Digital Commons Network^™

Gut-Lung Axis Of The Microbiome Alterations After Ultrafine Particles And Ozone Inhalation, Md Habibul Hasan Mazumder

Graduate Theses, Dissertations, and Problem Reports (ETD)

Air pollution poses a significant threat to public health. It is a mixture of particulate matter, gaseous substances, and other secondary substances. Despite epidemiological research indicating the interactive effects of various components of air pollution, existing studies and regulatory limits often focus on single-exposure scenarios. The emerging understanding of the microbiome’s role in regulating immune response, metabolism, and pathophysiology of various diseases points towards interactions between environmental exposures and microbial dysbiosis. In this dissertation, mice were exposed to relevant deposited doses of carbon black (CB) and ozone (O3), and lung inflammation as well as the lung-gut axis of the microbiome …

Application Of Computational Biophysics Techniques To Characterize Cell Membrane-Associated Events, Kyle Billings

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cell membranes are crowded environments which can modulate protein structure-function relationships through interaction with lipids, other proteins, carbohydrate structures and so on. This work focuses the impact of the membrane environment on two varieties of peptides: Microbial rhodopsin proteins, and cyclic peptides.

Life on Earth is dependent on the ability of plants and microbes to harness sunlight for energy production. Their ability to transform light into carbohydrates requires tailor-made machinery, and for a wealth of microorganisms, microbial rhodopsin proteins (MR) are critical for maintaining the concentration gradients used to produce the energy molecule Adenosine triphosphate (ATP). The central retinal molecule …

Exploiting The Advantages And Overcoming The Challenges Of The Cable In A Tethered Drone System, Rogerio Rodrigues Lima

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation proposes solutions for motion planning, localization, and landing of tethered drones using only tether variables. A tether-based multi-model localization framework for tethered drones is proposed. This framework comprises three independent localization strategies based on a different model. The first strategy uses simple trigonometric relations assuming that the tether is taut; the second method relies on a set of catenary equations for the slack tether case; the third estimator is a neural network-based predictor that can cover different tether shapes. Multi-layer perceptron networks previously trained with a dataset comprised of the tether variables (i.e., length, tether angles on the …

Exploring The Conceptualizations And Utilizations Of Learning Theories In Sport Settings, Kevin R. Lou

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to identify how integrating learning theories into the design of a formal university course helps facilitate students’ resources, goals, and orientations (Schoenfeld, 2011) of learning theories for their future career work in coaching, sport psychology consulting, or other sport-related professions. Sixteen students signed up for a fifteen-week fall semester course at a Mid-Atlantic university in America and were asked to annotate, create, and reflect upon examples of future work in their desired fields for their three major written assignments in the course. Students reflected on their learning experience through pre-and-post semi-structured interviews and most …

Examining The Relations Among Academic And Non-Cognitive Factors And Student Achievement, Dona Sachini Hasanjalie Hewagallage

Graduate Theses, Dissertations, and Problem Reports (ETD)

Since the 1980s, Physics Education Research (PER) has explored the factors influencing students' success in college. This manuscript reports three different studies to understand the impact of different factors on students' college physics achievement. The first study explored several academic (high school physics preparation, high school preparation, math readiness, and ACT or SAT verbal and mathematics scores) and non-cognitive (self-efficacy, personality, belonging, grade expectation, and demographic) factors using correlation and linear regression analysis to understand their relation to students' physics conceptual understanding measured by the Force and Motion Conceptual Evaluation (FMCE). High school preparation was found to be the most …

Investigating The Interactions Of The Iron-Sulfur Mitochondrial Protein, Mitoneet With Its Binding Partners, Ebenezer Osei Newton

Graduate Theses, Dissertations, and Problem Reports (ETD)

MitoNEET belongs to the CDGSH Iron-Sulfur Domain (CISD)-gene family of proteins and is a [2Fe-2S] cluster-containing protein found on the outer membrane of mitochondria. The specific functions of mitoNEET/CISD1 remain to be fully elucidated, but the protein is involved in regulating mitochondrial bioenergetics in several metabolic diseases. Unfortunately, drug discovery efforts targeting mitoNEET to improve metabolic disorders are hampered by the lack of ligand-binding assays for this mitochondrial protein. We have developed a protocol amenable for high-throughput screening (HTS) assay, by modifying an ATP fluorescence polarization method to facilitate drug discovery targeting mitoNEET. Based on our observation that adenosine triphosphate …

Improving The Health And Safety Of Manufacturing Workers By Detecting And Addressing Personal Protective Equipment (Ppe) Violations In Real-Time With The Use Of Automated Ppe Detection Technology, Joseph Olufemi Fasinu

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Centers for Disease Control and Prevention (CDC) emphasized that Personal Protective Equipment (PPE) can significantly reduce the risk of occupational injuries and illnesses. However, improper use, failure to use, and other PPE-related violations can still result in injuries and fatalities. Eye and face protection violation has been one of the top 10 most frequently violated OSHA standards in fiscal years 2018, 2019, 2020, 2021 and 2022 consecutively. A common practice among safety professionals to ensure PPE compliance has been to physically inspect or monitor PPE usage among workers, which has been found to be unsustainable on a continuous real-time …

Impacts Of Error Rate And Therapist Appearance On The Accuracy Of Fidelity Data Collection, Marisela A. Aguilar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Procedural fidelity is the extent to which a procedure is implemented as designed. Analyzing procedural-fidelity data can improve treatment outcomes. Fidelity data are generally collected by a supervisor or trained data collector using a checklist that operationalizes each component of the procedure and accounts for errors in implementation of the components. However, little is known about variables that may affect the accuracy of supervisor-collected data generally, and even less is known about variables that may affect the accuracy of procedural-fidelity data. Therefore, the current studies explored the extent to which Board Certified Behavior Analysts (BCBAs) accurately detected programmed fidelity errors …

Analysis And Performance Of Osvaldo Golijov’S Hebreische Milonga, Gerardo Sanchez Pastrana

Graduate Theses, Dissertations, and Problem Reports (ETD)

Argentinian composer Osvaldo Golijov is one of the most important and well-recognized composers of the 21^st century. His works are unique because of the diverse mixing of styles due to the interculturalism present in his music. In the program notes of his Hebreische Milonga, Golijov mentions that this piece can connect his Argentinian and Jewish roots as well as the influence of Astor Piazzolla’s music. In addition, there is a connection between the tango and the Jewish people residing in Buenos Aires, Argentina, that is not addressed frequently when discussing the history of the tango. This research begins …

Spatio-Temporal Deep Learning Approaches For Addressing Track Association Problem Using Automatic Identification System (Ais) Data, Md Asif Bin Syed

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the realm of marine surveillance, track association constitutes a pivotal yet challenging task, involving the identification and tracking of unlabelled vessel trajectories. The need for accurate data association algorithms stems from the urge to spot unusual vessel movements or threat detection. These algorithms link sequential observations containing location and motion information to specific moving objects, helping to build their real-time trajectories. These threat detection algorithms will be useful when a vessel attempts to conceal its identity. The algorithm can then identify and track the specific vessel from its incoming signal. The data for this study is sourced from the …

Factors Influencing High School Physical Education Teachers' Content Selection, Olivia J. Gillispie

Graduate Theses, Dissertations, and Problem Reports (ETD)

There is limited research that has examined the factors that influence the selection of content for high school physical education. Addressing this gap in the literature is important, as those decisions influence student attitudes and engagement in physical education. The purpose of this study is twofold. First, this study aimed to explore what factors influence high school physical education teachers’ decision-making processes when selecting content to include in their curriculum (phase one). Second, this study investigated the facilitators and barriers to selecting and teaching the content areas suggested in the SHAPE America (2013) High School Grade-Level Outcomes (phase two).

This …

The Effect Of Sequential Stimuli On Variable-Interval Schedule Performance And Resurgence, Amanda K. Miles

Graduate Theses, Dissertations, and Problem Reports (ETD)

Resurgence, or the recurrence of a previously established but not currently occurring response given a worsening of current conditions, is a systematic phenomenon with clinical implications; thus, understanding the variables that impact resurgence is important. Investigations into the impact of discriminative stimuli on resurgence have yielded mixed results about whether the stimuli associated with extinction mitigate or prevent resurgence. The current experiments were conducted with sequential stimuli, that is, two or more stimuli occurring in a fixed sequence, that allowed determination of the effect of discriminative stimuli across a continuum of reinforcement conditions (from most temporally distal to most proximal …

Optimal Deployment Of Air Vehicle As Communication Relay For Multiple Ground Vehicles, Juan David Pabon Arias

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heterogeneous teams of both air and ground mobile vehicles can combine the advantages of mobility, sensing capability, and operation time when performing complex tasks. However, when ground vehicles operate in cluttered environments with randomized obstacles, they may experience line of sight (LoS) obstructions and loss of communication due to those obstacles. To mitigate this issue, an airborne relay can be positioned in the vicinity of the ground vehicles to aid communication by establishing two-hop communication links between the vehicles.

This thesis develops an analytical framework to calculate the probability of spanning a two-hop communication between a pair of ground vehicles …

Understanding The Impact Of Scientific Testimony On Potential Jury Members: Independent And Interactive Effects Of Expert Characteristics And Jury Member’S Social Location, Ellory R. Dabbs

Graduate Theses, Dissertations, and Problem Reports (ETD)

As science and technology evolve, they impact society at different levels. With these changes, it is important to understand how members of society will be affected. One area where there has been a rise in the use of scientific information is in jury trials. Those who are on trial for a criminal offense are more often relying on forensic evidence, and forensic experts, to aid in their defense, and those who are prosecuting a criminal case are also relying on forensic evidence and forensic experts. However, forensic evidence is not consistent in type or interpretation – what one person may …

Fast Raising: Digital Fundraising As Interaction Rituals, Matthew P. Hartwell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Twice a year, GamesDoneQuick hosts events that showcase the Speed Running Community, a sub-set of the Video Game Community. Since its inception in 2014 through 2021 GDQ has raised $25.7 million that has been distributed to the Prevent Cancer Foundation and Médecins Sans Frontiers (Doctors without Borders). This collection of studies analyzes the Awesome Games Done Quick 2020 event utilizing the Interaction Ritual Theory framework of Randall Collins to understand how ritualistic social action of this community has been leveraged by event organizers to promote successful crowd funding efforts that benefits organizations outside of the community. Further it expands on …

“I’Ll Tell You No Lies”: An Exploration Of Trauma, Memory, And Violence Against Women In North Carolina Murder Ballads, Madison Ava Helman

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores trauma, memory and violence against women in Western North Carolina murder ballads “Tom Dooley,” “Poor Omie Wise,” “Poor Ellen Smith,” “The Ballad of the Lawson Family,” and “Frankie Silver.” I posit that these ballads were influenced by prescriptive societal conceptions of femininity, which in turn influenced societal ideations of violence against women. Using folklore performance theory, I analyze the text and context of these ballads and their subsequent histories, eventually arriving at a template for polyvocality that incorporates multiple ballad variants and encourages diverse performances.

“Ingenious Entanglements”: Sheriffs, Capitalism, And Civil Society In America, 1750-1850, Chad R. Holmes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sheriffs served as indispensable legal actors who facilitated the expansion of democracy and capitalist transformation, processes that eventually limited their ability to profit from their work and diminished their social status. This dissertation is organized around specific sheriffs and the actions they performed to illustrate how county officers influenced society beyond the execution of court orders. These men—Rhode Island’s Beriah Brown, Pennsylvania’s John Barker, and Massachusetts’s Elisha Porter, Luke Baldwin, and Charles P. Sumner—believed they understood how to balance community demands and state directives in ways that would produce personal profit and greater authority. The work of these officers and …

Quantifying The Impacts Of Genetically Engineered Crops And Deep Soil C Cycling On The Sustainability Of Bioenergy Crop Production, Zoe Pagliaro

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bioenergy can help mitigate climate change by providing a carbon-neutral fuel source. However, multiple challenges exist to achieving carbon neutrality including converting lignocellulosic materials to fuel and enhancing soil C sequestration during the growth of the feedstocks. To address these challenges, there have been recent efforts to genetically modify feedstocks to produce more energy dense oils that increase fuel conversion efficiency and to cultivate deep-rooted perennial feedstocks that can enhance soil C storage. However, the C consequences and efficacy of these solutions remain largely uncertain.

To examine the C consequences of enhancing oil content of bioenergy feedstocks, I examined the …

Measuring And Modeling How Plant-Microbe Interactions Control Soil Carbon And Nitrogen Cycling In Managed And Unmanaged Ecosystems, Joanna Ridgeway

Graduate Theses, Dissertations, and Problem Reports (ETD)

Our understanding of how plant-microbe interactions regulate carbon (C) and nitrogen (N) retention in soil organic matter (SOM) remains uncertain. Conflicting evidence suggests that microbial decomposition can lead to the loss of unprotected particulate SOM, but also that microbial decomposition produces simpler compounds that preferentially form more persistent aggregate- or mineral-protected SOM pools. Further, uncertainty remains in how plant-microbe interactions alter SOM retention in these different pools through litter chemistry controls on microbial decomposition traits and rhizosphere priming. As a result, this uncertainty limits our ability to sustainably manage ecosystems and understand future feedbacks between terrestrial ecosystems and the global …

Glial Cell-Specific Contribution Of Pkr-Like Er Kinase (Perk) In Neuroinflammation And Behavior, Anirudhya Lahiri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neurological disorders such as multiple sclerosis (MS) are a major public health concern in the US, with no available therapeutic cure. Chronic neuroinflammation and aberrant proteostasis in the central nervous system (CNS) are the major hallmarks of neurological diseases. Endoplasmic Reticulum (ER) is a major cellular organelle involved in protein synthesis, folding and maturation of various secretory and transmembrane proteins. Pathophysiological stressors such as trauma and infection result in misfolded protein accumulation in the endoplasmic reticulum (ER) lumen, which results in ER stress. To regain proteostasis (protein homeostasis), cells activate the unfolded protein response (UPR). UPR is an evolutionarily conserved …

Xanthine Oxidase-Induced Vascular Dysfunction In Nano-Tio2 Inhalation, Xena Marie Williams

Graduate Theses, Dissertations, and Problem Reports (ETD)

Inhalation of nano-TiO₂ is linked to adverse clinical outcomes that affect people worldwide, particularly those who work in manufacturing. For example, cardiovascular consequences and changes in microvascular responses are, in part, associated with exposure to engineered nanomaterials such as nano-TiO₂; however, the mechanism(s) driving this process is unknown. Nano-TiO₂ is an engineered nanomaterial (ENM) that is reported to, upon inhalation, impair endothelium-dependent vasodilation in several vascular beds via enhanced local oxidant generation and diminished nitric oxide bioavailability. This dissertation aims to address the health concerns generated by occupational exposure to nano-TiO₂ and identify a link …

Heat Shock Protein 90 (Hsp90) System In Health And Disease., Daniella Munezero

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cells rely on heat shock proteins (HSP) to facilitate and regulate the folding of the substrate proteins into their native state, and degradation if misfolding cannot be prevented. HSP90, a member of the HSP family, is a potential target for treatment of cancer and neurodegenerative diseases. Unfortunately, several clinical trials for cancer treatment have been discontinued due to cell toxicity accompanying HSP90 inhibition. HSP90 has four distinct but structurally similar paralogs. HSP90 inhibitors target all the paralogs despite increasing proof of functional differences among the paralogs. Understanding the in vivo function of HSP90 and the role played by each paralog …

Perception Of Bias In Chatgpt: Analysis Of Social Media Data, Abdullah Wahbeh, Mohammad Al-Ramahi, Omar F. El-Gayar, Tareq Nasralah, Ahmed Elnoshokaty

Research & Publications

In this study, we aim to analyze the public perception of Twitter users with respect to the use of ChatGPT and the potential bias in its responses. Sentiment and emotion analysis were also analyzed. Analysis of 5,962 English tweets showed that Twitter users expressed concerns regarding six predominant types of biases, namely: political, ideological, data and algorithmic, gender, racial, cultural, and confirmation biases. Sentiment analysis showed that most of the users reflected a neutral sentiment, followed by negative and positive sentiment. Emotion analysis mainly reflected anger, disgust, and sadness with respect to bias concerns with ChatGPT use.

The Well-Being Of A University: The Relationship Between Gratitude And Organizational Commitment On Faculty Members' Intention To Stay, Brenda Merkel, Kristi Bockorny, Amber Henderson, Aaron Scholl

Research & Publications

Retaining good employees can be difficult , and no organization is immune. This study investigated the relationship between gratitude and organizational commitment to determine if they can predict the intention to stay among university faculty. Specifically, this study analyzed gratitude, a construct that has not been researched much in the workplace. There was a significant relationship between gratitude on organizational commitment. Gratitude and organizational commitment were important predictors of intention to stay. Gratitude was supported as a moderator between organizational commitment and intention to stay. Organizations should incorporate posititve reinforcements to express gratitude to increase organizational commitment and intent to …

Developing Machine Learning And Deep Learning Soil Moisture Models For Precision Agricultural Applications, Xiaomo Zhang

Natural Resources Management

Monitoring soil moisture is increasingly becoming a research focus in the fields of agriculture, hydrology, meteorology, and ecology. While soil moisture measurements at points (<1 m²) and their estimation at larger scales (100-25,000 km²) have improved considerably, soil moisture modeling at the intermediate scales (10 to 100 m²) needs more attention. In this study, machine learning and deep learning models including multi-linear regression (MLR), support vector machine (SVM), Gaussian process regression (GPR), and convolutional neural networks (CNN) were built and compared for soil moisture predictions at different depths at the weather stations in the Red River Valley using locations, meteorological data, and soil physical properties. The results showed that the GPR (R²=0.80-0.90) outperformed other models including MLR (R²=68-0.82), SVM (R²=0.44-0.60), and CNN (R²=0.66-0.84) for soil moisture prediction. The prediction performance in the topsoil was better than in the subsoils. The GPR outperformed SVM when both models used the same kernel functions and kernel parameters.

The Magnetic Pull Of American Discovery: Second Thoughts About American Exceptionalism?, Richard L. Marcus

Faculty Scholarship

No abstract provided.

Data Integration With Diverse Data: Aerospace Industry Insights From A Systematic Literature Review, Cherie Noteboom, Olga Perera

Research & Publications

Data Integration (DI) is a technical framework that facilitates the integration of different data sources into a unified system. Often, organizational data is spread across various files, databases, and personal computers, resulting in data silos and difficulties in accessing vital organizational knowledge. The solution rests in the development of Information Systems capable of handling diverse data from multiple heterogeneous sources. This study presents a systematic literature review on data integration approaches, specifically focusing on the aerospace industry. We conducted a literature search on IEEE Xplore database with keywords ‘data integration aerospace’ for articles published between January 2000 and December 2022 …

The B-Cell Role In Autoimmunity, Marissa Marie Mindt

Microbiological Sciences

This review is focused on B-cell’s role in autoimmunity and was conducted by reading current papers across a variety of journals and compiling the information learned in this process. Specifically, this review paper encompasses an analysis of what autoimmune diseases are, as well as some of the characteristics of autoimmune diseases the introduction section of this paper serves as a crash course on B-cell. The disease write-up is where autoimmune diseases that are affected and mediated by B-cells, such as systemic lupus erythematosus, multiple sclerosis, and Chron’s disease, are explored. The next section will compare the mechanisms behind each of …

Concurrent Idh1 And Idh2 Mutations In Glioblastoma: A Case Report, Ali S Haider, Chibawanye I Ene, Paolo Palmisciano, Maryam Haider, Ganesh Rao, Leomar Y Ballester, Gregory N Fuller

Faculty, Staff and Students Publications

Isocitrate dehydrogenase (IDH) mutations are cornerstone diagnostic features in glioma classification. IDH mutations are typically characterized by mutually exclusive amino acid substitutions in the genes encoding for the IDH1 and the IDH2 enzyme isoforms. We report our institutional case of a diffuse astrocytoma with progression to secondary glioblastoma and concurrent IDH1/IDH2 mutations. A 49-year-old male underwent a subtotal resection of a lobular lesion within the right insula in 2013, revealing a WHO grade 3 anaplastic oligoastrocytoma, IDH1 mutated, 1p19q intact. Symptomatic tumor progression was suspected in 2018, leading to a surgical tumor biopsy that demonstrated WHO grade 4 IDH1 and …

Understanding Visitor Recreation Experiences On Montana's Public Lands, Kara Grau, Megan Schultz, Glenna Brown, Melissa Weddell

Institute for Tourism and Recreation Research Publications

The grandeur of Montana’s public lands attracts visitors from all over the world who want to experience the beautiful parks, wilderness, wildlife, and waters. Montana is ranked 10th in the nation in federal land ownership, with about 30% or 27 million acres, followed by state agencies that manage a little over 5 million acres. Moreover, Montana is the gateway to the iconic Glacier and Yellowstone National Parks.