Digital Commons Network^™

Investigating Trial Design Variability In Trials Of Disease-Modifying Therapies In Parkinson’S Disease: A Scoping Review Protocol, Marie Louise Zeissler, Timothy Boey, Danny Chapman, Gary Rafaloff, Thea Dominey, Karen G. Raphael, Susan Buff, Hari Venkatesh Pai, Emma King, Paul Sharpe, Fintan O’Brien, Camille B. Carroll

Peninsula Medical School

Introduction Parkinson’s disease (PD) is a debilitating neurological disorder for which the identification of disease-modifying interventions represents a major unmet need. Diverse trial designs have attempted to mitigate challenges of population heterogeneity, efficacious symptomatic therapy and lack of outcome measures that are objective and sensitive to change in a disease modification setting. It is not clear whether consensus is emerging regarding trial design choices. Here, we report the protocol of a scoping review that will provide a contemporary update on trial design variability for disease-modifying interventions in PD. Methods and analysis The Population, Intervention, Comparator, Outcome and Study design (PICOS) …

A Drosophila Heart Optical Coherence Microscopy Dataset For Automatic Video Segmentation, Matthew Fishman, Abigail Matt, Fei Wang, Elena Gracheva, Jiantao Zhu, Xiangping Ouyang, Andrey Komarov, Yuxuan Wang, Hongwu Liang, Chao Zhou

2020-Current year OA Pubs

The heart of the fruit fly, Drosophila melanogaster, is a particularly suitable model for cardiac studies. Optical coherence microscopy (OCM) captures in vivo cross-sectional videos of the beating Drosophila heart for cardiac function quantification. To analyze those large-size multi-frame OCM recordings, human labelling has been employed, leading to low efficiency and poor reproducibility. Here, we introduce a robust and accurate automated Drosophila heart segmentation algorithm, called FlyNet 2.0+, which utilizes a long short-term memory (LSTM) convolutional neural network to leverage time series information in the videos, ensuring consistent, high-quality segmentation. We present a dataset of 213 Drosophila heart videos, equivalent …

一种高效的且适用于多级计分 Cd-Cat 非参数选题方法, 李 俊杰, 郑 慧婧, 康 春花, 曾 平飞

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

与 0-1 计分相比，多级计分能够提供更加丰富和有价值的信息，研究提出一种适用于多级计分认知诊断计算机自适应测验(PCD-CAT)的非参数选题策略(MD-NDI)。模拟研究的结果发现: (1) MD-NDI 选题策略适用于 PCD-CAT 情境且比参数选题策略具有更高属性分类准确性; (2) MD-NDI 使用前无需预测，且对于题库中的题目使用更加均匀，有效的保证了题库的安全性; (3) 在变长 PCD-CAT 情境中，MD-NDI 在达到测验终止规则时，不仅能够缩减测验长度的同时，且具有更高属性掌握模式判准率。

An Efficient Non-Parametric Item Selection Method For Polytomous Scoring Cd-Cat, Junjie Li, Huijing Zheng, Chunhua Kang, Pingfei Zeng

Chinese/English Journal of Educational Measurement and Evaluation | 教育测量与评估双语期刊

In educational evaluations at home and abroad, polytomous scoring items are becoming increasingly important. They can provide richer and more valuable information, with unmatched advantages compared to binary (0-1 scoring) items. If used as a tool for teachers to diagnose and assess students in the classroom, CD-CAT (Cognitive Diagnostic Computerized Adaptive Testing) has significant implications for improving teaching effectiveness. However, in classroom teaching situations, it is not feasible to estimate item parameters accurately with a large sample, as in large-scale assessments. In such cases, non-parametric CD-CAT becomes the only viable option. Compared to parametric CD-CAT, non-parametric CD-CAT started later and …

Improving Disability Inclusion Through Professional Development, Carli Spina

Urban Library Journal

Building a shared understanding of the importance of disability inclusion and the concrete steps everyone at the library can take towards this goal, is an important first step towards improving services for disabled patrons and the work environment for disabled employees. Offering training on these specific topics can jumpstart this activity at virtually any library. Guided by existing research in the field, this article offers concrete guidance on creating and offering this training at libraries to improve disability inclusion in the community.

Criminal Justice Interventions For Individuals With Mental Health Disabilities: A Systematic Literature Review, Fidelis Azeke, Nassrine Noureddine

Pacific Journal of Health

In the criminal law, with few exceptions, for a finding of guilt, the physical act and the state of mind to commit the offense must be present at the time of the commission of the offense. People with mental disabilities often lack the state of mind required to commit the offense for which they are eventually charged for and or convicted. This paper examines the effectiveness of some past and present criminal justice system interventions that addresses the mental health disabilities of criminal offenders pre-adjudicative proceedings. A systematic review of the literature was used to examine past and present criminal …

Providing An Eco Mode Feature For Optical Modules, Antonio Carugati

Defensive Publications Series

Techniques are presented herein that leverage the reality that many optical link installations could safely operate even with a reduced transmission optical power level. Aspects of the presented techniques offer a new optical transceiver feature (which may be referred to herein as an 'Eco Mode') in which a module may be set to work with a lower transmission power level. Under such an approach, at least one extra power level is allowed beyond (i.e., in addition to) an existing nominal power level. Through an Eco Mode option, a 100 gigabits per second (G) transceiver that is deployed in a Quad …

Aligning Map Patches To Estimate Lane Marker Geometry, Daniel J. Lingenfelter, Stephen P. Russell, Simon Desai, Jonathan T. Barron, Daniel Sievers

Defensive Publications Series

Accurate lane marker geometry is important for autonomous vehicles to navigate roads safely and efficiently. Map patches provide valuable data for estimating lane marker geometry but need to be aligned before they can be used to estimate the lane marker geometry. Traditional feature-based approaches for aligning map patches are unsuitable for map patches that include only lane markers, which typically lack distinctive features. This disclosure describes techniques for aligning map patches, specifically aligning lane markers on road geometries. Per the technique, correspondence between lane markers is determined, focusing on smooth curves without distinct features. Map patch alignment technique combines sensor …

Ebenezer Williamsburg Property Records, Ebenezer United Methodist Church, Williamsburg

Methodist Local Church Records

No abstract provided.

Supreme Court Overreach Through Broad Discretionary Consideration Of Ameliorative Measures In International Child Abduction, Lauren Mayell

Global Business Law Review

This Note provides a critical analysis of the United States Supreme Court's recent decision in Golan v. Saada--a case setting precedent in the area of international child abduction by biological parents. It argues that the Supreme Court oversteps the presiding law in the field through the use of discretionary ameliorative measures. These ameliorative measures do not show evidence of protecting children from grave risk, directly usurp underlying custody proceedings, and hinder expeditious procedures, all of which are required by law in international child abduction cases. Additionally, this Note compares the European Union's approach to ameliorate analysis. Lastly this Note …

Board Of Trustees Meeting Minutes 2023-12-08, Bowling Green State University

Board of Trustees Meeting Minutes

The official meeting minutes of Bowling Green State University's Board of Trustees.

Exploring Lgbt Experiences With Family Planning And Reproductive Health, Isabella Lafratta

Honors Program Theses and Projects

The purpose of this research is to investigate Lesbian, Gay, Bisexual, Transgender (LGBT) healthcare experiences, specifically in relation to family planning and fertility counseling. Sixteen qualitative, individual interviews were completed with participants recruited from LGBT communities on campus, as well as personal contacts and the snowball effect. Data was analyzed using thematic analysis (Braun & Clarke, 2021), and major themes and subthemes were identified. The first overall theme was Uneasiness and Fear which captures the subtheme: Dysphoria Inducement. The second overarching theme, Lack of Focus on Individualized Needs, had the subthemes of Reproductive Care and Transgender Reproductive Care. This describes …

Robert Endrikat V. George Little

2023 Decisions

USDC for the Middle District of Pennsylvania

Anderson Excavating Llc V. Weiss World Lp

2023 Decisions

USDC for the Western District of Pennsylvania

Usa V. Iklas Davis

2023 Decisions

USDC for the Western District of Pennsylvania

Usa V. Michael Caraballo

2023 Decisions

USDC for the Middle District of Pennsylvania

2023 Fall Commencement Program: Winona State University, Winona State University

WSU Commencement Programs

This is the Winona State University Spring 2023 commencement program. Commencement was on Friday, December 8, 2023.

Sex And Race Differences In Obesity-Related Genetic Susceptibility And Risk Of Cardiometabolic Disease In Older Us Adults, Hairui Yu, Nicole Armstrong, Greg Pavela

APC Fund

Importance The fat mass and obesity–associated gene (FTO) is associated with obesity phenotypes, but the association is inconsistent across populations. Within-population differences may explain some of the variability observed.

Objective To investigate sex differences in the association between FTO single-nucleotide variants (SNVs) and obesity traits among self-identified non-Hispanic Black and non-Hispanic White US adults, to examine whether the SNVs were associated with cardiometabolic diseases, and to evaluate whether obesity mediated the association between FTO SNVs and cardiometabolic diseases.

Design, Setting, and Participants This cross-sectional study used data from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) …

Barriers To The Adoption Of Digitalization In The Construction Industry: Perspectives Of Owners, Contractors, And Contractors, Waleed Abu-Khader

Publications

Construction organizations are moving toward adopting digitalization in response to Industry 4.0. However, the slow adoption of digitalization has been observed. This study aimed to assess the level of digitalization adoption and evaluate the barriers to adopting digitalization in the Jordanian construction industry by all project parties in the public and private sectors. The study targets were achieved through a structured questionnaire using SPSS software for analysis through the following statistical tests: Normality test, Mann-Whitney U, Kruskal-Wallis H, and Exploratory Factor Analysis (EFA). Most respondents used software at the design stage, and less than half did not use any software …

Reflections On The 2023 Tiger Athletics Hall Of Fame Celebration, Part 2, December 8, 2023, Tisa Mason Ed.D.

Heart of a Tiger Columns

No abstract provided.

Barriers To The Adoption Of Digitalization In The Construction Industry: Perspectives Of Owners, Consultants, And Contractors, Rawan Al-Omari, Ghaleb Sweis, Waleed Abu-Khader, Rateb Sweis

Civil Engineering Faculty Publications

Construction organizations are moving toward adopting digitalization in response to Industry 4.0. However, the slow adoption of digitalization has been observed. This study aimed to assess the level of digitalization adoption and evaluate the barriers to adopting digitalization in the Jordanian construction industry by all project parties in the public and private sectors. The study targets were achieved through a structured questionnaire using SPSS software for analysis through the following statistical tests: Normality test, Mann-Whitney U, Kruskal-Wallis H, and Exploratory Factor Analysis (EFA). Most respondents used software at the design stage, and less than half did not use any software …

Design And Fabrication Of Transparent Ultrasonic Transducers For Optoelectronic Applications, Stephen Colby Warren

Theses and Dissertations

Acoustic levitation utilizes general principles of ultrasonics to trap particles in midair without external support. This is done by creating an array of ultrasonic transducers to propagate sound waves to a focused point in space. In order to optimize the particle trap it is necessary to design transducers that can produce enough sound to create pressure pockets. In this work I examine the fundamental principles of acoustics by testing the sound pressure levels (SPL) of a known transducer in both air and water mediums. A comparison between domed and bimorphed transducers are also examined. Experimentation was performed on the feasibility …

A Phenotypically Robust Model Of Spinal And Bulbar Muscular Atrophy In Drosophila, Kristin Richardson, Medha Sengupta, Alyson Sujkowski, Kozeta Libohova, Autumn C. Harris, Robert Wessells, Diane E. Merry, Sokol V. Todi

Department of Biochemistry and Molecular Biology Faculty Papers

Spinal and bulbar muscular atrophy (SBMA) is an X-linked disorder that affects males who inherit the androgen receptor (AR) gene with an abnormal CAG triplet repeat expansion. The resulting protein contains an elongated polyglutamine (polyQ) tract and causes motor neuron degeneration in an androgen-dependent manner. The precise molecular sequelae of SBMA are unclear. To assist with its investigation and the identification of therapeutic options, we report here a new model of SBMA in Drosophila melanogaster. We generated transgenic flies that express the full-length, human AR with a wild-type or pathogenic polyQ repeat. Each transgene is inserted into the same safe …

The Role Of Prediction Error In Episodic Memory, Natalie Chisam, Natalie Hsiao

Undergraduate Research Symposium Posters

Prediction Error and Memory: Memory encoding and retention is influenced by prediction errors (PE), which occur when observed events deviate from expectations. Predictive Based Theories: Several theories have been proposed to predict how PE influences memory.

Listener’S Judgement Of Tempo Is Influenced By Dance Speed, Carolina A. Herrera, Ryan K. Perez, Jared W. Leslie, Erin E. Hannon

Undergraduate Research Symposium Posters

The tempo of a musical composition is typically denoted by the number of beats per minute (BPM). Nevertheless, perception of tempo is inherently subjective, and it can be shaped by the listener's familiarity with both musical and dance elements [1, 2, 3, 4]. Even when songs have the same BPM, the perceived speed of the songs can differ based on the specific dance form and cultural context [1, 4]

Student Thinking Driving Collaboration And Teacher Knowledge, Rachel Cheney

Theses and Dissertations

The study in this paper examined how teachers engaged in their structured Professional Learning Community (PLC) time in a manner that focused their work on student mathematical thinking. The participants included two third-grade teachers and two fourth-grade teachers engaged in an alternative PLC process during their collaboration time. Interviews were conducted and focused on how the teachers thought about student thinking as the driving force of their collaboration. The teachers found their PLC time was more focused, student thinking led the discussions and lessons, they were more responsive to student needs, and their own mathematical understanding increased. The teachers also …

An Assessment Of Sentencing Disparities By Race In The State Of Arkansas, Viola Schaeffer

Theses and Dissertations

Past research has found that there are often disparities in sentencing outcomes due to extralegal factors such as race, gender, age, socioeconomic status, education level, and geographic location. The most prominent and widely studied of these factors, however, is race. Specifically, studies have shown that minority offenders (e.g., African Americans) were more likely to receive a lengthier sentence than their White peers. The purpose of this thesis is thus to examine if there is racial bias in sentences levied to violent offenders in Arkansas. This is be done by analyzing sentencing data from the Arkansas Office of the Courts between …

Chronic Kidney Disease Android Application, Paul Le

Computer Science and Engineering Senior Theses

Chronic kidney disease is increasingly recognized as a leading public health problem over the world that affects more than 10 percent of the population worldwide, where electrolytes and wastes can build up in your system. Kidney failure might not be noticeable until more advanced stages where it may then become fatal if not for artificial filtering or a transplant. As a result, it is important to detect kidney disease early on to prevent it from progressing to kidney failure. The current main test of the disease is a blood test that measures the levels of a waste product called creatine …

Bipartisan Legislation In Supermajority State Legislatures, Ashley R. Gustafson

Honors Thesis

We ask how partisan (im)balance affects the prevalence of bipartisan legislation in U.S. state legislative bodies. We conducted a quantitative analysis of all fifty state legislative bodies over five years, 2017 to 2022, examining both institutional and individual action. We analyze minority member behavior differences between supermajority and veto-proof legislative bodies as compared to simple majority legislatures. Our work shows that minority party legislators in Democrat supermajority state legislative bodies are more likely to sponsor bipartisan legislation, and the amount of bipartisan legislation sponsored overall in a state legislature is likely to decrease in Republican supermajority state legislative bodies. This …

Final 2023 Residential Metals Abatement Program (Rmap) Whitehall Borrow Submittal, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.