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Filling In The Gaps: A Multiple Imputation Approach To Estimating Aging Curves In Baseball, Quang Nguyen, Gregory J. Matthews

Mathematics and Statistics: Faculty Publications and Other Works

In sports, an aging curve depicts the relationship between average performance and age in athletes' careers. This paper investigates the aging curves for offensive players in the Major League Baseball. We study this problem in a missing data context and account for different types of dropouts of baseball players during their careers. In particular, the performance metric associated with the missing seasons is imputed using a multiple imputation model for multilevel data, and the aging curves are constructed based on the imputed datasets. We first perform a simulation study to evaluate the effects of different dropout mechanisms on the estimation …

Does The Osteopathic Pedal Pump Reduce Lower Limb Volume In Healthy Subjects?, Jill S. Adams, Sahil H. Parikh, Brandon J. Goodwin, Donald R. Noll

Rowan-Virtua School of Osteopathic Medicine Departmental Research

CONTEXT: Lymphatic treatments are gentle and passive techniques believed to enhance movement of lymph back into the central circulatory system. Animal studies provide supportive evidence, yet there are few studies in humans.

OBJECTIVES: The aim of this study is to investigate whether the osteopathic pedal pump protocol reduces volume in the lower limbs of healthy subjects.

METHODS: A total of 30 first- and second-year medical students were recruited. Subjects were excluded from participating if they had acute asthma, chronic obstructive pulmonary disease (COPD), congestive heart failure, active infections, fractures of the lower extremities, or metastatic cancer. A within-subjects study design …

A New Mechanism For Glymphatic Flow Of Interstitial Fluid In Branched Perivascular Spaces Of The Brain, Charles F. Babbs

Weldon School of Biomedical Engineering Faculty Working Papers

Objective. To explore the biophysics of interstitial tissue fluid flow in the brain, based upon the anatomy and mechanics of the perivascular spaces, in order to better understand how glymphatic flow happens. Methods. The dynamics of fluid flow at cardiac frequencies are investigated in rapidly computable, branched, geometric models of brain tissue at multiple scales. The models are supplied by intermingled trees of penetrating arteries and veins. They include pulsatile changes in intracranial pressure and intravascular pressure, elastic expansion of brain tissue, and nonlinear changes in resistance to flow of cerebrospinal fluid along the axis of the Virchow-Robin space. Resulting …

Harmful Speech And The Covid-19 Penumbra, Kenneth Grad, Amanda Turnbull

Canadian Journal of Law and Technology

We make two central claims in this essay. First, the themes of malinformation have remained remarkably consistent across pandemics. What has changed is only the manner of their spread through evolving technologies and globalization. Thus, as with pandemic preparedness more generally, our failure to take proactive measures reflects a failure to heed the lessons of the past. Second, we argue that the COVID-19 pandemic presents a unique opportunity to tackle online falsehoods and mitigate their impact in the future.

We proceed in three parts. Part one addresses the harmful speech that inevitably follows in pandemic’s wake. We illustrate this through …

January 2023 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Falls And Associated Risk Factors In A Sample Of Old Age Population In Egyptian Community, Abd El Hamied Ibrahim El Sayed, Mohamed T. Said, Omnia Mohsen, Aziza M. Abozied

Faculty Journal Articles

No abstract provided.

Supplementing Glycine And N-Acetylcysteine (Glynac) In Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, And Aging Hallmarks: A Randomized Clinical Trial, Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Faculty, Staff and Students Publications

BACKGROUND: Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid oxidation (MFO), and insulin resistance (IR). To test whether GlyNAC supplementation in OA could improve GSH deficiency, OxS, mitochondrial dysfunction, IR, physical function, and aging hallmarks, we conducted a placebo-controlled randomized clinical trial.

METHODS: Twenty-four …

Supplementing Glycine And N-Acetylcysteine (Glynac) In Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, And Aging Hallmarks: A Randomized Clinical Trial, Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Faculty, Staff and Students Publications

BACKGROUND: Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid oxidation (MFO), and insulin resistance (IR). To test whether GlyNAC supplementation in OA could improve GSH deficiency, OxS, mitochondrial dysfunction, IR, physical function, and aging hallmarks, we conducted a placebo-controlled randomized clinical trial.

METHODS: Twenty-four …

Supplementing Glycine And N-Acetylcysteine (Glynac) In Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, And Aging Hallmarks: A Randomized Clinical Trial, Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Faculty, Staff and Students Publications

BACKGROUND: Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid oxidation (MFO), and insulin resistance (IR). To test whether GlyNAC supplementation in OA could improve GSH deficiency, OxS, mitochondrial dysfunction, IR, physical function, and aging hallmarks, we conducted a placebo-controlled randomized clinical trial.

METHODS: Twenty-four …

Supplementing Glycine And N-Acetylcysteine (Glynac) In Older Adults Improves Glutathione Deficiency, Oxidative Stress, Mitochondrial Dysfunction, Inflammation, Physical Function, And Aging Hallmarks: A Randomized Clinical Trial, Premranjan Kumar, Chun Liu, James Suliburk, Jean W Hsu, Raja Muthupillai, Farook Jahoor, Charles G Minard, George E Taffet, Rajagopal V Sekhar

Faculty, Staff and Students Publications

BACKGROUND: Elevated oxidative stress (OxS), mitochondrial dysfunction, and hallmarks of aging are identified as key contributors to aging, but improving/reversing these defects in older adults (OA) is challenging. In prior studies, we identified that deficiency of the intracellular antioxidant glutathione (GSH) could play a role and reported that supplementing GlyNAC (combination of glycine and N-acetylcysteine [NAC]) in aged mice improved GSH deficiency, OxS, mitochondrial fatty-acid oxidation (MFO), and insulin resistance (IR). To test whether GlyNAC supplementation in OA could improve GSH deficiency, OxS, mitochondrial dysfunction, IR, physical function, and aging hallmarks, we conducted a placebo-controlled randomized clinical trial.

METHODS: Twenty-four …

The Gendered Face Of Ageism In The Workplace, Jasmin Tahmaseb-Mcconatha, V. Krishna Kumar, Jaqueline Magnarelli, Georgina Hanna

Psychology Faculty Publications

This qualitative study explores perceived age discrimination in the workplace. Increasing age diversity in the workplace has led to an associated increase in ageism. While a large percentage of older workers report being subjected to discriminatory treatment in the workplace, ageism also appears to be gendered. Older female workers are being victimized at a greater rate than their male counterparts. The intersection of age, gender, and other forms of discrimination results in increased stress, threatens the well-being of workers of all ages, and creates a toxic workplace climate. Analysis of 244 participants’ responses to openended items indicated that ageism is …

Quantification Of Localized Nad+ Changes Reveals Unique Specificity Of Nad+ Regulation In The Hypothalamus, Sean Johnson, Kiyoshi Yoshioka, Cynthia S Brace, Shin-Ichiro Imai

2020-Current year OA Pubs

Recently, it has become a consensus that systemic decreases in NAD

Ms 225 Guide To Thomas R. Cole, Phd Papers (1973-2002), Thomas R. Cole

Manuscript Finding Aids

The Thomas R. Cole, PhD papers consists of scholarly projects and history of the McGovern Center for Humanities and Ethics in the University of Texas' McGovern Medical School. The papers include articles, journals, monographs, correspondence, notes, transcripts, books, syllabi, DVDs/CDs, Betacam tapes, cassettes, realia, and research primarily chronicling Dr. Cole’s professional career. See more at MS 225.

Social Support And Technology Use And Their Association With Mental And Physical Health During The Covid-19 Pandemic Among Asian Americans: The Compass Cross-Sectional Study, Linda G. Park, Oanh L. Meyer, Marcelle M. Dougan, Bethany Golden, Kevin Ta, Bora Nam, Janice Y. Tsoh, Marian Tzuang, Van M.Ta Park

Faculty Research, Scholarly, and Creative Activity

BACKGROUND: The global COVID-19 pandemic disproportionately affected Asian Americans and Pacific Islanders (AAPIs) and revealed significant health disparities with reports of increased discrimination and xenophobia. Among AAPIs, the pandemic exacerbated their social, linguistic, and geographic isolation. Social support may be especially important for AAPIs given the salience of collectivism as a cultural value. Another mechanism for support among AAPIs was technology use, as it is generally widespread among this population. However, older adults may not perceive the same benefits. OBJECTIVE: We examined social support and technology use and their relationships with mental and physical health outcomes through the COVID-19 pandemic …

Investiture Ceremony- Inauguration Of Rhea F. Law, Tampa Campus, January 19, 2023, University Of South Florida

USF Graduation and Convocation Programs

Program for the investiture of the eighth President of the University of South Florida, Rhea F. Law

Usage Statistics: Project Counter R5 Tr_J1 Report Fy2022 - Journal Requests (Excluding Oa_Gold) By Title, Andrée J. Rathemacher

Technical Services Reports and Statistics

Project COUNTER R5 Report TR_J1 for the University of Rhode Island for the period from July 1, 2021 - June 30, 2022. The TR_J1 report is defined as "Journal Requests (Excluding OA_Gold)." This report presents an annual total only and only includes those platforms successfully configured for automated harvesting via SUSHI.

File for download is Excel spreadsheet generated by Alma Analytics.

Results:

Total Item Requests - 771,947

Unique Item Requests - 578,437

Implicit Bias Training In The Student Nurse Practitioner’S Curriculum, Macdana Selecon

DNP Qualifying Manuscripts

Background: Implicit bias (IB) training is not provided in all graduate nursing programs. As a result, graduate nursing students are not prepared to address poor health outcomes related to healthcare biases. This literature review examines the evidence for effective IB training methodologies.

Methods: CINAHL, Fusion, PubMed, Google Scholar, and Cochrane Database of Systematic Reviews were searched for peer-reviewed articles published between 2010 and 2022. The identified studies were critically appraised using the Johns Hopkins Nursing Evidence-Based Practice Level and Quality Guide Tool.

Results: Six articles were identified as eligible. Five studies implemented implicit bias training for graduate nursing students and …

Association Of Omega 3 Polyunsaturated Fatty Acids With Incident Chronic Kidney Disease: Pooled Analysis Of 19 Cohorts, Kwok Leung Ong, Matti Marklund, Liping Huang, Kerry-Anne Rye, Nicholas Hui, Xiong-Fei Pan, Casey M Rebholz, Hyunju Kim, Lyn M Steffen, Anniek C Van Westing, Johanna M Geleijnse, Ellen K Hoogeveen, Yun-Yu Chen, Kuo-Liong Chien, Amanda M Fretts, Rozenn N Lemaitre, Fumiaki Imamura, Nita G Forouhi, Nicholas J Wareham, Anna Birukov, Susanne Jäger, Olga Kuxhaus, Matthias B Schulze, Vanessa Derenji De Mello, Jaakko Tuomilehto, Matti Uusitupa, Jaana Lindström, Nathan Tintle, William S Harris, Keisuke Yamasaki, Yoichiro Hirakawa, Toshiharu Ninomiya, Toshiko Tanaka, Luigi Ferrucci, Stefania Bandinelli, Jyrki K Virtanen, Ari Voutilainen, Tharusha Jayasena, Anbupalam Thalamuthu, Anne Poljak, Sonia Bustamante, Perminder S Sachdev, Mackenzie K Senn, Stephen S Rich, Michael Y Tsai, Alexis C Wood, Markku Laakso, Maria Lankinen, Xiaowei Yang, Liang Sun, Huaixing Li, Xu Lin, Christoph Nowak, Johan Ärnlöv, Ulf Risérus, Lars Lind, Mélanie Le Goff, Cécilia Samieri, Catherine Helmer, Frank Qian, Renata Micha, Adrienne Tin, Anna Köttgen, Ian H De Boer, David S Siscovick, Dariush Mozaffarian, Jason Hy Wu

Faculty, Staff and Students Publications

OBJECTIVE: To assess the prospective associations of circulating levels of omega 3 polyunsaturated fatty acid (n-3 PUFA) biomarkers (including plant derived α linolenic acid and seafood derived eicosapentaenoic acid, docosapentaenoic acid, and docosahexaenoic acid) with incident chronic kidney disease (CKD).

DESIGN: Pooled analysis.

DATA SOURCES: A consortium of 19 studies from 12 countries identified up to May 2020.

STUDY SELECTION: Prospective studies with measured n-3 PUFA biomarker data and incident CKD based on estimated glomerular filtration rate.

DATA EXTRACTION AND SYNTHESIS: Each participating cohort conducted de novo analysis with prespecified and consistent exposures, outcomes, covariates, and models. The results were …

Connections Network: Harnessing The Collective Influence Of Grassroots Leaders To Address Health-Related Problems In Hawkins And Hancock County, Tn, Dr. Jodi L. Southerland, Teresa Buttry, Connie Johnson, Sheldon Livesay, Lisa Nichols, Priscilla Rogers

Journal of Appalachian Health

In March 2021, grassroots leaders in two counties in northeast Tennessee formed a new network called Connections. Leaders are working to strengthen the capacity of the network and member organizations by promoting partnerships as vital to address effectively rural social determinants of health. Connections provides network members with capacity-building tools and resources, including two funding opportunities, to achieve their missions and sustain impact. Network members are also aligning around common goals to address the socioeconomic conditions affecting health outcomes. Connections will utilize findings from network activities and collaborations to identify synergies that can accelerate improvements in community health and …

Review Of Storytelling In Queer Appalachia: Imagining The Unspeakable Other, Sandra L. Cotton Dnp, Rn, Anp-Bc, Fnap, Laurie A. Theeke Phd, James Messer

Journal of Appalachian Health

The Journal of Appalachian Health is committed to reviewing published media that relates to contemporary concepts affecting the health of residents of Appalachia. Improving the health in the region of Appalachia means knowing our people as they live and thrive in communities. The book reviewed here, Storytelling in Queer Appalachia: Imagining the Unspeakable Other (Edited by Glasby, Gradin, and Ryerson), is a must read for people who wish to gain insight on the real experience of being queer in Appalachia.

Rest And Sleep Patterns And Activities Of Residents In Long-Term Care Facilities: A Descriptive Study, Pei-Fen Chang, Kai-Lai Tsai, Clarissa Richard, Harriett A. Davidson, Gayle Hersch

The Open Journal of Occupational Therapy

Background:To facilitate healthy occupational participation and highlight the significance of rest and sleep for older adults, this study aimed to provide a description of rest and sleep patterns and activities of residents in long-term care facilities (LTCFs).

Method: Secondary analysis of rest and sleep data collected from a funded R21 study was conducted. Twenty-nine residents were interviewed using the Yesterday Interview (YI) to describe their time and daily activities, including rest and sleep patterns and activities.

Results: Average time spent sleeping was 10.22 (±1.77) hr and resting was 4.77 (±3.3) hr. Data were also collected on …

The Impact Of A Two-Visit Occupational Therapy Home Modification Model On Low-Income Older Adults, Anna Y. Grasso, Annmarie Murphy, Cynthia Abbott-Gaffney

The Open Journal of Occupational Therapy

Background: Various studies support the benefit of occupational therapist-led home modification to support successful aging in place for older adults. However, methodological differences limit generalizability. This study aimed to determine the impact of a replicable two-visit occupational therapy home modification program on occupational performance of low-income, community-dwelling older adults.

Method: The researcher used a quasi-experimental one group pretest-posttest design. The participants were low-income homeowners, age 55 years and older, with decreased performance and/or satisfaction in one or more ADLs and IADLs as determined by the COPM. An occupational therapist provided the participants with a home safety assessment using …

State Of The Journal: Introducing Assistant Editors, Diane Powers Dirette

The Open Journal of Occupational Therapy

No abstract provided.

Enhancing The Quality Of Life For Senior Citizens: A Facilitator’S Guidebook For Mindful Music And Movement, Shannon Sexton

Mindfulness Studies Theses

Music appreciation and enjoyment enhance well-being throughout the lifespan. The challenges and constraints that people experience as they age can lead to lack of access to music, decreased physical activity, and fewer avenues for creative expression. Group music and movement interventions created for older populations offer opportunities for social connection and improved quality of life. Mindful practices add further benefit when combined with these interventions. Current available programs are scarce and most often do not encompass mixed modalities. In addition, the benefits of these programs do not show long-term sustainability. The purpose of this thesis is to explore the effects …

Context And Indigenous Structures For Managing Family Violence In A Yoruba Community, Oluwasayo Bolarinwa Ogunlade Dr, Adekemi E. Olowokere Dr., Ojo M. Agunbiade Dr, Aanuoluwapo O. Olajubu Dr., Oyeyemi O. Oyelade, Omolola O. Irinoye Professor

The Qualitative Report

Most investigations on domestic violence in family relationships have centered around men as the perpetrators of violence without exploring the context of violence occurrence from a gender lens and other social factors. This study explored the meanings associated with family violence, the contexts for its occurrence, and the indigenous approaches to managing such conflicts among the Yoruba ethnic subgroup in southwest Nigeria. This was an exploratory cross-sectional study guided by an interpretative constructivist approach in which 20 community stakeholders were recruited through purposive sampling. The data were collected via in-depth interview (IDI) and focus group discussion (FGD). Findings from the …

Estimating Dementia Risk In An African American Population Using The Dctclock, Marissa Ciesla, Jeff Pobst, Joyce Gomes-Osman, Melissa Lamar, Lisa L Barnes, Russell Banks, Ali Jannati, David Libon, Rodney Swenson, Sean Tobyne, David Bates, John Showalter, Alvaro Pascual-Leone

Rowan-Virtua School of Osteopathic Medicine Departmental Research

The prevalence of Alzheimer's disease (AD) and related dementias (ADRD) is increasing. African Americans are twice as likely to develop dementia than other ethnic populations. Traditional cognitive screening solutions lack the sensitivity to independently identify individuals at risk for cognitive decline. The DCTclock is a 3-min AI-enabled adaptation of the well-established clock drawing test. The DCTclock can estimate dementia risk for both general cognitive impairment and the presence of AD pathology. Here we performed a retrospective analysis to assess the performance of the DCTclock to estimate future conversion to ADRD in African American participants from the Rush Alzheimer's Disease Research …

Investigating The Absence Of A Dietary Response At The Neuromuscular Junction In Larval Drosophila Melanogaster, Suzanna Louise Marbach

Honors Program Theses and Research Projects

Research in Drosophila melanogaster (D. melanogaster) has been growing in order to identify the fundamental processes of human disorders of the central nervous system such as Alzheimer’s disease, diabetes, and other neurological disorders at a molecular level. Altered insulin signaling itself has been linked to widespread nervous system dysfunction including cognitive dysfunction, neuropathies, and susceptibility to neurodegenerative disease. However, knowledge of the cellular mechanisms underlying the effects of insulin on nervous system function is still incomplete. The focus behind investigating the insulin signaling pathway is derived from our observations in the adult D. melanogaster neuromuscular junction (NMJ) to changes in …

Prospective Association Of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis, Amanda E. Paluch, Shivangi Bajpai, Marcel Ballin, David R. Bassett, Thomas W. Buford, Mercedes R. Carnethon, Ariel Chernofsky, Erin E. Dooley, Ulf Ekelund, Kelly R. Evenson, Deborah A. Galuska, Barbara J. Jefferis, Lingsong Kong, William E. Kraus, Martin G. Larson, I. Min Lee, Charles E. Matthews, Robert L. Newton, Anna Nordström, Peter Nordström, Priya Palta, Alpa V. Patel, Kelley Pettee Gabriel, Carl F. Pieper, Lisa Pompeii, Erika Rees-Punia, Nicole L. Spartano, Ramachandran S. Vasan, Peter H. Whincup, Shengping Yang, Janet E. Fulton

Population and Public Health Science Faculty Publications

Background: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines. Methods: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional …

Prospective Association Of Daily Steps With Cardiovascular Disease: A Harmonized Meta-Analysis, Amanda E Paluch, Shivangi Bajpai, Marcel Ballin, David R Bassett, Thomas W Buford, Mercedes R Carnethon, Ariel Chernofsky, Erin E Dooley, Ulf Ekelund, Kelly R Evenson, Deborah A Galuska, Barbara J Jefferis, Lingsong Kong, William E Kraus, Martin G Larson, I-Min Lee, Charles E Matthews, Robert L Newton, Anna Nordström, Peter Nordström, Priya Palta, Alpa V Patel, Kelley Pettee Gabriel, Carl F Pieper, Lisa Pompeii, Erika Rees-Punia, Nicole L Spartano, Ramachandran S Vasan, Peter H Whincup, Shengping Yang, Janet E Fulton, Steps For Health Collaborative

Faculty, Staff and Students Publications

Background: Taking fewer than the widely promoted "10 000 steps per day" has recently been associated with lower risk of all-cause mortality. The relationship of steps and cardiovascular disease (CVD) risk remains poorly described. A meta-analysis examining the dose-response relationship between steps per day and CVD can help inform clinical and public health guidelines.

Methods: Eight prospective studies (20 152 adults [ie, ≥18 years of age]) were included with device-measured steps and participants followed for CVD events. Studies quantified steps per day and CVD events were defined as fatal and nonfatal coronary heart disease, stroke, and heart failure. Cox proportional …

The Psychosocial, Economic And Physical Impacts Of Covid-19 Pandemic On Institutionalized Older People In Jordan, Manal Anabatwi, Shawqi Abdalrahman Alhajhassan, Tamara Adel Al Wreidat, Reham Ibrahim Abu Ghaboush, Asma Ibrahim Abdallah, Hmoud Salem Olimat, Talal Abd Alkareem Alqudah

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

This Qualitative study aims to discover and analyze the psychological, economic, social and physical effects of the Corona pandemic on older people, specifically those who reside in nursing homes. The qualitative approach was used, and 16 in-depth interviews were conducted with older women and men in August 2021 using the convenience sample. The study concluded that the corona pandemic has caused the elderly residents of the guest house to experience a variety of problems, including their increased fear of death as a result of the virus spread, as well as their feelings of loneliness, anxiety and mental disorders. The study …