Digital Commons Network^™

Protecting A Real Or Imagined Past: Justice Samuel Alito And The First Amendment, Derigan Silver, Dan V. Kozlowski

All Faculty Scholarship

This article examines the First Amendment jurisprudence of Justice Samuel Alito. In this article, we argue that the principles behind his decision-making are not always necessarily traditional methods of constitutional analysis, and litigants should understand the frames and lenses Alito uses to make decisions when making their arguments to him. The article concludes with a discussion of Alito’s overall approach to the law and some thoughts on how he is attempting to reshape the First Amendment. We write that, above all, it is clear he is seeking to protect a real or imagined past that, in his mind, is under …

"Love Divine: A Systematic Account Of God’S Love For Humanity" [Review] / Wessling, Jordan."

Andrews University Seminary Studies (AUSS)

This is a book review.

A Phenomenological Study Of K-12 Educators' Perceptions Of Social Emotional Learning For K-12 Students In Southern Illinois., Ruth Cahill

Murray State Theses and Dissertations

The objective of this Phenomenological study was to analyze K-12 educators’ lived experiences, opinions, and perceptions regarding the impact of social emotional learning implementation in a small school district in Southern Illinois. Results revealed four consistent codes: Educator competence – the participants revealed that they did not feel competent enough to correctly implement SEL due to lack of consistent, on-going SEL training; Efficacy – due to school closures, virtual instruction, and inconsistencies caused by the corona-virus pandemic, SEL implementation in the school district was discontinued until further notice; Perception – the participants expressed that when implemented correctly, they believe that …

Effects Of Plasma Sample Handling On Equine Insulin Assays, Lauren Willett

Murray State Theses and Dissertations

Often, the assumption is made that the results of the various laboratory tests being run are accurate, and that abnormal results reflect a physiologic change occurring in the patient. Unfortunately, this assumption is not always true. Inaccurate results, for various reasons, are an inherent part of diagnostic testing. Having inaccurate results is often worse than having no results at all, because they can lead to an incorrect diagnosis or result in unnecessary testing, wasting the client’s financial resources, or potentially expose the patient to unnecessary risks in pursuit of the cause of an abnormality that does not exist. With appropriate …

Comparison Of Corticosterone Concentrations Between Serum And Fecal Samples As A Measure Of Stress In Male Broilers., Kayla Weinacht

Murray State Theses and Dissertations

Stress has long been a topic of interest in the poultry industry due to its potential negative effects on chicken health and production of both eggs and meat. With increased global growth in egg and broiler production, more attention has been paid to the stressors that affect chickens in modern poultry operations, particularly environmental temperature and stocking density. Improving quantitative measurement of stress is always needed in poultry welfare research. In most studies, blood serum is measured for corticosterone, one of the biomarker hormones associated with stress in chickens. Methods of collecting blood serum are by their nature disruptive to …

The Effect Of An Afterschool Makerspace Program On Academic Achievement Of Sixth-Eighth Grade Students, Teresa Lampe

Murray State Theses and Dissertations

This quasi-experimental study investigated the effect of participation in an afterschool makerspace program on middle school students' academic achievement, grades, and school attendance. An experimental group of 237 sixth-eighth grade students participated in an afterschool makerspace program during the 2019-2020, 2020-2021, and 2021-2022 school years. A control group was selected using stratified random sampling of students from the same schools, grades, and special education designation who did not participate. The data included science and math NWEA scores, science and math grades, program attendance, school attendance, and gender. The data were analyzed using an independent t test with a 95% confidence …

An Exploratory Study Of Ergonomics In College Students, Wesley Ryan Tinker

Murray State Theses and Dissertations

Abstract

This study aimed to examine the relationship between poor ergonomic conditions and student physiological discrepancies. This examination provided great insight into students’ daily experiences and concerns for their futures. The methodology used for this study was quantitative as two source data sets were collected and analyzed. The tool REBA was used to measure the specific body angles while students sat working. A survey yielded great results, giving the students an opportunity to subjectively choose options.

This exploratory study allowed the researcher to use quantitative data to answer this study’s research questions. The research questions asked from this study were …

Self-Diagnosis & Pathologizing Normality During The Information Age, Chelsey Eaton

Murray State Theses and Dissertations

Self-diagnosis has become a concern for medical and mental health diagnoses. More people are engaging in self-diagnosis based on information that was obtained from the internet, including websites, social media platforms, and online forums. There are several reasons one may choose to self-diagnose. Some common reasons outlined in research are the desire to fit in with others who share similar characteristics and having a label to explain one’s experiences. Past research has shown that people frequently search for mental health information online, but they may not understand or may misinterpret the information that is found. This study aimed to address …

The Relationship Between Student Performance In English Language Proficiency And Academic Content Assessments, Rosa Wolford

Murray State Theses and Dissertations

As the number of English Learner (EL) students continue to increase in the United States and accountability increases for their growth and achievement in both English language proficiency and state content assessments, it is essential that educational agencies examine the predictive relationships between the assessments to ensure appropriate supports for English Learners are provided. Subsequently, the purpose of this study was to determine if there is a predictive relationship between the WIDA ACCESS Literacy and Overall Composite scores and the TNReady English Language Arts and Mathematics assessments scores of sampled EL students in fourth through twelfth grades among the subgroups …

Women Pursuing An Agricultural Systems Technology Degree, Tanya Milam

Murray State Theses and Dissertations

Abstract

This phenomenological research study examined the factors influencing women to pursue an Agricultural Systems Technology (AST) degree and their self-efficacy in that field of study. Two research questions guided this study and data was analyzed from interviewing women enrolled in an Agricultural Systems Technology (AST) program at a mid-western university. The resulting four categories of Agricultural Experiences, Aptitude, Support, and Motivation were broken down into themes. The results were also applied to the theoretical framework of self-efficacy associated with career choice theories. Limitations of scope and generalizability indicate that further investigation of this topic is highly recommended.

Keywords: …

Peer Response And Assistance To Suicidal Thoughts And Behavior In University Students, Lindsey Katherine Hunter

Murray State Theses and Dissertations

Suicide represents the second leading cause of death in adolescents and young adults (CDC, 2022). Many interventions employed on college campus focus on peer support which has been previously related to reductions in suicidal thoughts and behaviors (STB, e.g., suicidal ideation, suicidal plan, suicide attempts), but students may not have the experience needed to increase confidence or knowledge in providing support (Hirsch & Barton, 2011; King et al., 2008). Further, previous research has identified factors including exposure to STB, direct engagement in STB, knowledge, and stigma regarding suicide which have had mixed impact on confidence and helping intentions in supporting …

An Analysis Of P-20 Education At San Ildefonso Pueblo In Northern New Mexico, United States, Martin Edward Strones

Murray State Theses and Dissertations

This research study provides an inquiry by conducting a qualitative analysis of the conditions and issues associated with students at the San Ildefonso Pueblo in Northern New Mexico. For decades the education of San Ildefonso and Native Americans who live in the State of New Mexico has been ignored. This has been just the way it was, that is, until Wilhelmina Yazzie, a Native American, saw her son struggling in an unsatisfactory school system and decided to take action. This case was originally filed in McKinley Country, New Mexico, in 2014, home to largely Native American students for the Navajo …

Pov - You Have Adhd: Examining Predictors Of Self-Diagnosis Of Adhd On Tiktok, Olivia Bowden

Murray State Theses and Dissertations

Online self-diagnosis refers to an individual using the internet and applying their own knowledge to diagnose themself with a disorder without the input of a professional (Farnood, 2021). Social media platforms, such as TikTok, have created an environment full of mental health related information that may not always be correct. Individuals on this app may believe the videos they watch and which may ultimately lead to self-diagnosis. There has been a trend of popular mental health disorders on appearing TikTok, such as ADHD. The present study sought to examine potential predictors of self-diagnosis of ADHD through TikTok. This study examined …

Relationship Between Social-Emotional Learning And Post-Secondary Job Satisfaction, Sean Demaree

Murray State Theses and Dissertations

This dissertation aims to respond to two challenges. The first is a gap in literature and research around the impact of social-emotional learning (SEL) beyond graduation from high school. While many studies have been conducted on the impact of SEL in schools, few examine how the use of SEL schools supports students in their post-secondary success. The second challenge centers on the current job market crisis in the Kansas City Metropolitan Area, specifically with job satisfaction and retention of employees. This study invited employees at five large companies in the Kansas City Metropolitan Area to respond to a two-part survey. …

Can Middle School Students Learn Agriculture From Behind A Computer Screen? A Comparative Analysis Case Study Of Online Vs Traditional Middle School Agricultural Courses In Rural Georgia, Roseanna Volz

Murray State Theses and Dissertations

Online education is growing in popularity. Traditional schooling is losing the monopoly of being the only teaching method available to students (Nguyen, 2015). Online learning has evolved throughout the development of online education (Sun & Chen, 2016). Many schools focus on the core content classes for online education like math, science, social studies, and English language arts, but school systems are starting to grow their curricula (Bedard & Knox-Pipes, 2006). This quantitative study was a comparative analysis of an online and traditionally taught agricultural education course. Middle school students completed 12 assignments throughout six weeks. The grades from the assignments …

Histopathological Evaluation Of Onchocerca Volvulus Nodules By Microscopy And By Digital Image Analysis For The Study Of Macrofilaricidal Drug Efficacy, Kerstin Fischer, Bettina Dubben, Linda B Debrah, Janina M Kuehlwein, Arcangelo Ricchiuto, Alexander Y Debrah, Achim Hoerauf, Gary J Weil, Peter U Fischer, Ute Klarmann-Schulz

2020-Current year OA Pubs

BACKGROUND: Novel drugs or drug combinations that kill or permanently sterilize adult

MATERIAL AND METHODS: Two expert microscopists independently assessed 605 nodules by direct microscopy. At least two sections with two different stains hematoxylin & eosin (H&E, APR immunostain) of paraffin-embedded, ethanol-fixed whole-nodule cross-sections were analyzed. After variables were identified prone to observer discrepancies, we performed a second study to compare consolidated results for 100 nodules obtained by the two readers by microscopy and by analysis of scanned, high resolution digital images (20x magnification). The last data set analyzed was a quality panel of 100 nodules that has been previously …

Health Disparities In Aging: Improving Dementia Care For Black Women, Caleigh A Findley, Makayla F Cox, Adam B Lipson, Ratasha Bradley, Kevin N Hascup, Carla Yuede, Erin R Hascup

2020-Current year OA Pubs

In the United States, 80% of surveyed Black patients report experiencing barriers to healthcare for Alzheimer's disease and related dementias (ADRD), delaying the time-sensitive treatment of a progressive neurodegenerative disease. According to the National Institute on Aging, Black study participants are 35% less likely to be given a diagnosis of ADRD than white participants, despite being twice as likely to suffer from ADRD than their white counterparts. Prior analysis of prevalence for sex, race, and ethnicity by the Centers for Disease Control indicated the highest incidence of ADRD in Black women. Older (≥65 years) Black women are at a disproportionately …

Conserved Gene Signatures Shared Among Mapt Mutations Reveal Defects In Calcium Signaling, Miguel A Minaya, Sidhartha Mahali, Abhirami K Iyer, Abdallah M Eteleeb, Rita Martinez, Guangming Huang, John Budde, Sally Temple, Alissa L Nana, William W Seeley, Salvatore Spina, Lea T Grinberg, Oscar Harari, Celeste M Karch

2020-Current year OA Pubs

No abstract provided.

The Vacc-Seqqc Project: Benchmarking Rna-Seq For Clinical Vaccine Studies, Johannes B Goll, Richard D Head, Et Al.

2020-Current year OA Pubs

[This corrects the article DOI: 10.3389/fimmu.2022.1093242.].

Objective Response To Immune Checkpoint Inhibitor Therapy In Nras-Mutant Melanoma: A Systematic Review And Meta-Analysis, Zachary J Jaeger, Neel S Raval, Natalia K A Maverakis, David Y Chen, George Ansstas, Angela Hardi, Lynn A Cornelius

2020-Current year OA Pubs

INTRODUCTION:

METHODS: We performed a comprehensive literature search across several large databases. Inclusion criteria were trials, cohorts, and large case series that analyzed the primary outcome of objective response rate by

RESULTS: Data on 1770 patients from ten articles were pooled for meta-analysis, and the objective response rate to ICIs was calculated to compare

DISCUSSION: In this meta-analysis evaluating the impact of

Predicting Continuous Amyloid Pet Values With Csf And Plasma Aβ42/Aβ40, Julie K Wisch, Brian A Gordon, Anna H Boerwinkle, Patrick H Luckett, James G Bollinger, Vitaliy Ovod, Yan Li, Rachel L Henson, Tim West, Mathew R Meyer, Kristopher M Kirmess, Tammie L S Benzinger, Anne M Fagan, John C Morris, Randall J Bateman, Beau M Ances, Suzanne E Schindler

2020-Current year OA Pubs

INTRODUCTION: Continuous measures of amyloid burden as measured by positron emission tomography (PET) are being used increasingly to stage Alzheimer's disease (AD). This study examined whether cerebrospinal fluid (CSF) and plasma amyloid beta (Aβ)42/Aβ40 could predict continuous values for amyloid PET.

METHODS: CSF Aβ42 and Aβ40 were measured with automated immunoassays. Plasma Aβ42 and Aβ40 were measured with an immunoprecipitation-mass spectrometry assay. Amyloid PET was performed with Pittsburgh compound B (PiB). The continuous relationships of CSF and plasma Aβ42/Aβ40 with amyloid PET burden were modeled.

RESULTS: Most participants were cognitively normal (427 of 491 [87%]) and the mean age was …

Glaucoma And Microglia-Induced Neuroinflammation, Makoto Ishikawa, Yukitoshi Izumi, Kota Sato, Taimu Sato, Charles F Zorumski, Hiroshi Kunikata, Toru Nakazawa

2020-Current year OA Pubs

Glaucoma is a multifactorial neurodegenerative disease characterized by a progressive optic neuropathy resulting in visual field defects. Elevated intraocular pressure (IOP) is the greatest risk factor for the development of glaucoma, and IOP reduction therapy is the only treatment currently available. However, there are many cases in which retinal degeneration progresses despite sufficient control of IOP. Therefore, it is important to elucidate the pathophysiology of glaucoma that is resistant to current IOP lowering therapies. Experiments using animal glaucoma models show the relationships between microglial neuroinflammatory responses and damage of retinal ganglion cells (RGCs). Inhibition of neuroinflammatory pathways associated with microglial …

Case Report: Peptide Receptor Radioligand Therapy In Metastatic Pediatric Neuroendocrine Tumors, Khanyisile Hlongwa, Olumayowa Kolade, Abdulilah Alnabulsi, Rachelle Steyn, Anita Brink, Vikas Prasad, Stuart More

2020-Current year OA Pubs

Neuroendocrine tumors (NETs) are not commonly diagnosed in children. Metastatic NETs tend to have poor outcomes, and this is seen in adult and pediatric populations. The role of somatostatin receptor imaging using [

Inhibition Of Mirna Associated With A Disease-Specific Signature And Secreted Via Extracellular Vesicles Of Systemic Lupus Erythematosus Patients Suppresses Target Organ Inflammation In A Humanized Mouse Model, Nicholas A Young, Emily Schwarz, Braden M Zeno, Shane Bruckner, Rosana A Mesa, Kyle Jablonski, Lai-Chu Wu, Elisha D O Roberson, Wael N Jarjour

2020-Current year OA Pubs

INTRODUCTION: Distinct, disease-associated intracellular miRNA (miR) expression profiles have been observed in peripheral blood mononuclear cells (PBMCs) of systemic lupus erythematous (SLE) patients. Additionally, we have identified novel estrogenic responses in PBMCs from SLE patients and demonstrated that estrogen upregulates toll-like receptor (TLR)7 and TLR8 expression. TLR7 and TLR8 bind viral-derived single-stranded RNA to stimulate innate inflammatory responses, but recent studies have shown that miR-21, mir-29a, and miR-29b can also bind and activate these receptors when packaged and secreted in extracellular vesicles (EVs). The objective of this study was to evaluate the association of EV-encapsulated small RNA species in SLE …

Plasma And Cerebrospinal Fluid Proteomic Signatures Of Acutely Sleep-Deprived Humans: An Exploratory Study, Ana Vaquer-Alicea, Jinsheng Yu, Haiyan Liu, Brendan P Lucey

2020-Current year OA Pubs

STUDY OBJECTIVES: Acute sleep deprivation affects both central and peripheral biological processes. Prior research has mainly focused on specific proteins or biological pathways that are dysregulated in the setting of sustained wakefulness. This exploratory study aimed to provide a comprehensive view of the biological processes and proteins impacted by acute sleep deprivation in both plasma and cerebrospinal fluid (CSF).

METHODS: We collected plasma and CSF from human participants during one night of sleep deprivation and controlled normal sleep conditions. One thousand and three hundred proteins were measured at hour 0 and hour 24 using a high-scale aptamer-based proteomics platform (SOMAscan) …

Development Of An In-Vitro High-Throughput Screening System To Identify Modulators Of Genitalia Development, Yan Yin, Meade Haller, Tian Li, Liang Ma

2020-Current year OA Pubs

Sexually dimorphic outgrowth and differentiation of the embryonic genital tubercles (GTs) give rise to the penis in males and the clitoris in females. Defects in androgen production or in response to androgen signaling can lead to various congenital penile anomalies in both mice and humans. Due to lack of a high-throughput screening system, identification of crucial regulators of GT sexual differentiation has been slow. To overcome this research barrier, we isolated embryonic GT mesenchymal (GTme) cells to model genitalia growth and differentiation in vitro. Using either a mechanical or fluorescence-activated cell sorting-assisted purification method, GTme cells were isolated and assayed …

Intra-Articular Aav9 Α-L-Iduronidase Gene Replacement In The Canine Model Of Mucopolysaccharidosis Type I, Raymond Yu-Jeang Wang, Shih-Hsin Kan, Haoyue Zhang, Jodi D Smith, Afshin Aminian, Elizabeth Snella, Jackie K Jens, Sarah P Young, Patricia I Dickson, N Matthew Ellinwood

2020-Current year OA Pubs

Mucopolysaccharidosis type I (MPS I), an inherited lysosomal storage disorder characterized by deficiency of

Case Report: Insulin Hypersensitivity In Youth With Type 1 Diabetes, Einas H Alkhatib, Jody B Grundman, Anna M Adamusiak, Melena D Bellin, Joel P Brooks, Kevin S Buckley, Erin M Janssen, Maleewan Kitcharoensakkul, Kyle P Mcnerney, Thea L Pfeifer, Brooke I Polk, Brynn E Marks

2020-Current year OA Pubs

OBJECTIVE: Immediate type I, type III, and delayed type IV hypersensitivity reactions to insulin are rare, but potentially serious complications of exogenous insulin administration required for the treatment of type 1 diabetes (T1D).

METHODS: We present four cases of insulin hypersensitivity reactions occurring in youth with T1D and a literature review of this topic.

RESULTS: Insulin hypersensitivity reactions included types I, III, and IV with presentations ranging from localized urticaria, erythematous nodules, and eczematous plaques to anaphylaxis with respiratory distress. Reactions occurred in youth with newly diagnosed T1D and in those with long-standing T1D who were using both injection and …

Factors Influencing Delayed Clearance Of High Dose Methotrexate (Hdmtx) In Pediatric, Adolescent, And Young Adult Oncology Patients, Ema Mosleh, Stacy Snyder, Ningying Wu, Daniel N Willis, Rema Malone, Robert J Hayashi

2020-Current year OA Pubs

PURPOSE: To identify modifiable risk factors associated with prolonged clearance of methotrexate in pediatric, adolescent, and young adult (AYA) oncology patients receiving high dose methotrexate (HDMTX).

DESIGN/METHOD: A single institution, retrospective chart review of patients receiving HDMTX between 2010-2017. Patients had a diagnosis of either leukemia or osteosarcoma. Data included demographics, concurrent intravenous (IV) medications, IV fluids (IVF) administered, urine output (UO), and rises in serum creatinine (RSC) reflective of renal toxicity (RT). Outcome measures included 1) delayed targeted MTX clearance (DC), 2) actual time to clearance (TTC) and 3) length of stay (LOS).

RESULTS: Data from 447 HDMTX administrations …

Gene-Educational Attainment Interactions In A Multi-Population Genome-Wide Meta-Analysis Identify Novel Lipid Loci, Lisa De Las Fuentes, Karen L. Schwander, Yun Ju Sung, Mary F. Feitosa, Ahn Do, C. Charles Gu, Treva K. Rice, Mary K. Wojczynski, Michael M. Province, Dabeeru C. Rao, Et Al.

2020-Current year OA Pubs

No abstract provided.