Digital Commons Network^™

Two-Pore Channel-2 And Inositol Trisphosphate Receptors Coordinate Ca2+ Signals Between Lysosomes And The Endoplasmic Reticulum, Yu Yuan, Vikas Arige, Ryo Saito, Qianru Mu, Gabriela C. Brailoiu, Gustavo J.S. Pereira, Stephen R. Bolsover, Marco Keller, Franz Bracher, Christian Grimm, Eugen Brailoiu, Jonathan S. Marchant, David I. Yule, Sandip Patel

College of Pharmacy Faculty Papers

Lysosomes and the endoplasmic reticulum (ER) are Ca2+ stores mobilized by the second messengers NAADP and IP3, respectively. Here, we establish Ca2+ signals between the two sources as fundamental building blocks that couple local release to global changes in Ca2+. Cell-wide Ca2+ signals evoked by activation of endogenous NAADP-sensitive channels on lysosomes comprise both local and global components and exhibit a major dependence on ER Ca2+ despite their lysosomal origin. Knockout of ER IP3 receptor channels delays these signals, whereas expression of lysosomal TPC2 channels accelerates them. High-resolution Ca2+ imaging reveals elementary events upon TPC2 opening and signals coupled to …

The Legality Of Military Involvement In Law Enforcement Operations Against Criminal Armed Groups In Indonesia’S Papua Province, Sefriani -, Nur Gemilang Mahardhika

Asia-Pacific Social Science Review

This paper intends to (a) analyze whether the conflict in Papua meets the requirements to be categorized as a non-international armed conflict (NIAC) and (b) analyze the legality of the involvement of Indonesian National Armed Forces (Tentara Nasional Indonesia, TNI) in the Papuan conflict using the principles found in international human rights law and international humanitarian law. This normative juridical research employs the conceptual, statutory, and comparative approaches. The results of the study indicate that the threshold of NIAC has not been met in the Papuan conflict, especially the requirements for determining the organized armed groups, as well as the …

Learners’ Beliefs And Teachers’ Practice Of Grammar- Focused Written Corrective Feedback In The Malaysian Primary Esl Classrooms: A Pilot Study, Kuet Poh Pui, Wun Chiew Pung, Ai Ping Ho

Asia-Pacific Social Science Review

Written corrective feedback (WCF) is utilized by language teachers to address learners’ mistakes in writing. Although WCF studies should strike a balance between the viewpoints of teachers and learners, studies that focused on learners, especially young learners, have been limited. This study investigated Malaysian primary school learners’ beliefs of how they would like to receive written corrective feedback to grammatical mistakes (GWCF) in their essays, as well as what teachers actually did when providing GWCF in learners’ essays. Findings from the survey showed that the majority of the learners believed all the grammatical mistakes in writing should be indicated and …

Factors Associated With Postacute Covid-19 Syndrome Among Patients In Malaysia, Ahtheemathurra Ballasingam, Farida Islahudin, Siti Azdiah Abdul Aziz, Mohd Makmor-Bakry

Makara Journal of Health Research

Background: Post-acute COVID-19 is known to affect multiple organs. It is essential to determine factors that affect post-acute COVID-19 syndrome and medications needed by patients for optimized care.

Methods: A prospective cohort study was conducted among patients recruited by stratified sampling from two COVID-19 hospitals in Malaysia. Patients were followed up for 6 months using a standard questionnaire to identify demographics, symptoms, medications taken, and factors associated with post-acute COVID-19 syndrome.

Results: A total of 388 were successfully followed up. The most frequently reported symptom was respiratory symptoms (N = 168, 43.30%), of which cough (N = …

Russian Authoritarian Discourse Of The 20th And 21st Centuries As A Subject Of Study In The University Classroom, Yulia Denisova

Russian Language Journal

The ability of students to recognize and interpret various forms of propagandist speech within the context of authoritarian discourse is crucial for effective information literacy education. This article emphasizes the need to introduce a specialized section within university courses on Russian cultural history for foreign students learning Russian. We propose naming this section “Russian Authoritarian Discourse: Features of Propaganda Language.” Focusing on the relationship between language and social structures and exploring the typology of linguistic situations shaped by social factors, the proposed section is grounded in a sociolinguistic approach. The article presents practical tools for analyzing real-life and immediately relevant …

Tracking Current Events In The Russian-Language Classroom, Cori Anderson, Daniel Brooks

Russian Language Journal

Given weaponized disinformation about recent US elections and the ongoing Russian invasion of Ukraine, media literacy has become an essential part of a 21st-century liberal arts education, in line with the AAC&U’s Essential Learning Outcomes. By including news media in the language classroom, instructors can introduce students to the products and practices of the target culture and enhance their comprehension of Russian-language texts. We describe a current events blog project, appropriate at any level of instruction, with specific examples from second- and sixth-semester university-level Russian-language courses. Students follow current events in the Russian-speaking world on a topic of their choosing, …

Constructing A Course On Russian Media Analysis For Learners At Ilr 3+/4 Proficiency, Olga Mukhortova

Russian Language Journal

The proficiency movement of the 1980s and ‘90s in foreign language teaching and learning demonstrated that U. S. students can attain Intermediate-level proficiency by the end of a four-year post-secondary course of study. Language programs can now pay more attention to enabling students to reach the Advanced1 and Superior levels (ACTFL, 2012; Interagency Language Roundtable (ILR); Martin, 2020, p. 43). One can observe the particular demand for ILR 3/4 speakers from the U. S. government in the diversity of state-sponsored initiatives in foreign languages aiming for Superior-level (ILR 3/3+) and higher proficiency. Understandably, the need for speakers of Russian at …

Digital Dissidence: Russian Foreign Agents And The Media Of Opposition, Matthew Mangold

Russian Language Journal

Over the last ten years the Russian state has veered steadily toward authoritarianism, passing new socially repressive laws and harnessing television and radio to state propaganda and disinformation about Ukraine and the west. At the same time, platforms like Vimeo and Youtube have made uploading, sharing, and viewing digital content in high-quality formats more accessible to author-producers and viewers globally. These social changes have been followed by a movement of independent, fact-grounded digital storytelling built on documentary forms and deft investigative reporting that reveals the Russian state’s negligence, corruption, and efforts at social control. This article addresses the digital environment …

Enough Excuses On Drug Importation: A New Transnational Paradigm For Fda Regulation And Lower Us Drug Prices, Gabriel Levitt

Brooklyn Journal of International Law

The US Food and Drug Administration (FDA), which enforces drug safety laws, asserts that under most circumstances the importation of prescription drugs is illegal. Yet because of high drug prices in the United States, over the past couple of decades, tens of millions of Americans have imported prescription drugs for personal use. For many, this was their only way to afford them. A unique array of federal laws, regulations, and policies, including the de facto decriminalization of the practice of personal drug importation, have in effect permitted personal drug importation. The same exceptions, however, are not available for commercial drug …

Enterprise, Liability, And Insolvency: An Essay In Honor Of Aaron Twerski, Edward J. Janger

Brooklyn Journal of Corporate, Financial & Commercial Law

Modern tort law links concepts of duty, duty of care, causation, and compensatory damages in a manner that, it is hoped, simultaneously communicates moral suasion, redresses wrongs, and incentivizes “reasonable” socially appropriate behavior. Deterrence and corrective justice differ fiercely about the scope of and rationale for liability, but both assume that tortfeasors are good for their debts (or at least insured). This is not always the case. Sometimes, debtors are insolvent. Bankruptcy law provides individuals with a route to a fresh start, and this paper considers the relationship between modern tort law and the discharge of debt in bankruptcy. The …

Predictive Metabolites For Incident Myocardial Infarction: A Two-Step Meta-Analysis Of Individual Patient Data From Six Cohorts Comprising 7897 Individuals From The Consortium Of Metabolomics Studies, Ana Nogal, Taryn Alkis, Yura Lee, Domagoj Kifer, Jie Hu, Rachel A Murphy, Zhe Huang, Rui Wang-Sattler, Gabi Kastenmüler, Birgit Linkohr, Clara Barrios, Marta Crespo, Christian Gieger, Annette Peters, Jackie Price, Kathryn M Rexrode, Bing Yu, Cristina Menni

Faculty, Staff and Student Publications

AIMS: Myocardial infarction (MI) is a major cause of death and disability worldwide. Most metabolomics studies investigating metabolites predicting MI are limited by the participant number and/or the demographic diversity. We sought to identify biomarkers of incident MI in the COnsortium of METabolomics Studies.

METHODS AND RESULTS: We included 7897 individuals aged on average 66 years from six intercontinental cohorts with blood metabolomic profiling (n = 1428 metabolites, of which 168 were present in at least three cohorts with over 80% prevalence) and MI information (1373 cases). We performed a two-stage individual patient data meta-analysis. We first assessed the associations …

The Effect Of Bakuchiol In The Skin Aging Process: A Systematic Review, Olivia Jovina Priyanto, Yosef Ferdinand Rahmat Sugiyanto, Darryl Samuel Salim

Journal of General - Procedural Dermatology and Venereology Indonesia

Background: With aging, the skin gradually loses its structural and morphological coherence, decreasing its function. With aging and chronic ultraviolet (UV) exposure, the skin becomes thin and loses elasticity, and wrinkles, pigmentation, and texture irregularities appear. Today, people of all ages become interested in the cosmetic industry, aiming to make their skin appropriate to their age or look younger. Bakuchiol is a pure meroterpene phenol found mainly in the seeds of the Indian plant Psoralea corylifolia (babchi). It triggers antioxidant and anti-inflammatory activity and has anti-aging properties like retinol. The study aimed to know the effect of bakuchiol on …

Psychometric Properties And Factor Of Intercultural Competence Based On The Intercultural Development Continuum For Undergraduate Students, Pisit Banchong, Chayut Mutuwong, Jutathip Ngoenbamrung, Pitchanan Mahantagasi, Nuttaporn Lawthong

Journal of Education Studies

The purpose of this research is to analyze the psychometric properties and components of intercultural competence using the concept of the Intercultural Development Continuum. The sample consisted of 131 undergraduate students in the Faculty of Education. The research tool was a situational test for evaluating intercultural competence. Data were analyzed using content validity, Exploratory Factor Analysis (EFA), correlation coefficients, variance analysis, and difficulty and discriminant analysis using the Graded-Response Model (GRM). The research findings indicate that: 1) The questions were all content-valid. 2) Intercultural competence comprises three components, namely (1) conflict management, (2) respecting differences in ideas and (3) adhering …

Financial Contagion And Financial Lockdowns, Gabriele Camera, Alessandro Gioffré

ESI Working Papers

Extreme financial shocks often elicit extraordinary policy interventions that preclude financial activity on a large scale, for example as the 1933 U.S. “bank holiday.” We study these interventions using a random matching framework where the financial contagion process is explicit and the diffusion of the initial shock can be analytically characterized. The study suggests that there is scope for forced closures of individual firms or even economy-wide financial lockdowns only when firms are financially vulnerable and policy institutions are not well-functioning. Here, ordinary policy alone cannot prevent or sufficiently mitigate contagion, while complementing it with a lockdown or individual closures …

Application Of Quantum Algorithms In The Synthesis Of Dynamic Objects, Noilakhon Yakubova

Chemical Technology, Control and Management

Around the world, the food industry is focusing on achieving energy and resource efficiency. One of the main challenges in the field of process automation is the creation of effective control systems using intelligent technologies to improve the quality of processes and achieve the production of high-quality products with less energy and resources. Therefore, it is necessary to work with a large amount of data. Particular attention is paid to the development of computational algorithms for automated high-speed computational analysis systems for processing this data at high speed. Therefore, the article discusses the use of quantum computing methods in controlling …

Altered Outer Retinal Structure, Electrophysiology And Visual Perception In Parkinson's Disease, Katie K N Tran, Pei Ying Lee, David I Finkelstein, Allison M Mckendrick, Bao N Nguyen, Bang V Bui, Christine T O Nguyen

Faculty, Staff and Student Publications

BACKGROUND: Visual biomarkers of Parkinson's disease (PD) are attractive as the retina is an outpouching of the brain. Although inner retinal neurodegeneration in PD is well-established this has overlap with other neurodegenerative diseases and thus outer retinal (photoreceptor) measures warrant further investigation.

OBJECTIVE: To examine in a cross-sectional study whether clinically implementable measures targeting outer retinal function and structure can differentiate PD from healthy ageing and whether these are sensitive to intraday levodopa (L-DOPA) dosing.

METHODS: Centre-surround perceptual contrast suppression, macular visual field sensitivity, colour discrimination, light-adapted electroretinography and optical coherence tomography (OCT) were tested in PD participants (n = …

Kids Having Kids: Perspectives Of Adolescents And Young Adults Of Los Baños, Laguna, Philippines On Teenage Pregnancy, Alvaro Calara, Irene R. Tanzo, Mara Sherleen D.G. Talento

Asia-Pacific Social Science Review

The study focused on establishing the knowledge, attitude, and behavior of Grade 12 learners about teenage pregnancy (TP). The study was conducted among students from different high schools in Los Baños, Laguna. As a municipality, Los Baños has manifested a relatively high case of TP over the last 10 years from 2009 to 2018. A mixed method was used, which started with focus group discussions (FGD) that were geared towards survey implementation. Three FGDs were completed with a mixture of male and female participants. The survey had a total of 42 respondents. Results showed that students had high knowledge scores …

الدور الوسيط لسـلوكيات التسيس التنظيمي فى العلاقة بين الأنومية التنظيمية والانحراف التنظيمي: دراسة تحليلية لأراء عينة من الأفراد العاملين في مستشفيات جامعة المنصورة بمصر, سامر احمد محمد

Muthanna Journal of Administrative and Economics Sciences

أن الغرض من هذا البحث هو تحري عن العلاقة بين الأنومية التنظيمية وسلوكيات التسييس التنظيمي والانحراف التنظيمي لعينة من جميع العاملين بمستشفيات جامعة المنصورة، وبالاعتماد على عينة عشوائية طبقية من العاملين بالجهة محل الدراسة تم توزيع عدد (360) استمارة استبانة وبلغت قوائم الاستقصاء الصحيحة (277) قائمة بمعدل اســــتجابة (77٪)، وتم تحــليل البيانات باســــتخدام أســــلوب نمذجة المعـــادلة الهيكلية (PLS-SEM)، بواســـــطة برنامج (26.V AMOS)، (26. (SPSS V، وتبرز أهمية البحث من ندرة الدراسات التي اهتمت بتحديد طبيعة العلاقة الأنومية التنظيمية وسلوكيات التسييس التنظيمي والانحراف التنظيمي ووجود مشكلة واقعية تؤثر بشكل كبير على الأداء بمستشفيات جامعة المنصورة، وأظهرت النتائج النظرية وجود فجوة معرفية …

The Impact Of Isil And Covid-19 On The Financial Performance Of Banks Listed On The Iraq Stock Exchange: A Comparative Study, Farqad Faisal Jadaan Sallal

Muthanna Journal of Administrative and Economics Sciences

This study aims to demonstrate the impact of the ISIL crisis and the COVID-19 pandemic crisis on the financial performance of banks listed on the Iraq Stock Exchange by comparing the profitability ratios of the banks in the research sample. In order to achieve this aim, a sample of 10 banks listed on the Iraq Stock Exchange was selected for the period 2011-2021. Using annual financial reports for the periods before and after the emergence of ISIS. Before and after the emergence of the COVID-19 pandemic, the profitability ratios were extracted (represented by return on assets, equity, and deposits). The …

Genetic Inactivation Of Β-Catenin Is Salubrious, Whereas Its Activation Is Deleterious In Desmoplakin Cardiomyopathy, Melis Olcum, Siyang Fan, Leila Rouhi, Sirisha Cheedipudi, Benjamin Cathcart, Hyun-Hwan Jeong, Zhongming Zhao, Priyatansh Gurha, Ali J Marian

Faculty, Staff and Student Publications

AIMS: Mutations in the DSP gene encoding desmoplakin, a constituent of the desmosomes at the intercalated discs (IDs), cause a phenotype that spans arrhythmogenic cardiomyopathy (ACM) and dilated cardiomyopathy. It is typically characterized by biventricular enlargement and dysfunction, myocardial fibrosis, cell death, and arrhythmias. The canonical wingless-related integration (cWNT)/β-catenin pathway is implicated in the pathogenesis of ACM. The β-catenin is an indispensable co-transcriptional regulator of the cWNT pathway and a member of the IDs. We genetically inactivated or activated β-catenin to determine its role in the pathogenesis of desmoplakin cardiomyopathy.

METHODS AND RESULTS: The Dsp gene was conditionally deleted in …

Exploring Basic Science Knowledge Retention Within A Cohort Of Undergraduate Medical Students In The United Kingdom: A Longitudinal Study, Idrees Zafar, John Chilton, James Edwards, Helen Watson, Daniel Zahra

Peninsula Medical School

Background Clinical reasoning is reliant on students having acquired a strong foundation in the basic sciences. However, there remains uncertainty regarding whether medical students are maintaining this knowledge over the span of their degrees. Therefore, this project aimed to assess long-term retention of basic science knowledge within a cohort of students from an undergraduate medical school in the United Kingdom (UK). Methods This longitudinal study followed a cohort of students, from their first to final year. In their final year, participants sat a bespoke formative basic science knowledge assessment that utilised 46 single-best-answer questions. To examine for long-term attainment differences, …

Dual Mode Control Of An Inverted Pendulum: Design, Analysis And Experimental Evaluation, Laura Alvarez Hidalgo, Ian Howard

School of Engineering, Computing and Mathematics

We present an inverted pendulum design using readily available V-slot rail components and 3D printing to construct custom parts. To enable the examination of different pendulum characteristics, we constructed three pendulum poles of different lengths. We implemented a brake mechanism to modify sliding friction resistance and built a paddle that can be attached to the ends of the pendulum poles. A testing rig was also developed to consistently apply disturbances by tapping the pendulum pole, characterizing balancing performance. We perform a comprehensive analysis of the behavior and control of the pendulum. This begins by considering its dynamics, including the nonlinear …

Molecular Docking Analysis Of Acanthus Ilicifolius Compounds Toward Cul4b-Ddb1-Ahr-Erα Complex Protein For Antiosteoporosis Discovery, Binar Asrining Dhiani, Sarmoko Sarmoko, Retno Wahyuningrum, Akbar Yulianto

Pharmaceutical Sciences and Research

Osteoporosis represents a significant global public health issue, particularly among the aging population. Its incidence reaches 18.3% of the total population, with the highest prevalence observed in elderly postmenopausal women. A key factor in osteoporosis is the decreased expression level of estrogen receptor alpha (ERα), attributed to its degradation by the ubiquitin ligase protein complex Cullin4B (CUL4B), DNA damage binding 1 (DDB1), and aryl hydrocarbon receptor (AhR), collectively known as CUL4BAhR. Acanthus ilicifolius L contains compounds exhibiting antiosteoporosis activity, primarily by inhibiting osteoclastogenesis via RANKL. However, no reports exist of antiosteoporosis agents that act by inhibiting ERα degradation via CUL4BAhR. …

Current Practice In The First Aid Management Of Epistaxis By Nursing Staff Working At The Emergency Departments Of Baghdad Hospitals, Baseem Natheer Abdulhadi

Muthanna Medical Journal

In otolaryngology, epistaxis—nosebleeds—are prevalent and severe. It is estimated that 10% to 60% of people will have at least one serious episode in their lives. This research will question people on how they stop nosebleeds and compare their replies to the medically recommended practice. This cross-sectional study assessed 105 paramedics in Baghdad's Emergency Wards, focusing on their demographics, education, and experience in managing epistaxis (nosebleeds). Key evaluation areas included the patient's position, pressure application on the nose, duration and method of pressure, use of nasal packs, ice application, and decision-making about when to call specialists. Their skills were scored on …

The Nexus Between Teaching And Research: Exploring The Synergies That Drive Innovation, Joseph Ching Velasco

Asia-Pacific Social Science Review

No abstract provided.

A Study On The Influence Of Digital Finance On Bank Account Ownership Of Filipinos, Ian Carlo Antonio, Maire Carroline Magante

Asia-Pacific Social Science Review

Financial inclusion remains a recurring problem that various governments need to address. Despite digitalization, financial institutions struggle to make their products and services available to the public. The Philippines has among the weakest financial inclusion coverages, as shown by the minimal account penetration of the population. This study used the 2019 Financial Inclusion Survey (FIS), specifically mobile phone usage in financial transactions and other socioeconomic characteristics as determinants of financial inclusion measured by bank account ownership. The findings show that mobile phones, financial literacy, and urbanity remain as significant players in accessing financial products and services, but in varying degrees …

Surgical Approaches For Thoracic Outlet Decompression In The Treatment Of Thoracic Outlet Syndrome, Stijn B. J. Teijink, Jens Goeteyn, Niels Pesser, Bart F. L. Van Nuenen, Robert W. Thompson, Joep A. W. Teijink

2020-Current year OA Pubs

Thoracic outlet syndrome (TOS) is a controversial and uncommon syndrome. Three different diagnoses can be made based on the compressed structure: arterial TOS, venous TOS, and neurogenic TOS. Diagnosing TOS, especially neurogenic TOS, remains difficult since a single diagnostic tool does not exist. Although this resulted in a lot of confusion, standardization of care and outcome improved daily care practice measures in the last decade. Current treatment algorithms consist of both conservative and surgical treatment approaches, which should be chosen depending on the type of TOS and extend of the complaints. Surgical treatment of TOS is performed via thoracic outlet …

Dual Effect Of Secondary Solutes On Binding Equilibria: Contributions From Solute–Reactant Interactions And Solute–Water Interactions, Daryl Eggers, Jennifer M. Le, Nhi T. Nham, Duc N. Pham, Bria M. Castellano

Faculty Research, Scholarly, and Creative Activity

This study examines the role of water in binding equilibria with a special focus on secondary solutes (cosolutes) that influence the equilibrium but are not constituents of the final product. Using a thermodynamic framework that includes an explicit term for the release of water molecules upon binding, this investigation reveals how solutes may alter equilibria by changing the activity of the reactants, reflected in ΔG°(obs), and by changing the chemical potential of the solvent, reflected in ΔGS. The framework is applied to four experimental binding systems that differ in the degree of electrostatic contributions. The model …

Impact Of Psychiatry Clerkship Rotation In Attitudes Towards Mental Illness And Psychiatry As A Career Among Medical Students, Jae Kim, Brian Blum, Shivani Kaushal, Sara Khan, Patrick Hardigan, Clara Alvarez Villaba

HCA Healthcare Journal of Medicine

Background

Stigma associated with mental illness (MI) permeates many professions, including healthcare. Recognizing and correcting bias is critical in delivering impartial and beneficial healthcare for all patients. Early educational interventions providing exposure to individuals with MI have shown to be effective at reducing MI stigma. The primary aim of our study was to assess the impact of a psychiatry clerkship on attitudes to MI. A secondary aim was to determine if the psychiatry clerkship influenced medical students’ perceptions of psychiatry as a career.

Methods

A cohort of third-year medical students in Florida was invited to complete an online survey before …

Factors Influencing The Occurrence Of Rework In Terms Of Risk-Based Communication Management In Construction Projects, Virani Mayniana, Rossy Armyn Machfudiyanto

Smart City

Rework in a construction project is an unplanned and unwanted activity that requires an action to repeat part or all the work to meet project standards or requirements and, in its implementation, causes increased work, time, and costs. Based on previous studies that discuss the factors that cause rework, poor communication management or coordination between stakeholders is one of the causes of rework. Therefore, a literature study was conducted to identify project communication management risks that allow rework to occur and resulted in 54 communication management risk factors. Furthermore, the results of the literature study were validated by experts who …