tumorigenesis In Fusion Negative Rhabdomyosarcoma By Preventing Differentiation Through P57kip2 Targeting, Silvia Pomella, Matteo Cassandri, Lucrezia D’Archivio, Antonella Porrazzo, Cristina Cossetti, Doris Phelps, Clara Perrone, Michele Pezzella, Antonella Cardinale, Marco Wachtel, Sara Aloisi, David Milewski, Marta Colletti, Prethish Sreenivas, Zoë S. Walters, Giovanni Barillari, Angela Di Giannatale, Giuseppe Maria Milano, Cristiano De Stefanis, Rita Alaggio, Sonia Rodriguez-Rodriguez, Nadia Carlesso, Christopher R. Vakoc, Enrico Velardi, Beat W. Schafer, Ernesto Guccione, Susanne A. Gatz, Lucio Miele

School of Medicine Faculty Publications

Rhabdomyosarcomas (RMS) are pediatric mesenchymal-derived malignancies encompassing PAX3/7-FOXO1 Fusion Positive (FP)-RMS, and Fusion Negative (FN)-RMS with frequent RAS pathway mutations. RMS express the master myogenic transcription factor MYOD that, whilst essential for survival, cannot support differentiation. Here we discover SKP2, an oncogenic E3-ubiquitin ligase, as a critical pro-tumorigenic driver in FN-RMS. We show that SKP2 is overexpressed in RMS through the binding of MYOD to an intronic enhancer. SKP2 in FN-RMS promotes cell cycle progression and prevents differentiation by directly targeting p27Kip1 and p57Kip2, respectively. SKP2 depletion unlocks a partly MYOD-dependent myogenic transcriptional program and strongly affects stemness and tumorigenic …

Road To Recovery For Craniotomy Patients, Louisa Ustrzynski

Doctor of Nursing Practice Projects

Complications from craniotomy surgery can range from 8-33%, leading to prolonged hospital stays, increased costs, increased risks for complications, and decreased satisfaction. An extensive literature was conducted highlighting Enhanced Recovery After Surgery (ERAS) protocol enhances patient outcomes by emphasizing education, early mobilization, pain management, and proper medication use before surgery. This quality improvement project focused on implementing preoperative and postoperative education in a tertiary hospital outpatient setting targeting adults undergoing craniotomy surgery. The process was implemented by a preoperative checklist and education materials to aid in educating patients on ERAS protocol to decrease the length of stay and increase patient …

Spatial Subsetting Enables Integrative Modeling Of Oral Squamous Cell Carcinoma Multiplex Imaging Data, Jakob Einhaus, Dyani K. Gaudilliere, Julien Hedou, Dorien Feyaerts, Michael G. Ozawa, Masaki Sato, Edward A. Ganio, Amy S. Tsai, Ina A. Stelzer, Karl C. Bruckman, Jonas N. Amar, Maximilian Sabayev, Thomas A. Bonham, Joshua Gillard, Maïgane Diop, Amelie Cambriel, Zala N. Mihalic, Tulio Valdez, Stanley Y. Liu, Leticia Feirrera, David K. Lam, John B. Sunwoo

Pacific Faculty Work

Oral squamous cell carcinoma (OSCC), a prevalent and aggressive neoplasm, poses a significant challenge due to poor prognosis and limited prognostic biomarkers. Leveraging highly multiplexed imaging mass cytometry, we investigated the tumor immune microenvironment (TIME) in OSCC biopsies, characterizing immune cell distribution and signaling activity at the tumor-invasive front. Our spatial subsetting approach standardized cellular populations by tissue zone, improving feature reproducibility and revealing TIME patterns accompanying loss-of-differentiation. Employing a machine-learning pipeline combining reliable feature selection with multivariable modeling, we achieved accurate histological grade classification (AUC = 0.88). Three model features correlated with clinical outcomes in an independent cohort: granulocyte …

Engaging Older Immigrants To Learn English: Advocating For Late-In-Life Learning For Everyone, Susan Marie Filous

Master's Projects and Capstones

In the United States, late-in-life and aging-in-place immigrants require basic English language skills to support their ability to independently access economic, medical, housing, legal, and social services. Older immigrants typically rely on family members, potentiating the risks of neglect and dependency. There is an opportunity to expand their agency in society by increasing their English proficiency.

Foreign language geragogy supports differentiated educational strategies for older learners. There is no upper age limit on the ability to learn a new language, and there are new methods and practices to teach foreign languages to older students. It is insufficient to mainstream older …

Living Among Wildlife: Elevating Human-Wildlife Interactions And Coexistence, Bridget Rebecca Murphy

Graduate Student Portfolios, Professional Papers, and Capstone Projects

After a semester of learning, both in class and in nature, my writing honed in further on this human-nature divide. To me, I see humans as part of nature – as we are mammals, animals, part of the food chain, biological beings no higher than others on our planet. We have simply constructed this false narrative around us within our societies, minds and media that embeds this division between us and nature, between us and wildlife. Humans have been managing, stewarding, living off and within landscapes for thousands of years. As time and technology evolved, a lot of people began …

Creativity Of Librarians As Determinant Of Job Performance In Some Selected Polytechnic Libraries In Delta State, Nigeria, Patrick Chukwuma Iheme Mr, Chika Chinonso Ejiakor Mrs, Peter O. Moneke, Oluchi Juliet Nwagu, Ufuoma Eruvwe Dr

Library Philosophy and Practice (e-journal)

The study investigated the creativity of librarians as determinant of job performance in some selected polytechnic libraries in Delta State. The study adopted a descriptive survey using questionnaire to collect data. The population of the study consists of 45 librarians. A total of 45 questionnaires were distributed only 33 were retrieved using descriptive statistics, the mean and percentage of the data were calculated. A mean score of 2.5 or above and a percentage score of 50% were taken into consideration. The study revealed five (5) creativity factors possess by librarians in some selected polytechnic libraries in Delta state as experience, …

A Case Of Filgrastim-Induced Neutrophilic Dermatosis Of The Dorsal Hands In A Patient With Felty Syndrome, Tejas P Joshi, Yelena Dokic, Gordana Verstovsek, Theodore Rosen

Faculty, Staff and Students Publications

Neutrophilic dermatosis of the dorsal hands (NDDH) is a variant of Sweet syndrome that presents with erythematous bullae, papules/plaques, or pustules on the dorsal hands. It is most commonly associated with hematologic and solid organ malignancies, though cases of NDDH associated with inflammatory bowel disease, rheumatologic disorders, and medication exposure have also been described in the literature. Felty syndrome is a rare complication of long-standing rheumatoid arthritis characterized by neuropathy, splenomegaly, and neutropenia. Granulocyte colony stimulating factors (e.g., filgrastim) can be utilized to rescue the neutropenia observed in Felty syndrome, but this treatment may subsequently cause Sweet syndrome. Herein, we …

Paradas: Utilizing The Organizational Structure Of Spatial Agency In Migrant Labor Posts, Erik Duque

Theses

Sustainability is a subject dominated by topics involving the environment and economy. An overlooked pillar is that of the socio-political sphere, as it is a subgenre of sustainability that involves a wide range of variables. Fortunately, there exists a multitude of ways one can relieve social tensions, but unfortunately, as socio-political issues are much more complex to measure. Our current Latin/US-based issues are rooted in racism, colonialization, and imperialism. These past wrongs have affected Latin American countries' development in that corruption, economic instability, violence, lack of education and poverty are the outcomes that push people into migrating. Latin American migrants …

Unsupervised Multi-Resolution Analysis Of Protein-Protein Abundance Patterns In Infectious Exacerbation Of Copd, Eric Everingham

Theses

Despite consistently appearing as a top 5 cause of death domestically and internationally, understandings of the underlying biological interactions of COPD remain insufficient. Particularly, early identification of highly vulnerable patients that may experience more severe infectious exacerbation is a challenge during diagnostics. This project leverages unsupervised clustering and multi-resolution decomposition of proteomic abundance profiles in a small cohort of COPD subjects to identify candidate biomarkers of heightened exacerbation risk. As part of an ongoing study, serum and sputum samples were collected during well visits (stable illness) from n=67 subjects, and analyzed using quantitative proteomics. A scores principal component analysis was …

Retreat Village Design In Letchworth State Park Region: An Architecture Development In A Highly Valued State Park Meets The Triple Bottom Line Of Sustainability, Jing Hua

Theses

Letchworth State Park, located in Livingston and Wyoming counties, New York, renowned as the “Grand Canyon of the East”, is one of the most scenically magnificent areas in the eastern United States. However, there are no well-developed leisure centers around or in the park. The lack of good accommodations, in contrast to the availability of restaurants with local character, leisure activities, and other supporting facilities in the area, fails to fully achieve the development potential of the natural scenery of the region. This thesis demonstrates that a retreat complex village that brings people closer to the natural landscape of Letchworth …

Evaluating The Impact Of Biosimilars In The Drug Market, Olivia Sitter

Theses

Drug pricing has increase to the point where many Americans are unable to afford prescriptions for both long- and short-term diseases. Within the last decade, U.S lawmakers have changed legislation so that biosimilars can be added into the drug market in hopes of creating affordable products. Biosimilars allow more options for consumers and add increased competition for manufactures which should decrease the overall price of the original biopharmaceutical the biosimilar is modeled after. In current research, the impact of biosimilars within the European Union has been investigated heavily, but the US approved biosimilars much later and there is less information …

Thermodynamics Of Ice Arena Geometry, Low- Emissivity Of Building Materials, And Natural Ventilation: An Energy Efficiency Study Of An Ice Arena In Rochester, Ny, Jonathan Sutton

Theses

This thesis explores the thermodynamic relationship between an ice arena’s ice sheet and building form. This exploration was conducted through an experiment focusing on the effects of architectural geometry, building material, and natural ventilation on ice heat gain. Ice arenas are giant refrigeration systems meant to sustain a sheet of ice in any climate, which is energy-intensive. There are many mechanical solutions to improving energy efficiency within ice arenas, leaving a gap for architectural solutions. Thermodynamics is how heat transfers or moves between space or objects. Heat or temperature wants to reach equilibrium, which means cold surfaces, objects, or air …

Convicting The Innocent: The Impact Of Wrongful Conviction In The U.S. Criminal Legal System, Aubrie Entwood

Theses

Wrongful conviction is a justice system error with far-reaching consequences. This capstone project looks at four different issues within wrongful conviction and exoneration in the U.S. criminal legal system. Chapter 1 focuses on the impacts of wrongful conviction for female exonerees, highlighting the way they are different from male exonerees, the factors that contribute to wrongful conviction that are more salient to females, and the specific ways the police and courts contribute to the wrongful conviction of females. Special attention is paid to the “crimes” of female exonerees and the additional psychological consequences that many female exonerees suffer. Ways in …

Introduction To Lgbtq+ Studies, Allison P. Brown, Deborah P. Amory

Milne Library

Introduction to LGBTQ+ Studies was a collaborative, multi-year open textbook project that engaged faculty authors, librarians, a university press, and OER professionals. The resulting textbook takes a cross-disciplinary approach to the study of LGBTQ+ issues that helps students grasp core concepts through a variety of different perspectives. The text offers accessible, academically sound information on a wide range of topics, including history, culture, and Queer Theory; an exploration of LGBTQ+ relationships, families, parenting, health, and education; and how to conduct research on LGBTQ+ topics. This case study will cover the project’s transformation through years of development, including engaging a large …

Gender Representation In Indian Television Advertisements From 2011 To 2020, Himika Akram

Electronic Theses & Dissertations

This thesis delves into the ways in which gender is portrayed in Indian television advertisements, with a focus on key areas such as male and female ratio as primary characters, in voiceovers, at home, outdoor, and workplace settings, and finally, in product categories. The thesis draws on a content analysis of 120 strategically selected Indian television advertisements from 120 brands from 2011 to 2020. Findings reveal that men were portrayed as the primary characters in 54.6% of these advertisements, and females were portrayed as the primary characters in 45.4% of advertisements. For voiceovers, the male ratio was 70.1%, and the …

Habitat And Demography Of The Ozark Chinquapin (Castanea Ozarkensis) At Roaring River State Park In Barry County, Missouri, Danielle Evilsizor

Electronic Theses & Dissertations

The Ozark chinquapin, Castanea ozarkensis Ashe, is a chestnut tree with a range concentrated in the Interior Highlands of North America. Like other North American members of Castanea, it was reduced from an overstory tree to an understory shrub by the invasive chestnut blight fungus (Cryphonectria parasitica [Murrill] M.E. Barr) during the early 20^th century. However, relatively little is known about the habitat of this species or its health and reproductive capability post chestnut blight. Chapter one of this study analyzed the habitat of this species through a random forest species distribution model (SDM) to predict where …

Microplate-Like Metal Pyrophosphate Engineered On Ni-Foam Towards Multifunctional Electrode Material For Energy Conversion And Storage, Rishabh Srivastava

Electronic Theses & Dissertations

High clean energy demand, dire need for sustainable development, and low carbon footprints are the few intuitive challenges, leading researchers to aim for research and development for high-performance energy devices. The development of materials used in energy devices is currently focused on enhancing the performance, electronic properties, and durability of devices. Tunning the attributes of transition metals using pyrophosphate (P₂O₇) ligand moieties can be a promising approach to meet the requirements of energy devices such as water electrolyzers and supercapacitors, although such a material’s configuration is rarely exposed for this purpose of study.

Herein, we grow …

Exploring Soybean Oil-Based Polyol And Effect Of Non-Halogenated Flame Retardants In Rigid Polyurethane Foam, Sahithi Kondaveeti

Electronic Theses & Dissertations

To address the increasing demand for sustainable biomaterials due to the depletion of fossil fuel resources and growing environmental concerns, a new type of biodegradable and environmentally friendly rigid polyurethane foam (RPUF) has been synthesized. These foams are derived from chemically modified soybean oil-based polyol obtained from soybean oil by epoxidation followed by a ring-opening reaction. Polyurethane foam is generally used in construction, furniture, and automobile industries but is highly flammable and releases toxic gases and smoke during combustion. In this study, a highly efficient synergistic effect halogen-free flame-retardant (FR) melamine salt, 2-carboxyethyl(phenyl)phosphinic acid melamine salt (CMA) was synthesized from …

Enhanced Mechanical Strength Of Soybean Oil-Based Non-Isocyanate Polyurethane Adhesive For Wood Application By Introducing Nanofillers, Vatsal Chaudhari

Electronic Theses & Dissertations

Polyurethane (PU) is a versatile material that finds extensive use in various industries including bedding, construction, automotive, and packaging. Historically, this particular polymer relied significantly on petrochemical resources, a practice that was considered to have negative environmental impacts. The conventional method for preparing PU involves the use of isocyanate, which is a disadvantage due to its negative impact on the environment and human health. The resolution of this problem entails identifying an appropriate substitute for petroleum-derived products that minimize their impact on both the environment and human health. The researchers earlier utilized soybean oil, for the formulation of PUs in …

“I Felt We Were Actually Learning Things, Then Applying Them” Students’ Perceptions Of A Service-Learning Course, Christina Gipson, Jessica A. Mutchler, Arshpreet Kaur Mallhi, Amanda Lambert

Health Sciences & Kinesiology: Faculty Publications

Academic journals continue to produce articles that highlight record levels of student disengagement and lack of motivation. Faculty have been encouraged to use high impact, active learning strategies to increase student engagement and success (Patrick et al., 2016). One technique, service learning, allows students to become active learners through applying learned skills and theory from the classroom to community settings (Connolly, et al., 2017). The purpose of this study was to highlight students’ perceptions and experiences through three semester-long service-learning courses where students provided a fitness and mindfulness program to local teachers to help them address stressors. Undergraduate sports management …

Give Love With Lovenox: Improving Nurse Education On Lovenox Prophylaxis To Reduce Pulmonary Embolism Risk On The Postpartum Unit, Jennifer G. Domingo Rn

Master's Projects and Capstones

This quality improvement project aims to improve nurse education about Lovenox prophylaxis to reduce the risk of pulmonary emboli – post-discharge – amongst high-risk postpartum women who underwent vaginal and cesarean deliveries on the family baby unit. This project took place in a Family Baby/Postpartum Unit at Hospital SC. This unit has a total of 25 beds with an increased prevalence of pulmonary embolism following cesarean delivery. Nurses were given anonymous pre- and post-survey questionnaires and provided educational sessions with distributed handouts. A unit needs assessment was conducted using the 5 P’s. Out of the 72 nurses on the staff …

Improving Education On Preeclampsia With Non-Severe Features And Frequency Of Assessment Among Nurses In The Maternal-Child Postpartum Unit, Alyssa J. Willsher

Master's Projects and Capstones

Problem: This Quality Improvement (QI) project aims to improve preeclampsia education among nurses and reduce the frequency of preeclampsia assessments among patients(without severe features) (SF) in the Mother-Baby postpartum unit at Hospital A. Nurses often stated that patients are unable to have uninterrupted rest periods with frequent assessments, which research shows is necessary for reducing patient blood pressure.

Context: The QI project is implemented in a 25-bed postpartum unit that cares for women and their newborns in the postpartum period. The unit’s nurse educator and nurse manager requested that the visiting University of San Francisco research group focus on simplifying …

Digital Literacy For Older Adult English Language Learners, Talley Caruso

Master's Projects and Capstones

When essential services transition to digital platforms, individuals with limited digital proficiency, immigrant English Language Learners (ELLs), and older adults aged 65 and above face challenges accessing these resources, leading to potential exclusion.

The COVID-19 pandemic accelerated the shift to online interactions and services due to lockdown measures, reducing face-to-face interactions. This sudden transition left individuals without digital skills unable to access healthcare, essential services, and maintain connections with their support networks. Addressing this issue presents an opportunity to promote inclusivity, empowerment, and community engagement through targeted digital literacy training.

Digital literacy encompasses the ability to navigate technology such as …

Queer Theory In The Metal Music Scene: How These Cultures Influence Each Other, Dalton A. Dalton

Faculty Curated Undergraduate Works

Queer theory has existed in the metal music scene since its beginning. In this paper, many aspects of both topics are dissected. Focusing on metal fashion and its crossover into queer armor, Queer coding, and its translation to metal archetypes on television. And the analysis of queer comfortability in metal music spaces by using queer theory as it applies to mass cultures and subculture

The Impact Of An Educational Cooking Class On Inflammatory Potential Of Diet In Cancer Survivors, Mariah K. Jackson

Theses & Dissertations

Cancer survivors face long-term effects from cancer treatments, with cognitive dysfunction being an important, yet understudied, consequence of cancer treatment. Inflammation is a proposed mechanism for impaired cognition status. As research demonstrates diet is associated with both pro- and anti-inflammatory effects, diet may represent a novel strategy to mitigate cognitive decline in cancer survivors. The purpose of this study was to 1) quantify the impact of an educational cooking class on inflammatory potential of diet (measured by the Dietary Inflammatory Index (DII)) in cancer survivors and 2) determine the relationship between dietary changes and cognitive function in cancer survivors. Dietary …

Acceptability And Use Of An Online Health Priorities Self-Identification Tool For Older Adults: A Qualitative Investigation, Emily L Mroz, Kizzy Hernandez-Bigos, Jessica Esterson, Eliza Kiwak, Aanand Naik, Mary E Tinetti

Faculty, Staff and Student Publications

OBJECTIVE: To examine the use of a web-based, self-directed health priorities identification tool for older adults with multiple chronic conditions (MCCs).

METHODS: We recruited a gender- and racially-diverse, highly educated sample of older adults with MCCs to engage with our My Health Priorities tool, then complete a semi-structured interview. Thematic analysis was used to examine interview transcripts.

RESULTS: Twenty-one participants shared perspectives on the acceptability and use of the tool. Three themes (with eleven subthemes) were generated to describe: website

CONCLUSION: Participants found this tool acceptable and easy to use, describing a variety of benefits of the priorities self-identification process …

Understanding The Lived Experiences Of Ethnic-Racial Minority Former Foster Youth Who Identify As Queer, Cristian A. Lemus

Doctoral Dissertations

This qualitative study used Interpretative Phenomenological Analysis to explore the lived experiences and meaning making of former foster youth of color who identify as both ethnic-racial minorities and as either gender or sexual minorities. A total of three participants took part in this study. All participants identified as a former foster youth with at least one foster care placement in the United States, as an ethnic-racial minority, and as a gender or sexual minority. In the lived experiences of the participants three themes, and several subthemes, emerged: identity, cultural prejudice, and power dynamics. The findings supported the hypothesis former foster …

A Descriptive Analysis Of Fatal Outcomes In Immune Thrombotic Thrombocytopenic Purpura In The Ustma Ttp Registry, Mouhamed Yazan Abou-Ismail, Chong Zhang, Angela Presson, Shruti Chaturvedi, Ana G. Antun, Andrew Farland, Ryan Woods, Ara Metjian, Yara Park, Gustaaf De Ridder, Briana Gibson, Raj S. Kasthuri, Darla K. Liles, Frank Akwaa, Todd Clover, Lisa Baumann Kreuziger, Meera Sridharan, Ronald S. Go, Keith R. Mccrae, Harsh Vardhan Upreti, Radhika Gangaraju, Nicole Katlyn Kocher, X Long Zheng, Jay S. Raval, Camila Masias, Spero R. Cataland, Andrew David Johnson, Elizabeth Davis, Michael D. Evans, Marshall Mazepa, Ming Y. Lim

Pathology Research and Scholarship

No abstract provided.

Unravelling The Potential Mortality Benefits Of Mass Drug Administration With Azithromycin In Niger, Zulfiqar Ahmed Bhutta

Centre of Excellence in Women and Child Health

No abstract provided.

Disinfecting The Criminal Legal System Of Punitive Deterrence, Joseph Dole

DePaul Journal for Social Justice

No abstract provided.