Digital Commons Network^™

Adapting Higher Education: Revamping Curricula For The Inclusion Of Theatre Students With Disabilities, Kevin Kemler

Theses and Dissertations

Equity, Diversity, and Inclusion initiatives in higher education have been largely driven by administrators who have little to no contact with the students for whom they are working for. This top-down approach negatively impacts marginalized students and disproportionately affects the quality of experience for students with Disabilities, an often-overlooked demographic. For Disabled students enrolled in performance programs, barriers to access and inclusion don’t just exist at the institutional level, they also exist in the traditional classroom or studio as well. Through a dismantling of ableist structures inherent within higher education (i.e., American grading practices, the Western and Theatrical Canons), I …

Contribution Of Metabolic Cell Swelling On Microcirculatory Perfusion In Septic Shock, Charles E. Payne

Theses and Dissertations

Sepsis, a systemic immunological response that leads to organ-dysfunction, the development of septic shock, and death has mortality rate of 15-25%. A subset of sepsis, septic shock, has an in-hospital mortality rate of 30-50%. Sepsis and its treatment are the most expensive healthcare problem in the United States with the US Agency for Healthcare Research and Quality estimating annual costs over $20 billion. Hypoxia experienced in septic shock induces metabolic cell and tissue swelling leading to further microcirculatory dysfunction and poor tissue perfusion. Reversing metabolic cell swelling corrects these perfusion defects. Two models were used in rats to induce septic …

The Age And Primary Reason For The First Dental Visit In Children With Special Health Care Needs, Amanda Dickerson

Theses and Dissertations

Purpose: The aim of this project is to evaluate the average age and primary reason for the first dental visit among patients with special health care needs as well as to examine socioeconomic factors and other barriers related to children with special health care needs accessing care.

Methods: This is a cross-sectional survey that was distributed to caregivers of children with special health care needs. Study data was collected through REDCap, a secure web-based survey application. The inclusion criteria for participating in the survey included having a child with a special health care need that presented for a recall or …

Utilization Of Intraoral Scanners For Fabrication Of Obturators For Patients Born With Cleft Lip/ Palate (Clp), Swara Fadnis

Theses and Dissertations

Objective: The goal of this cross-sectional study was to assess the knowledge and attitude of providers regarding incorporating a digital scanner for impression taking in children born with cleft lip and/or palate (CLP). Methods: A survey was sent out to members of the American Association of Pediatric Dentistry (AAPD). The survey included questions regarding the providers’ perception of incorporating digital intraoral scanners for impressions for fabrication of obturators. The survey also included questions about the providers’ reservations in using this technology in practice, what their experience has been with the incorporation of this technology into practice, and what is …

Dune Building Dynamics Impact Cross-Island Connectivity And Barrier Island Characteristics, Alexander Sabo

Theses and Dissertations

Located at the land-sea interface, barrier islands are important protective features that reduce wave energy and erosion from mainland areas. Further, barrier islands provide habitat for many different organisms and serve as popular areas for recreation and tourism. As sandy landforms, barrier islands are easily disturbed, but often recover after disturbance as a result of island plant communities, specifically dune building grasses. Disturbance on barrier islands is driven by storms, tides, and overwash events. After disturbance has occurred, dune grasses colonize the dunes allowing for dune building and habitat restoration. On the Virginia barrier islands, there are three dominant dune …

The Wound Healing And Antibacterial Properties Of Mesenchymal Stromal Cell Extracellular Matrix Nanoparticles, Emily N. Wandling

Theses and Dissertations

Treatments for acute respiratory distress syndrome (ARDS) are still unavailable and the prevalence of the disease has only increased due to the Covid-19 pandemic. Mechanical ventilation regiments are still utilized to support declining lung function, but they also contribute to lung damage and increase the risk of bacterial infection. The anti-inflammatory and pro-regenerative abilities of mesenchymal stromal cells (MSCs) have shown to be a promising therapy for ARDS. We propose to utilize the regenerative effects of MSC secretome and the extracellular matrix (ECM) into a nanoparticle. Our mouse MSC (MMSC) ECM nanoparticles were characterized using size, zeta-potential, and mass spectrometry …

Combining Novel Direction Modulated Brachytherapy Tandem-And-Ovoids Applicators For Treatment Planning Of Multi-Institutional Cervical Cancer Cases: Removing Needles In Intracavitary-Interstitial Techniques, Sharmin Alam

Theses and Dissertations

Lack of standard guidelines for optimal needle insertion during high-dose-rate (HDR) intracavitary-interstitial (IC-IS) brachytherapy of the cervix means a sophisticated and technical skillset of inserting needles next to IC applicators must be developed to enhance plan quality. This study sought to evaluate the performance of two separate direction modulated brachytherapy (DMBT) tandem applicators used in conjunction with one set of novel DMBT ovoids, to effectively obviate the need for IS needles.

A cohort of 32 retrospective clinical HDR brachytherapy plans was re-planned with Varian’s BrachyVision^® treatment planning system, using VEGO^® inverse optimization algorithm, with dose heterogeneity accounted for …

Incorporating A Developmental Perspective Into Gene Identification Models For Alcohol Use Behaviors, Nathaniel S. Thomas

Theses and Dissertations

Frequent alcohol use can lead to alcohol use disorder, which accounts for three million deaths and over 133 million life years lost to disability and death worldwide per year. Alcohol use behaviors unfold across development, beginning with initiation of drinking and progressing through various escalating stages of use. Alcohol use behaviors are also under genetic influence. Genome-wide association represents the state-of-the-science statistical methodology for identifying genes associated with alcohol use outcomes. However, contemporary genome-wide association study (GWAS) methods typically do not account for variability in genetic effects throughout development. In this project, I applied novel multivariate genomic methods to combine …

A Prevention Strategy For Children Receiving Full Mouth Dental Rehabilitation Under General Anesthesia: A Randomized Controlled Trial, Jessica Gonzalez

Theses and Dissertations

Purpose: This two-arm, parallel-group randomized controlled trial aims to compare the effectiveness of a new prevention strategy versus traditional verbal education and post-operative instructions in increasing caregivers’ compliance to follow-up of their children who have had full mouth dental rehabilitation (FMDR) under general anesthesia (GA). Methods: Caregivers of children who presented for FMDR under GA were recruited and randomly assigned to either the control or treatment groups. Caregivers in the treatment arm received oral health anticipatory guidance through a combination of motivational interviewing, individualized goal setting, visual aids, and verbal education. Caregivers in the control arm received the same information …

An Introduction To Theatrical Scent Design As Compared To Traditional Design Areas With A Consideration For The Scientifically Notated Physical And Emotional Effects On The Human Body As It Potentially Relates To Future Creative Endeavors: A Framework, Katherine R. Holland

Theses and Dissertations

Traditional areas of theatrical design are established to the point of having a solid foundation for current and future designers to rely on as they strive to innovate. The same cannot be said for scent. I believe that art, like science, is a sector where the imagination is used to push the boundaries of what we currently know and can do. Artists are therefore entrusted with the responsibility to continue testing those boundaries, and that is what my topic lays the foundation for when it comes to scent. With my topic, I plan to look at the practical and ethical …

Predictive Modeling Of Thermophysical Properties Of Shocked Solid Diamond, Peter Muto

Theses and Dissertations

PREDICTIVE modeling of thermophysical properties of shocked solid diamond

Peter Muto and Gennady Miloshevsky

Virginia Commonwealth University, Department of Mechanical and Nuclear Engineering, 401 West Main St, Richmond, VA 23284-3015

Background

Shocks are high pressure waves that propagate in a material above the local speed of sound and induce severe pressure, density, and temperature changes, thus it is critical to be able to predict these effects.

Methods

The shock Hugoniot Equations of State (EoS) allow for the calculation of Hugoniot pressure and volume in a shocked material, but require a linear relationship between shock velocity and particle velocity, both experimentally …

Pre-Clinical Trials With Precision-Medicine Based Therapeutics In Basal-Like Patient-Derived Xenografts, David C. Boyd

Theses and Dissertations

Breast cancer treatments have improved over time, but the diseases seeing the most benefit from these improvements have the estrogen receptor, progesterone receptor, or are positive for HER2. Basal-like breast cancer tends to not have these biomarkers, which necessitates their treatment to be traditional, untargeted therapeutics which are less effective and tend to have harsh adverse effect profiles – this is an important unmet need. These studies utilize a variety of techniques, including tissue culture, viability assays, high-throughput screening, in vivo drug treatments and imaging, pathway analyses, molecular techniques such as Western blot, antibody arrays, RNA sequencing, sc RNA sequencing, …

Acculturative Stress And Quality Of Life Among Older Korean Immigrants: Do Religiosity And Resilience Matter?, Sunghwan Cho

Theses and Dissertations

The impact of acculturative stress on the quality of life among older adults has been widely acknowledged in previous literature. However, few studies have explored the role of religiosity and resilience in this relationship among older Korean immigrants. This dissertation explores the relationships between acculturative stress, religiosity, resilience, and quality of life among 300 older adults aged 65 years and over who live in an ethnic Korean enclave of Queens, New York. The study employs path analysis and multiple regression analyses to test hypothesized relationships among these variables.

The key findings of the study are as follows: (1) higher acculturative …

The Type Iv Pilus Secretin Bfpb: Structural Analysis And Binding Interactions, Janay I. Little

Theses and Dissertations

Enteropathogenic Escherichia coli (EPEC) causes severe diarrhea in young children. The type IV pilus (T4P) of EPEC, known as the bundle-forming pilus (BFP), plays an important role in EPEC pathogenesis. T4Ps are a family of surface appendages that are important for adhesion, colonization, biofilm formation, virulence, twitching motility and many other functions. One essential component of the BFP system is the secretin, BfpB. Secretins are a large family of integral outer membrane proteins found in T4Ps as well as type II and type III secretion systems, and filamentous phages. Details of the secretin structure have been limited to the overall …

Wifi Sensing At The Edge Towards Scalable On-Device Wireless Sensing Systems, Steven M. Hernandez

Theses and Dissertations

WiFi sensing offers a powerful method for tracking physical activities using the radio-frequency signals already found throughout our homes and offices. This novel sensing modality offers continuous and non-intrusive activity tracking since sensing can be performed (i) without requiring wearable sensors, (ii) outside the line-of-sight, and even (iii) through the wall. Furthermore, WiFi has become a ubiquitous technology in our computers, our smartphones, and even in low-cost Internet of Things devices. In this work, we consider how the ubiquity of these low-cost WiFi devices offer an unparalleled opportunity for improving the scalability of wireless sensing systems. Thus far, WiFi sensing …

Pms And Gas Pollutants Removal By Electret Filter Media And Metal-Organic Frameworks (Mofs), Yu Zhang

Theses and Dissertations

Indoor air quality (IAQ) has been becoming a major concern worldwide because statistical data showed that the indoor concentrations of gas pollutants, e.g., volatile organic compounds (VOCs) and particulate matters (PMs) are often 2–5 times higher than that of outdoors. Especially, people spend 87% of their time indoors and increasing to more than 90% during COVID-19 pandemic. The high concentration of these indoor air pollutants is mainly due to the reduced air exchange rate for the design of energy-efficient building construction and the increased usage of furnishings, glues, paints, furnaces, etc., leading to VOC outgassing and particle emission. Evidence has …

Characterization Of A Solid-State Detector For Dosimetry In The Diagnostic Energy Range With Verification Via Monte Carlo Estimation Of Average Breast Dose In Mammography, Areej Aljabal

Theses and Dissertations

This dissertation aims to develop a simplified QA metric for estimating radiation dose in mammography. This metric, the Mid-Breast Dose (MDB) Index, maybe be proposed as an alternative dose index, consistent with average glandular dose (AGD), for routine QA. MBD was obtained using “Phantom mid-point Air Kerma (AK) measurement” for conventional mammography. The advantage of this method is that MBD can be measured directly without requiring multiple conversion factors. The accuracy of clinical measurements in computing the MBD was assessed by comparing it with the AGD estimated by the Dance formalism experimentally and Monte Carlo simulation.

MBD methodology relies on …

Code Beats - Teaching Computer Programming Coding Via Hip Hop Beats, Douglas Lusa Krug

Theses and Dissertations

Computer programming is a crucial skill for future professionals, not only those working as computer programmers but most modern workers. To train the next generation, society has created many initiatives to introduce computer programming to young students. These initiatives range from classes in a formal academic setting to informal, extracurricular sessions in after-school and summer camps. Even with the increasing offer of these initiatives to expand the opportunities to learn computer programming, the interest in computer programming remains low, especially among populations underrepresented in computing. This lack of interest could be impacted by stereotypical views of computer programming as tedious …

Exploring The Effect Of Early Motor Delay And Physical Therapy Interventions On The Parent-Child Relationship, Rebecca Molinini

Theses and Dissertations

Emotional availability (EA) or the ability of the parent-child dyad to engage emotionally and partake in congruent and mutually enjoyable interactions, is essential for familial health and well-being. EA is considered the “connective tissue” of healthy parent-child relationships and is associated with secure attachment, maternal mental health, and children’s adaptive development. Most evidence supporting the integral role of EA on healthy outcomes is supported by typically developing populations in which adults present with a social or biological risk factor such as experiencing past traumas of adversities with mental health. In line with the transactional model of development, children are equal …

I. Preparation Of Strategic Synthetic Building Blocks For World Health Organization Essential Medicines. Ii. Applying The Principles Of Process Intensification To The Synthesis Of Fluoroquinolone Antibiotics., Jeffrey M. Noble

Theses and Dissertations

The synthesis of active pharmaceutical ingredients is often a time-consuming and expensive process. Due to the nature of pharmaceutical manufacturing, these costs are carried forward to the final purchase price by the consumer. Although there are many factors which are involved in the final costing of a pharmaceutical, the cost associated with the synthesis is the primary one which can be managed by chemists and engineers.

This work discusses the synthetic routes of four active pharmaceutical ingredients as well as the synthetic techniques and equipment used with an emphasis on how the application of specific techniques can be applied to …

Variability In Causal Effects On A Binary Outcome And Noncompliance In A Multisite Randomized Trial, Xinxin Sun

Theses and Dissertations

Noncompliance to treatment assignment is widespread in randomized trials and presents challenges in causal inference. In the presence of noncompliance, the most commonly estimated effect of treatment assignment, also known as intent-to-treat (ITT) effect, is biased. Of interest in this setting is the complier average causal effect (CACE), the ITT effect among compliers. Further complication arises when the outcome variable is partially observed.

My research focuses on estimating the distribution of a site-specific CACE in a multisite randomized controlled trial (MRCT) by maximum likelihood (ML). Assuming compliance missing at random (MAR). We express the likelihood as an integral with respect …

Intrinsic Efficacy As A Determinant Of Opioid Effectiveness In Treatment Of Pain-Depressed Behavior, Edna Santos

Theses and Dissertations

Pain is a major public health concern that is commonly associated with behavioral depression, and a major goal in pain treatment is alleviation of pain-related behavioral depression. High-efficacy mu opioid receptor (MOR) agonists (e.g. fentanyl, morphine, oxycodone) are effective to treat pain, but their use is limited by side effects that not only endanger the patient but may also obscure analgesic rescue of pain-depressed behavior. The ongoing epidemic of opioid abuse and overdose deaths has stimulated research to discover non-opioid alternative analgesics; however, this search neglects the clinical potential of safer intermediate-efficacy MOR agonists (e.g. buprenorphine). The objective of the …

Exploring The Role Of Institutional Culture In Student Affairs Assessment Practitioners’ Experiences Implementing Equity-Centered Assessment, Jaime L. Williams

Theses and Dissertations

Student affairs assessment is a field in higher education that emphasizes the measurement of effectiveness and student learning in student serving programs that take place outside of the classroom. Outcomes-based assessment is the basis of most assessment practices in student affairs, and focuses on the continuous improvement of out-of-classroom programs, services, and student learning. Many assessment practices stem from traditional research methods, which have been developed by people who hold mostly majority identities. These methods were not created with the rapidly changing demographics of today’s college-going students in mind. To help address the increasing diversity of college students and the …

Novel Development Of A Low-Cost, Micrometer-Scale Tip-Enhanced Raman Spectroscopy System, John Yates

Theses and Dissertations

Modern scientific instruments are significant capital investments for universities. These investments can be outside of the funding capabilities of some smaller universities or departments and can be a significant barrier in the pursuit of scientific breakthroughs. This project aims to provide a template for universities or research groups to upgrade, at a reasonable price, an existing Raman spectroscopy system to a Tip-Enhanced Raman Spectroscopy (TERS) system. This system can serve as a permanent upgrade to an existing system or as a bridge necessary to prove the viability of a research path before significant capital investment in a commercial TERS system. …

Unraveling The Consequence Of Adult Onset Sulfatide Depletion: Its Implications In Myelin And Axonal Heath In The Context Of Neurodegenerative Disease, Elizabeth Dustin

Theses and Dissertations

Multiple Sclerosis is an immune mediated disease of the CNS. MS is diagnosed through detection of demyelinated regions. However, recent studies demonstrate that Normal Appearing White Matter (NAWM) contains substantial pathology. One such pathology observed in the NAWM is the reduction of sulfatide. The proper stoichiometry of lipids in myelin acts to maintain rapid conduction velocity, provide trophic support to the neuron, and protect the axon from degeneration. We previously characterized a mouse lacking sulfatide’s synthesizing enzyme, CST through constitutive gene disruption and demonstrate that sulfide is required for proper stability of the myelin sheath. However, since MS is typically …

Investigating The Dynamics And Fragmentation Of Nitroaromatic Radical Cations Through Femtosecond Time-Resolved Mass Spectrometry And Computational Chemistry, Hugo Andres Lopez Pena

Theses and Dissertations

Chemists have sought to control molecular dissociation with lasers for decades. Effective control of unimolecular dissociation was only achieved with the development of high-intensity ultrashort pulsed lasers and coherent control techniques that operate on timescales faster than vibrational energy redistribution. In view of this, our lab has specialized in the study of polyatomic radical cations using femtosecond time-resolved mass spectrometry (FTRMS). The interest in radical cations stems from the fact that they are highly reactive species that contribute to many physical, chemical, and biological processes. For instance, radical cations participate in shock initiation of detonated energetic materials used as explosives …

Development Of Tangible Code Blocks For The Blind And Visually Impaired, Hyun Woo Kim

Theses and Dissertations

The fields of Science, Technology, Engineering, and Mathematics (STEM) have been growing at an accelerating rate in recent times. Knowing how to program has become one key skill for entering all of these STEM fields. However, many students find programming difficult. The block based programming language, Scratch, was specifically designed to lower hurdles to learning how to program for sighted students. Unfortunately, although very effective and widely used in K12 classrooms, Scratch, similar to other block based languages, is inaccessible to students who are blind and visually impaired (BVI). This thesis is part of a larger project to make the …

Blockchain Security And Applications, Phuc D. Thai

Theses and Dissertations

Cryptocurrencies, such as Bitcoin and Ethereum, have proven to be highly successful. In a cryptocurrency system, transactions and ownership data are stored digitally in a ledger that uses blockchain technology. This technology has the potential to revolutionize the future of financial transactions and decentralized applications. Blockchains have a layered architecture that enables their unique method of authenticating transactions. In this research, we examine three layers, each with its own distinct functionality: the network layer, consensus layer, and application layer. The network layer is responsible for exchanging data via a peer-to-peer (P2P) network. In this work, we present a practical yet …

Norteada - In The Greater Geologic Span Of Time, Just Fine, Clara Cruz

Theses and Dissertations

In this thesis I will spend some time talking to the dead. We’ll discuss callously mercurial and aquarian takes on things including LIVED TIME, DEATH, ART and VIBES. Keep in mind that this is just the beginning and these are just the bones - some fleshed out, some sucked to the marrow, some picked apart. Remind me that I will have forgotten at least half of what I meant to write and lost my keys three times before we’re done.

Homeworld, Ilana Dodelson

Theses and Dissertations

This thesis explores the experience of being tied to many worlds at once, and how that can be represented through paint.