Digital Commons Network^™

A Phase I Trial Of Bevacizumab And Temsirolimus In Combination With Valproic Acid In Advanced Solid Tumors, Blessie Elizabeth Nelson, Apostolia M Tsimberidou, Xueyao Fu, Siqing Fu, Vivek Subbiah, Anil K Sood, Jordi Rodon, Daniel D Karp, George Blumenschein, Scott Kopetz, Shubham Pant, Sarina A Piha-Paul

Faculty, Staff and Student Publications

BACKGROUND: Preclinical models suggest synergy between anti-angiogenesis therapy, mammalian target of rapamycin (mTOR), and histone deacetylase inhibitors to promote anticancer activity.

METHODS: This phase I study enrolled 47 patients between April 2012 and 2018 and determined safety, maximum tolerated dose (MTD), and dose-limiting toxicities (DLTs) when combining bevacizumab, temsirolimus, and valproic acid in patients with advanced cancer.

RESULTS: Median age of enrolled patients was 56 years. Patients were heavily pretreated with a median of 4 lines of prior therapy. Forty-five patients (95.7%) experienced one or more treatment-related adverse events (TRAEs). Grade 3 TRAEs were lymphopenia (14.9%), thrombocytopenia (8.5%), and mucositis …

Ultrafast Electronic Relaxation Pathways Of The Molecular Photoswitch Quadricyclane, Kurtis D. Borne, Joseph C. Cooper, Michael N. R. Ashfold, Julien Bachmann, Surjendu Bhattacharyya, Rebecca Boll5, Matteo Bonanomi, Michael Bosch, Carlo Callegari, Martin Centurion, Marcello Coreno, Basile F. E. Curchod, Miltcho B. Danailov, Alexander Demidovich, Michele Di Fraia, Benjamin Erk, Davide Faccialà, Raimund Feifel, Ruaridh J. G. Forbes, Christopher S. Hansen, David M. P. Holland, Rebecca A. Ingle, Roland Lindh, Lingyu Ma, Henry G. Mcghee, Sri Bhavya Muvva, Joao Pedro Figueira Nunes, Asami Odate, Shashank Pathak, Oksana Plekan, Kevin C. Prince, Primoz Rebernik, Arnaud Rouzée, Artem Rudenko, Alberto Simoncig, Richard J. Squibb, Anbu Selvam Venkatachalam, Caterina Vozzi, Peter M. Weber, Adam Kirrander, Daniel Rolles

Martin Centurion Publications

The light-induced ultrafast switching between molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Prior work observed signatures of ultrafast molecular dynamics in both isomers upon ultraviolet excitation but could not follow the electronic relaxation all the way back to the ground state experimentally. Here we study the electronic relaxation of quadricyclane after exciting in the ultraviolet (201 nanometres) using time-resolved gas-phase extreme ultraviolet photoelectron spectroscopy combined with non-adiabatic molecular dynamics simulations. We identify two competing pathways by which electronically excited quadricyclane molecules relax to the electronic ground state. The fast pathway (<100 femtoseconds) is distinguished by effective coupling to valence electronic states, while the slow pathway involves initial motions across Rydberg states and takes several hundred femtoseconds. Both pathways facilitate interconversion between the two isomers, albeit on different timescales, and we predict that the branching ratio of norbornadiene/ quadricyclane products immediately after returning to the electronic ground state is approximately 3:2.

Review Of "Three In One: Analogies For The Trinity", Steve Emerson

The Christian Librarian

No abstract provided.

Review Of "40 Questions About Women In Ministry", Keilah Villa

The Christian Librarian

No abstract provided.

Grifters, Roger Mensink

Valparaiso Fiction Review

No abstract provided.

You Bury Me, William O'Reilly

Valparaiso Fiction Review

No abstract provided.

Evaluating Militant Decision-Making With Information Science: The Irish Republican Movement During The "Troubles", Joshua C. Eastin, Emily Kalah Gade, Michael Gabbay

Political Science Faculty Publications and Presentations

Why do militant groups decide to escalate or deescalate their use of violence in conflict? Examining the case of the “Troubles” in Northern Ireland, we analyze groups that adopt violence as a political strategy and evaluate factors that influence its application. To do so, we adopt a novel empirical approach to the study of militant groups. Drawn from information science, this approach enables estimation of variable influence and uncertainty within structured case studies, and is thus ideal for topics such as militant decision-making where systematic data collection is difficult.

Reassessment Of Amblyscirtes Hegon (Hesperiidae) As A Complex Of Four Distinct Species Revealed By Genomic Analysis, Harry Pavulaan, Ricky Patterson, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

After the discovery of a unique phenotype in the southern United States with a different ventral ground color than nominotypical Amblyscirtes hegon (Scudder, 1863), which occurs in the northeastern United States, genomic analysis revealed that A. hegon is a species complex. Phenotypic, genitalic, and genomic differences of the complex are presented here. Four species are identified: A. hegon; A. nemoris (W. H. Edwards, 1864), stat. rest.; A. matheri Patterson, Pavulaan & Grishin, sp. n. (TL: USA, Mississippi, Warren County); and A. gelidus Grishin, Patterson & Pavulaan, sp. n. (TL: USA, Michigan, Van Buren County).

Episode 6: For The Kids, Sara Gras

Season 01

When I started thinking about how to address the issue of trans exclusion from youth sports, I knew I needed to include the culture/industry of youth sports as part of the discussion. The pressure to compete and perform at a high level in athletics is reaching kids earlier than ever before, facilitated by parents who see success in sports as the ticket to success in life. This episode explores the relationship between the increased parental investment in kids' athletic achievements and the social acquiescence to the exclusion of trans kids from sports.

Kirsten Jones
Peak Performance Coach, Podcast Host, Author …

Mirror Therapy Rehabilitation In Low Back Pain Patients, Claudia L. Altergott

Honors Capstones

Low back pain is a common occurrence experienced by many individuals. An estimated 75-85% of Americans experience some form of back pain during their lives [1]. While low back pain can be uncomfortable and debilitating, approximately 90% of cases are temporary and can resolved without surgery; however, 50% of patients will experience recurrent episodes of back pain. Low back pain that has persisted for more than twelve weeks is considered chronic low back pain [1]. Many researchers and therapists have been seeking the optimal treatment plans for individuals suffering from low back pain. Mirror therapy (MT) is a type of …

Ddx170.1 Principles Of Design: Motif Example 2, Sae University College

Exemplars

DDX170 Project 1 Motif

Inverted Pendulum With Swing-Up And Center-Stabilization System Design, Caleb Osmond

Honors Program: Senior Projects (Public)

The inverted pendulum is a classic problem for testing control techniques. This paper details the implementation of multiple PID control schemes and the overall design of an inverted pendulum capable of swing-up and center stabilization.

Enhancing Information Delivery Services For Distance Education Programmes In Cross River State, Nigeria, Mayen Ndaro Igajah Dr, Christopher Okoi Offem Mr, Mary Mfon Bassey Mrs

Library Philosophy and Practice (e-journal)

The paper assessed information delivery services for distance education programmes. The study traces briefly the history of the National Open University and the National Teacher Institute. The e-resources and current issues on services provided by librarians. The study adopted the survey design methods. The questionnaire was used as an instrument for data collection. From the analysis of the data collected, it was found that the current issues on information services are in support of open and distance education programmes, technologies used in the delivery of information services for distance learners, concepts of distance education in Nigeria, value of social media …

Predicting Cost Contingency In Retrofit Projects Using Machine Learning Techniques, Dana Amin

Theses

Project contingency is one of the most important preliminary processes in any project estimation as it ensures the project risk for cost over-run due to uncertainties , in light of that, it is also important to make sure that the project contingency is not overestimated to maintain competitiveness in the market. This project aims to develop contingency decision support tool using ML techniques in order to predict the optimum contingency cost that balances between maintaining business competitiveness in the market and achieving project objectives. Different ML ways were evaluated and based on accuracy level ; Random Forest was found to …

Development Of Discharge Planning For Stroke Patients, Muhammad Imron Rosadi, Fitri Arofiati

Folia Medica Indonesiana

Highlights: 1. Given the frequent long-term complications of stroke, this study identified the ideal approach to discharge planning to improve the quality of life of patients and hospital care. 2. This study provides evidence supporting the effectiveness of a conventional discharge planning approach that incorporates specific educational intervention with interactive learning through audiovisual media. 3. The approaches presented in this study may offer valuable perspectives on enhancing health service provisions, particularly regarding the discharge planning process for nurses. Abstract The quality improvement of discharge planning is essential throughout the development of discharge planning, which guarantees a seamless transition of care …

The Ppp1r15 Family Of Eif2-Alpha Phosphatase Targeting Subunits (Gadd34 And Crep), Danielle Hicks, Krithika Giresh, Lisa A. Wrischnik, Douglas C. Weiser

Pacific Faculty Work

The vertebrate PPP1R15 family consists of the proteins GADD34 (growth arrest and DNA damage-inducible protein 34, the product of the PPP1R15A gene) and CReP (constitutive repressor of eIF2α phosphorylation, the product of the PPP1R15B gene), both of which function as targeting/regulatory subunits for protein phosphatase 1 (PP1) by regulating subcellular localization, modulating substrate specificity and assembling complexes with target proteins. The primary cellular function of these proteins is to facilitate the dephosphorylation of eukaryotic initiation factor 2-alpha (eIF2α) by PP1 during cell stress. In this review, we will provide a comprehensive overview of the cellular function, biochemistry and pharmacology of …

Revolutionizing Attention Training In Autism Spectrum Disorder: Pioneering Virtual Reality And Artificial Intelligence, Bhavya Sri Sanku, Selena He, Joy Li

Master of Science in Computer Science Theses

In the realm of educational technology, attention training plays a critical role in tailoring learning experiences to individual needs, especially for learners with autism spectrum disorder (ASD). This study presents an advanced framework that provides insights into the efficacy of reinforcement strategies by predicting their impact on attention enhancement in educational virtual reality (VR) settings, utilizing physiological biomarkers such as eye-tracking (ET), heart rate (HR), and electrodermal activity (EDA). A comprehensive comparative analysis was undertaken to evaluate the performance metrics of various machine learning (ML) and deep learning (DL) algorithms. The results showcased the robustness of gradient boosting (GB) and …

Microstructural Alterations Of Major Thalamic Nuclei In The Chronic Pediatric Spinal Cord Injured Population, K. Kang, K. Fleming, A. Sathe, J. Muller, J. Harrop, D. Middleton, J. Heller, A. Sharan, F. Mohamed, L. Krisa, M. Alizadeh

Department of Radiology Faculty Papers

BACKGROUND: The brain undergoes reorganization following spinal cord injury (SCI), but little is known about how the thalamus is affected in pediatric SCIs.

PURPOSE: To characterize microstructural alterations in the thalamus after SCI with diffusion tensor imaging (DTI) metrics.

METHODS: 18 pediatric participants with chronic SCI (8-20 years) were stratified using the American Spinal Injury Association Impairment Scale (AIS) into groups: A, B, and C/D. DTI of the brain used a 3 T Siemens Verio MRI using the parameters: 20 directions, number of averages = 3, b = 1000 s/mm

DATA ANALYSIS: DTI metrics were acquired by superimposing the AAL3 …

Indexes: The Heart Of Research, Laura M. Ladwig, Jamey M. Wilkes, Lori Thornton, Sarah Wessel

The Christian Librarian

This article, originally a presentation at ACL’s 2023 conference, will delineate the enduring value of indexes for librarians and researchers alike, giving some examples of how indexes have evolved in a technology-driven age.

Relation Of Salivary Alpha-Amylase (Saa) Concentration To Fatigue Biomarkers In Palm Oil Office Workers In Jambi Province: Preliminary Study, David Kusmawan, Willia Novita Eka Rini, Wahyu Indah Dewi Aurora

Makara Journal of Science

The salivary α-amylase (sAA) concentration has a potential role as a biological indicator of occupational fatigue. This study aimed to determine the levels of sAA and its influencing factors. This research used a cross-sectional design with a sample of 40 office staff respondents at PT. X (Persero). Mental workload (MWL), sleep quality, and occupational fatigue were measured using the NASA-Total Load Index (TLX), Pittsburgh Sleep Quality Index, and Industrial Fatigue Research Committee, respectively. Meanwhile, the basic sAA levels was measured through the sandwich enzyme-linked immunosorbent assay method using the Bioenzy® Kit Assay. Descriptive analysis showed that the workers were mostly …

The Need For Energy Storage On Renewable Energy Generator Outputs To Lessen The Geeth Effect, I.E. Short-Term Variations Mainly Associated With Wind Turbine Active Power Output, Tony Kealy

Articles

Many studies investigating the short-term variations associated with the power output from wind turbine generators utilise simulated or modelled data in the analysis. This current study uses short-term empirical data downloaded directly from operational wind turbines via electrical power quality meters. The empirical data shows that the short-term variations (one-second or sub-one-second timeframe) occur continuously over most of the power output range. A novel name is proposed, the Geeth Effect, for this variability phenomenon. The Geeth Effect is measured using the coefficient of variation mathematical expression and is likely contributing to (i) lower-than-expected financial and environmental benefits associated with …

Exploring The Nexus Of Cybersecurity Leadership, Human Factors, Emotional Intelligence, Innovative Work Behavior, And Critical Leadership Traits, Sharon L. Burton, Darrell Norman Burrell, Calvin Nobles, Laura A. Jones

Publications

Data shows that 12% of leaders are rated as 'very effective' at leadership. This research emphasizes the importance of understanding human behavior and its impact on leadership effectiveness, innovative work behavior (IWB), and the ability to respond to complex cyber threats, particularly in the realm of cybersecurity leadership. Emotional intelligence (EI), a key human factor, is highlighted as a crucial element that can stimulate cognitive absorption, leading to innovative work behavior and improved innovation efficiency (IE). This underscores the need for leaders to not only be technically proficient but also emotionally intelligent to effectively manage their teams and respond to …

Could Ernest Boyer’S Foundational Perspective Of The Scholarship Of Teaching Help Save Faculty Librarians?, Douglas Wayman

The Christian Librarian

This is a recovery project for Ernest Boyer's scholarship of teaching as presented in Scholarship Reconsidered. It addresses a reinterpretation of Boyer’s scholarship of teaching promulgated by his Carnegie successor, Lee Shulman and popularized throughout the Academy. Serendipitously, that reinterpretation gave birth to what is now known as the Scholarship of Teaching and Learning (SoTL), which has undoubtedly benefitted the Academy. While this project focuses on the reinterpretation's ramifications for tenure-track academic library faculty who teach, it also argues that the foundational interpretation of Boyer's model could benefit the Academy at large, and that the two interpretations are not mutually …

How Do Librarians Preach, Worship And Pray?: Insights From The Reformers, Garrett Trott

The Christian Librarian

Luther, Calvin, and Zwingli have become common names in many Protestant churches because they were key figures in the Reformation. Many components of life were impacted by their initiatives to bring about change in the Catholic church. Many of us understand the distinct doctrinal components of that transformation, but did that doctrine impact other facets of life? This brief essay will look at how the Reformation changed preaching, prayer, and worship and how those changes impacted (and can further impact) the practice of librarians.

Ornithological Multitudes, Hanson C. Robbins

Bird Observer

No abstract provided.

Book Review: Birds Of Massachusetts By Richard R. Veit And Wayne R. Petersen, Frederick Purnell Jr.

Bird Observer

No abstract provided.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.

Similarities Between Birding Identification And Medical Diagnosis, Stephen Davis

Bird Observer

No abstract provided.

The Piper's Progress, Scott Hecker

Bird Observer

No abstract provided.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.