Digital Commons Network^™

Photoplethysmography-New Applications For An Old Technology: A Sleep Technology Review, Scott Ryals, Ambrose Chiang, Sharon Schutte-Rodin, Arvind Chandrakantan, Nitun Verma, Steven Holfinger, Fariha Abbasi-Feinberg, Anuja Bandyopadhyay, Kelly Baron, Sumit Bhargava, Ken He, Joseph Kern, Jennifer Miller, Ruchir Patel, Dulip Ratnasoma, Maryann C Deak

Faculty, Staff and Students Publications

Education is integral to the American Academy of Sleep Medicine (AASM) mission. The AASM Emerging Technology Committee identified an important and evolving piece of technology that is present in many of the consumer and clinical technologies that we review on the AASM #SleepTechnology (https://aasm.org/consumer-clinical-sleep-technology/) resource—photoplethysmography. As more patients with sleep tracking devices ask clinicians to view their data, it is important for sleep providers to have a general understanding of the technology, its sensors, how it works, targeted users, evidence for the claimed uses, and its strengths and weaknesses. The focus in this review is photoplethysmography—a sensor type …

Factors Affecting The Decision Making To Use Thai Traditional Medical Postpartum Care Services Among Pregnant And Postpartum Women In Bangkok, Thailand, Lunlalin Sirichai

Chulalongkorn University Theses and Dissertations (Chula ETD)

After giving birth, there will be changes in the body during the postpartum period to return to the normal state as before pregnancy. Postpartum women often have common problems, such as lower back pain, breast engorgement, plugged milk ducts, mastitis, and not having enough breast milk. In Thai traditional medicine, there has been postpartum care for a long time. Thai traditional medicine postpartum care services, also referred to as Yu-Fai, can assist in easing postpartum discomfort. But at present, the number of people receiving postpartum care services with Thai traditional medicine is still low. Therefore, this study aimed to determine …

Association Between Oral Health Behavior,Oral Hygiene Status, And Oral Health Status Among Primary School Children In Bangkok, Thailand : A Latent Class Analysis, Pemmika Intato

Chulalongkorn University Theses and Dissertations (Chula ETD)

Oral health affects both the overall health and quality of life of children. Dental caries and gingivitis are one of the most common global oral health problems among school children, including those in Thailand. Both problems are diet- and behavioral-related diseases, with various risk factors contribute to dental caries and gingivitis. This study aims to classify the clusters of oral health status among primary school children in Bangkok, Thailand, and identify association between the identified classes, oral health behavior, and oral hygiene status. The study utilized secondary data from dental chart records in the School Oral Health Promotion Program, Department …

The Effectiveness Of Using Facebook And Instant Communications Application (Line) To Reduce Alcohol Consumption Of Alcohol Promoters And Entertainers (Pretty Or Pr) In Bangkok, Thailand, Paladd Sakulthanit

Chulalongkorn University Theses and Dissertations (Chula ETD)

The deleterious health consequences associated with alcohol consumption, ranging from addiction and liver disease to accidents and mental health disorders, have been extensively documented. This study aimed to assess the efficacy of an educational program utilizing Facebook and Line platforms in mitigating alcohol consumption intentions among such workers in Bangkok. Utilizing a randomized controlled trial methodology, the study focused in Bangkok. A total of forty-four participants were allocated into either the intervention (n=22) or control (n=22) groups. The intervention group received health education sessions and live video broadcasts on Facebook, while the control group received standard care messages. Outcome measures …

Influencing Factors On Chinese Tourists’ Health Behavior Prevention Toward Post Covid-19 In Beijing, China, Sihang Li

Chulalongkorn University Theses and Dissertations (Chula ETD)

The global travel and tourism landscape has been profoundly impacted by the COVID-19 pandemic, requiring precautionary measures to keep travelers and local communities safe. In this context, it is of great significance to understand the factors that influence the adoption of healthy behavioral prevention among Chinese tourists. This study delves into the complex connections between risk perceptions, knowledge, attitudes, social norms, accessibility, communication, and cultural factors that influence mask-wearing behavior among tourists in China post-COVID-19. This study aims to identify the prevalence of preventive health behaviors among Chinese tourists during post-COVID-19 and investigate the association between influencing factors and tourists’ …

Association Between Related Factors And Communication Channels Among Women With Abortion Service At Private Clinics In Thailand, Xiao Wang

Chulalongkorn University Theses and Dissertations (Chula ETD)

In February 2021, abortion was officially permitted in Thailand. In the delivery of abortion services, communication channel is a key factor in assisting clients to access services. Research on clients' choices of communication channels is important for increasing clients' access to legal abortion services. This secondary data cross-sectional study aims to identify the association between factors related to communication channels among the clients who receive abortion services at The Planned Parenthood Association of Thailand (PPAT)’s clinic. The study samples covered 3,734 clients who get abortion service at PPAT’s clinic from February 2021 to December 2022. The researcher employed socio-demographic characteristic, …

Development Of Probiotic Fermented Beverage From Gac Fruit (Momordica Cochinchinensis) And Its Functional Properties On Gut Health, Marisa Marnpae

Chulalongkorn University Theses and Dissertations (Chula ETD)

The study aimed to develop a probiotic beverage using gac fruit and assess its characteristics and functional properties related to gut health through probiotic lactic acid fermentation. Gac juice (GJ) at 5–10 g/100 g was fermented with Lactobacillus paracasei subsp. paracasei (L. CASEI 431®), and various aspects were explored, including probiotic viability, physicochemical properties, phytochemicals, antioxidant activity, functional properties, volatile flavor compounds, and sensory acceptability of fermented GJ (FGJ). The results indicated a decrease in pH and sugar content, alongside an increase in lactic acid, acetic acid, and probiotic viability, up to 108 CFU/mL, post-fermentation. Notably, FGJ, particularly at 10 …

M2 Macrophages In Human Periapical Lesions In Relation To Histopathological Diagnosis, Clinical Features, And Lesion Volume, Supanant Visarnta

Chulalongkorn University Theses and Dissertations (Chula ETD)

This study evaluated M1 and M2 macrophage polarization in human periapical cysts and granulomas through an immunohistochemical analysis and investigated the correlation between the macrophage polarization and histopathological diagnosis, clinical features and lesion volume using cone-beam computed tomography. The periapical biopsies histopathologically diagnosed as radicular cyst (n=52) and periapical granuloma (n=51) were analyzed by immunohistochemical method. Immuno-expressions of CD68 and CD163 were quantified. The CD68/CD163 ratio was adopted to represent M1 or M2 macrophage polarization. Pathological diagnosis, patients’ age, gender, clinical signs and symptoms, tooth location of the periapical lesion, and history of root canal treatment were obtained from treatment …

The Alleviating Effects Of Epidermal Growth Factor On An In Vitro Oral Mucositis Model In The Presence Of Fusobacterium Nucleatum, Tien Thi Trieu Truong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objectives: 5-fluorouracil (5-FU) is commonly used as a chemotherapy drug for head and neck cancers. However, it often produces an adverse cytotoxic effect on the oral epithelia leading to oral mucositis (OM) in cancer patients. Thus, reversing this cytotoxic effect locally with novel bioactive drugs or factors is necessary. This study aimed to investigate the rescue effect of Nicotiana benthamiana plant-derived epidermal growth factor (P-EGF) on human normal oral keratinocytes (NOKs) exposed to 5-FU-induced cytotoxicity in the presence of Fusobacterium nucleatum (Fn). Materials and Methods: Cytotoxicity and ATP-dependent proliferation and metabolism of NOK monolayer cultures were assessed after 48 hours …

A Machine Learning Predictive Model For The Extension Of Operation Time And The Operation Cost Overrun : A Case Study Of Vietnamese Bot-Ppp Transportation Projects, Pham Van Hoai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Public-Private Partnership (PPP) projects in Vietnam's transportation sector are vital for infrastructure development but frequently encounter significant risk factors (RFs) during the operation phase. These RFs often lead to the extension of operation time (EOPT) and operation cost overruns (OPCO), undermining project success and investor returns. Despite the importance of the operation phase, most research has focused on the project feasibility and construction stages, with limited attention given to the operation phase. This research fills this gap by developing predictive models to manage the EOPT and OPCO caused by RFs during the operation phase of Build-Operate-Transfer (BOT) transportation projects in …

Development Of A Chitosan Nano-Immersion Vaccine Against Aeromonas Veronii Infection In Red Tilapia (Oreochromis Sp.), Pimwarang Sukkarun

Chulalongkorn University Theses and Dissertations (Chula ETD)

Red tilapia (Oreochromis sp.) is a prominent freshwater fish in Thai aquaculture. It has long been afflicted by severe bacterial diseases, ulcerative syndrome, and hemorrhagic septicemia, primarily caused by Aeromonas veronii. Vaccination is a key strategy for control and prevention. In this study a chitosan nano-immersion vaccine has been developed using a nanoemulsion technique and surface modification method with chitosan polymers. The physicochemical properties, mucoadhesive properties, immune response assays, and vaccine efficacy were investigated. The results showed that the vaccine is spherical-shaped, nanometer-sized, and having monodispersed positive charge. The mucoadhesive characterization, observed by SEM and fluorescence microscope imaging, demonstrated that …

Upscale Production Of Canine Adipose-Derived Mesenchymal Stem Cell-Derived Exosomes For Wound Healing In Vitro, Yudith Violetta Pamulang

Chulalongkorn University Theses and Dissertations (Chula ETD)

Mesenchymal stem cell-derived exosomes (MSC-derived exosomes) have been previously reported to enhance wound healing across different phases. However, its practical application has been hindered due to challenges regarding low productivity and the lack of efficient production protocol. Additionally, the usage of exosome-based regenerative treatments in the veterinary field remains relatively unexplored. Hence, this study aimed to address these gaps by establishing a potential upscaling protocol producing canine adipose-derived mesenchymal stem cell-derived exosomes (cAD-MSC-exosomes) and exploring their wound healing potential in vitro. To facilitate production protocol establishment, an in-house exosome-collecting media, designated as VSCBIC-3, was preliminarily developed. Building upon this foundation, …

โครงการศึกษาการพัฒนาบริการสุขภาพปฐมภูมิด้านโรคผิวหนังในผู้สูงอายุ, ชินมนัส เลขวัต

Chulalongkorn University Theses and Dissertations (Chula ETD)

ประชากรโลกมีอายุสูงขึ้นอย่างรวดเร็ว การพัฒนาการจัดบริการสุขภาพปฐมภูมิด้านโรคผิวหนังในผู้สูงอายุจึงมีความสำคัญและมีความจำเป็น เพื่อให้ผู้สูงอายุเข้าถึงการวินิจฉัยและรักษาได้อย่างมีประสิทธิภาพอย่างต่อเนื่องและเท่าเทียมกัน การศึกษานี้ใช้กระบวนการวิจัยเชิงปฏิบัติการแบบมีส่วนร่วม (Participatory action research; PAR) โดยศึกษาองค์ประกอบ, ระบบงาน, เส้นทางการมารับบริการ, ความจำเป็นทางสุขภาพและความคาดหวังของผู้สูงอายุในการมารับบริการสุขภาพปฐมภูมิด้านโรคผิวหนัง โดยทำกิจกรรมสนทนากลุ่ม, การสัมภาษณ์เชิงลึก, การสำรวจด้วยแบบสอบถาม แล้วนำผลไปออกแบบแนวทางการพัฒนาบริการสุขภาพปฐมภูมิด้านโรคผิวหนัง ผลการศึกษาพบว่า การพัฒนาบริการสุขภาพปฐมภูมิด้านโรคผิวหนังควรประกอบด้วย 8 สิ่งสำคัญ คือ 1. การคัดกรองผู้ป่วย 2. การอธิบายการวินิจฉัยรักษาและมียาเพียงพอ 3. การพัฒนาศักยภาพของบุคลากรสาธารณสุข 4. การส่งต่อผู้ป่วย 5. การปรึกษาและเครือข่ายแพทย์ผิวหนัง 6. การนัดหมาย 7. การดูแลตนเองและการดูแลจากอาสาสมัครสาธารณสุขประจำหมู่บ้าน 8. สถานที่และอุปกรณ์เพียงพอ จากการสำรวจความเห็นของหน่วยบริการปฐมภูมิ 12 เขตสุขภาพและได้รับการตอบกลับจากโรงพยาบาลอำเภอและโรงพยาบาลส่งเสริมสุขภาพตำบล 397 แห่งจาก 576 แห่ง (อัตราการตอบกลับ 68.9%) มีความเห็นว่า มีความเป็นไปได้ในการทำวิธีการพัฒนาด้วย PAR 71%, มีประโยชน์ 96% และน่าจะทำได้ในระยะเวลา 6-12 เดือน ส่วนรูปแบบการพัฒนาการจัดบริการสุขภาพปฐมภูมิด้านโรคผิวหนัง มีความเป็นไปได้ 82%, มีประโยชน์ 98% และน่าจะทำได้ในระยะเวลามากกว่า 12 เดือน สรุปผลการศึกษาได้ว่า การพัฒนาการจัดบริการสุขภาพปฐมภูมิด้านโรคผิวหนังมีความจำเป็นและหน่วยบริการปฐมภูมิส่วนใหญ่ลงความเห็นว่าการพัฒนาการจัดบริการสุขภาพปฐมภูมิด้านโรคผิวหนังมีความเป็นไปได้และมีประโยชน์

Development Of Sensors For Bacteria And Wound Environment Monitoring, Pannawich Thirabowonkitphithan

Chulalongkorn University Theses and Dissertations (Chula ETD)

Diabetes mellitus (DM) is a leading cause of death and reduces life expectancy. Complications from diabetes have wreaked havoc not only on patients' quality of life, but also on the global burdens of public health and socioeconomic development. The most frequent complication among patients with diabetes mellitus is diabetic wounds, particularly diabetic foot ulcers because of the damage to sensory nerves and blood vessel issues brought on by elevated blood glucose levels. As a result, chronic wounds eventually develop and are prone to infection. In this study, several novel analytical devices for the detection of wound infections and the wound …

Visual Literacy: A Critical Literacy Competency In 21st Century Higher Education [Presentation Slides], Elizabeth Bucciarelli

Faculty Scholarship 2023

No abstract provided.

Exploring Academic Libraries' Core Values [Presentation Slides], Julia K. Nims

Faculty Scholarship 2023

Many academic libraries create mission and vision statements to communicate their purpose, priorities, and aspirations to both internal and external stakeholders. Core values, which express a library’s guiding principles or behaviors, are often included as part of these foundational documents. However, while there is already a significant and growing body of literature examining academic library mission and vision statements, such as their inclusion of specific library roles or functions, far less attention has been paid to libraries’ core values. To better understand these public declarations of convictions, the core values from 24 academic libraries in Michigan and Ohio were collected …

Nourishing The Brain On Deep Space Missions: Nutritional Psychiatry In Promoting Resilience, Nihar N Pathare, Flavia Fayet-Moore, Jennifer A Fogarty, Felice N Jacka, Philip Strandwitz, Gary E Strangman, Dorit B Donoviel

Faculty, Staff and Students Publications

The grueling psychological demands of a journey into deep space coupled with ever-increasing distances away from home pose a unique problem: how can we best take advantage of the benefits of fresh foods in a place that has none? Here, we consider the biggest challenges associated with our current spaceflight food system, highlight the importance of supporting optimal brain health on missions into deep space, and discuss evidence about food components that impact brain health. We propose a future food system that leverages the gut microbiota that can be individually tailored to best support the brain and mental health of …

Impact Of Gastrointestinal Polymerase Chain Reaction Panels On Antibiotic Utilization In Hospitalized Adult Patients, Gillean A Kelly, Roumen Iordanov, Alex Franklin, Amna Ahmed, Krithika Srinivasan, Jesica Hayon, Todd Lasco, Rosie Amini, Sabra Shay, Prathit A Kulkarni, Mayar Al Mohajer

Faculty, Staff and Students Publications

Multiplex stool polymerase chain reaction (PCR) panels offer rapid comprehensive testing for patients with infectious diarrhea. We compared antibiotic utilization among hospitalized patients with suspected infectious diarrhea who underwent diagnostic testing with either a stool culture or stool PCR panel. No significant differences in antibiotic utilization were identified.

Intermel: An International Biorepository And Clinical Database To Uncover Predictors Of Survival In Early-Stage Melanoma, Irene Orlow, Keimya D Sadeghi, Sharon N Edmiston, Jessica M Kenney, Cecilia Lezcano, James S Wilmott, Anne E Cust, Richard A Scolyer, Graham J Mann, Tim K Lee, Hazel Burke, Valerie Jakrot, Ping Shang, Peter M Ferguson, Tawny W Boyce, Jennifer S Ko, Peter Ngo, Pauline Funchain, Judy R Rees, Kelli O'Connell, Honglin Hao, Eloise Parrish, Kathleen Conway, Paul B Googe, David W Ollila, Stergios J Moschos, Eva Hernando, Douglas Hanniford, Diana Argibay, Christopher I Amos, Jeffrey E Lee, Iman Osman, Li Luo, Pei-Fen Kuan, Arshi Aurora, Bonnie E Gould Rothberg, Marcus W Bosenberg, Meg R Gerstenblith, Cheryl Thompson, Paul N Bogner, Ivan P Gorlov, Sheri L Holmen, Elise K Brunsgaard, Yvonne M Saenger, Ronglai Shen, Venkatraman Seshan, Eduardo Nagore, Marc S Ernstoff, Klaus J Busam, Colin B Begg, Nancy E Thomas, Marianne Berwick, Intermel Consortium

Faculty, Staff and Students Publications

INTRODUCTION: We are conducting a multicenter study to identify classifiers predictive of disease-specific survival in patients with primary melanomas. Here we delineate the unique aspects, challenges, and best practices for optimizing a study of generally small-sized pigmented tumor samples including primary melanomas of at least 1.05mm from AJTCC TNM stage IIA-IIID patients. We also evaluated tissue-derived predictors of extracted nucleic acids' quality and success in downstream testing. This ongoing study will target 1,000 melanomas within the international InterMEL consortium.

METHODS: Following a pre-established protocol, participating centers ship formalin-fixed paraffin embedded (FFPE) tissue sections to Memorial Sloan Kettering Cancer Center for …

Contextual Variation Of Clinical Notes Induced By Ehr Migration, Kurt Miller, Sungrim Moon, Sunyang Fu, Hongfang Liu

Faculty, Staff and Student Publications

The structure and semantics of clinical notes vary considerably across different Electronic Health Record (EHR) systems, sites, and institutions. Such heterogeneity hampers the portability of natural language processing (NLP) models in extracting information from the text for clinical research or practice. In this study, we evaluate the contextual variation of clinical notes by measuring the semantic and syntactic similarity of the notes of two sets of physicians comprising four medical specialties across EHR migrations at two Mayo Clinic sites. We find significant semantic and syntactic variation imposed by the context of the EHR system and between medical specialties whereas only …

Digital Solutions Observed In Clinical Trials: A Formative Feasibility Scoping Review, Taylor M Harrison, Sungrim Moon, Liwei Wang, Sunyang Fu, Hongfang Liu

Faculty, Staff and Student Publications

Growing digital access accelerates digital transformation of clinical trials where digital solutions (DSs) are increasingly and widely leveraged for improving trial efficiency, effectiveness, and accessibility. Many factors impact DS success including technology barriers, privacy concerns, or user engagement activities. It is unclear how those factors are considered or reported in the literature. Here, we perform a formative feasibility scoping review to identify gaps impacting DS quality and reproducibility in trials. Articles containing digital terms published in English from 2009 to 2022 were collected (n=4,167). 130 articles published between 2016 and 2022 were randomly selected for full-text review. Eligible articles (n=100) …

Milder Loss Of Insulin-Containing Islets In Individuals With Type 1 Diabetes And Type 2 Diabetes-Associated Tcf7l2 Genetic Variants, Maria J Redondo, Sarah J Richardson, Daniel Perry, Charles G Minard, Alice L J Carr, Todd Brusko, Irina Kusmartseva, Alberto Pugliese, Mark A Atkinson

Faculty, Staff and Students Publications

AIMS/HYPOTHESIS: TCF7L2 variants are the strongest genetic risk factor for type 2 diabetes. In individuals with type 1 diabetes, these variants are associated with a higher C-peptide AUC, a lower glucose AUC during an OGTT, single autoantibody positivity near diagnosis, particularly in individuals older than 12 years of age, and a lower frequency of type 1 diabetes-associated HLA genotypes. Based on initial observations from clinical cohorts, we tested the hypothesis that type 2 diabetes-predisposing TCF7L2 genetic variants are associated with a higher percentage of residual insulin-containing cells (ICI%) in pancreases of donors with type 1 diabetes, by examining genomic data …

The Health-Promoting Effects And The Mechanism Of Intermittent Fasting, Simin Liu, Min Zeng, Weixi Wan, Ming Huang, Xiang Li, Zixian Xie, Shang Wang, Yu Cai

Faculty, Staff and Student Publications

Intermittent fasting (IF) is an eating pattern in which individuals go extended periods with little or no energy intake after consuming regular food in intervening periods. IF has several health-promoting effects. It can effectively reduce weight, fasting insulin levels, and blood glucose levels. It can also increase the antitumor activity of medicines and cause improvement in the case of neurological diseases, such as memory deficit, to achieve enhanced metabolic function and prolonged longevity. Additionally, IF activates several biological pathways to induce autophagy, encourages cell renewal, prevents cancer cells from multiplying and spreading, and delays senescence. However, IF has specific adverse …

Data Mining Pipeline For Covid-19 Vaccine Safety Analysis Using A Large Electronic Health Record, Yan Huang, Xiaojin Li, Deepa Dongarwar, Hulin Wu, Guo-Qiang Zhang

Faculty, Staff and Student Publications

We developed a novel data mining pipeline that automatically extracts potential COVID-19 vaccine-related adverse events from a large Electronic Health Record (EHR) dataset. We applied this pipeline to Optum® de-identified COVID-19 EHR dataset containing COVID-19 vaccine records between December 11, 2020 and January 20, 2022. We compared post-vaccination diagnoses between the COVID-19 vaccine group and the influenza vaccine group among 553,682 individuals without COVID-19 infection. We extracted 1,414 ICD-10 diagnosis categories (first three ICD10 digits) within 180 days after the first dose of the COVID-19 vaccine. We then ranked the diagnosis codes using the adverse event rates and adjusted odds …