Digital Commons Network^™

Pediatric Bipolar Disorder: Evolution In Clinical And Biological Markers And Future Perspectives, Kirti Saxena, Kiki Chang, Gabriele Sani

Faculty, Staff and Students Publications

No abstract provided.

The Current Burden And Future Solutions For Preoperative Cataract-Refractive Evaluation Diagnostic Devices: A Modified Delphi Study, Bonnie An Henderson, Jaime Aramberri, Robin Vann, Adi Abulafia, Margaret Ainslie-Garcia, John Berdahl, Nicole Ferko, Kjell Gunnar Gundersen, So Goto, Preeya Gupta, Samuel Multack, Elizabeth Persaud, Duna Raoof, Giacomo Savini, H John Shammas, Li Wang, Wendy Zhi Wang

Faculty, Staff and Students Publications

Purpose: To obtain consensus on the key areas of burden associated with existing devices and to understand the requirements for a comprehensive next-generation diagnostic device to be able to solve current challenges and provide more accurate prediction of intraocular lens (IOL) power and presbyopia correction IOL success.

Patients and methods: Thirteen expert refractive cataract surgeons including three steering committee (SC) members constituted the voting panel. Three rounds of voting included a Round 1 structured electronic questionnaire, Round 2 virtual face-to-face meeting, and Round 3 electronic questionnaire to obtain consensus on topics related to current limitations and future solutions for preoperative …

Prefrontal Network Engagement By Deep Brain Stimulation In Limbic Hubs, Anusha Allawala, Kelly R Bijanki, Denise Oswalt, Raissa K Mathura, Joshua Adkinson, Victoria Pirtle, Ben Shofty, Meghan Robinson, Matthew T Harrison, Sanjay J Mathew, Wayne K Goodman, Nader Pouratian, Sameer A Sheth, David A Borton

Faculty, Staff and Students Publications

Prefrontal circuits in the human brain play an important role in cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these circuits are being used with increasing frequency to treat a host of neuropsychiatric disorders. However, the detailed neurophysiological effects of stimulation to these hubs are largely unknown. Here, we performed intracranial recordings across prefrontal networks while delivering electrical stimulation to two well-established white matter hubs involved in cognitive regulation and depression: the subcallosal cingulate (SCC) and ventral capsule/ventral striatum (VC/VS). We demonstrate a shared frontotemporal circuit consisting of the ventromedial prefrontal cortex, amygdala, and lateral orbitofrontal …

Modeling Suicidality With Multimodal Impulsivity Characterization In Participants With Mental Health Disorder, Nidal Moukaddam, Bishal Lamichhane, Ramiro Salas, Wayne Goodman, Ashutosh Sabharwal

Faculty, Staff and Students Publications

INTRODUCTION: Suicide is one of the leading causes of death across different age groups. The persistence of suicidal ideation and the progression of suicidal ideations to action could be related to impulsivity, the tendency to act on urges with low temporal latency, and little forethought. Quantifying impulsivity could thus help suicidality estimation and risk assessments in ideation-to-action suicidality frameworks.

METHODS: To model suicidality with impulsivity quantification, we obtained questionnaires, behavioral tests, heart rate variability (HRV), and resting state functional magnetic resonance imaging measurements from 34 participants with mood disorders. The participants were categorized into three suicidality groups based on their …

Optimizing Human Performance In Extreme Environments Through Precision Medicine: From Spaceflight To High-Performance Operations On Earth, Michael A Schmidt, Jeffrey A Jones, Christopher E Mason

Faculty, Staff and Students Publications

Humans operating in extreme environments often conduct their operations at the edges of the limits of human performance. Sometimes, they are required to push these limits to previously unattained levels. As a result, their margins for error in execution are much smaller than that found in the general public. These same small margins for error that impact execution may also impact risk, safety, health, and even survival. Thus, humans operating in extreme environments have a need for greater refinement in their preparation, training, fitness, and medical care. Precision medicine (PM) is uniquely suited to address the needs of those engaged …

Heart Failure Drug Treatment-Inertia, Titration, And Discontinuation: A Multinational Observational Study (Evolution Hf), Gianluigi Savarese, Takuya Kishi, Orly Vardeny, Samuel Adamsson Eryd, Johan Bodegård, Lars H Lund, Marcus Thuresson, Biykem Bozkurt

Faculty, Staff and Students Publications

Background: Guidelines recommend early initiation of multiple guideline-directed medical therapies (GDMTs) to reduce mortality/rehospitalization in patients with heart failure and reduced ejection fraction. Understanding GDMT use is critical to improving clinical practice.

Objectives: This study sought to describe GDMT use in Japan, Sweden, and the United States in contemporary real-world settings.

Methods: EVOLUTION HF (Utilization of Dapagliflozin and Other Guideline Directed Medical Therapies in Heart Failure Patients: A Multinational Observational Study Based on Secondary Data) is an observational cohort study using routine-care databases. Patients initiating any GDMT within 12 months of a hospitalization for heart failure (hHF) discharge were included. …

Lead Cap Use In Interventional Cardiology: Time To Protect Our Head In The Cardiac Catheterisation Laboratory?, Yasar Sattar, Prasanna M Sengodan, Mustafa Sajjad Cheema, Nismat Javed, Shoaib Ashraf, Sadaf Fakhra, Anas Alharbi, Moinuddin Syed, Mahboob Alam, Islam Y Elgendy, Affan Haleem, Akram Kawsara, M Chadi Alraies, Ramesh Daggubati

Faculty, Staff and Students Publications

Background: Radiation exposure is an occupational hazard for interventional cardiologists and cardiac catheterisation laboratory staff that can manifest with serious long-term health consequences. Personal protective equipment, including lead jackets and glasses, is common, but the use of radiation protective lead caps is inconsistent.

Methods: A systematic review qualitative assessment of five observational studies using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines protocol was performed.

Results: It was concluded that lead caps significantly reduce radiation exposure to the head, even when a ceiling-mounted lead shield was present.

Conclusion: Although newer protective systems are being …

The Use Of Reframing: Increasing The Importance Of Lifestyle Medicine, Molly R Vega, Saad Nadeem, Elizabeth M Vaughan, Craig A Johnston

Faculty, Staff and Students Publications

Lifestyle behavior modification is an essential component to prevention and treatment of non-communicable diseases worldwide. For the last 40 years, studies have recognized that there is suboptimal training of physicians in lifestyle medicine and its implementation in clinical settings. The lack of nutrition and exercise counseling occurring in the medical office does not reflect the high level of evidence supporting its use. Lifestyle behavior counseling is complex; as are the individualized needs of patients. Therefore, we suspect that the lack of knowledge in nutrition and exercise prescriptions are not the only barriers to providing optimal care. Reframing lifestyle medicine interventions …

Emergency Department Presentations Of Diabetic Ketoacidosis In A Large Cohort Of Children, Lise E Nigrovic, Nathan Kuppermann, Simona Ghetti, Jeff E Schunk, Michael J Stoner, Arleta Rewers, Julie K Mcmanemy, Kimberly S Quayle, Jennifer L Trainor, Leah Tzimenatos, Jonathan E Bennett, Maria Y Kwok, Sage R Myers, Kathleen M Brown, T Charles Casper, Cody S Olsen, Nicole S Glaser

Faculty, Staff and Students Publications

Background: Diabetic ketoacidosis (DKA) is a potentially life-threatening complication of childhood diabetes. However, the influence of demographic factors on presentation are not well-defined.

Methods: We included children from 12 centers who were < 18 years with DKA (glucose > 300 mg/dL, serum pH < 7.25, or serum bicarbonate < 15 mEq/L) enrolled in the Pediatric Emergency Care Applied Research Network (PECARN) Fluid Therapies Under Investigation in DKA (FLUID) Trial. Data were also collected for children who presented to the centers during the enrollment period but were not enrolled due to disease or treatment-related reasons. We compared demographic, clinical, and biochemical findings among children with newly and previously diagnosed diabetes and children in different age groups.

Results: Of the 1,679 DKA episodes in 1,553 children, 799 (47.5%) episodes occurred in children with newly diagnosed diabetes and 396 (23.6%) were severe (pH < 7.1). Newly diagnosed children < 6 years of age were not more likely to have severe DKA in terms of pH, but had more severe hypocarbia and higher blood urea nitrogen levels, factors previously associated with the risk of cerebral injury. Lower socioeconomic status (SES) (based on family income and maternal education level) were associated with more severe DKA in new onset children, and recurrent DKA in the previously diagnosed children.

Conclusions: Greater efforts are needed to identify the children with diabetes early and to prevent recurrent DKA, particularly among children in low-SES groups. Young children with DKA may need more intensive monitoring due to higher risk of cerebral injury.

Transfer Information Online: Websites And Articulation Agreements At The City University Of New York, A. W. Logue, Chet Jordan, Matthew Townsell, Nicol Bellettiere, Rhina Torres

Publications and Research

Objective: Transfer students face a range of potential challenges as they prepare to move from one college to another. Websites are critical resources for transfer students because they can be easily accessible sources of information concerning credit transfer, advising, articulation agreements, and additional transfer administrative policies and procedures. Detailed assessments of colleges’ website transfer information can provide information useful to higher education institutions regarding how transfer information should and should not be communicated online. Methods: The present study examined transfer information on the websites of 19 colleges of The City University of New York (CUNY). This examination assessed the presence …

Comparison Of Gis Methods For Estimating The Social Vulnerability In Response To Natural Hazards In The West Part Of The City Of Tualatin, Alex Troy

Geography Masters Research Papers

The influence of natural hazards on social vulnerability is an important topic in the risk analysis of natural disasters in the human-environment system. Due to the difficulty of directly measuring social vulnerability, composite indexes are used as a surrogate. Social vulnerability indexes attempt to characterize access to societal and local social services during or after disastrous events, using various indicators such as age, gender, ethnicity, socioeconomic status, housing organization, access to shelters, and medical facilities. Geographic information systems (GIS) are used for vulnerability analysis due to their visualization methods and demographic data analysis. However, limitations in GIS applications for social …

Malignant Insulinoma Arising From Nonfunctioning Pancreatic Neuroendocrine Tumor, Ritodhi Chatterjee, Basim Ali, Son H Nguyen, Rui Chen, Yvonne H Sada

Faculty, Staff and Students Publications

Pancreatic neuroendocrine tumors are rare neoplasms characterized into nonfunctioning (NF-PNET) and functioning (F-PNET) subtypes. F-PNETs typically involve overt symptoms related to excessive hormone secretion but may rarely present first as NF-PNETs with delayed transformation. We present a patient with known NF-PNET with liver metastases who developed hypoglycemia 2 years after initial diagnosis due to malignant insulinoma. Hypoglycemia was refractory to continuous dextrose but improved temporarily after diazoxide and hepatic artery embolization. Malignant insulinomas are usually metastatic at presentation and portend poor prognosis. Hypoglycemia may be medically managed with steroids, somatostatin analogues, and diazoxide, along with therapies to reduce tumor burden.

Corrigendum: Clinical And Immunological Effects Of P53-Targeting Vaccines, Shan Zhou, Chunmei Fan, Zhaoyang Zeng, Ken H Young, Yong Li

Faculty, Staff and Students Publications

[This corrects the article DOI: 10.3389/fcell.2021.762796.].

Cup Is Essential For Oskar Mrna Translational Repression During Early Drosophila Oogenesis, Livia V. Bayer, Samantha Milano, Stephen K. Formel, Harpreet Kaur, Rishi Ravichandran, Juan A. Cambeiro, Lizaveta Slinko, Irina E. Catrina, Diana P. Bratu

Publications and Research

Study of the timing and location for mRNA translation across model systems has begun to shed light on molecular events fundamental to such processes as intercellular communication, morphogenesis, and body pattern formation. In D. melanogaster, the posterior mRNA determinant, oskar, is transcribed maternally but translated only when properly localized at the oocyte’s posterior cortex. Two effector proteins, Bruno1 and Cup, mediate steps of oskar mRNA regulation. The current model in the field identifies Bruno1 as necessary for Cup’s recruitment to oskar mRNA and indispensable for oskar’s translational repression. We now report that this Bruno1-Cup interaction leads …

Single Inclusive Hadron Production In Dis At Small X: Next To Leading Order Corrections, Filip Bergabo, Jamal Jalilian-Marian

Publications and Research

We calculate the one-loop corrections to single inclusive hadron production in Deep Inelastic Scattering (DIS) at small x in the forward rapidity region using the Color Glass Condensate formalism. We show that the divergent parts of the next to leading order (NLO) corrections either cancel among each other or lead to x (rapidity) evolution of the leading order (LO) dipole cross section according to the JIMWLK evolution equation and DGLAP evolution of the parton-hadron fragmentation function. The remaining finite parts constitute the NLO (α_s) corrections to the LO single inclusive hadron production cross section in DIS at …

Active Learning For Efficient Soil Monitoring In Large Terrain With Heterogeneous Sensor Network, Hui Chen, Ju Wang

Publications and Research

Soils are a complex ecosystem that provides critical services, such as growing food, supplying antibiotics, filtering wastes, and maintaining biodiversity; hence monitoring soil health and domestication is required for sustainable human development. Low-cost and high-resolution soil monitoring systems are challenging to design and build. Compounded by the sheer size of the monitoring area of interest and the variety of biological, chemical, and physical parameters to monitor, naive approaches to adding or scheduling more sensors will suffer from cost and scalability problems. We investigate a multi-robot sensing system integrated with an active learning-based predictive modeling technique. Taking advantage of advances in …

Lear’S Daughters? Unenumerated Fundamental Rights And The Constitution, Thomas Halper

Publications and Research

How to determine whether fundamental unenumerated constitutional rights exist, and if so, what they are? The questions are of obvious enormous importance—witness the current controversy over abortion—and yet courts have generally been content to address the issues superficially, sometimes, cavalierly. Their treatment of the most common rationale, an historical/traditional consensus, exemplifies this shallow approach. The underdeveloped character of the argumentation on this topic stubbornly remains one of the most glaring shortfalls of modern constitutional law.

Ecological Niche Comparison Among Closely Related Tree Species Of Lauraceae Using Climatic And Edaphic Data, Laura J. Giraldo-Kalil, Gonzalo E. Pinilla Buitrago, Andrés Lira-Noriega, Francisco Lorea-Hernández, Juan Núñez-Farfán

Publications and Research

ABSTRACT:

Edaphic specialization is considered to promote ecological differentiation among closely related species of Damburneya (Lauraceae) occurring in sympatry. However, little is known about the effects of soil and other key environmental factors like climate on the ecological niche and distribution of these tree species. Here, we assessed the role of climate and soil on niche divergence and potential distribution of four Damburneya species whose distributions span Central America and Mexico. We performed ecological niche modeling with MaxEnt using three sets of environmental data: climatic-only, edaphic-only, and a combination of both, to characterize species niches and suitable distribution areas. Niche …

Radiation-Induced Gastrointestinal (Gi) Syndrome As A Function Of Age, Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao, Guoqiang Hua, Ryan Glass, Phillip B. Paty, Zvi Fuks, Richard Kolesnick, Karen Hubbard, Adriana Haimovitz-Friedman

Publications and Research

Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher levels of apoptotic stem cells in small intestinal crypts that correlated with sphingomyelinase activity, a source of pro-apoptotic ceramide. The objective of this study is to determine whether the cycling crypt base columnar cells (CBCs) in aging animals are specifically more sensitive to radiation effects than the CBCs in young adult mice, and to identify factors that contribute to increased radiosensitivity. Mortality induced by subtotal body radiation was …

Hamiltonian Structure Of 2d Fluid Dynamics With Broken Parity, Gustavo Machado Monteiro, Alexander G. Abanov, Sriram Ganeshan

Publications and Research

Isotropic fluids in two spatial dimensions can break parity symmetry and sustain transverse stresses which do not lead to dissipation. Corresponding transport coefficients include odd viscosity, odd torque, and odd pressure. We consider an isotropic Galilean invariant fluid dynamics in the adiabatic regime with momentum and particle density conservation. We find conditions on transport coefficients that correspond to dissipationless and separately to Hamiltonian fluid dynamics. The restriction on the transport coefficients will help identify what kind of hydrodynamics can be obtained by coarse-graining a microscopic Hamiltonian system. Interestingly, not all parity-breaking transport coefficients lead to energy conservation and, generally, the …

Inclusive Random Sampling In Graphs And Networks, Yitzchak Novick, Amotz Bar-Noy

Publications and Research

It is often of interest to sample vertices from a graph with a bias towards higher-degree vertices. One well-known method, which we call random neighbor or RN, involves taking a vertex at random and exchanging it for one of its neighbors. Loosely inspired by the friendship paradox, the method is predicated on the fact that the expected degree of the neighbor is greater than or equal to the expected degree of the initial vertex. Another method that is actually perfectly analogous to the friendship paradox is random edge, or RE, where an edge is sampled at random, and then one …

Logic As Applied Mathematics — With Particular Application To The Notion Of Logical Form, Graham Priest

Publications and Research

The word ‘logic’ has many senses. Here we will understand it as meaning an account of what follows from what and why. With contemporary methodology, logic in this sense – though it may not always have been thought of in this way – is a branch of applied mathematics. This has various implications for how one understands a number of issues concerning validity. In this paper I will explain this perspective of logic, and explore some of its consequences with respect to the notion of logical form.

Potential Anti-Alzheimer Properties Of Mogrosides In Vitamin B12-Deficient Caenorhabditis Elegans, Denia Cai Shi, Chunlin Long, Ella Vardeman, Edward J. Kennelly, Michael A. Lawton, Rong Di

Publications and Research

Vitamin B12 deficiency can lead to oxidative stress, which is known to be involved in neurodegenerative diseases such as Alzheimer’s disease (AD). Mogrosides are plant-derived triterpene glycosides that exhibit anti-inflammatory and antioxidant activity in animal cell lines and mouse models. Since amyloid-β toxicity is known to cause oxidative stress and damage to brain cells, we hypothesized that mogrosides may have a protective effect against AD. In this study, we investigated the potential anti-AD effect of mogrosides in vitamin B12-deficient wild-type N2 and in transgenic CL2355 Caenorhabditis elegans expressing amyloid-β peptide. Our data indicated that mogrosides have a beneficial effect on …

Differences Between Monolinguals And Bilinguals In Phonetic And Phonological Learning And The Connection With Auditory Sensory Memory, Laura Spinu, Jiwon Hwang, Mariana Vasilita

Publications and Research

Bilingualism has been linked with improved function regarding certain aspects of linguistic processing, e.g., novel word acquisition and learning unfamiliar sound patterns. Two non mutually-exclusive approaches might explain these results. One is related to executive function, speculating that more effective learning is achieved through actively choosing relevant information while inhibiting potentially interfering information. While still controversial, executive function enhancements attributed to bilingual experience have been reported for decades. The other approach, understudied to date, emphasizes the role of sensory mechanisms, specifically auditory sensory memory. Bilinguals outperformed monolinguals in tasks involving auditory processing and episodic memory recall, but the questions whether …

Adaptive Single Low-Light Image Enhancement By Fractional Stretching In Logarithmic Domain, Thaweesak Trongtirakul, Sos S. Agaian, Shiqian Wu

Publications and Research

Low-light image enhancement is a challenging task that aims to improve the visibility and quality of images captured in dark environments. However, existing methods often introduce undesirable artifacts such as color distortion, halo effects, blocking artifacts, and noise amplification. In this paper, we propose a novel method that overcomes these limitations by using the logarithmic domain fractional stretching approach to estimate the reflectance component of the image based on the improved Retinex theory. Moreover, we apply a simple adaptive gamma correction algorithm to the Lab color-space to adjust the brightness and saturation of the image. Our method effectively reduces the …

Fabrication And Errors In The Bibliographic Citations Generated By Chatgpt, William H. Walters, Esther Isabelle Wilder

Publications and Research

Although chatbots such as ChatGPT can facilitate cost-effective text generation and editing, factually incorrect responses (hallucinations) limit their utility. This study evaluates one particular type of hallucination: fabricated bibliographic citations that do not represent actual scholarly works. We used ChatGPT-3.5 and ChatGPT-4 to produce short literature reviews on 42 multidisciplinary topics, compiling data on the 636 bibliographic citations (references) found in the 84 papers. We then searched multiple databases and websites to determine the prevalence of fabricated citations, to identify errors in the citations to non-fabricated papers, and to evaluate adherence to APA citation format. Within this set of documents, …

Can Mild Traumatic Brain Injury Alter Cognition Chronically? A Limbic-Cenc Multicenter Study, William C Walker, Maya E O'Neil, Zhining Ou, Terri K Pogoda, Heather G Belanger, Randall S Scheibel, Angela P Presson, Shannon R Miles, Elisabeth A Wilde, David F Tate, Maya Troyanskaya, Mary Jo Pugh, Amy Jak, David X Cifu

Faculty, Staff and Students Publications

Objective: While outcome from mild traumatic brain injury (mTBI) is generally favorable, concern remains over potential negative long-term effects, including impaired cognition. This study examined the link between cognitive performance and remote mTBIs within the Long-term Impact of Military-relevant Brain Injury Consortium-Chronic Effects of Neurotrauma Consortium (LIMBIC-CENC) multicenter, observational study of Veterans and service members (SMs) with combat exposure.

Method: Baseline data of the participants passing all cognitive performance validity tests (n = 1,310) were used to conduct a cross-sectional analysis. Using multivariable regression models that adjusted for covariates, including age and estimated preexposure intellectual function, positive mTBI history …

People Are Curious About Immoral And Morally Ambiguous Others, Jordan Wylie, Ana Gantman

Publications and Research

Looking to the popularity of superheroes, true crime stories, and anti-heroic characters like Tony Soprano, we investigated whether moral extremity, especially moral badness, piques curiosity. Across five experiments (N = 2429), we examine moral curiosity, testing under what conditions the moral minds of others spark explanation-seeking behavior. In Experiment 1, we find that among the most widely watched Netflix shows in the US over a five-month period, the more immoral the protagonist, the more hours people spent watching. In Experiments 2a and 2b, we find that when given a choice to learn more about morally good, bad, ambiguous, or …

Astrophysics With The Laser Interferometer Space Antenna, Pau Amaro-Seoane, Jeff Andrews, Manuel Arca Sedda, Abbas Askar, Quentin Baghi, Razvan Balasov, Imre Bartos, Simone S. Bavera, Jillian Bellovary, Christopher P. L. Berry, Emanuele Berti, Stefano Bianchi, Laura Blecha, Stéphane Blondin, Tamara Bogdanović, Samuel Boissier, Matteo Bonetti, Silvia Bonoli, Elisa Bortolas, Katelyn Breivik, Pedro R. Capelo, Laurentiu Caramete, Federico Cattorini, Maria Charisi, Sylvain Chaty, Xian Chen, Martyna Chruślińska, Alvin J. K. Chua, Ross Church, Monica Colpi, Daniel D’Orazio, Camilla Danielski, Melvyn B. Davies, Pratika Dayal, Alessandra De Rosa, Andrea Derdzinski, Kyriakos Destounis, Massimo Dotti, Ioana Duţan, Irina Dvorkin, Gaia Fabj, Thierry Foglizzo, Saavik Ford, Jean-Baptiste Fouvry, Alessia Franchini, Tassos Fragos, Chris Fryer, Massimo Gaspari, Davide Gerosa, Luca Graziani, Paul Groot, Melanie Habouzit, Daryl Haggard, Zoltan Haiman, Wen-Biao Han, Alina Istrate, Peter H. Johansson, Fazeel Mahmood Khan, Tomas Kimpson, Kostas Kokkotas, Albert Kong, Valeriya Korol, Kyle Kremer, Thomas Kupfer, Astrid Lamberts, Shane Larson, Mike Lau, Dongliang Liu, Nicole Lloyd-Ronning, Giuseppe Lodato, Alessandro Lupi, Chung-Pei Ma, Tomas Maccarone, Ilya Mandel, Alberto Mangiagli, Michela Mapelli, Stéphane Mathis, Lucio Mayer, Sean Mcgee, Barry Mckernan, M. Coleman Miller, David F. Mota, Matthew Mumpower, Syeda S. Nasim, Gijs Nelemans, Scott Noble, Fabio Pacucci, Francesca Panessa, Vasileios Paschalidis, Hugo Pfister, Delphine Porquet, John Quenby, Angelo Ricarte, Friedrich K. Röpke, John Regan, Stephan Rosswog, Ashley Ruiter, Milton Ruiz, Jessie Runnoe, Raffaella Schneider, Jeremy Schnittman, Amy Secunda, Alberto Sesana, Naoki Seto, Lijing Shao, Stuart Shapiro, Carlos Sopuerta, Nicholas C. Stone, Arthur Suvorov, Nicola Tamanini, Tomas Tamfal, Thomas Tauris, Karel Temmink, John Tomsick, Silvia Toonen, Alejandro Torres-Orjuela, Martina Toscani, Antonios Tsokaros, Caner Unal, Verónica Vázquez-Aceves, Rosa Valiante, Maurice Van Putten, Jan Van Roestel, Christian Vignali, Marta Volonteri, Kinwah Wu, Ziri Younsi, Shenghua Yu, Silvia Zane, Lorenz Zwick, Fabio Antonini, Vishal Baibhav, Enrico Barausse, Alexander Bonilla Rivera, Marica Branchesi, Graziella Branduardi-Raymont, Kevin Burdge, Srija Chakraborty, Jorge Cuadra, Kristen Dage, Benjamin Davis, Selma E. De Mink, Roberto Decarli, Daniela Doneva, Stephanie Escoffier, Poshak Gandhi, Francesco Haardt, Carlos O. Lousto, Samaya Nissanke, Jason Nordhaus, Richard O’Shaughnessy, Simon Portegies Zwart, Adam Pound, Fabian Schussler, Olga Sergijenko, Alessandro Spallicci, Daniele Vernieri, Alejandro Vigna-Gómez

Publications and Research

The Laser Interferometer Space Antenna (LISA) will be a transformative experiment for gravitational wave astronomy, and, as such, it will offer unique opportunities to address many key astrophysical questions in a completely novel way. The synergy with ground-based and space-born instruments in the electromagnetic domain, by enabling multi-messenger observations, will add further to the discovery potential of LISA. The next decade is crucial to prepare the astrophysical community for LISA’s first observations. This review outlines the extensive landscape of astrophysical theory, numerical simulations, and astronomical observations that are instrumental for modeling and interpreting the upcoming LISA datastream. To this aim, …

Mir-124-3p Target Genes Identify Globus Pallidus Role In Suicide Ideation Recovery In Borderline Personality Disorder, Macarena S Aloi, Guillermo F Poblete, John Oldham, Michelle A Patriquin, David A Nielsen, Thomas R Kosten, Ramiro Salas

Faculty, Staff and Students Publications

Borderline personality disorder (BPD) is characterized by patterns of unstable affect, unstable interpersonal relationships, and chronic suicidal tendencies. Research on the genetics, epigenetics, and brain function of BPD is lacking. MicroRNA-124-3p (miR-124-3p) was recently identified in a Genome-Wide Association Study as likely associated with BPD. Here, we identified the anatomical brain expression of genes likely modulated by miR-124-3p and compared morphometry in those brain regions in BPD inpatients vs. controls matched for psychiatric comorbidities. We isolated lists of targets likely modulated by miR-124-3p from TargetScan (v 8.0) by their preferentially conserved targeting (Aggregate PCT > 0.99, see Supplementary Table 1). …