Digital Commons Network^™

Olanzapine Pharmacokinetics: A Clinical Review Of Current Insights And Remaining Questions, Priyanka Kolli, Grace Kelley, Marianela Rosales, Justin Faden, Ryan Serdenes

Department of Psychiatry and Human Behavior Faculty Papers

Olanzapine is one of the most widely used antipsychotics since its initial approval by the US Food and Drug Administration in 1996 and has undergone extensive pharmacokinetic study. Despite being utilized in clinical psychiatry for decades, there remain questions regarding the variety of available formulations, the utility of therapeutic drug monitoring, altered kinetic properties in special populations/medical illnesses, the use of high-dose olanzapine, and drug interactions, among many others. We performed a narrative literature review of olanzapine pharmacokinetics in June 2023 using the US National Library of Medicine's PubMed.gov resource (https://www.ncbi.nlm.nih.gov/pubmed) and Google Scholar. Herein, we review clinically relevant aspects …

Long Oligodeoxynucleotides: Chemical Synthesis, Isolation Via Catching-By-Polymerization, Verification Via Sequencing, And Gene Expression Demonstration, Yipeng Yin, Reed Arneson, Alexander Apostle, Adikari M.D.N. Eriyagama, Komal Chillar, Emily Burke, Martina Jahfetson, Yinan Yuan, Shiyue Fang

Michigan Tech Publications

Long oligodeoxynucleotides (ODNs) are segments of DNAs having over one hundred nucleotides (nt). They are typically assembled using enzymatic methods such as PCR and ligation from shorter 20 to 60 nt ODNs produced by automated de novo chemical synthesis. While these methods have made many projects in areas such as synthetic biology and protein engineering possible, they have various drawbacks. For example, they cannot produce genes and genomes with long repeats and have difficulty to produce sequences containing stable secondary structures. Here, we report a direct de novo chemical synthesis of 400 nt ODNs, and their isolation from the complex …

The Inevitability Of Sin, Kevin Timpe

University Faculty Publications and Creative Works

Part of the traditional Christian doctrine of sin is the claim that, due to the effects of original sin, acts of sin are inevitable. Of course, our reflection on sinful actions is shaped by how we think about human freedom and divine providence more broadly. Some have argued that libertarians have a difficult time accounting for the inevitability of sin. This paper uses David Lewis’s work on counterfactuals and possible worlds to give an account of how the inevitability of sin can be understood. It then shows how both theological determinism and Molinism can give an account of sin’s inevitability …

Counseling And Artificial Intelligence: Forging A Path Forward (Commentary), Russell Fulmer

Journal of Technology in Counselor Education and Supervision

The thesis of this editorial is twofold. First, counselors should work with Artificial Intelligence (AI), and AI should work with counseling. Second, counselors should increase their involvement with, essentially, all things AI. Counseling should forge a path forward with artificial intelligence. This editorial is a bit premature for pragmatists. Where is artificial intelligence (AI) in mental health? The answer is seemingly a paradox, everywhere yet nowhere. Everywhere, through AI subfields like machine learning, natural language processing applications, chatbots, and the myriad ways that large language models find correlations in data hidden from the human eye. Also, AI is nowhere to …

Artificial Intelligence, Virtual Reality, And Augmented Reality In Counseling: Distinctions, Evidence, And Research Considerations, Sidney Shaw, Sophie Oswin, Yue Xi, Fallon Calandriello, Russell Fulmer

Journal of Technology in Counselor Education and Supervision

Technology is experiencing a growing presence in counseling and mental health, attracting attention from counselors, researchers, and the general public. This growth has the potential to change counseling practice, counselor education, and how users access mental health services. In this article we provide definitions of and distinctions between three common technologies that are used in the counseling field—Artificial Intelligence, Virtual Reality, and Augmented Reality. We also provide examples of the use of each technology, ethical implications, research support, and recommendations for future research.

Risk Sensitivity Analysis Of Ais Cyber Security Through Maritime Cyber Regulatory Frameworks, Omer Soner, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam

School of Engineering, Computing and Mathematics

Given the increasing frequency and sophistication of methods and strategies employed in cyberattacks, cyber resilience has become a basic notion of cyber risk management. To be cyber-resilient against cyber risks, shipping companies must be proactive in establishing and implementing actions, constructing effective strategies, and adopting mitigation methods to strengthen their assets. However, shipping companies have only lately tended to fully recognize the necessity for a cybersecurity perspective to enable effective cyber risk management and mitigation of increasing cyberattacks. Aside from deficiencies in system design, integration, or maintenance, human factors are the prime weakness that potentially jeopardizes the ship's cybersecurity by …

Missing The Point- The Disappointed Hope Of Self- Publishing Authors, Simone Schroff

School of Law, Humanities and Social Sciences

Trade book publishing is characterised by authors with weaker bargaining power than the commercial intermediaries, including publishers and distributors. One key solution representing the empowerment of authors is self-publishing works, thereby cutting out the gatekeeper. However, self-publication has failed to improve the position of authors: their incomes continue to fall across the sector. Using social network analysis as well as industry practices, this article examines UK trade book publishing dynamics. It argues that the reason for the self-publication route’s ‘underperformance’ is structural, explained by a realistic view of the publishing sector and the relationships it entails. The self- publishing author …

Consistent Across Situations? A Person Specific Approach To Examining A Long-Standing Paradox., Muchen Xi

Arts & Sciences Graduate Student Theses and Dissertations

Bem and Allen (1974) address the person situation debate by proposing that there are some people behave more consistently, which can be better “explained” try personality traits, than others who are more influenced by situations. However, with failures to directly replicate Bem and Allen’s study, the existence of individual difference in cross situation consistency of behaviors remaining unclear. The current study addressed open questions that arose from the personality consistency debate by employing Mixed Effect Location Scale Model (MELSM) in an intensive longitudinal study. We found 1) there are individual difference in the overall behavioral consistency across situations; 2) there …

Characterizing The Relationship Between Accented Speech Intelligibility And Listening Effort, Mel Mallard

Arts & Sciences Graduate Student Theses and Dissertations

Unfamiliar accents can make speech communication difficult, both by reducing speech intelligibility and by increasing the effort listeners must put forth to understand speech. However, these two constructs, while related, are independent: for example, two 100% intelligible utterances may require different amounts of effort to accurately process. To better characterize the relationship between intelligibility and effort, this study presents speakers of four intelligibility levels (one natively-accented English speaker, and three Mandarin-accented English speakers) within a dual-task paradigm (featuring a vibrotactile secondary task) to measure listening effort. We found a negative nonlinear relationship between intelligibility and effort, with the steepest slope …

Exploring Attitudes Toward “Sugar Relationships” Across 87 Countries: A Global Perspective On Exchanges Of Resources For Sex And Companionship, Norbert Meskó, Marta Kowal, András Láng, Ferenc Kocsor, Szabolcs A. Bandi, Adam Putz, Piotr Sorokowski, David A. Frederick, Felipe E. García, Leonardo A. Aguilar, Anna Studzinska, Chee Seng Tan, Biljana Gjoneska, Taciano L. Milfont, Bulut M Topcu, Dmitry Grigoryev, Toivo Aavik, Mahmoud Boussena, Alan D.A. Mattiassi, Reza Afhami, Rizwana Amin, Roberto Baiocco, Hamdaoui Brahim, Ali R. Can, Joao Carneiro, Hakan Çetinkaya, Dimitri Chubinidze, Eliane Deschrijver, Yahya Don, Dmitrii Dubrov, Izzet Duyar, Marija Jovic, Julia A. Kamburidis, Farah Khan, Hareesol Khun-Inkeeree, Maida Koso-Drljevic, David Lacko, Karlijn Massar, Mara Morelli, Jean C. Natividade, Ellen K. Nyhus, Ju Hee Park, Farid Pazhoohi, Ekaterine Pirtskhalava, Koen Ponnet, Pavol Prokop, Dušana Šakan, Singha Tulyakul, Austin H. Wang, Sibele D. Aquino, Derya D. Atamtürk, Nana Burduli, Antonio Chirumbolo, Seda Dural, Edgardo Etchezahar, Moharrampour N Ghahraman, Balazs Aczel, Luca Kozma, Samuel Lins, Efisio Manunta, Tiago Marot, Moises Mebarak, Kirill G. Miroshnik, Katarina Misetic, Marietta Papadatou-Pastou, Bence Bakos, Fatima Zahra Sahli, Sangeeta Singh, Çağlar Solak, Tatiana Volkodav, Anna Wlodarczyk, Grace Akello, Marios Argyrides, Ogeday Çoker, Katarzyna Galasinska, Yepes T Gómez, Aleksander Kobylarek, Miguel Landa-Blanco, Marlon Mayorga, Barış Özener, Ma Criselda T. Pacquing, Marc Eric S. Reyes, Ayşegül Şahin, William Tamayo-Agudelo, Gulmira Topanova, N/A Toplu-Demir

School of Psychology

The current study investigates attitudes toward one form of sex for resources: the so-called sugar relationships, which often involve exchanges of resources for sex and/or companionship. The present study examined associations among attitudes toward sugar relationships and relevant variables (e.g., sex, sociosexuality, gender inequality, parasitic exposure) in 69,924 participants across 87 countries. Two self-report measures of Acceptance of Sugar Relationships (ASR) developed for younger companion providers (ASR-YWMS) and older resource providers (ASR-OMWS) were translated into 37 languages. We tested cross-sex and cross-linguistic construct equivalence, cross-cultural invariance in sex differences, and the importance of the hypothetical predictors of ASR. Both measures …

Efficacy And Safety Of Teprotumumab In Patients With Thyroid Eye Disease Of Long Duration And Low Disease Activity, Raymond S Douglas, Steven Couch, Sara T Wester, Brian T Fowler, Catherine Y Liu, Prem S Subramanian, Rosa Tang, Quang T Nguyen, Robi N Maamari, Shoaib Ugradar, Kate Hsu, Michael Karon, Marius N Stan

2020-Current year OA Pubs

CONTEXT: Early inflammatory thyroid eye disease (TED) can lead to symptomatic chronic disease, including disabling proptosis. Teprotumumab, an insulin-like growth factor-1 receptor (IGF-1R) inhibitor, previously demonstrated efficacy in acute, high-inflammation TED trials.

OBJECTIVE: We present data from the first placebo-controlled trial with teprotumumab in chronic/low disease activity TED.

METHODS: This randomized double-masked, placebo-controlled trial, conducted at 11 US centers, enrolled adult participants with TED duration of 2 to 10 years, Clinical Activity Score (CAS) ≤ 1 or no additional inflammation or progression in proptosis/diplopia for ≥1 year, proptosis ≥3 mm from before TED and/or from normal, euthyroid/mildly hypo/hyperthyroid, no prior …

Releasing The Captives: How The National Labor Relations Board Can Correct The Anomalous Captive Audience Meeting Doctrine, Adam J. Drapcho

University of Cincinnati Law Review

No abstract provided.

Value Judgments In Judicial Reasoning, And The Instability Of The Fact-Law Distinction, Stephen A. Simon

University of Cincinnati Law Review

No abstract provided.

Must Courts Recalibrate Tort Law Governing Firearms In Light Of The Second Amendment?, Lars Noah

University of Cincinnati Law Review

The rules governing the scope of liability in cases where firearms cause injuries—some well-established, others fairly novel—help to define the responsibilities of users, owners, and sellers of these popular but dangerous products. As the U.S. Supreme Court has recently expanded an individual’s right to keep and bear arms, some have wondered whether the Second Amendment might operate to limit the reach of these various tort doctrines. Sixty years ago, the Court started to constitutionalize various aspects of state common law, most famously using the First Amendment to limit defamation claims but in other respects as well. A comparable approach to …

Voluntary Dismissals, Jurisdiction & Waiving Appellate Review, Bryan Lammon

University of Cincinnati Law Review

Litigants have long tried to manufacture a final, appealable decision by voluntarily dismissing their claims after an adverse interlocutory decision. Recently—and especially since the Supreme Court’s decision in Microsoft Corp. v. Baker—courts have thought that these dismissals created a jurisdictional problem. Either the voluntary dismissal did not produce a final decision, or the dismissal extinguished Article III jurisdiction. But the problem with these appeals is not jurisdictional. It’s waiver. A voluntary dismissal after an adverse interlocutory decision waives the right to appellate review. This Article shows the flaws in the jurisdictional rejection of this kind of manufactured finality and …

Pooling And Exchanging Competitively Sensitive Information Among Rivals: Absolutely Illegal Not Just Unreasonable, Peter C. Carstensen, Annkathrin Marschall

University of Cincinnati Law Review

An agreement to exchange competitive sensitive information among rivalrous competitors usually results from an intent to inhibit or restrict the discretion of those firms to engage in competition. Basic economic logic about competition leads to that conclusion. Hence, such an exchange is in itself a naked agreement in restraint of trade without legal justification. Currently, case law requires a more convoluted and irrelevant inquiry into market definition and market power before a court can condemn such agreements. This is the result of ambiguous Supreme Court decisions as well as the recognition that in a few instances there are plausible arguments …

Perceived Importance Of Ultrasound Vascular Access Education Among Residents, Raquel Lamarche, Jared Marx, Jihyun Ma, Stephanie Claudy

Graduate Medical Education Research Journal

Background: Peripheral intravenous catheter (PIVC) failure and difficult intravenous access (DIVA) are pervasive issues causing patient suffering and increased costs. Despite their prevalence, there is a gap in internal medicine and pediatric resident training to manage these challenges effectively.

Objective: This study aimed to assess the value of ultrasound-guided-PIVC (USGPIVC) education for internal medicine and pediatric residents and the impact of a 1-hour multidisciplinary workshop on their knowledge and confidence.

Methods: A cross-sectional survey study was conducted at an academic medical center in 2022 to assess residents’ perceptions of USG-PIVC education. This was followed by a USG-PIVC simulation-based workshop with …

"Being On God’S Side": Biblical Leaders On Wokeness, Social Justice, Cancel Culture, White Privilege, And Other Controversial Terms, Hershey H. Friedman, Svetlana Vlady

The Journal of Values-Based Leadership

Terms such as “woke,” “social justice,” “cancel culture,” “identity politics,” “politically correct,” “critical race theory,” and “DEI” have been increasingly misused and politicized by both the left and the right in recent years. This paper will examine the Hebrew Bible and explore what it says about social justice, compassion for the indigent, inclusion, and many other terms causing such an uproar. The authors assert that the ancient prophets, the true social justice warriors, would be horrified by the actions of both the left and right.

What American Business Leaders Can Learn About Leadership Development From Toyota?, Mostafa Sayyadi, Michael J. Provitera

The Journal of Values-Based Leadership

An applied solution to the leadership development dilemma is a common interest point for all companies in the US. Toyota's way can teach American business leaders how to develop leadership more effectively. This article presents a road map that can be used to improve the effectiveness of leadership development and build a more stable future for American companies.

Top Directed, Bottom Driven: Subaru Tackles Waste (Interview With Denise Coogan, Subaru), Elizabeth Gingerich

The Journal of Values-Based Leadership

No abstract provided.

Authentic Leadership Measures: An Authentic Measure For Authentic Leadership?, Mitch Butterworth, Jessica Black, Robert Terry

The Journal of Values-Based Leadership

This study broadly addresses some of the criticisms associated with authentic leadership theory related to measurement and antecedents. Measurement: One purpose of this study was to verify the dimensionality of authentic leadership by testing the construct validity of three measures for authentic leadership: the Authentic Leadership Questionnaire (ALQ), the Authentic Leadership Inventory (ALI), and the Authentic Leadership Integrated Questionnaire (AL-IQ), proposed by Levesque-Cote et al. (2018) as an improvement on the previous two scales. This study was designed to replicate and extend Levesque-Cote et al. (2018) study with an English-speaking sample to further test the structural validity of the AL-IQ. …

Winter/Spring 2024

The Journal of Values-Based Leadership

No abstract provided.

Critically Analyzing The Meanings Of “Critical” Media Literacy, W. James Potter

Journal of Media Literacy Education

This study provides a critical analysis into how authors of publications about critical media literacy express what they mean by the term. The use of multiple strategies to examine the degree to which these authors exhibit a sharing of meaning led to the conclusion that there are far more differences than commonalities across definitions of critical media literacy. The implications of this conclusion raise important questions about the value of a literature where authors seem to express so many different meanings for the concept that they use to label their common concern.

Industrial Education 4.0: The Role Of Human, Technology, And Data Literacy, Suparno Suparno, Dedi Purwana, Agus Wibowo, Bagus Shandy Narmaditya

Journal of Media Literacy Education

This study aims to confirm the effect of industrial education 4.0 on data, technology, and human literacy among postgraduate students in Indonesia. The research adopted covariance-based structural equation modeling by employing AMOS 25 to examine the relationship between variables. The model estimation was performed using confirmatory factor analysis as a standard model for measuring industrial education 4.0 and involved structural model analysis to confirm the hypotheses. The population in this research paper was 2.958 postgraduate students in 32 study programs, while the sample was 312 respondents, which was determined using the proportional random sampling technique. This study tested the three …

Teaching Critical Race Media Literacy Through Black Historical Narratives, Christine Mcwhorter, Tiffany Mitchell Patterson

Journal of Media Literacy Education

On the 400th anniversary of American enslavement the New York Times (NYT) 1619 project launched an interactive digital experience including a popular podcast centering the contributions and narratives of Black Americans. This study sought to understand how HBCU students responded to learning Black music history through what we term a “pop culture podcast.” This study explored the ways in which this particular podcast could support the development of Critical Race Media Literacy (CRML) based on a media discourse at a Historically Black College/University (HBCU). This study employed survey research and focus group discussions with HBCU students in two courses. The …

The Complexities Of Green Infrastructure, Troy Weber

Purdue Journal of Service-Learning and International Engagement

The Wabash River is the most extensive river system in Indiana. The river drains two-thirds of Indiana’s 92 counties, which can have issues associated with stormwater runoff (Weist, 1981). As precipitation runs off impervious surfaces, it can carry high concentrations of pollutants, such as excess nitrogen and phosphorus, pet waste, and automobile fuel. Prior to impervious runoff entering the river, preexisting contaminants include industrial waste (acid mine drainage and oil field brines), municipal waste, and sediment (Weist, 1981). Thus, stormwater runoff can negatively impact the Wabash River watershed. On top of this pollution, Lafayette and West Lafayette have combined sewer …

The Impact Of Using Instagram On The Purchase Decision Of Pink Marketing Customers: (An Applied Study Of The Beauty Centers In Amman), Elaph Nayef Alhamad, Abdel-Aziz Ahmad Sharabati Prof. Dr.

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

The article aims to investigate the effect of using Instagram on the purchase decisions of Pink Marketing Customers. This study uses a quantitative descriptive cause-effect and cross-sectional approach. To implement this study, data were collected from 41 beauty centers in Amman using a questionnaire. After confirming the suitability of the data, it was coded against SPSS. Then normal distribution, validity, and reliability of the tool were assured, followed by descriptive analysis and correlation between the variables. Finally, the effect was tested by multiple regressions. The study showed many results, most notably the presence of an effect of using Instagram with …

أثر وحدة تعليمية مطورة في مادة العلوم وفق منحى Steam في تنمية الدافعية العقلية والتحصيل لطلبة الصف الثالث األساسي, Nariman Jehad Almasri, Jawaher Yousif Abu Loheh, Mohammed Mahmood Hileh Prof.

Journal of the Association of Arab Universities for Research in Higher Education مجلة اتحاد الجامعات العربية للبحوث في التعليم العالي

هدف المقال إلى تطوير وحدة دراسية من مادة العلوم الصف الثالث األساسي وفق منحى STEAM وذلك إلستقصاء أثر الوحدة المطورة في مادة العلوم وفق منحى STEAM في تنمية الدافعية العقلية والتحصيل لدى طلبة الصف الثالث االساسي في لواء الجامعة، ولتحقيق أهداف الدراسة تم اعتماد المنهج شبه التجريبي، تكونت عّينة الدراسة من )60(

طالبا وطالبة تم ً

توزيعها عشوائيا الى مجموعتين تجريبية وضابطة اشتملت كل ً منهما على )30( طالباً وطالبة من طلبة الصف الثالث األساسي في مدرسة الكمالية االساسية التابعة لمديرية التربية والتعليم "لواء الجامعة". تكونت أداة الدراسة من مقياس للدافعية العقلية يشتمل على )35( فقرة شملت مجاالت الدافعية العقلية …

Lebanon Eastover Property Records, Lebanon United Methodist Church, Eastover

Methodist Local Church Records

No abstract provided.

Lebanon Eastover Church Council Minutes, Lebanon United Methodist Church, Eastover

Methodist Local Church Records

No abstract provided.