Digital Commons Network^™

In The Words Of Early Adolescents: A Novel Assessment Of Positive Psychological Well-Being Predicts Young Adult Depressive Symptoms, Julia K. Boehm, Farah Qureshi, Laura D. Kubzansky

Psychology Faculty Articles and Research

Purpose

Methods

Single-Nuclei Resolution Kidney Profiling In Physiological And Disease Settings, Ruiyang Liu

Arts & Sciences Graduate Student Theses and Dissertations

The kidney is a critical organ responsible for the maintenance of fluid, electrolyte and metabolites in the body. Recent advancements in kidney research, including the use of single-nuclei RNA Sequencing (snRNA-Seq), have uncovered a complex landscape that encompasses both physiological and pathological conditions. The scope of my thesis covers two important aspects: (1) the exploration of kidney sexual dimorphism, (2) a detailed investigation of polycystic kidney disease (PKD). To obtain a comprehensive understanding of the molecular regulation of kidney sexual dimorphism, we integrated single nucleus RNA and ATAC sequencing (snRNA-Seq and snATAC-Seq) and Visium spatial transcriptomics (ST) data to build …

Identification Of Candidate Dna Methylation Biomarkers Related To Alzheimer’S Disease Risk By Integrating Genome And Blood Methylome Data, Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu

Faculty, Staff and Student Publications

Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is critical to identify novel blood-based DNA methylation biomarkers to better understand the extent of the molecular pathways affected in AD. Two sets of blood DNA methylation genetic prediction models developed using different reference panels and modelling strategies were leveraged to evaluate associations of genetically predicted DNA methylation levels with AD risk in 111,326 (46,828 proxy) cases and 677,663 controls. A total of 1,168 cytosine-phosphate-guanine (CpG) sites showed a significant association with AD risk at a false discovery rate (FDR) < 0.05. Methylation levels of 196 CpG sites were correlated with expression levels of 130 adjacent genes in blood. Overall, 52 CpG sites of 32 genes showed consistent association directions for the methylation-gene expression-AD risk, including nine genes (CNIH4, THUMPD3, SERPINB9, MTUS1, CISD1, FRAT2, CCDC88B, FES, and SSH2) firstly reported as AD risk genes. Nine of 32 genes were enriched in dementia and AD disease categories (P values ranged from 1.85 × 10-4 to 7.46 × 10-6), and 19 genes in a neurological disease network (score = 54) were also observed. Our findings improve the understanding of genetics and etiology for AD.

Epigenomic Mapping Reveals Distinct B Cell Acute Lymphoblastic Leukemia Chromatin Architectures And Regulators, Kelly R Barnett, Robert J Mobley, Jonathan D Diedrich, Brennan P Bergeron, Kashi Raj Bhattarai, Alexander C Monovich, Shilpa Narina, Wenjian Yang, Kristine R Crews, Christopher S Manring, Elias Jabbour, Elisabeth Paietta, Mark R Litzow, Steven M Kornblau, Wendy Stock, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Charles G Mullighan, Mary V Relling, Shondra M Pruett-Miller, Russell J H Ryan, Jun J Yang, William E Evans, Daniel Savic

Faculty, Staff and Student Publications

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a resource. Differential chromatin accessibility and transcription factor (TF) footprint profiling were employed and identified B-ALL cell of origin, TF-target gene interactions enriched in B-ALL, and key TFs associated with accessible chromatin sites preferentially active in B-ALL. We further identified over 20% of …

The Emotional Experience Of Representative Bureaucrats In A Contested Public Policy Environment, Shaun Damien Heckstall

Walden Dissertations and Doctoral Studies

No abstract provided.

A System For Multi-Level, Multi-Variate Embedding Framework For Risk Scoring, Hao Xu, Anurag Tangri, Chiranjeet Chetia

Defensive Publications Series

The present disclosure provides a novel system for multi-level multi-variate embedding framework for risk scoring. In the present disclosure, risk factors within each category are aggregated as one score using Level-1 embedding, while a global risk score is obtained using Level-2 embedding. The framework models different scores considering the interactive effects among different factors and scores. Also, any auxiliary variables that are important for global risk scoring can be easily integrated. The coefficients in multi-level embedding can be determined within one process based on historical data of user interested activities. A penalized loss is used to optimize the model structure …

E-Governance: The Implication Of Next Social Generation Welfare Information System, Yaya Mulyana Abdul Aziz, Andre Ariesmansyah

Smart City

Accelerating bureaucracy can be performed by e-governance present in order to improve the quality of government administration in the world. E-governance draft is closely related to the development of information and communication technology (ICT) globally. One form of embodiment of e-governance is the implementation of a smart city. smart cities are expected to be able to become a liaison between the demands of the community in appropriate, effective, and efficient services from the city government, by utilizing ICT. There are various related definitions of smart city in this world. One of them is as explained by Nam and Pardo who …

Abortion In The Fiction Of Laclos, Rousseau, Isabelle De Charrière, Montesquieu, Servanne Woodward

ABO: Interactive Journal for Women in the Arts, 1640–1830

Eighteenth-century French fiction containing episodes on abortion are influenced by the seventeenth-century scandal of La Voisin, and by the 1731 legal suit involving the Jesuit Priest Père Girard and Catherine Cadière. Two observations may be derived from eighteenth-century French novels: women's abortions are monitored, instigated, and decided by fathers, husbands and lovers, who select for them, if they are to remain celibate, and whose children they bear. And as well, abortion tests or reveals the limits of a woman’s individual freedom and right to care for herself.

The Quick And The Dead (And The Transported), Manushag N. Powell

ABO: Interactive Journal for Women in the Arts, 1640–1830

In most nations that still execute prisoners—including the U.S.—it is illegal to execute a pregnant person. In English common law, women have been permitted to “plead the belly” in one form or another since the 14^th century, and this fact is sometimes misconstrued by anti-choice and forced-birth advocates as evidence of a long legal tradition of protection for the lives of fetuses. In fact, it is merely evidence of a long history of legal inconsistencies in the ways laws were applied and sentences carried out against women, for whom there were fewer options for clemency than for men. This …

Review Of Giving Birth In Eighteenth-Century England, By Sarah Fox, Chelsea Phillips

ABO: Interactive Journal for Women in the Arts, 1640–1830

A Review of Giving Birth in Eighteenth-Century England, by Sarah Fox

Review Of Sister Novelists, By Devoney Looser, Katherine Binhammer Prof.

ABO: Interactive Journal for Women in the Arts, 1640–1830

Review of Sister Novelists by Devoney Looser.

Teaching Anne Finch’S Satire In The British Literature Survey Classroom, Amanda Hiner

ABO: Interactive Journal for Women in the Arts, 1640–1830

This article argues for the intentional inclusion of Anne Finch’s diverse and compelling satires in the undergraduate British literature survey course and for the recognition of Finch as an accomplished theorist and practitioner of satire. The article includes practical strategies for pairing Finch’s satires with other well-known and anthologized satires; examines her satires in the context of the Revolution of 1688; and provides an analysis of her innovative rhetorical strategies, including her efforts to dissociate herself from satire while simultaneously producing sharp and defiant satires. The article argues that cultivating a deeper understanding of Finch’s contributions to eighteenth-century satire enriches …

Introduction: Concise Collection On Teaching The Works Of Anne Finch, Part One, Jennifer Keith

ABO: Interactive Journal for Women in the Arts, 1640–1830

This essay introduces Part One of the two-part “Concise Collection on Teaching the Works of Anne Finch," guest edited by Jennifer Keith (Aphra Behn Online, vol. 13, no. 2, 2023). The second part of this collection is scheduled for Spring 2024.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.

Letter To The Editor, Paul Baicich

Bird Observer

No abstract provided.

About Books: Birding In Full Battle-Rattle: A Conversation With Jonathan Trouern-Trend, Mark Lynch

Bird Observer

No abstract provided.

About Books: A Trip Of Plovers, A Leash Of Merlins, A Parcel Of Oystercatchers, And Meatloaf On A Stick And A Gaggle Of Guides, Mark Lynch

Bird Observer

No abstract provided.

Adventures Of The Rowley Dump Girls (And Boys), Mary Cunningham

Bird Observer

No abstract provided.

Yellow-Legged Claphangers: The Image Of The Birder In Film And Television, Mark Lynch

Bird Observer

No abstract provided.

Tenth Annual Report Of The Massachusetts Avian Records Committee (Marc), Marjorie Rines

Bird Observer

No abstract provided.

At A Glance: December 2005, Wayne R. Petersen

Bird Observer

No abstract provided.

Ten Tips For Maintaining Your Birding Partner, John Nelson

Bird Observer

No abstract provided.

White Memorial Foundation: Litchfield And Morris, Connecticut, Buzz Devine, Dwight G. Smith

Bird Observer

No abstract provided.

The Underpinnings Of Breeding Behaviors, Brandi Van Roo

Bird Observer

No abstract provided.

The "Wellesley Boys" - Contributions To Continental Birding, David B. Freeland

Bird Observer

No abstract provided.

The Importance Of Naturalists In Identifying Global Warming In Our Backyards, Abraham J. Miller-Rushing, Richard B. Primack

Bird Observer

No abstract provided.

Ninth Annual Report Of The Massachusetts Avian Records Committee (Marc), Marjorie Rines

Bird Observer

No abstract provided.

Making The Rounds, 1996, V1 N15, April 8, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Making the Rounds in Health, Faith, & Ethics", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue has a feature on narrative ethics, and an interview with Martha Holstein about societal responsibility and children.

Making The Rounds, 1996, V1 N17, May 5, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Making the Rounds in Health, Faith, & Ethics", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue features a roundtable discussion on the new legal status of physician-assisted suicide in the state of Washington.

Making The Rounds, 1996, V1 N18, May 20, Advocate Aurora Health

Historical Documents - Combined

The Park Ridge Center, Chicago, IL: Issue of "Making the Rounds in Health, Faith, & Ethics", a publication from The Park Ridge Center for the Study of Health, Faith and Ethics, associated with Lutheran General Hospital. This issue has a feature case study about a patient exploring alternative treatments, as well as a commentary from a holistic physician. There is also a media round-up about the court case in Washington covered in the previous issue.