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Articles 31 - 60 of 45855
Full-Text Articles in Entire DC Network
Gaining A Deeper Understanding Of The Meaning Of The Carelessness Parameter In The 4pl Irt Model And Strategies For Estimating It, Timbul Pardede, Agus Santoso, Diki Diki, Heri Retnawati, Ibnu Rafi, Ezi Apino, Munaya Nikma Rosyada
Gaining A Deeper Understanding Of The Meaning Of The Carelessness Parameter In The 4pl Irt Model And Strategies For Estimating It, Timbul Pardede, Agus Santoso, Diki Diki, Heri Retnawati, Ibnu Rafi, Ezi Apino, Munaya Nikma Rosyada
REID (Research and Evaluation in Education)
Three popular models are used to describe the characteristics of the test items and estimate the ability of examinees under the dichotomous IRT model, namely the one-, two-, and three-parameter logistic models. The three-item parameters are discriminating power, difficulty, and pseudo-guessing. In the development of the dichotomous IRT model, carelessness or upper asymptote parameter was proposed, which forms a four-parameter logistic (4PL) model to accommodate a condition where a high-ability examinee gives an incorrect response to a test item when he/she should be able to respond to the test item correctly. However, the carelessness parameter and the 4PL model have …
Determinant Factors Affecting The Research Performance Of Lecturers Receiving External Funds, Haryanto Haryanto, Nur Kholis, Samsul Hadi, Ezi Apino, Muh. Asriadi Am, Cerry Kartika Trizkyana
Determinant Factors Affecting The Research Performance Of Lecturers Receiving External Funds, Haryanto Haryanto, Nur Kholis, Samsul Hadi, Ezi Apino, Muh. Asriadi Am, Cerry Kartika Trizkyana
REID (Research and Evaluation in Education)
Quality research can positively impact the development of science and technology and improve the reputation of universities. This study investigates the determinant factors that affect the research performance of lecturers who obtain external funding. The sample was 41 lecturers who obtained external research funds from various institutions (e.g., Directorate of Research, Technology and Community Service, Ministry of Education, Culture, Research and Technology of the Republic of Indonesia; National Research and Innovation Agency of the Republic of Indonesia; and similar institutions) for the last three years (2021 - 2023). Cluster analysis using secondary data (Science and Technology Index or SINTA data) …
Measuring Students' Generic Skills Through National Assessment, Toha Makhshun, Bassam Abul A'La, Kusaeri Kusaeri
Measuring Students' Generic Skills Through National Assessment, Toha Makhshun, Bassam Abul A'La, Kusaeri Kusaeri
Jurnal Penelitian dan Evaluasi Pendidikan
This study aims to measure the generic skills (GS) of Madrasah Aliyah (MA) students in Indonesia. Respondents who participated in this study were madrasah students scattered in East Java and Central Java as representatives of MAs in Indonesia. The method used in this research is a survey distributed via Google Form. Three dimensions are mentioned in the research instrument for measuring GS: religious moderation, critical and creative thinking skills, and interpersonal skills. Using SPPS version 16 software, a descriptive analysis was employed as the data analysis technique. The results of this study showed that the GS of students with religious …
Instrument And Evaluation Of Students' Involvement In Learning Mathematics In 21-Century Skills At Senior High Schools Of Riau Province, Dedek Andrian, Leo Adhar Effendi
Instrument And Evaluation Of Students' Involvement In Learning Mathematics In 21-Century Skills At Senior High Schools Of Riau Province, Dedek Andrian, Leo Adhar Effendi
Jurnal Penelitian dan Evaluasi Pendidikan
Student engagement is the most crucial factor in learning activities because it is the main factor in improving student learning outcomes in class. This study aims to develop instruments and evaluate student involvement in learning mathematics to achieve maximum learning outcomes at school. The population in this study was all high school students in Riau Province. The sample is 150 high school students selected by multiple-stage random sampling based on high, medium, and low student achievement levels. Data analysis in this study was carried out four times: (1) data analysis based on the results of expert assessment of the instrument …
A Meta-Analysis Of The Relationship Between Self-Assessment And Mathematics Learning Achievement, Fransidha Sidhara Hadi, Janu Arlinwibowo, Gupita Nadindra Fatima
A Meta-Analysis Of The Relationship Between Self-Assessment And Mathematics Learning Achievement, Fransidha Sidhara Hadi, Janu Arlinwibowo, Gupita Nadindra Fatima
Jurnal Penelitian dan Evaluasi Pendidikan
This study uses a meta-analysis model to describe the relationship between self-assessment and achievement in learning mathematics. This meta-analysis covers articles published from 2011 to 2022 and is restricted to studies published in English. Indexed articles by Google Scholar were chosen. The data must meet these criteria: quantitative research, containing correlational research on the relationship between self-assessment and mathematics learning achievement (including correlation values and sample size). Through the data screening process with predetermined criteria, 12 research results were obtained, containing 43 studies to be analyzed. This meta-analysis uses a random effect model due to the heterogeneous data distribution. A …
Analysis Of Students' Perceptions On The Freedom Of Learning - Independent Campus (Mbkm) Program At Chemistry Study Program Of Ma Chung University, Yuyun Yuniati, Lilis Lestari Wilujeng
Analysis Of Students' Perceptions On The Freedom Of Learning - Independent Campus (Mbkm) Program At Chemistry Study Program Of Ma Chung University, Yuyun Yuniati, Lilis Lestari Wilujeng
Jurnal Penelitian dan Evaluasi Pendidikan
Considering that Indonesian education has gone through such a long journey from 1922 to 2022 now, it is necessary to have an educational program that is able to meet the demands of workers' needs in this era of globalization. In the end, the Directorate General of Higher Education, Research, and Technology designed an education policy system in the realm of higher education, namely "Freedom of Learning - Independent Campus", as an accurate strategy for optimizing academics in today's Indonesia. In this study, a survey was aimed at 40 undergraduate students of the Chemistry Study Program at Ma Chung University. Data …
Item Quality Analysis Using The Rasch Model To Measure Critical Thinking Ability In The Material Of The Human Digestive System Of Biology Subject In High School, Wanda Agus Prasetya, Anggi Tias Pratama
Item Quality Analysis Using The Rasch Model To Measure Critical Thinking Ability In The Material Of The Human Digestive System Of Biology Subject In High School, Wanda Agus Prasetya, Anggi Tias Pratama
Jurnal Penelitian dan Evaluasi Pendidikan
This study aims to determine the quality of the Biology instrument items on the digestive system material with the Rasch model for analyzing critical thinking skills. The research employed a quantitative descriptive method involving 63 students of senior high schools in Yogyakarta. The data were collected using a critical thinking skills description test and processed using the Rasch model with the Winstep 5.0.3.4 program. The study shows that the overall validity is acceptable. The item validity did not require improvement in items 14, 3, 8, 13, 12, 1, 4, 10, 6, 2, 7, 11, 15, and 9, and required improvement …
A Study Of The Readiness Of Post-Pandemic Computer-Based Four-Tier Diagnostic Test (Cbftdt): A Review Of Economic Level, School Grades, And Device Accessibility, Edi Istiyono, Wipsar Sunu Brams Dwandaru, Made Rai Shanti Ayub, Duden Saepuzaman, Rizki Zakwandi, Anisyah Rachman, Eri Yusron, Purwoko Haryadi Santoso
A Study Of The Readiness Of Post-Pandemic Computer-Based Four-Tier Diagnostic Test (Cbftdt): A Review Of Economic Level, School Grades, And Device Accessibility, Edi Istiyono, Wipsar Sunu Brams Dwandaru, Made Rai Shanti Ayub, Duden Saepuzaman, Rizki Zakwandi, Anisyah Rachman, Eri Yusron, Purwoko Haryadi Santoso
Jurnal Penelitian dan Evaluasi Pendidikan
Student readiness for using computer-based assessment was affected by economic level, school grade, and device accessibility. This study analyzed student readiness using a computer-based assessment, the four-tier diagnostic test (CBFTDT). The data in this study were students' responses to a questionnaire consisting of 16 statements about three aspects: mental access, skill access, and usage. The questionnaire consists of 16 statements with three aspects: items, media, and effectivity. The questionnaire was proved valid by experts and its estimated reliability score was 0.99. This study proved that the Student is still not ready to use the computer-based assessment, with an average readiness …
The Online Evaluation Of The Teacher Certification Program Using The Cipp Model, Intan Kemala Sari, Lili Kasmini, Rosdiana Rosdiana, Mayor M. H. Manurung
The Online Evaluation Of The Teacher Certification Program Using The Cipp Model, Intan Kemala Sari, Lili Kasmini, Rosdiana Rosdiana, Mayor M. H. Manurung
Jurnal Penelitian dan Evaluasi Pendidikan
The Teacher Certification Program (PPG) is a government program to support competency improvement and standardization of teachers in Indonesia. Program organizers are LPTKs that have met the requirements for further preparation and fulfillment of human resources, infrastructure, and supporting policies. Evaluation of the PPG Program is essential, especially for LPTKs still new to implementation. Evaluation of the PPG Program is carried out using the CIPP Model, an evaluation model in terms of Context, Input, Process, and Product. The evaluation was carried out using a qualitative descriptive approach using observation, documentation, interviews, and survey instruments. The PPG program on the subject …
The Emotional Intelligence And Burnout Of In-Service English Teachers In Yogyakarta, Shabrina Yumna Azhra, Yasir Alsamiri, Nur Hidayanto Pancoro Setyo Putro
The Emotional Intelligence And Burnout Of In-Service English Teachers In Yogyakarta, Shabrina Yumna Azhra, Yasir Alsamiri, Nur Hidayanto Pancoro Setyo Putro
Jurnal Penelitian dan Evaluasi Pendidikan
Emotional intelligence and burnout of teachers are highly discussed in previous studies. This study set out to examine (1) the dimensions of emotional intelligence, (2) the dimensions of burnout, (3) the level of burnout, and (4) the relationship among the dimensions of in-service English teachers in Yogyakarta. The method used in this study is a quantitative correlational study through a survey. The instruments used were questionnaires adapted from the Maslach Burnout Inventory (MBI) and The Schutte Self-Report Emotional Intelligence Test (SSEIT). The participants of this study were 204 in-service English teachers in Yogyakarta. The data were analyzed using Confirmatory Factor …
2022-2023 Season Brochure, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University
2022-2023 Season Brochure, Office Of Arts + Cultural Programming, Peak Performances At Montclair State University
2022-2023 Artists Invoke the Powers of Community as They Bring Audiences Into Fiery, Mysterious, Illuminating Visions of Our World
No abstract provided.
Literature Review: Nutrition Supplementation For Muscle Fatigue In Athletes, Mardiana Mardiana, Apoina Kartini, Dwi Sutiningsih, Suroto Suroto, Muhammad Solihuddin Muhtar
Literature Review: Nutrition Supplementation For Muscle Fatigue In Athletes, Mardiana Mardiana, Apoina Kartini, Dwi Sutiningsih, Suroto Suroto, Muhammad Solihuddin Muhtar
Jurnal Keolahragaan
The use of natural or conventional-based supplementation has become a popular strategy among athletes seeking to reduce oxidative stress, improve recovery, and enhance athletic performance. This literature review searched four reputable international electronic databases, including PubMed, MedRxiv, Cochrane, and Clinical Trial.gov until December 2021, using Boolean operators with keywords and Mesh methods. The keywords used were "Supplementation", AND "Muscle Fatigue Recovery", AND "Athletes", which yielded 24 articles as study findings. The literature review found that exhaustive exercise can induce a neutrophil antioxidant response by increasing antioxidant enzymes. Nutritional supplements, specifically antioxidant supplements, Branched Chain Amino Acid (BCAA), citrulline, omega-3, and …
Development Of Physical Activity Games In Improving The Physical Motor Ability Of Children Aged 10-11 Years At The Elementary School Level, Sabaruddin Yunis Bangun, Miftahul Irfanda Harahap, R. Syaifullah D. Sihombing
Development Of Physical Activity Games In Improving The Physical Motor Ability Of Children Aged 10-11 Years At The Elementary School Level, Sabaruddin Yunis Bangun, Miftahul Irfanda Harahap, R. Syaifullah D. Sihombing
Jurnal Keolahragaan
The purpose of this study was to develop physical activity games to improve the physical motor ability of children aged 10-11 years at the elementary school level. Using research and development/R&D methods. Data collection techniques through questionnaires/questions given to experts and students, the data analysis technique used in this study is quantitative percentages. Validated by material experts, game experts, and language experts. The percentage of product design validation by experts is 80%, based on the information in the expert validation assessment table, the average value is in the range of 80%-100% valid meaning is used. The percentage of small group …
Characterization Of Pathogen-Specific Metabolites By Thin-Film Solid Phase Microextraction Analytical Tool, Keerthana S, Gouri Illanad, Chiranjit Ghosh Dr.
Characterization Of Pathogen-Specific Metabolites By Thin-Film Solid Phase Microextraction Analytical Tool, Keerthana S, Gouri Illanad, Chiranjit Ghosh Dr.
Manipal Journal of Science and Technology
Respiratory infection caused by the bacterial species is a leading cause of morbidity and mortality globally, especially in immunocompromised people. All available diagnostic techniques for pneumonia detection are relatively limited due to time-consuming stages, selectivity, and the need for invasive procedures. To overcome the current challenges, we developed an analytical technique, utilizing a carbon mesh-supported thin film solid-phase microextraction (TF-SPME) technique coupled to gas chromatography-mass spectrometry for monitoring of pathogen-specific metabolites from bacterial culture media of E. coli bacterial strain. We exposed the TF-SPME device from the headspace of the culture media of the bacteria and extracted the metabolites during …
The Flipped-Classroom Instructional Procedure Development And Its Implementation Effectiveness In Improving Procedural Knowledge Learning Outcomes At Vocational High Schools, Admaja Dwi Herlambang, Olivia Dyah Fransisca, Tri Afirianto
The Flipped-Classroom Instructional Procedure Development And Its Implementation Effectiveness In Improving Procedural Knowledge Learning Outcomes At Vocational High Schools, Admaja Dwi Herlambang, Olivia Dyah Fransisca, Tri Afirianto
Elinvo (Electronics, Informatics, and Vocational Education)
The students' number limitation in a classroom and the compression of face-to-face time challenge teachers to present practical learning scenarios to achieve learning objectives. This study aims to develop student learning procedures with the flipped classroom (FC) instructional model and determine its use in improving student learning outcomes. The research was conducted at a public information technology vocational high school in Malang, East Java Province, Indonesia. The FC instructional procedure development approach is based on the ADDIE (analysis, design, development, implementation, and evaluation) phase. The FC instructional procedure was developed in conjunction with a constructivist instructional strategy, consisting of five …
Cross-Language Tourism News Retrieval System Using Google Translate Api On Sebi Search Engine, H. Husni, Arif Muntasa, Sigit Susanto Putro, Zulfi Osman
Cross-Language Tourism News Retrieval System Using Google Translate Api On Sebi Search Engine, H. Husni, Arif Muntasa, Sigit Susanto Putro, Zulfi Osman
Elinvo (Electronics, Informatics, and Vocational Education)
Cross-Language Information Retrieval (CLIR) is responsible for retrieving information stored in a language different from the language of the query provided by the user. Some translation methods commonly used in CLIR are Dictionary, Parallel corpora, Comparable corpora, Machine translator, Ontology, and Transitive-based. The query must be translated to the target language, followed by preprocessing and calculating the similarity between the query and all documents in the corpus. The problem is the time and accuracy of query translation. Moreover, the queries are not written as complete sentences according to certain language rules. Stemming, for example, every language has its own method. …
Design And Development Of Industrial Practice Monitoring And Assessment Systems Using Tsukamoto Fuzzy Logic, Tri Yuli Pahtoni, Fatchul Arifin
Design And Development Of Industrial Practice Monitoring And Assessment Systems Using Tsukamoto Fuzzy Logic, Tri Yuli Pahtoni, Fatchul Arifin
Elinvo (Electronics, Informatics, and Vocational Education)
Vocational high schools are given flexibility for their students to carry out direct learning in the industry as part of the practical education activities of implementing student skills. The implementation of industrial practice requires a special way to find out and monitor each student's activities so that the achievements of the implementation of industrial practice can be carried out properly. The implementation of industrial work practice assessment has several assessment criteria. These criteria include attendance, neatness, attitude, skills, and knowledge. The problems found in the assessment system are still done manually so that the effectiveness is minimal. This study aims …
Periodization Method Of Physical Exercise For Obese People, Chikih Chikih, Angelica Anggunadi
Periodization Method Of Physical Exercise For Obese People, Chikih Chikih, Angelica Anggunadi
Jurnal Keolahragaan
During the COVID-19 pandemic, The Centers for Disease Control and Prevention CDC, stated that obesity prevalence increased by 52%. In Indonesia, the prevalence of obesity is 21.8%. Obesity triggers an increase in pro-inflammatory cytokines, which induces chronic inflammation both locally and systemically, which can cause health problems, such as cardiovascular disease, diabetes mellitus, metabolite syndrome, and an increased risk of infection. One of the components of obesity management is increasing physical activity. One of the domains of physical activity is exercise. Exercise with the appropriate frequency, duration, intensity, type, and periodization can influence cytokine modulation so that it can reduce …
The Psychological Skill Characteristics Of Indonesian Volleyball Players From Player Positions, Khoirul Anwar Pulungan, Satya Perdana, Arief Ibnu Haryanto, Meri Haryani, Sulasikin Sahdi Kadir
The Psychological Skill Characteristics Of Indonesian Volleyball Players From Player Positions, Khoirul Anwar Pulungan, Satya Perdana, Arief Ibnu Haryanto, Meri Haryani, Sulasikin Sahdi Kadir
Jurnal Keolahragaan
This study means to decide: (1) the characteristics of the psychological capacities of Indonesian volleyball players, (2) the nature of the psychological capacities of Indonesian volleyball players concerning what is going on. The kind of investigation utilized in this test is enlightening quantitative investigation, utilizing a procedure survey. with a causal-like survey focusing on the arrangement. The populace in this study were Indonesian volleyball players who participated in the eighteenth Asian Games in 2018 in Indonesia adding up to 28 Indonesian players comprising of 14 male players and 14 female players, with a commonplace time of male volleyball players matured …
Content Validity Of Men's U-21 Soccer Physical Test, Yuliance Adii, Tri Setyo Guntoro, Sutoro Sutoro, Dewi Nurhidayah, Japhet Ndayisenga
Content Validity Of Men's U-21 Soccer Physical Test, Yuliance Adii, Tri Setyo Guntoro, Sutoro Sutoro, Dewi Nurhidayah, Japhet Ndayisenga
Jurnal Keolahragaan
The purpose of this study was to test the content validity of the men's U21 football physical test. This research is a quantitative descriptive research with survey techniques using the delphy method. The sample in this study consisted of 7 experts, namely 2 physical condition experts, 2 football game experts, 2 soccer coaches, and 1 analyzer of the input results of each expert. A self design rubric used as an instrument in this study. The data analysis technique in this study uses the aiken-v formula. The finding showed the men's U21 football physical test has high content validity based on …
Development Of Interactive Sport Measurement Test Learning Media, Afri Tantri, Abdul Hakim Siregar, Nurman Hasibuan, Benny Aprial. M
Development Of Interactive Sport Measurement Test Learning Media, Afri Tantri, Abdul Hakim Siregar, Nurman Hasibuan, Benny Aprial. M
Jurnal Keolahragaan
Media is one of the factors that support the success of the learning process, but there are still several shortcomings in the use of media to support learning. The aim of this research is to produce learning media in the physical education measurement test subject based on interactive multimedia, with product results in the form of mobile applications, interactive VCDs, printed books, and indexed reputable international journals which will later be used both in learning activities and in independent learning to facilitate in delivering learning material for physical education measurement tests. This study used the research and development approach from …
A Perspective On The Strategy For Advancing Etvax, An Anti-Etec Diarrheal Disease Vaccine, Into A Field Efficacy Trial In Gambian Children: Rationale, Challenges, Lessons Learned, And Future Directions, M Jahangir Hossain, Ann-Mari Svennerholm, Nils Carlin, Umberto D'Alessandro, Thomas F Wierzba
A Perspective On The Strategy For Advancing Etvax, An Anti-Etec Diarrheal Disease Vaccine, Into A Field Efficacy Trial In Gambian Children: Rationale, Challenges, Lessons Learned, And Future Directions, M Jahangir Hossain, Ann-Mari Svennerholm, Nils Carlin, Umberto D'Alessandro, Thomas F Wierzba
Faculty and Staff Publications
For the first time in over 20 years, an Enterotoxigenic Escherichia coli (ETEC) vaccine candidate, ETVAX®, has advanced into a phase 2b field efficacy trial for children 6-18 months of age in a low-income country. ETVAX® is an inactivated whole cell vaccine that has gone through a series of clinical trials to provide a rationale for the design elements of the Phase 2b trial. This trial is now underway in The Gambia and will be a precursor to an upcoming pivotal phase 3 trial. To reach this point, numerous findings were brought together to define factors such as safe and …
Criteria For Assessing And Ensuring The Trustworthiness In Qualitative Research, Zia Ul Haq Kakar, Rizwana Rasheed, Aamir Rashid, Salma Akhter
Criteria For Assessing And Ensuring The Trustworthiness In Qualitative Research, Zia Ul Haq Kakar, Rizwana Rasheed, Aamir Rashid, Salma Akhter
Publications and Research
The trustworthiness of qualitative data has been debatable, yet it has strong support from its supporters. However, the importance and worth of qualitative data cannot be undermined. This paper presents a critical review of the trustworthiness of the qualitative data. The degree of trustworthiness of qualitative research can be measured by ensuring the credibility, transferability, dependability, and conformability of research design, process, and action. The guarantee of trustworthiness in qualitative research is more complex than in quantitative research due to its subjective nature. Many researchers and experts denied the generalizability of qualitative research. However, few researchers, like Guba (1985), developed …
Be: Fall/Winter 2023–2024 Issue, Be: A Journal Of Black Experimental And Interdisciplinary Work
Be: Fall/Winter 2023–2024 Issue, Be: A Journal Of Black Experimental And Interdisciplinary Work
Publications and Research
Our fall/winter issue explores, with a cool and objective eye, memory and history; it may give you some necessary de ja vu, as we think of family, books, and films we want to preserve. This is our interview/review issue, and we’ve spoken to people or reviewed work that seems necessary for building better futures. Our interview with Amos White argues for the preservation of life-giving and life-affirming trees. We’ve also included reviews of heart-opening books — Tara Christina’s “More than a Drop” and Caron Knauer’s “American Slavery on Film” — that reinforce the significance of familial and collective memory. And …
Systematic Assessment Of The Literature On Healthcare Supply Chain Sustainability Practices And Methodological Trends, Yusta Simwita, Gladness Salema
Systematic Assessment Of The Literature On Healthcare Supply Chain Sustainability Practices And Methodological Trends, Yusta Simwita, Gladness Salema
Business Management Review
The ever-growing uncertainties and complexities in health supply chains attract the need to implement sustainability practices in their operations. This study applies a systematic literature review to conduct a comprehensive review from 2008-2023 to identify commonly used sustainability practices and methodological trends. After a comprehensive analysis, 31 articles were included in the final analysis. We observed that several sustainability practices in all three sustainability pillars had been implemented in the healthcare supply chain. This includes employee welfare and well-being, understanding and managing demand, and green practices. This review found that sustainable practices have great benefits, such as empowering employees and …
Exploring The Role Of Knowledge In The Pharma Workplace Of The Future: An Interactive Workshop Exploring Culture, Km And Opex, Stephanie Friedrichsen, Nuala Calnan (Editor), Martin J. Lipa
Exploring The Role Of Knowledge In The Pharma Workplace Of The Future: An Interactive Workshop Exploring Culture, Km And Opex, Stephanie Friedrichsen, Nuala Calnan (Editor), Martin J. Lipa
Level 3
This article presents a summary of an interactive workshop facilitated by Nuala Calnan and Stephanie Friedrichsen during the conference: ‘ICH Q9(R1): The Next Frontier’ held in Technological University Dublin, Ireland, on 1 June 2023. The summary was prepared by the workshop facilitators in conjunction with Martin Lipa who was a participant at the workshop. The article is written to give a high-level overview of the discussions which took place during the workshop and is not intended to be a complete representation of all the activities, insights and findings.
Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office
Operating Fund Budget/ Expenditure Detail Report 2023-24, Csusb Budget Office
University Budget Office records
No abstract provided.
Images Of Maps And Connotative Tendencies In Early Republican America, Kerr Houston
Images Of Maps And Connotative Tendencies In Early Republican America, Kerr Houston
Art Inquiries
No abstract provided.
Benzodioxane-Benzamides As Promising Inhibitors Of Escherichia Coli Ftsz, Lorenzo Suigo, Begoña Monterroso, Marta Sobrinos-Sanguino, Carlos Alfonso, Valentina Straniero, Germán Rivas, Silvia Zorrilla, Ermanno Valoti, William Margolin
Benzodioxane-Benzamides As Promising Inhibitors Of Escherichia Coli Ftsz, Lorenzo Suigo, Begoña Monterroso, Marta Sobrinos-Sanguino, Carlos Alfonso, Valentina Straniero, Germán Rivas, Silvia Zorrilla, Ermanno Valoti, William Margolin
Faculty, Staff and Student Publications
The conserved process of cell division in bacteria has been a long-standing target for antimicrobials, although there are few examples of potent broad-spectrum compounds that inhibit this process. Most currently available compounds acting on division are directed towards the FtsZ protein, a self-assembling GTPase that is a central element of the division machinery in most bacteria. Benzodioxane-benzamides are promising candidates, but poorly explored in Gram-negatives. We have tested a number of these compounds on E. coli FtsZ and found that many of them significantly stabilized the polymers against disassembly and reduced the GTPase activity. Reconstitution in crowded cell-like conditions showed …
Assessing The Burden Of An Excessive Sms Size On The Effective Implementation Of The Ism Code, Li An Xian
Assessing The Burden Of An Excessive Sms Size On The Effective Implementation Of The Ism Code, Li An Xian
World Maritime University Dissertations
No abstract provided.