Digital Commons Network^™

The Pace Of Biological Aging Helps Explain The Association Between Insomnia And Chronic Low Back Pain, Edwin N Aroke, Asia M Wiggins, Joanna M Hobson, Vinodh Srinivasasainagendra, Tammie L Quinn, Pooja Kottae, Hemant K Tiwari, Robert E Sorge, Burel R Goodin

2020-Current year OA Pubs

Chronic low back pain (cLBP) is associated with insomnia and advanced age. Emerging evidence suggests that the severity of both sleep disorders (like insomnia) and chronic pain are associated with a faster pace of biological aging. We aimed to determine whether the pace of biological age mediates the relationship between insomnia and the impact of cLBP in a sample of community-dwelling adults ages 19 to 85 years. Participants (49 with no pain, 32 with low-impact pain, and 37 with high-impact pain) completed sociodemographic, pain, insomnia, and short physical performance battery assessments. We calculated the pace of biological aging using DunedinPACE …

Down Syndrome And Alzheimer's Disease: A Scoping Review Of Functional Performance And Fall Risk, Selena E Washington, Emily Cler, Cameron Lowery, Susan L Stark

2020-Current year OA Pubs

INTRODUCTION: Alzheimer's disease (AD) occurs in aging adults with Down syndrome (DS) at a higher prevalence and an earlier age than in typical aging adults. As with the general aging adult population, there is an urgent need to understand the preclinical and early phases of AD progression in the adult population with DS. The aim of this scoping review was to synthesize the current state of the evidence and identify gaps in the literature regarding functional activity performance and falls and their significance to disease staging (i.e., mild, moderate, and severe defined staging criteria) in relation to Alzheimer's disease and …

Feasibility And Acceptability Of Remote Smartphone Cognitive Testing In Frontotemporal Dementia Research, Jack Carson Taylor, Nupur Ghoshal, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Remote smartphone assessments of cognition, speech/language, and motor functioning in frontotemporal dementia (FTD) could enable decentralized clinical trials and improve access to research. We studied the feasibility and acceptability of remote smartphone data collection in FTD research using the ALLFTD Mobile App (ALLFTD-mApp).

METHODS: A diagnostically mixed sample of 214 participants with FTD or from familial FTD kindreds (asymptomatic: CDR®+NACC-FTLD = 0 [

RESULTS: It was feasible for participants to complete the ALLFTD-mApp on their own smartphones. Participants reported high smartphone familiarity, completed ∼ 70% of tasks, and considered the time commitment acceptable (98% of respondents). Greater disease severity …

Toward A Computational Theory Of Manifold Untangling: From Global Embedding To Local Flattening, Xin Li, Shuo Wang

2020-Current year OA Pubs

It has been hypothesized that the ventral stream processing for object recognition is based on a mechanism called cortically local subspace untangling. A mathematical abstraction of object recognition by the visual cortex is how to untangle the manifolds associated with different object categories. Such a manifold untangling problem is closely related to the celebrated kernel trick in metric space. In this paper, we conjecture that there is a more general solution to manifold untangling in the topological space without artificially defining any distance metric. Geometrically, we can either

A New Measure For Multi-Professional Medical Team Communication: Design And Methodology For Multilingual Measurement Development, Sara Malone, Kim Prewitt, Lara Counts, Douglas A Luke, Et Al.

2020-Current year OA Pubs

BACKGROUND: As implementation science in global health continues to evolve, there is a need for valid and reliable measures that consider diverse linguistic and cultural contexts. A standardized, reproducible process for multilingual measure development may improve accessibility and validity by participants in global health settings. To address this need, we propose a rigorous methodology for multilingual measurement development. We use the example of a novel measure of multi-professional team communication quality, a determinant of implementation efforts.

METHODS: The development and translation of this novel bilingual measure is comprised of seven steps. In this paper, we describe a measure developed in …

Adapting A Mobile App To Support Patients With Anorexia Nervosa Following Post-Acute Care: Perspectives From Eating Disorder Treatment Center Stakeholders, Anneliese Haas, Agatha A Laboe, Claire G Mcginnis, Marie-Laure Firebaugh, Jillian Shah, Anna M Bardone-Cone, Kathleen M Pike, C Barr Taylor, Denise E Wilfley, Ellen E Fitzsimmons-Craft

2020-Current year OA Pubs

INTRODUCTION: Anorexia nervosa (AN) is a harmful, life-threatening illness. Patients with severe AN often receive acute treatment but, upon discharge, experience high relapse rates. Evidence-based, outpatient treatment following acute care is critical to preventing relapse; however, numerous barriers (e.g., location, financial limitations, low availability of providers) preclude individuals from accessing treatment. mHealth technologies may help to address these barriers, but research on such digital approaches for those with AN is limited. Further, such technologies should be developed with all relevant stakeholder input considered from the outset. As such, the present study aimed to garner feedback from eating disorder (ED) treatment …

Identification Of Prok2 Gene Polymorphisms As Predictors Of Methamphetamine Use Disorder Risk And Indicators Of Craving Scale In The Chinese Han Population, Zhao Jiang, Tianxiao Zhang, Wei Han, Jing Xiao, Wenpei Zhang, Xiaochen Wang, Jianing Liu, Ying Yang, Congying Yang, Fanglin Guan, Tao Li, John P Rice

2020-Current year OA Pubs

No abstract provided.

Assessment Of Cochlear Synaptopathy By Electrocochleography To Low Frequencies In A Preclinical Model And Human Subjects, Raymond A Haggerty, Kendall A Hutson, William J Riggs, Kevin D Brown, Harold C Pillsbury, Oliver F Adunka, Craig A Buchman, Douglas C Fitzpatrick

2020-Current year OA Pubs

Cochlear synaptopathy is the loss of synapses between the inner hair cells and the auditory nerve despite survival of sensory hair cells. The findings of extensive cochlear synaptopathy in animals after moderate noise exposures challenged the long-held view that hair cells are the cochlear elements most sensitive to insults that lead to hearing loss. However, cochlear synaptopathy has been difficult to identify in humans. We applied novel algorithms to determine hair cell and neural contributions to electrocochleographic (ECochG) recordings from the round window of animal and human subjects. Gerbils with normal hearing provided training and test sets for a deep …

Women's Preferences For A New Contraceptive Under Development: An Exploratory Study, Tessa Madden, Sarah Y Cohen, Rachel Paul, Emily G Hurley, Michael A Thomas, Giovanni Pauletti

2020-Current year OA Pubs

OBJECTIVE: Currently available contraceptive methods do not meet the needs of all users. We sought to explore preferences of potential end-users regarding an on-demand, non-hormonal female contraceptive currently under development, using a web-based survey.

STUDY DESIGN: We recruited respondents for an exploratory survey via web link on Amazon Mechanical Turk (MTurk). Individuals were eligible if they were 18-44 years of age, identified as cis-gender female, were English-speaking, not pregnant, and had used barrier contraception previously. Respondents provided demographic characteristics and a basic reproductive history. We then provided a brief description of the potential contraceptive. Respondents were asked about their interest …

Clinical Applications Of Electrical Stimulation For Peripheral Nerve Injury: A Systematic Review, Meredith C Costello, Emily L Errante, Taylor Smartz, Wilson Z Ray, Allan D Levi, Stephen Shelby Burks

2020-Current year OA Pubs

INTRODUCTION: Peripheral nerve injuries are common neurologic injuries that are challenging to treat with current therapies. Electrical stimulation has been shown to accelerate reinnervation and enhance functional recovery. This study aims to review the literature on clinical application of electrical stimulation for peripheral nerve injury.

METHODS: PubMed and Embase were sourced from 1995 to August 2022. Selection was based on predetermined inclusion/exclusion criteria. Eight hundred and thirty-five articles were screened with seven being included in this review.

RESULTS: Two hundred and twenty-nine patients with peripheral nerve injuries were represented. Six of the studies were randomized controlled trials. A variety of …

Caregiver Perspectives On The Continued Impact Of The Covid-19 Pandemic On Children With Intellectual/Developmental Disabilities, R A Northrup, E Jones, V Singh, C Holingue, M Meck, C A Gurnett, M Van Stone, L G Kalb

2020-Current year OA Pubs

The COVID-19 pandemic has significantly impacted caregivers, especially those raising a child with an intellectual/developmental disability (IDD). While research has shown substantial disruption to the family, school, and occupational lives of the IDD community, little is known about the long-term impacts of COVID-19. To address this question, 249 caregivers were surveyed via an online questionnaire, between April and August of 2022 (more than 2 years into the pandemic) about potential impacts of the COVID-19 pandemic on their child's access to health- and school-based therapeutic services, caregiver mental health, and family life. The majority of caregivers reported disruptions in access to …

Neurobridge: A Prototype Platform For Discovery Of The Long-Tail Neuroimaging Data, Lei Wang, Janine Bijsterbosch, Rick Herrick, Daniel Marcus, Stephen M Moore, Et Al.

2020-Current year OA Pubs

INTRODUCTION: Open science initiatives have enabled sharing of large amounts of already collected data. However, significant gaps remain regarding how to find appropriate data, including underutilized data that exist in the long tail of science. We demonstrate the NeuroBridge prototype and its ability to search PubMed Central full-text papers for information relevant to neuroimaging data collected from schizophrenia and addiction studies.

METHODS: The NeuroBridge architecture contained the following components: (1) Extensible ontology for modeling study metadata: subject population, imaging techniques, and relevant behavioral, cognitive, or clinical data. Details are described in the companion paper in this special issue; (2) A …

Recruitment Methods And Yield Rates For A Multisite Clinical Trial Exploring Risk Reduction For Alzheimer's Disease (Rrad), Amanda N Szabo-Reed, Monica Sewell, Ellen F Binder, Et Al.

2020-Current year OA Pubs

INTRODUCTION: The risk reduction for Alzheimer's disease (rrAD) trial was a multisite clinical trial to assess exercise and intensive vascular pharmacological treatment on cognitive function in community-dwelling older adults at increased risk for Alzheimer's disease.

METHODS: Eligibility, consent, and randomization rates across different referral sources were compared. Informal interviews conducted with each site's project team were conducted upon study completion.

RESULTS: Initially, 3290 individuals were screened, of whom 28% were eligible to consent, 805 consented to participate (87.2% of those eligible), and 513 (36.3% of those consented) were randomized. Emails sent from study site listservs/databases yielded the highest amount (20.9%) …

Critcom: Assessment Of Quality Of Interdisciplinary Communication Around Deterioration In Pediatric Oncologic Patients, Jocelyn Rivera, Sara Malone, Kim Prewitt, Lara Counts, Douglas A Luke, Et Al.

2020-Current year OA Pubs

BACKGROUND: High-quality clinical care requires excellent interdisciplinary communication, especially during emergencies, and no tools exist to evaluate communication in critical care. We describe the development of a pragmatic tool focusing on interdisciplinary communication during patient deterioration (CritCom).

METHODS: The preliminary CritCom tool was developed after a literature review and consultation with a multidisciplinary panel of global experts in communication, pediatric oncology, and critical care to review the domains and establish content validity iteratively. Face and linguistic validity were established through cognitive interviews, translation, and linguistic synthesis. We conducted a pilot study among an international group of clinicians to establish reliability …

Protecting A Real Or Imagined Past: Justice Samuel Alito And The First Amendment, Derigan Silver, Dan V. Kozlowski

All Faculty Scholarship

This article examines the First Amendment jurisprudence of Justice Samuel Alito. In this article, we argue that the principles behind his decision-making are not always necessarily traditional methods of constitutional analysis, and litigants should understand the frames and lenses Alito uses to make decisions when making their arguments to him. The article concludes with a discussion of Alito’s overall approach to the law and some thoughts on how he is attempting to reshape the First Amendment. We write that, above all, it is clear he is seeking to protect a real or imagined past that, in his mind, is under …

Association Of Human Leukocyte Antigen Alleles With Carbamazepine-Or Lamotrigine-Induced Stevens-Johnson Syndrome And Toxic Epidermal Necrolysis In An Iranian Population: A Case-Control Study, Ladan Dastgheib, Farima Rostami, Behrouz Gharesi-Fard, Ali Akbar Asadi-Pooya, Saba Namjoo, Foroozan Tahmasebi, Maryam Hadibarhaghtalab

Department of Neurology Faculty Papers

Background: Genetic diversity in human leukocyte antigen (HLA) alleles across populations is a significant risk factor for drug-induced severe cutaneous adverse reactions (SCARs), e.g., carbamazepine (CBZ)- and lamotrigine (LTG)-induced StevensJohnson syndrome (SJS), and toxic epidermal necrolysis (TEN). The present study aimed to investigate the frequency of different HLA alleles in Iranian patients with CBZ- and LTG-induced SJS/TEN.

Methods:A case-control study was conducted from 2011 to 2018 at various hospitals affiliated with Shiraz University of Medical Sciences (Shiraz, Iran). A total of 31 patients receiving anticonvulsant drugs (CZB or LTG) were recruited and divided into two groups. The drug-induced group …

Safety And Tolerability Results Of Atogepant For The Preventive Treatment Of Episodic Migraine From A 40-Week, Open-Label Multicenter Extension Of The Phase 3 Advance Trial, Brad C Klein, Rosa Miceli, Lawrence Severt, Peter Mcallister, Laszlo Mechtler, Jennifer Mcvige, Merle Diamond, Michael J. Marmura, Hua Guo, Michelle Finnegan, Joel M Trugman

Department of Neurology Faculty Papers

Background: Atogepant is a United States Food and Drug Administration-approved oral calcitonin gene-related peptide receptor antagonist for the preventive treatment of episodic migraine. The study objective was to evaluate the long-term safety and tolerability of atogepant in participants who completed the phase 3 ADVANCE trial (NCT03777059).

Methods: This 40-week, open-label extension trial (NCT03939312) monitored safety in participants receiving oral atogepant 60 mg once daily, followed by a four-week safety follow-up period.

Results: Of the 685 participants taking at least one dose of atogepant, the treatment period was completed by 74.6% of participants with a mean (standard …

The Role Affiliation Membership Plays In An Ffa Chapter: A Qualitative View From Kentucky, Jacob Falwell, Kristie B. Guffey

Murray State Theses and Dissertations

Research exists to demonstrate the benefits of FFA membership and the three-circle model of agriculture education. FFA membership had shown minimal growth in the 20 years following the rebranding. The innovative approach of affiliation membership has ushered in a steady growth of FFA membership, but not all chapters are participating in affiliation. FFA membership is provided to every student who is enrolled in agriculture education classes with affiliation, and the dues collection process is eliminated. This study investigated the view of affiliation membership in Kentucky High School Agriculture Education programs by researching the enrollment, involvement, and educational outcomes of affiliated …

What Factors Keep Late-Career Agriculture Teachers In Georgia Motivated To Continue In The Profession?, Catherine I. Davis

Murray State Theses and Dissertations

Most agriculture teachers leave the profession by the time they reach their mid-career phase. While there is significant research indicating factors why agriculture teachers choose to leave the career there is a void in the knowledge as to why late career agriculture teachers have persevered and are still choosing to stay in the classroom. This qualitative study identifies factors as to why agriculture teachers have chosen to stay in the profession. The researcher interviewed late career agriculture teachers in Georgia with 20 or more years in the classroom and are currently still teaching today. These interviews lead to common themes …

The Effects Of Inspiratory Muscle Training On Exercise-Induced Laryngeal Obstruction In Young Adults, Allison Lyman

Murray State Theses and Dissertations

Exercise-induced laryngeal obstruction (EILO) is a condition that results from abnormal vocal fold adduction upon inspiration (Abdel-Hamid, 2018). Symptoms of this ailment include dyspnea, choking sensations, an audible stridor, and/or coughing during physical exertion (Marcinow et al., 2014). These symptoms affect an individual’s ability to breathe adequately during exercise. A review of current literature suggests that there are a variety of interventions that can be used to reduce perceived dyspnea in individuals who suffer from EILO. One such intervention is known as inspiratory muscle training (IMT), which works to reduce dyspnea by strengthening the primary muscle of inspiration: the posterior …

Sequencing Of Extended Reality Welder Training, Monica Donohue

Murray State Theses and Dissertations

Abstract

This study used a quasi-experimental design to evaluate the efficacy of integrating XR welding simulations into traditional training programs. The performance outcomes of participants were assessed by an independent American Welding Society (AWS) Certified Welding Instructor (CWI). Participants were evaluated using the NCCER Performance Accreditation Tasks evaluation. After 20 hours of training, the participants used a traditional welder to perform a vertical 3F weld on a steel weld coupon. Three treatment groups were used to evaluate the sequence of extended reality welding simulators in a traditional welding program. Results indicate that sequencing XR practice before live welding did not …

A Phenomenological Study Of K-12 Educators' Perceptions Of Social Emotional Learning For K-12 Students In Southern Illinois., Ruth Cahill

Murray State Theses and Dissertations

The objective of this Phenomenological study was to analyze K-12 educators’ lived experiences, opinions, and perceptions regarding the impact of social emotional learning implementation in a small school district in Southern Illinois. Results revealed four consistent codes: Educator competence – the participants revealed that they did not feel competent enough to correctly implement SEL due to lack of consistent, on-going SEL training; Efficacy – due to school closures, virtual instruction, and inconsistencies caused by the corona-virus pandemic, SEL implementation in the school district was discontinued until further notice; Perception – the participants expressed that when implemented correctly, they believe that …

Effects Of Plasma Sample Handling On Equine Insulin Assays, Lauren Willett

Murray State Theses and Dissertations

Often, the assumption is made that the results of the various laboratory tests being run are accurate, and that abnormal results reflect a physiologic change occurring in the patient. Unfortunately, this assumption is not always true. Inaccurate results, for various reasons, are an inherent part of diagnostic testing. Having inaccurate results is often worse than having no results at all, because they can lead to an incorrect diagnosis or result in unnecessary testing, wasting the client’s financial resources, or potentially expose the patient to unnecessary risks in pursuit of the cause of an abnormality that does not exist. With appropriate …

Comparison Of Corticosterone Concentrations Between Serum And Fecal Samples As A Measure Of Stress In Male Broilers., Kayla Weinacht

Murray State Theses and Dissertations

Stress has long been a topic of interest in the poultry industry due to its potential negative effects on chicken health and production of both eggs and meat. With increased global growth in egg and broiler production, more attention has been paid to the stressors that affect chickens in modern poultry operations, particularly environmental temperature and stocking density. Improving quantitative measurement of stress is always needed in poultry welfare research. In most studies, blood serum is measured for corticosterone, one of the biomarker hormones associated with stress in chickens. Methods of collecting blood serum are by their nature disruptive to …

The Effect Of An Afterschool Makerspace Program On Academic Achievement Of Sixth-Eighth Grade Students, Teresa Lampe

Murray State Theses and Dissertations

This quasi-experimental study investigated the effect of participation in an afterschool makerspace program on middle school students' academic achievement, grades, and school attendance. An experimental group of 237 sixth-eighth grade students participated in an afterschool makerspace program during the 2019-2020, 2020-2021, and 2021-2022 school years. A control group was selected using stratified random sampling of students from the same schools, grades, and special education designation who did not participate. The data included science and math NWEA scores, science and math grades, program attendance, school attendance, and gender. The data were analyzed using an independent t test with a 95% confidence …

An Exploratory Study Of Ergonomics In College Students, Wesley Ryan Tinker

Murray State Theses and Dissertations

Abstract

This study aimed to examine the relationship between poor ergonomic conditions and student physiological discrepancies. This examination provided great insight into students’ daily experiences and concerns for their futures. The methodology used for this study was quantitative as two source data sets were collected and analyzed. The tool REBA was used to measure the specific body angles while students sat working. A survey yielded great results, giving the students an opportunity to subjectively choose options.

This exploratory study allowed the researcher to use quantitative data to answer this study’s research questions. The research questions asked from this study were …

Self-Diagnosis & Pathologizing Normality During The Information Age, Chelsey Eaton

Murray State Theses and Dissertations

Self-diagnosis has become a concern for medical and mental health diagnoses. More people are engaging in self-diagnosis based on information that was obtained from the internet, including websites, social media platforms, and online forums. There are several reasons one may choose to self-diagnose. Some common reasons outlined in research are the desire to fit in with others who share similar characteristics and having a label to explain one’s experiences. Past research has shown that people frequently search for mental health information online, but they may not understand or may misinterpret the information that is found. This study aimed to address …

The Relationship Between Student Performance In English Language Proficiency And Academic Content Assessments, Rosa Wolford

Murray State Theses and Dissertations

As the number of English Learner (EL) students continue to increase in the United States and accountability increases for their growth and achievement in both English language proficiency and state content assessments, it is essential that educational agencies examine the predictive relationships between the assessments to ensure appropriate supports for English Learners are provided. Subsequently, the purpose of this study was to determine if there is a predictive relationship between the WIDA ACCESS Literacy and Overall Composite scores and the TNReady English Language Arts and Mathematics assessments scores of sampled EL students in fourth through twelfth grades among the subgroups …

Higher Education Awareness Amongst Noncommissioned Officers In The United States Army, Amanda Houser

Murray State Theses and Dissertations

Insufficient research exists concerning why active-duty enlisted noncommissioned officers do not pursue education past a high school diploma. Although higher education is becoming a minimum qualification in the civilian world, only 17% of enlisted servicemembers have higher than a high school degree. The purpose of this study is to explore the lived experiences, beliefs, and awareness of Army education benefits and the disconnect between higher education enrollment and active-duty noncommissioned officers. Two-hundred and sixty-five enlisted active-duty noncommissioned officers participated in an online survey and fifty-two noncommissioned officers participated in a one-on-one interview. Using a qualitative, grounded theory research design, both …

Women Pursuing An Agricultural Systems Technology Degree, Tanya Milam

Murray State Theses and Dissertations

Abstract

This phenomenological research study examined the factors influencing women to pursue an Agricultural Systems Technology (AST) degree and their self-efficacy in that field of study. Two research questions guided this study and data was analyzed from interviewing women enrolled in an Agricultural Systems Technology (AST) program at a mid-western university. The resulting four categories of Agricultural Experiences, Aptitude, Support, and Motivation were broken down into themes. The results were also applied to the theoretical framework of self-efficacy associated with career choice theories. Limitations of scope and generalizability indicate that further investigation of this topic is highly recommended.

Keywords: …