Digital Commons Network^™

The Full And The Empty. A Dialogue Between Chinese Painting And Design, Estelle Berger, Dominique Christian

IASDR Conference Series

This pictorial paper stages the generative dialogue between a designer-researcher-teacher and a philosopher-teacher-painter in the Chinese tradition. Through cultural decentring and exchange of perspectives, we aim at questioning designers’ posture. More specifically, the polarities of “empty” and “full” are used to discuss the sense of authorship, and the balance between engagement and letting go in practice. The paintings that punctuate the text are neither used as simple illustrations nor as achievements, they constitute another type of narrative thread in our dialogue, that we hope will trigger readers’ sensitivity, reflection, and action.

The Future Archives: A Speculative Approach For Visualising The Impacts Of 6g-Enabled Infrastructure In Japan, Georgia Mackenzie, Federico Trucchia, Hemal Dias

IASDR Conference Series

6G-enabled technologies are set to become an integral part of the infrastructure within the next decade. This paper provides a speculative design-based approach to shape future technology development. We do this by leveraging current technologies to simulate future network capabilities. Specifically, we focus on how the 6G network could transform mobility in Japan. We begin with an overview of the country’s societal macro trends, the current state of technologies, and the expected novel capabilities of 6G. We then introduce four scenarios, used as the basis for developing two types of outcomes. These include physical prototypes to simulate novel interactions enabled …

Hitonami (人波): Speculative Design For Overcrowded Mobility Arenas In The 6g Era, Yaara Schattner, Tom Reznikov, Yuri Klebanov, Guy Blander, Niv Yashar, Tal Nisim, Adi Simon, Naomi Slaney, Romi Mikulinsky

IASDR Conference Series

The future of urban mobility is expected to experience significant changes with the introduction of emerging technologies: non-human actors, immersive experiences, and location accuracy. Speculative design processes that enable walkable urban environments will become critical for sustainable and inclusive cities. This paper explores challenges and opportunities in designing walkability for Japanese train stations, known for unique features and high density. The paper proposes a framework for improving walkability using a multicultural approach that combines field research with speculative design tactics and lo-fi prototyping. The proposed framework leverages collective movement models and design paradigms to enhance individual and collective walkability. The …

Tools For A Warming Planet, Beth Ferguson, Sara Dean

IASDR Conference Series

We live on a planet in flux--warming waters and land, chaotic weather, and unknown futures. Our adaptability and ingenuity are crucial to our collective survival, and our planet’s ability to thrive. In response to this condition, innovative new tools for understanding, engaging, and responding to our current and future environment are needed. Tools for a Warming Planet is a crowd-sourced collection of 50 tools that engage in the urgency of climate change. This community archive and living lab was created by using print and digital submission tools shared by a variety of art, design, and cultural institutions. The collection represents …

Pedagogy Of Experimental Design: Scientific Research Methods In Architectural Education, Assia Crawford

IASDR Conference Series

Bio-design is a growing field in architecture that focuses on integrating biological processes and systems into the design of buildings and urban environments. This approach draws inspiration from nature and seeks to create sustainable and regenerative structures that can adapt to changing environmental conditions. Architecture students are increasingly becoming involved in the design and execution of bio-design experiments, leveraging their interdisciplinary knowledge and design skills to create innovative solutions that integrate biology and design principles. This allows students to explore new avenues of research and to develop a deeper understanding of the intersection between design and the natural world. This …

Domestic Infrastructure Of Food: Thoughts On Community Engagement Through Food, Furniture, And Architectural Exhibition, Leyuan Li

IASDR Conference Series

Over the past decades, the attention towards fresh food ingredients has promoted the emergence of growing vegetables in domestic spaces and sharing homemade ingredients with neighbors. The introduction of producing and exchanging food in domestic territories not only creates new forms of recreation, but also foregrounds inhabitants' anxieties concerning food security and community engagement, especially amidst global unrest during the pandemic. Within this imperative context, the pictorial essay intends to introduce food as a collective medium and a social act. By showing a series of representations and photographs of an installation project, the essay speculates on the performative and spatial …

Picturing Interactivity: Design Exploration Of A Highly Interactive Picturebook, Nicholas Vanderschantz, Claire Timpany, Kristy Wright

IASDR Conference Series

Picturebooks and interactivity are two critical features of early learning in the home and during education. Picturebooks afford opportunities for shared reading and learning through active participation by each reader. Picturebook research has explored a range of concepts, yet very little research to date synergises these investigations using a lens that will help to design transformative interactive books that positively impact shared reading. This research offers the design rationale, and process followed to develop a highly interactive printed picturebook. The design considerations employed are presented in our paper and serve as inspiration for designers developing books that may support multiple …

Review Of Wild Sound: Maryanne Amacher And The Tenses Of Audible Life, By Amy Cimini, Charissa Noble

Music: Faculty Scholarship

The first book dedicated to the life and work of composer Maryanne Amacher (1938- 2009), Wild Sound: Maryanne Amacher and the Tenses of Audible Life begins in medias res. Author Amy Cimini introduces us to Amacher by peering into one of her brainstorming sessions, depicting an imaginative scene set in the 1990s at Mills College. Cimini describes Amacher seated at her desk, passionately inscribing a “big quote” (announced in “heavy black Sharpie,” Cimini notes) from feminist scholar Donna Haraway’s Simians, Cyborgs and Women (1991): “I want a feminist writing….” Then, as Amacher ponders the quote’s implications for her own creative …

Clinical Characteristics Of Monkeypox Vaccine Injection Site Reactions: A Cohort Of Seven Patients, Anthony A. Gaspari

Department of Dermatology and Cutaneous Biology Faculty Papers

Background

Monkeypox (Mpox) infections are considered a public health emergency, prompting the need for the administration of a preventative vaccine to high-risk individuals.

Objectives

To describe the clinical course of dermatologic reactions to Mpox vaccine over time.

Methods

Seven recipients of the Mpox vaccine, administered via intradermal injection, were observed over time, and the dermatologic reactions to this vaccine were recorded.

Results

All seven recipients experienced mild to moderate localized reactions to Mpox vaccine to either the primary or booster injections. These reactions were characterized by erythema, induration and pruritus. These reactions eventually healed without any sustained reactions, eschar or …

The Utah Statesman, October 9, 2023, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

Assembly Of An Inexpensive Rat Jugular Catheter Button Based On A Split-Septum Needleless Intravenous System, Mauricio Suarez, Elizabeth J. Cantrell, Ken T. Wakabayashi, Caroline E. Bass

Department of Psychology: Faculty Publications

Rat intravenous self-administration is a widely-used animal model in the study of substance use disorders. Rats are tethered to a drug delivery system usually through a port or button that inter- faces the drug delivery system with a chronic indwelling jugular vein catheter. These buttons can be purchased commercially but are costly, presenting a significant economic barrier for many researchers. Many researchers manufacture buttons in-house from a combination of individual custom made and commercially available components, resulting in large variation in terms of how the animals are handled and the longevity of catheter patency. We have developed a jugular catheter …

Chapter Iii — The Ethiopian Forces Of Survival, Messay Kebede

Ethiopian Modernization: Opportunities and Derailments

To account for the protracted endurance of Ethiopia, the last chapter hinted at two requisites, namely, a system of power suited for defense and the sense of shouldering a mandate. Such a successful record, in addition to presupposing a robust and effective ability for self-defense, necessitates a leadership that feels entrusted with a mission. From a cursory examination of Ethiopian history, one can confidently surmise that, at least until the overthrow of the last emperor, Ethiopia survived for so long thanks to a system of power that was protective of survival and bearer of a mission. The system rested on …

Ready Worker One? High-Res Vr For The Home Office, Anastasia Ruvimova, Felipe Fronchetti, Boden A. Kahn, Luiz Henrique Susin, Zekeya Hurley, Thomas Fritz, Mark Hancock, David Shepherd

Faculty Publications

Many employees prefer to work from home, yet struggle to squeeze their office into an already fully-utilized space. Virtual Reality (VR) seemingly offered a solution with its ability to transform even modest physical spaces into spacious, productive virtual offices, but hardware challenges - such as low resolution - have prevented this from becoming a reality. Now that hardware issues are being overcome, we are able to investigate the suitability of VR for daily work. To do so, we (1) studied the physical space that users typically dedicate to home offices and (2) conducted an exploratory study of users working in …

Focus, 2023, Summer, Andrews University

Focus

FOCUS (ISSN 1077-9345) is published quarterly, free of charge, for alumni and friends of Andrews University, an institution owned and operated by the Seventh-day Adventist Church.

Chimes: October 9, 2023, Calvin University

Chimes

Calvin Knights post strong h9omecoming performances by Dillion Baumchen

Chapel attendance generally remains consistent, doubles for Thursday service by Nolan Cowan

Calvin's Spanish dual enrollment program expands and evolves by Ethan Meyers

Creation Care Summit held on Calvin's campus by Grace Buller

Abstraction to host coding competition on Nov. 4 by Jacob Westra

Calvin's international orientation equips students for life in the US by Savannah Shustack

From Calvin College to Los Angeles: A Q&A with Calvin alum Glenn Bulthuis about his musical career by Gabriel Choi

Being at Calvin has helped me understand and accept my disability by Ethan Meyers

Metabolomic Insights Into Tuberculosis: Machine Learning Approaches For Biomarker Identification, Miftahul Khair Akbar, Arief Aulia Rahman

Indonesian Journal of Medical Chemistry and Bioinformatics

The lung parenchyma is largely impacted by the infectious condition known as pulmonary tuberculosis (pulmonary TB) when the immune system creates a wall around the germs in the lungs, a tiny, hard bulge known as a tubercle develops, earning the disease the name tuberculosis. Although the majority of TB germs target the lungs, they can also harm other bodily organs. The identification of TB biomarkers, which are crucial for diagnosis, treatment monitoring, risk analysis, and prognosis, has been the subject of extensive research. Differences in metabolites between normal cells and tuberculosis are considered to be able to support the diagnosis …

Ccdc50 Promotes Tumor Growth Through Regulation Of Lysosome Homeostasis, Penghui Jia, Tian Tian, Zibo Li, Yicheng Wang, Yuxin Lin, Weijie Zeng, Yu Ye, Miao He, Xiangrong Ni, Ji'an Pan, Xiaonan Dong, Jian Huang, Chun-Mei Li, Deyin Guo, Panpan Hou

Faculty, Staff and Student Publications

The maintenance of lysosome homeostasis is crucial for cell growth. Lysosome-dependent degradation and metabolism sustain tumor cell survival. Here, we demonstrate that CCDC50 serves as a lysophagy receptor, promoting tumor progression and invasion by controlling lysosomal integrity and renewal. CCDC50 monitors lysosomal damage, recognizes galectin-3 and K63-linked polyubiquitination on damaged lysosomes, and specifically targets them for autophagy-dependent degradation. CCDC50 deficiency causes the accumulation of ruptured lysosomes, impaired autophagic flux, and superfluous reactive oxygen species, consequently leading to cell death and tumor suppression. CCDC50 expression is associated with malignancy, progression to metastasis, and poor overall survival in human melanoma. Targeting CCDC50 …

Restructuring The Constitution For Human Resilience, Martha T. Mccluskey

Contributions to Books

Published as Chapter 1 in Law, Vulnerability, and the Responsive State: Beyond Equality and Liberty, Martha Albertson Fineman & Laura Spitz, eds.

Social Determinants Of Health And Disparate Disability Accumulation In A Cohort Of Black, Hispanic, And White Patients With Multiple Sclerosis, Michael C Robertson, Brian Downer, Paul E Schulz, Rafael Samper-Ternent, Elizabeth J Lyons, Sadaf Arefi Milani

Faculty, Staff and Student Publications

OBJECTIVES: Mexico has a rapidly aging population at risk for cognitive impairment. Social and leisure activities may protect against cognitive decline in older adults. The benefits of these behaviors may vary by patterns of cognitive impairment. The objectives of this study were to identify latent states of cognitive functioning, model the incidence of transitions between these states, and investigate how social and leisure activities were associated with state transitions over a 6-year period in Mexican adults aged 60 and older.

METHODS: We performed latent transition analyses to identify distinct cognitive statuses in the 2012 and 2018 waves of the Mexican …

Impact Of Post-Pci Ffr Stratified By Coronary Artery, Carlos Collet, Nils P Johnson, Takuya Mizukami, William F Fearon, Colin Berry, Jeroen Sonck, Damien Collison, Bon-Kwon Koo, Nicolas Meneveau, Shiv Kumar Agarwal, Barry Uretsky, Abdul Hakeem, Joon-Hyung Doh, Bruno R Da Costa, Keith G Oldroyd, Jonathon A Leipsic, Umberto Morbiducci, Charles Taylor, Brian Ko, Pim A L Tonino, Divaka Perera, Toshiro Shinke, Claudio Chiastra, Andrei C Sposito, Antonio Maria Leone, Olivier Muller, Stephane Fournier, Hitoshi Matsuo, Julien Adjedj, Nicolas Amabile, Zsolt Piróth, Fernando Alfonso, Fernando Rivero, Jung-Min Ahn, Gabor G Toth, Abdul Ihdayhid, Nick E J West, Tetsuya Amano, Eric Wyffels, Daniel Munhoz, Marta Belmonte, Hirofumi Ohashi, Koshiro Sakai, Emanuele Gallinoro, Emanuele Barbato, Thomas Engstrøm, Javier Escaned, Ziad A Ali, Morton J Kern, Nico H J Pijls, Peter Jüni, Bernard De Bruyne

Faculty, Staff and Student Publications

Background: Low fractional flow reserve (FFR) after percutaneous coronary intervention (PCI) has been associated with adverse clinical outcomes. Hitherto, this assessment has been independent of the epicardial vessel interrogated.

Objectives: This study sought to assess the predictive capacity of post-PCI FFR for target vessel failure (TVF) stratified by coronary artery.

Methods: We performed a systematic review and individual patient-level data meta-analysis of randomized clinical trials and observational studies with protocol-recommended post-PCI FFR assessment. The difference in post-PCI FFR between left anterior descending (LAD) and non-LAD arteries was assessed using a random-effect models meta-analysis of mean differences. TVF was defined as …

Investigating The Environmental Weathering Of Plastics Used Within The Agricultural Fields, Gholamreza .. Bonyadinejad

Electronic Theses and Dissertations Archive

The soaring accumulation of discarded plastics in the environment is a pressing global issue, primarily driven by increased plastic usage and improper waste management. From 2012 to 2019, among various applications of plastic products, the global utilization of plastics in agriculture witnessed a notable rise, surging from 4.4 million tons to 7.4 million tons, creating plastic pollution problems. Plastic pollution within the farmlands threatens food safety and negatively impacts soil health. Therefore, this dissertation focuses on studying the environmental weathering of plastic residuals within the terrestrial environment and investigating their impacts on the plastic particles' fate within the aquatic systems. …

The George-Anne Reflector Magazine Newsletter, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Let Them Play! Integrating More Play Into Kindergarten Curriculum And Classrooms, Danielle N. Johnson

Masters Projects

Research reinforces how play in the classroom can greatly benefit students in academic, social, emotional and behavioral ways. Today, students in kindergarten are being pressured to adhere to rigorous academic standards .While teachers are centering instruction around these standards, play is no longer seen as an essential piece of the classroom. The standards in kindergarten are becoming more intense and similar to higher grade levels. Developmentally, play can be a very advantageous way to help students grow in literacy and their learning. With scaffolding and modeling, teachers have the opportunity to teach through play and give students space to grow …

Sox7-Positive Endothelial Progenitors Establish Coronary Arteries And Govern Ventricular Compaction, Ivy Kn Chiang, David Humphrey, Richard J Mills, Peter Kaltzis, Shikha Pachauri, Matthew Graus, Diptarka Saha, Zhijian Wu, Paul Young, Choon Boon Sim, Tara Davidson, Andres Hernandez-Garcia, Chad A Shaw, Alexander Renwick, Daryl A Scott, Enzo R Porrello, Emily S Wong, James E Hudson, Kristy Red-Horse, Gonzalo Del Monte-Nieto, Mathias Francois

Faculty, Staff and Students Publications

The cardiac endothelium influences ventricular chamber development by coordinating trabeculation and compaction. However, the endothelial-specific molecular mechanisms mediating this coordination are not fully understood. Here, we identify the Sox7 transcription factor as a critical cue instructing cardiac endothelium identity during ventricular chamber development. Endothelial-specific loss of Sox7 function in mice results in cardiac ventricular defects similar to non-compaction cardiomyopathy, with a change in the proportions of trabecular and compact cardiomyocytes in the mutant hearts. This phenotype is paralleled by abnormal coronary artery formation. Loss of Sox7 function disrupts the transcriptional regulation of the Notch pathway and connexins 37 and 40, …

Evaluation Of Land Preparation Methods For Soil Stabilization, Revegetation, And Renewed Productivity In Semi-Arid Climates, Jarrett Lardy, North Dakota State University, Miranda Meehan, Aaron L. M. Daigh, James Staricka, Nathan Derby

Department of Agronomy and Horticulture: Faculty Publications

In the Williston Basin, land-preparation treatments have not been compared in side-by-side trials to evaluate performance for parameters such as runoff, erosion, and vegetation establishment. Thus, four treatments of wheat-straw crimping, land imprinting, wood-fiber hydromulch, and the combination of land imprinting and hydromulch were evaluated against a bare soil control in a replicated and randomized completed block field experiment near Williston, ND. Rainfall simulations were performed in September 2020 and June 2021 to examine the effectiveness of the treatments to reduce runoff and sediment losses. Vegetation establishment was also evaluated in August 2021. The wheat straw treatment reduced the equivalent …

20231009_Hslic Welcomes A New Faculty Member, Ingrid Hendrix

HSLIC Blog Post

No abstract provided.

Mathematical Modeling Of Radiotherapy: Impact Of Model Selection On Estimating Minimum Radiation Dose For Tumor Control, Achyudhan R Kutuva, Jimmy J Caudell, Kosj Yamoah, Heiko Enderling, Mohammad U Zahid

Faculty, Staff and Student Publications

INTRODUCTION: Radiation therapy (RT) is one of the most common anticancer therapies. Yet, current radiation oncology practice does not adapt RT dose for individual patients, despite wide interpatient variability in radiosensitivity and accompanying treatment response. We have previously shown that mechanistic mathematical modeling of tumor volume dynamics can simulate volumetric response to RT for individual patients and estimation personalized RT dose for optimal tumor volume reduction. However, understanding the implications of the choice of the underlying RT response model is critical when calculating personalized RT dose.

METHODS: In this study, we evaluate the mathematical implications and biological effects of 2 …

Enzyme-Mediated Depletion Of Methylthioadenosine Restores T Cell Function In Mtap-Deficient Tumors And Reverses Immunotherapy Resistance, Donjeta Gjuka, Elio Adib, Kendra Garrison, Jianfeng Chen, Yuxue Zhang, Wenjiao Li, Daniel Boutz, Candice Lamb, Yuri Tanno, Amin Nassar, Talal El Zarif, Neil Kale, Mehrdad Rakaee, Tarek H Mouhieddine, Sarah Abou Alaiwi, Alexander Gusev, Thomas Rogers, Jianjun Gao, George Georgiou, David J Kwiatkowski, Everett Stone

Faculty, Staff and Student Publications

Chromosomal region 9p21 containing tumor suppressors CDKN2A/B and methylthioadenosine phosphorylase (MTAP) is one of the most frequent genetic deletions in cancer. 9p21 loss is correlated with reduced tumor-infiltrating lymphocytes (TILs) and resistance to immune checkpoint inhibitor (ICI) therapy. Previously thought to be caused by CDKN2A/B loss, we now show that it is loss of MTAP that leads to poor outcomes on ICI therapy and reduced TIL density. MTAP loss causes accumulation of methylthioadenosine (MTA) both intracellularly and extracellularly and profoundly impairs T cell function via the inhibition of protein arginine methyltransferase 5 (PRMT5) and by adenosine receptor agonism. Administration of …

Table Of Contents, Seattle University Law Review

Seattle University Law Review

Table of Contents

Homogenization And Thermal Processing Reduce The Concentration Of Extracellular Vesicles In Bovine Milk, Anna P. Colella, Anuradha Prakash, John Miklavcic

Food Science Faculty Articles and Research

Extracellular vesicles (EVs) in bovine milk confer beneficial physiologic effects to consumers. Industrial processing treatments may affect the amount or bioactivity of EVs intrinsic to bovine milk. We investigated how the content and concentration of EVs were affected by homogenization and thermal processing of raw bovine milk. Raw milk was processed by homogenization, low-temperature (LT) heat, or pasteurization [high-temperature short-time (HTST) and ultra-high-temperature (UHT)] in a pilot processing facility. EVs were isolated from the raw and processed bovine milk using differential ultracentrifugation and quantified using a nanoparticle tracking analyzer. Bovine milk EVs were assessed for total miRNA and protein concentrations …