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Ypfs Lessons Learned Oral History Project: An Interview With William English, William B. English, Sandra Ward

Documents

No abstract provided.

The Ninth Amendment: The "Hard Problem" Of U.S. Constitutional Law, Jorge M. Farinacci Fernós

Journal Articles

Like with the mythical lamp that can grant any three wishes, federal courts in the United States have buried the Ninth Amendment of the U.S. Constitution deep within the sands of American law in order to avoid coming to terms with its potential regarding the protection of unenumerated constitutional rights. Courts have been able to do so, in part, because of the seemingly impossible task of extracting from the text and history of the Ninth Amendment sufficient elements needed to identify which unenumerated rights may be subject to judicial enforcement.

This impossibility is an illusion and is contrary to the …

Your Mission, Should You Choose To Attempt It, Is To Save The Mona Lisa! Gamification As A Method For Teaching Art, Caleb Ovard

Theses and Dissertations

To increase student engagement in their classroom, the author created an art curriculum using gamification methods that incorporates elements of tabletop role-playing games. The Role-playing Art Curriculum is a key element of this thesis. Possible research approaches involving game-based learning and gamification were examined to point toward future research and reflection regarding games and game-like content into an art curriculum. Action research methods were used to create and run the Role-playing Art Curriculum. The author concludes that the gamified curriculum took extra preparation and required more management to run then other traditional art curriculums.

Estimating And Detecting Slow-Wave Events In Eeg Signals, Zhenghao Xiong

McKelvey School of Engineering Graduate Student Theses & Dissertations

Slow wave activity (SWA) is an electroencephalogram (EEG) pattern commonly occurring during anesthesia and deep sleep, and is hence a candidate biomarker to quantify such states and understand their connection to various phenotypes. SWA consists of individual slow waves (ISW), high-amplitude deflections lasting for approximately 0.5 to 1 second, and occurring quasi-periodically. This latter fact poses a challenge for conventional power spectral density EEG analysis methods that perform best when there is persistency of oscillatory activity. In this work, we pursue a time-domain detection framework for identifying and quantifying ISWs as a metric for SWA. Our method works, in essence, …

Harm Reduction In Undergraduate And Graduate Medical Education: A Systematic Scoping Review, Kelsey R. Smith, Nina K. Shah, Abby L. Adamczyk, Lara C. Weinstein, Erin L. Kelly

Department of Family & Community Medicine Faculty Papers

BACKGROUND: Substance use increasingly contributes to early morbidity and mortality, which necessitates greater preparation of the healthcare workforce to mitigate its harm. The purpose of this systematic scoping review is to: 1) review published curricula on harm reduction for substance use implemented by undergraduate (UME) and graduate medical education (GME) in the United States and Canada, 2) develop a framework to describe a comprehensive approach to harm reduction medical education, and 3) propose additional content topics for future consideration.

METHODS: PubMed, Scopus, ERIC: Education Resources Information Center (Ovid), and MedEdPORTAL were searched. Studies included any English language curricula about harm …

Cancer Survivorship And Subjective Cognitive Decline In The Us: Results From A Nationally Representative Sample, Monique J. Brown, Ally Hucek, Jingkai Wei, Loretta Anderson, Muzi Na

Faculty Publications

Cancer may be associated with objective cognitive decline. However, studies examining the link between cancer and subjective cognitive decline (SCD), which occurs earlier during cognitive trajectories, are lacking. In addition, research assessing risk factors for SCD among cancer survivors is scant. Therefore, this study aimed to examine the association between cancer and SCD in the past year, and assess the association between age of diagnosis, cancer treatment, and SCD among cancer survivors. Data were obtained from the 2021 Behavioral Risk Factor Surveillance System (N=15,447). Crude and adjusted logistic regression models, controlling for sociodemographic characteristics, were used to determine the association …

27-Hydroxycholesterol And Dna Damage Repair: Implication In Prostate Cancer, Gloria Cecilia Galvan, Nadine Friedrich, Sanjay Das, James Daniels, Sara Pollan, Shweta Dambal, Ryusuke Suzuki, Sergio Sanders, Sungyong You, Hisashi Tanaka, Yeon-Joo Lee, Wei Yuan, Johann De Bono, Irina Vasilevskaya, Karen Knudsen, Michael Freeman, Stephen Freedland

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

INTRODUCTION: We previously reported that cholesterol homeostasis in prostate cancer (PC) is regulated by 27-hydroxycholesterol (27HC) and that CYP27A1, the enzyme that converts cholesterol to 27HC, is frequently lost in PCs. We observed that restoring the CYP27A1/27HC axis inhibited PC growth. In this study, we investigated the mechanism of 27HC-mediated anti-PC effects.

METHODS: We employed in vitro models and human transcriptomics data to investigate 27HC mechanism of action in PC. LNCaP (AR+) and DU145 (AR-) cells were treated with 27HC or vehicle. Transcriptome profiling was performed using the Affymetrix GeneChip™ microarray system. Differential expression was determined, and gene set enrichment …

Leptin Decreases Gluconeogenesis And Gluconeogenic Substrate Availability In Patients With Lipodystrophy, Emmanuel Quaye, Shaji Chacko, Megan Startzell, Rebecca J Brown

Children’s Nutrition Research Center Staff Publications

Context: The effects of leptin, an adipocyte-derived hormone that signals overall energy sufficiency, can only be studied in leptin-deficient conditions. In patients with lipodystrophy, a rare disease and unique model of leptin deficiency, treatment with recombinant leptin (metreleptin) improves glycemia and decreases energy expenditure. We hypothesized that these improvements might be mediated by reduced gluconeogenesis (GNG), an energy-requiring process.

Objective: To determine the effects of metreleptin on GNG and GNG substrates.

Methods: This was a single-arm prospective study of metreleptin administration in 15 patients with lipodystrophy, 9 of whom had data on GNG (NIH, 2013-2018). We analyzed total GNG, insulin-mediated …

Every Story Has A Beginning, But What About An End?: Disney’S Expiring Copyrights, Marisol Jimenez Gastelum

Loyola of Los Angeles Law Review

The Walt Disney Company is one of the most powerful and influential media companies in the world that has revolutionized animated films. Steamboat Willie, the cartoon featuring the first version of Mickey Mouse, was released in 1928 and is set to enter the public domain on January 1, 2024. This iconic character has stayed out of the public domain for nearly a century because of Congress’s extension of copyright duration in response to lobbying efforts by Disney and other copyright holders. Although Disney has not made another effort to lobby Congress for an extension to its copyrights, Disney’s development of …

Harnessing The Power Of Student Voice: A Case Study Of Hybrid Proficiency-Based And Co-Created Curriculum And Assessment, Kaitlyn A. Seamons

Theses and Dissertations

Assessment has become a dirty word in arts education, because art is notoriously difficult to assess. Assessment, which is often disliked or even disavowed by arts educators, due to its history of incompatibility with the idiosyncratic nature of arts learning, should ideally be utilized as a means of measuring student progress and help teachers understand how to help students succeed. While assessment can also be used to evaluate programs and teachers and to compare student successes relative to those of other students, I will be focusing on measuring individual student progress for my thesis and building a curriculum to support …

Playing To Grow. Roundtable Interview On Games, Education, And Character, Owen Gottlieb, Matthew Farber, Paul Darvasi

Articles

In this roundtable interview moderated by Paul Darvasi, lecturer at the University of Toronto and co-founder of Gold Bug Interactive, Owen Gottlieb and Matthew Farber discuss research and practice at the intersection of religion, character education, and games in schools. Gottlieb is an associate professor at the Rochester Institute of Technology, founder and lead faculty at the Initiative in Religion, Culture, and Policy at the MAGIC center, and founder and director of the Interaction, Media, and Learning Lab at RIT, where he specializes in interactive media, learning, religion, and culture. Farber is an associate professor of educational technology and coordinator …

Parallel Neural Pathways Control Sodium Consumption And Taste Valence, Yameng Zhang, Allan-Hermann Pool, Tongtong Wang, Lu Liu, Elin Kang, Bei Zhang, Liang Ding, Kirsten Frieda, Richard Palmiter, Yuki Oka

Faculty, Staff and Student Publications

The hedonic value of salt fundamentally changes depending on the internal state. High concentrations of salt induce innate aversion under sated states, whereas such aversive stimuli transform into appetitive ones under sodium depletion. Neural mechanisms underlying this state-dependent salt valence switch are poorly understood. Using transcriptomics state-to-cell-type mapping and neural manipulations, we show that positive and negative valences of salt are controlled by anatomically distinct neural circuits in the mammalian brain. The hindbrain interoceptive circuit regulates sodium-specific appetitive drive , whereas behavioral tolerance of aversive salts is encoded by a dedicated class of neurons in the forebrain lamina terminalis (LT) …

Technology Justice: Taxation Of Our Collective And Cumulative Cognitive Inheritance, Hilary G. Escajeda

Loyola of Los Angeles Law Review

As artificial intelligence and robotic technologies accelerate economic transformation, outdated property and tax laws will increasingly fail American workers with ordinary skills that perform routine job functions. Because technology may render millions of workers redundant, U.S. policymakers must make significant social, economic, and legal structural changes to (1) improve the lives of average workers, (2) support the economy, and (3) maintain political stability.

Inspired by Thomas Paine’s Agrarian Justice, this twenty-first century Article argues that “Technology Justice” requires that humans benefit from the cognitive endowment created by our ancestors’ minds. Specifically, it asserts that our collective and cumulative cognitive …

Cárcel De Amor / The Prison Of Love, Laura Francis, Álvaro Garrote Pascual

Medieval Feminist Forum: A Journal of Gender and Sexuality

No abstract provided.

Olanzapine Pharmacokinetics: A Clinical Review Of Current Insights And Remaining Questions, Priyanka Kolli, Grace Kelley, Marianela Rosales, Justin Faden, Ryan Serdenes

Department of Psychiatry and Human Behavior Faculty Papers

Olanzapine is one of the most widely used antipsychotics since its initial approval by the US Food and Drug Administration in 1996 and has undergone extensive pharmacokinetic study. Despite being utilized in clinical psychiatry for decades, there remain questions regarding the variety of available formulations, the utility of therapeutic drug monitoring, altered kinetic properties in special populations/medical illnesses, the use of high-dose olanzapine, and drug interactions, among many others. We performed a narrative literature review of olanzapine pharmacokinetics in June 2023 using the US National Library of Medicine's PubMed.gov resource (https://www.ncbi.nlm.nih.gov/pubmed) and Google Scholar. Herein, we review clinically relevant aspects …

Optimizations Of Graphite Anode For High Capacity And High Power Usage, Poom Sittisomwong

McKelvey School of Engineering Graduate Student Theses & Dissertations

The increasing demand for high-performance electric vehicles drives the need for fast-charging, high-capacity, and long-lasting energy storage devices. This thesis work consists of two sections.

In the first study, we focused on investigating the effect of silicon amount in silicon graphite anode on the capacity and cycle life. We found that the capacity of the anode does not increase if silicon content exceeds 40% of the mass of active material. In the second study, we focused on the effect of electrolytes on the fast-charging capability of graphite anode. We found that 1,3-dioxolane enables graphite anode to dedicate capacity up to …

Immunosequencing Applications In Cutaneous T-Cell Lymphoma, Jenna Mandel, Laura Gleason, Daniel Joffe, Safiyyah Bhatti, Neda Nikbakht

Department of Dermatology and Cutaneous Biology Faculty Papers

Immunosequencing has emerged as a newer clinical test for assessment of T-cell clonality in the blood and skin of cutaneous T-cell lymphoma (CTCL) patients. Utilization of immunosequencing, also known as high-throughput sequencing of the T-cell receptor (HTS-TCR), enables identification and quantification of the precise genetic signature of dominant T-cell clones. Although immunosequencing is more sensitive than commonly used methods such as polymerase chain reaction (PCR) paired with capillary electrophoresis or flow cytometry, it remains underutilized for CTCL management. Nonetheless, incorporation of HTS-TCR in clinical practice offers distinct advantages compared to other molecular analyses that may improve diagnostic evaluation, prognostication, and …

Ints6 And The Integrator Phosphatase Module Tune The Efficiency Of Select Premature Transcription Termination Events, Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P Shah, Matthew Tracey, Xu-Kai Ma, Christopher J Fields, María Saraí Mendoza-Figueroa, Michele C Meline, Deirdre C Tatomer, Li Yang, Jeremy E Wilusz

Children’s Nutrition Research Center Staff Publications

The metazoan-specific Integrator complex catalyzes 3' end processing of small nuclear RNAs (snRNAs) and premature termination that attenuates the transcription of many protein-coding genes. Integrator has RNA endonuclease and protein phosphatase activities, but it remains unclear if both are required for complex function. Here, we show IntS6 (Integrator subunit 6) over-expression blocks Integrator function at a subset of Drosophila protein-coding genes, although having no effect on snRNAs or attenuation of other loci. Over-expressed IntS6 titrates protein phosphatase 2A (PP2A) subunits, thereby only affecting gene loci where phosphatase activity is necessary for Integrator function. IntS6 functions analogous to a PP2A regulatory …

The Involvement Of Hepatic Cytochrome P450s In The Cytotoxicity Of Lapatinib, Si Chen, Xilin Li, Yuxi Li, Xiaobo He, Matthew Bryant, Xuan Qin, Feng Li, Ji-Eun Seo, Xiaoqing Guo, Nan Mei, Lei Guo

Faculty, Staff and Students Publications

Lapatinib, an oral tyrosine kinase inhibitor used as a first-line treatment for HER2-positive breast cancer, has been reported to be associated with hepatotoxicity; however, the underlying mechanisms remain unclear. In this study, we report that lapatinib causes cytotoxicity in multiple types of hepatic cells, including primary human hepatocytes, HepaRG cells, and HepG2 cells. A 24-h treatment with lapatinib induced cell cycle disturbances, apoptosis, and DNA damage, and decreased the protein levels of topoisomerase in HepG2 cells. We investigated the role of cytochrome P450 (CYP)-mediated metabolism in lapatinib-induced cytotoxicity using our previously established HepG2 cell lines, which express each of 14 …

Breaking The Non-Compete Cycle: A Legal And Economic Analysis Of The Ftc's Power Move, Stephen Fox

University of Cincinnati Law Review

No abstract provided.

A Right Without A Remedy: How One Cincinnatian's Story Illustrates Terrorism Victims' Inability To Obtain Compensation Under The Foreign Sovereign Immunities Act, Christopher T. Colloton

University of Cincinnati Law Review

No abstract provided.

Becoming "Audit" It Can Be: Improving Public School Funding Through A Streamlined Sales And Use Tax Agreement For Real Property Tax, Megan E. Bowling

University of Cincinnati Law Review

No abstract provided.

Value Judgments In Judicial Reasoning, And The Instability Of The Fact-Law Distinction, Stephen A. Simon

University of Cincinnati Law Review

No abstract provided.

Engaging Community Partners To Enrich Preschoolers Learning Experiences With Dramatic Inquiry, Kathleen M. Farrand, Wendy Peia Oakes, Megan Troxel Deeg, Katelyn Jaworksi, Veronica Leon

Journal of the Arts and Special Education

Interdisciplinary teams of adults are needed to enhance the capacity of schools to provide the most appropriate educational experiences for young children who have or are at risk for developmental delays and disabilities (Division for Early Childhood, 2014). When educators, families, and community partners connect around shared goals, we begin to reimagine instructional opportunities and create more equitable access to educational resources for children and families. We share insights from community partners who participated in a collaborative dramatic inquiry study designed to enrich preschoolers’ learning experiences and serve children and families.

Book Review: Inequality In America: Causes And Consequences, Eya Mahouachi

The Journal of Values-Based Leadership

Inequality in America: Causes and Consequences is a recent book authored by Rycroft (economics, Univ. of Mary Washington, Fredericksburg, VA) and Kinsley (business law, Univ. of Mary Washington, Fredericksburg, VA) and was written by scholars, advanced graduate students, and expert practitioners. Their book attempts to bridge the gap in scholarship and practice by incorporating the causes and consequences of history, the current state of inequality in the United States, and future consequences if left unresolved. This book is structured according to fundamental topics such as education, healthcare, housing, environmental issues, and the justice system. Using an effective approach to teaching …

Top Directed, Bottom Driven: Subaru Tackles Waste (Interview With Denise Coogan, Subaru), Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

Authentic Leadership Measures: An Authentic Measure For Authentic Leadership?, Mitch Butterworth, Jessica Black, Robert Terry

The Journal of Values-Based Leadership

This study broadly addresses some of the criticisms associated with authentic leadership theory related to measurement and antecedents. Measurement: One purpose of this study was to verify the dimensionality of authentic leadership by testing the construct validity of three measures for authentic leadership: the Authentic Leadership Questionnaire (ALQ), the Authentic Leadership Inventory (ALI), and the Authentic Leadership Integrated Questionnaire (AL-IQ), proposed by Levesque-Cote et al. (2018) as an improvement on the previous two scales. This study was designed to replicate and extend Levesque-Cote et al. (2018) study with an English-speaking sample to further test the structural validity of the AL-IQ. …

Winter/Spring 2024

The Journal of Values-Based Leadership

No abstract provided.

Book Review Reading Images: The Grammar Of Visual Design, Wim Honders

Journal of Media Literacy Education

No abstract provided.

Critically Analyzing The Meanings Of “Critical” Media Literacy, W. James Potter

Journal of Media Literacy Education

This study provides a critical analysis into how authors of publications about critical media literacy express what they mean by the term. The use of multiple strategies to examine the degree to which these authors exhibit a sharing of meaning led to the conclusion that there are far more differences than commonalities across definitions of critical media literacy. The implications of this conclusion raise important questions about the value of a literature where authors seem to express so many different meanings for the concept that they use to label their common concern.