Digital Commons Network^™

Genotype-Stratified Treatment For Monogenic Insulin Resistance: A Systematic Review, Robert K. Semple, Kashyap A. Patel, Sungyoung Auh, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy, Viswanathan Mohan, Shivani Misra, James B. Meigs, Nestoras Mathioudakis, Chantal Mathieu, Ronald C.W. Ma, Ruth J.F. Loos, Siew S. Lim, Lori M. Laffel

Clinical Research Faculty Publications

Background: Monogenic insulin resistance (IR) includes lipodystrophy and disorders of insulin signalling. We sought to assess the effects of interventions in monogenic IR, stratified by genetic aetiology. Methods: Systematic review using PubMed, MEDLINE and Embase (1 January 1987 to 23 June 2021). Studies reporting individual-level effects of pharmacologic and/or surgical interventions in monogenic IR were eligible. Individual data were extracted and duplicates were removed. Outcomes were analysed for each gene and intervention, and in aggregate for partial, generalised and all lipodystrophy. Results: 10 non-randomised experimental studies, 8 case series, and 23 case reports meet inclusion criteria, all rated as having …

Impact Of Individual And Environmental Factors On Dietary Or Lifestyle Interventions To Prevent Type 2 Diabetes Development: A Systematic Review, Dhanasekaran Bodhini, Robert W. Morton, Vanessa Santhakumar, Mariam Nakabuye, Hugo Pomares-Millan, Hugo Pomares-Millan, Christoffer Clemmensen, Stephanie L. Fitzpatrick, Marta Guasch-Ferre, James S. Pankow, Mathias Ried-Larsen, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Toni I. Pollin, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Rinki Murphy

Clinical Research Faculty Publications

Background: The variability in the effectiveness of type 2 diabetes (T2D) preventive interventions highlights the potential to identify the factors that determine treatment responses and those that would benefit the most from a given intervention. We conducted a systematic review to synthesize the evidence to support whether sociodemographic, clinical, behavioral, and molecular factors modify the efficacy of dietary or lifestyle interventions to prevent T2D. Methods: We searched MEDLINE, Embase, and Cochrane databases for studies reporting on the effect of a lifestyle, dietary pattern, or dietary supplement interventions on the incidence of T2D and reporting the results stratified by any effect …

The Use Of Precision Diagnostics For Monogenic Diabetes: A Systematic Review And Expert Opinion, Rinki Murphy, Rinki Murphy, Kevin Colclough, Toni I. Pollin, Jennifer M. Ikle, Pernille Svalastoga, Kristin A. Maloney, Kristin A. Maloney, Cécile Saint-Martin, Janne Molnes, Paul W. Franks, Stephen S. Rich, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Emily K. Sims, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Maria J. Redondo, Leanne M. Redman, Richard E. Pratley, Rodica Pop-Busui, Wei Perng, Ewan R. Pearson, Susan E. Ozanne, Katharine R. Owen, Richard Oram, Viswanathan Mohan, Shivani Misra, James B. Meigs

Clinical Research Faculty Publications

Background: Monogenic diabetes presents opportunities for precision medicine but is underdiagnosed. This review systematically assessed the evidence for (1) clinical criteria and (2) methods for genetic testing for monogenic diabetes, summarized resources for (3) considering a gene or (4) variant as causal for monogenic diabetes, provided expert recommendations for (5) reporting of results; and reviewed (6) next steps after monogenic diabetes diagnosis and (7) challenges in precision medicine field. Methods: Pubmed and Embase databases were searched (1990-2022) using inclusion/exclusion criteria for studies that sequenced one or more monogenic diabetes genes in at least 100 probands (Question 1), evaluated a non-obsolete …

Disease-Modifying Therapies And Features Linked To Treatment Response In Type 1 Diabetes Prevention: A Systematic Review, Jamie L. Felton, Kurt J. Griffin, Kurt J. Griffin, Richard A. Oram, Richard A. Oram, Cate Speake, S. Alice Long, Suna Onengut-Gumuscu, Stephen S. Rich, Stephen S. Rich, Gabriela S.F. Monaco, Carmella Evans-Molina, Linda A. Dimeglio, Heba M. Ismail, Andrea K. Steck, Dana Dabelea, Randi K. Johnson, Marzhan Urazbayeva, Stephen Gitelman, John M. Wentworth, Maria J. Redondo, Emily K. Sims, Emily K. Sims, Paul W. Franks, Robert Wagner, Tina Vilsbøll, Kimberly K. Vesco, Miriam S. Udler, Tiinamaija Tuomi, Arianne Sweeting, Jennifer L. Sherr, Robert K. Semple, Rebecca M. Reynolds, Leanne M. Redman

Clinical Research Faculty Publications

Background: Type 1 diabetes (T1D) results from immune-mediated destruction of insulin-producing beta cells. Prevention efforts have focused on immune modulation and supporting beta cell health before or around diagnosis; however, heterogeneity in disease progression and therapy response has limited translation to clinical practice, highlighting the need for precision medicine approaches to T1D disease modification. Methods: To understand the state of knowledge in this area, we performed a systematic review of randomized-controlled trials with ≥50 participants cataloged in PubMed or Embase from the past 25 years testing T1D disease-modifying therapies and/or identifying features linked to treatment response, analyzing bias using a …

Author Correction: Predicting Alzheimer’S Disease Progression Using Multi-Modal Deep Learning Approach (Scientific Reports, (2019), 9, 1, (1952), 10.1038/S41598-018-37769-Z), Garam Lee, Kwangsik Nho, Byungkon Kang, Kyung Ah Sohn, Dokyoon Kim, Michael W. Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John Morris, Leslie M. Shaw, Zaven Khachaturian, Greg Sorensen, Maria Carrillo, Lew Kuller, Marc Raichle, Steven Paul, Peter Davies, Howard Fillit, Franz Hefti, Davie Holtzman, M. Marcel Mesulam, William Potter, Peter Snyder, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter

Clinical Research Faculty Publications

Correction to: Scientific Reports, published online 13 February 2019 This Article contains errors. A Supplementary Information file was omitted from the original version of this Article. The Supplementary Information file is now linked to this correction notice.

Increased Lipogenesis Is Important For Hexavalent Chromium-Transformed Lung Cells And Xenograft Tumor Growth, James T.F. Wise, Kazuya Kondo

Faculty Publications

Hexavalent chromium, Cr(VI), is a known carcinogen and environmental health concern. It has been established that reactive oxygen species, genomic instability, and DNA damage repair deficiency are important contributors to the Cr(VI)-induced carcinogenesis mechanism. However, some hallmarks of cancer remain under-researched regarding the mechanism behind Cr(VI)-induced carcinogenesis. Increased lipogenesis is important to carcinogenesis and tumorigenesis in multiple types of cancers, yet the role increased lipogenesis has in Cr(VI) carcinogenesis is unclear. We report here that Cr(VI)-induced transformation of three human lung cell lines (BEAS-2B, BEP2D, and WTHBF-6) resulted in increased lipogenesis (palmitic acid levels), and Cr(VI)-transformed cells had an increased …

Deep Learning For Enhanced Free-Space Optical Communications, M. P. Bart, N. J. Savino, P. Regmi, L. Cohen, H. Safavi, H. C. Shaw, S. Lohani, T. A. Searles, B. T. Kirby, H. Lee, R. T. Glasser

Faculty Publications

Atmospheric effects, such as turbulence and background thermal noise, inhibit the propagation of light used in ON-OFF keying (OOK) free-space optical (FSO) communication. Here we present and experimentally validate a convolutional neural network (CNN) to reduce the bit error rate of FSO communication in post-processing that is significantly simpler and cheaper than existing solutions based on advanced optics. Our approach consists of two neural networks, the first determining the presence of bit sequences in thermal noise and turbulence and the second demodulating the bit sequences. All data used for training and testing our network is obtained experimentally by generating OOK …

Author Correction: Multiphoton Quantum Van Cittert-Zernike Theorem (Npj Quantum Information, (2023), 9, 1, (50), 10.1038/S41534-023-00720-W), Chenglong You, Ashe Miller, Roberto De J. León-Montiel, Omar S. Magaña-Loaiza

Faculty Publications

Correction to: npj Quantum Information, published online 26 May 2023 In the abstract for this article, the sentence “This fundamental theorem demonstrates that the quantum statistical fluctuations, which define the nature of diverse light sources, can be modified upon propagation in the absence of light-matter interactions” was inadvertently truncated after the text ‘quantum statistical fluctuations; the following text was missing ‘which define the nature of diverse light sources’. The original article has been corrected.

Multiphoton Quantum Van Cittert-Zernike Theorem, Chenglong You, Ashe Miller, Roberto De J. León-Montiel, Omar S. Magaña-Loaiza

Faculty Publications

Recent progress on quantum state engineering has enabled the preparation of quantum photonic systems comprising multiple interacting particles. Interestingly, multiphoton quantum systems can host many complex forms of interference and scattering processes that are essential to perform operations that are intractable on classical systems. Unfortunately, the quantum coherence properties of multiphoton systems degrade upon propagation leading to undesired quantum-to-classical transitions. Furthermore, the manipulation of multiphoton quantum systems requires nonlinear interactions at the few-photon level. Here, we introduce the quantum van Cittert-Zernike theorem to describe the scattering and interference effects of propagating multiphoton systems. This fundamental theorem demonstrates that the quantum …

Thermally Initiated Cationic Frontal Polymerization Of Epoxies And Vinyl Ethers Through A Lone Onium Salt, Brecklyn R. Groce, Madison M. Ferguson, John A. Pojman

Faculty Publications

Frontal polymerization (FP) of epoxy monomers is typically achieved with a radical-induced cationic frontal polymerization (RICFP) process that combines a thermal radical initiator with an onium salt superacid generator. In this paper, we show that both thermal and UV-initiated cationic frontal polymerizations are possible for common epoxy and vinyl ether monomers with only an iodonium superacid generator in the absence of a standalone thermal radical initiator. Increasing superacid generator concentration resulted in an increase in front velocity, as did the addition of vinyl ether to epoxies. The front velocity is reduced by the addition of 4-methoxyphenol (MeHQ), indicating free-radicals play …

Trends Of Autumn Phenology In Response To Environmental And Meteorological Variables, Meagan Renee Maguire

Masters Theses

Previous studies have identified that changes in plant phenology are most likely induced by climate variability. One such change is the end of season (EOS) for deciduous forests in the United States. In essence, the EOS represents the end of plant productivity for a given year; the phase in which plant dormancy is reached. However, our wealth of knowledge on plant phenology largely overlooks the phases that occur in autumn, especially the EOS, with many previous studies focusing on spring phenology. This study uses remote sensing MODIS aerial imagery data and historical meteorological data to analyze any relationships that may …

Educational Interests And Information-Seeking Behaviors Of Utah Residents, Amanda D. Ali, Lendel K. Narine

Journal of Human Sciences and Extension

With a limited body of literature examining residents’ preferences for Extension topic areas, this brief report examined the educational interests of Utah residents. It explores opportunities for future programming based on residents’ preferences for topic areas and their information-seeking behaviors. Data were gathered from Utah residents in May 2021 via an online Qualtrics survey (n = 668). Results showed the topics of highest interest to Utah residents were strengthening family relationships, emergency preparedness, mental health, food storage, and healthy couples’ relationships. Residents’ information-seeking behaviors were somewhat consistent with their interests; residents searched most frequently for information on mental health, strengthening …

Equipping Extension Professionals To Lead Volunteer Systems: An Evaluation Of An Online Course, Kandi O'Neil, Rachelle Vettern, Sarah Maass, Rebecca Harrington, Kari Robideau, Patricia Mcglaughlin, Josset Gauley

Journal of Human Sciences and Extension

Extension professionals enter their role with content-specific expertise; however, experience in volunteer leadership and management competencies is often limited. This study focused on the effectiveness of the Achieving the Extension Mission Through Volunteers (AEMTV) course in preparing professionals to use the Identification, Selection, Orientation, Training, Utilization, Recognition, Evaluation (ISOTURE) model to learn and apply volunteer systems concepts in a cohort-based online learning environment. We used quantitative and qualitative methods to assess how the course impacted participants and the programs they lead. Data from 127 participants indicated they increased their knowledge, improved volunteer systems, and influenced the quality of programming delivered …

Determining The Health Literacy Skills Of Extension Audiences In Maryland, Beverly Jackey, Heejung Song, Lisa Mccoy, Virginia Brown

Journal of Human Sciences and Extension

Strong health literacy skills empower people to make informed health decisions, especially those with chronic health conditions striving for positive health outcomes. Half of all people living in Maryland report having at least one chronic disease. Research examining the health literacy of Marylanders is limited. This paper reports how establishing a baseline for health literacy levels of Marylanders can identify major factors affecting the health literacy skills of Extension audiences and lays the important groundwork to develop Extension programs and explore the best delivery methods tailored to the needs of subpopulations. Using the Newest Vital Sign, a …

Self-Reflections Through A Screen: Self-Identity, Social Media, And Psychological Well-Being, Jeremy J. Serio

Undergraduate Honors Thesis Collection

Social media use among emerging adults is assumed to be related to a variety of negative psychological outcomes and has, in recent years, become a widely studied phenomenon (Kim, 2017, Pew Research Center, 2018). Despite the widespread assumption, the results from empirical studies of the effects of social media use on mental health in this population have been inconsistent and inconclusive (Keles et al., 2020, Yang et al., 2021). Several meta-analyses (e.g., Keles et al., 2020) demonstrate these inconsistent results across studies and point to the need to consider individual difference factors when researching this issue. Different self-identity styles have …

Distributionally Robust Optimization Through The Lens Of Submodularity, Karthik Natarajan, Divya Padmanabhan, Arjun Ramachandra

Working Papers

Distributionally robust optimization is used to solve decision making problems under adversarial uncertainty where the distribution of the uncertainty is itself ambiguous. In this paper, we identify a class of these instances that is solvable in polynomial time by viewing it through the lens of sub modularity. We show that the sharpest upper bound on the expectation of the maximum of affine functions of a random vector is computable in polynomial time if each random variable is discrete with finite support and upper bounds (respectively lower bounds) on the expected values of a finite set of submodular (respectively supermodular) functions …

Policy For A Singular Neurodevelopmental Disorder: A Multiple Streams Analysis Of The Combating Autism Act Of 2006 Using Kingdon’S Framework, Michelle C. Fong

Integrative Learning Experience (ILE) Theses

The Combating Autism Act of 2006 (CAA) is a single-disorder law for the population with autism spectrum disorder (ASD), one of six neurodevelopmental disorders (NDDs). All NDDs have common origins, overlapping symptoms, and lifelong adverse individual and societal impacts. Yet, no analogous policy exists for the other NDDs. The inequity between related disorders is a curiosity, and moreover, it results in health and economic inequities with devastating consequences. This analysis examines the conditions that led to the CAA, which has been reauthorized three times since 2006 and is now known as the Autism Collaboration, Accountability, Research, Education, and Support (CARES) …

Exploring The Impact Of High-Temperature Stress On Physiological, Anatomical, Molecular, Productive, And Quality Parameters In Diverse Olive Cultivars, Bassam F. Alowaiesh, Taghreed S. Alnusaire

The Philippine Agricultural Scientist

Olive (Olea europaea L.) is one of the most important horticultural crops in Saudi Arabia. High temperatures are typical in most regions during the summer season. This study explored the effect of high temperatures on diverse olive cultivars (Manzanillo, Chemlali, and Picual) grown in three different geographical locations in Saudi Arabia (Sakaka, Basita, and Al-Qurayyat). Sakaka region was classified as a hot region, while the Basita and Al-Qurayyat regions were characterized by relatively mild or low temperatures. Genotypic components were assessed by studying Amplified Fragment Length Polymorphism (AFLP) molecular markers and physiological, anatomical, productive, and oil quality parameters. The …

Implementation Of A Protocol To Improve The Intake Assessment And Treatment With Suboxone Among Patients’ Dependent On Opioids On Two Mental Health Crisis Units, Maeghan Dillon

Doctor of Nursing Practice Scholarly Projects

Abstract

Background: In 2021,106,699 people died from a drug overdose and of these deaths, over 75% were related to illicit or prescription opioids (Centers for Disease Control, 2023). At two in-patient community crisis stabilization units for psychiatric care, many patients have a comorbid diagnosis of a substance use disorder and another mental illness. Treatment with Buprenorphine/naloxone (Suboxone) is associated with decreased opioid overdoses and related deaths; however, Suboxone inductions have not been a part of admission treatment.

Methods: This quality improvement (QI) project initiated a Suboxone protocol for eligible patients on two crisis in-patient stabilization units. The outcomes …

Justice Delayed: Government Officials' Authority To Wind Down Constitutional Violations, Neil H. Buchanan, Michael C. Dorf

UF Law Faculty Publications

Upon finding that a government program is unconstitutional, courts in the United States sometimes allow executive officials a grace period to wind it down rather than insisting on its immediate cessation. Courts likewise occasionally afford a legislature a grace period to repeal an unconstitutional law. Yet no one has even attempted to explain the source of authority for allowing ongoing constitutional violations or to prescribe the limits on permissible compliance delays. Until now.

Judicial toleration of a continuing constitutional violation can be conceptualized as an exercise of the equitable discretion to withhold injunctive relief, but that rationale does not justify …

Why Moffet Matters Now, Stephen Lafer, Jonathan M. Marine

The Journal of the Assembly for Expanded Perspectives on Learning

James Porter Moffett (1929–1996) was a ground-breaking teacher, author, and theorist of language learning who had a profound impact on the fields of English Education, Language Arts, Composition, and Educational Psychology in the mid to late 20th century and was the first member of the Assembly for Expanded Perspectives on Learning (AEPL). In the inaugural Moffett’s Corner, Steve Lafer and Jonathan Marine discuss how they came together, why they wanted to start this column, and what they hope to accomplish.

Getting Beyond “Craap”: Scientific Literacy In Fyw And Wad, Erica Duran, Lauren M. Springer

The Journal of the Assembly for Expanded Perspectives on Learning

While first-year writing (FYW) programs often bear the responsibility for teaching students to write across the disciplines (Downs and Wardle), too often students restrict the concepts learned in FYW to the humanities, or even worse, a single class. Moreover, students frequently complete research assignments in FYW which restrict them to scholarly or peer-reviewed sources, hindering their ability to learn how to assess popular sources. This can be especially problematic with scholarly STEM sources, which are laden with unfamiliar technical terms. Although the writing and research skills learned in FYW are often intended to be interdisciplinary, FYW faculty have opportunities to …

The Dynamics Of Informal Institutions And Counter-Hegemony: Introducing A Brics Convergence Index, Mihaela Papa, Zhen 'Arc' Han, Frank O'Donnell

Political Science & Global Affairs Faculty Publications

Informal institutions are important platforms for renegotiating global governance, but there is disagreement on how they operate and challenge the United States (US). Realists view some informal institutions like Brazil, Russia, India, China and South Africa (BRICS) as counter-hegemonic entities, while rational institutionalists focus on their structure and performance in specific areas. However, neither approach explains the internal dynamics that make these institutions robust and potentially counter-hegemonic. To fill this gap, we first develop a new convergence approach for analysing informal institutional dynamics, and then we apply this approach to examine BRICS robustness and BRICS–US relations. Our BRICS Convergence Index …

Reforming The New York Lieutenant Governor Replacement Process: A Policy Recommendation, Fordham Law School Rule Of Law Clinic, Spencer Shih, Chase Cooper, Harry Solomon

Rule of Law Clinic

New York's governor has unilateral power to fill vacancies in the lieutenant governor's office. This unchecked power is undemocratic and risks elevating unqualified officials. In this report, the Fordham Law School Rule of Law Clinic recommends reforming the lieutenant governor replacement process. Building on a recommendation advanced by the New York State Bar Association, the clinic recommends providing the Legislature an opportunity to confirm the governor's nominees. If the Legislature rejects two nominations, the governor could choose a new lieutenant governor from among a group of elected and Senate-confirmed officials.

A Cross-Sectional Analysis Of The Sports Nutrition Knowledge, Attitudes, And Behaviors Among Student Athletes At The University Of Alaska Anchorage, Emily J. Thompson

Student Projects for Graduate Degrees

Nutrition is essential for college athletes. However, many athletes may not meet nutrition recommendations for their specific sport due to a lack of knowledge or because they do not believe that proper nutrition is essential for their performance. To ensure that programs best meet the needs of athletes, it is important to understand athletes’ current knowledge, attitudes, and behaviors (KAB) related to sports nutrition to improve nutritional awareness and elicit desired behavior change. The idea that improving KAB can lead to behavior change specific to nutrition is well-studied and has its foundations in social cognitive theory. However, there is a …

Continuing Education Program For Paraprofessionals At The Special Supplemental Nutrition Program For Women, Infants, And Children, Brianna Ussery

Student Projects for Graduate Degrees

The Special Supplemental Nutrition Program for Women, Infants and Children (WIC) in Alaska uses paraprofessionals to determine nutrition risk and provide education for their clients. Through discussions with administration and other staff at Alaska’s state WIC office, it was determined that there was a need for more in-depth nutrition education for paraprofessionals. Specific educational topics were identified by WIC nutrition experts and from client feedback. These topics included vitamin D, iron, portion sizes, picky eating and bottle weaning, and food safety. An e-learning portfolio was developed around these 5 topics to provide further education for paraprofessionals through stand-alone modules. This …

December 1, 2023 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

In Modeling Digital Learning, Remember Pictorial Competence., Georgene Troseth, Gabrielle Strouse

School of Education Faculty Publications

Barr and Kirkorian summarize decades of research about young children’s learning and transfer from screen media, offer a new theoretical model of factors involved in early multimedia learning, and suggest a future research agenda to study learning from commercial media products “in the wild” of everyday family life outside the lab. In this commentary, the authors offer background on the development of symbolic understanding and “pictorial competence” for young children’s learning from screen media and attempt to deepen the discussion of cognitive factors and individual differences that affect early learning.

States As Laboratories: Colorado Constitution (Reactants) + Independent State Constitutionalism (Catalyst) = Constitutional Lgbtq+ Protections (Products), Pelecanos

Denver Law Review

This Article began as a research project on the current state of LGBTQ+ rights under the Constitution of the State of Colorado during an internship at the American Civil Liberties Union of Colorado. It quickly became an extensive examination of state constitutionalism, Colorado history, and queer theory. Ultimately, this Article imagines how the Colorado Supreme Court might interpret Colorado constitutional provisions to create more protections for LGBTQ+ people.

Passing The Buck: The Perils Of Oklahoma V. Castro-Huerta, Adam Crepelle, Timothy Purdon, Brendan Johnson

Denver Law Review

The Supreme Court’s 2022 decision in Oklahoma v. Castro-Huerta upended federal Indian law by allowing states to prosecute crimes involving Indians committed in Indian country. Castro-Huerta created a concurrent jurisdiction over Indian country crimes involving non-Indians. While concurrent jurisdiction increases the number of law enforcement agents with jurisdiction, it also creates opportunities for those law enforcement agents to shirk responsibility. Neither state nor federal law enforcement is accountable to tribes, so Castro-Huerta is likely to create a pass the buck mentality among non-Indian law enforcement. Moreover, there is little to indicate expanding state authority over tribes will benefit Indians. In …