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Hippo Pathway Knockdown Gene Therapy In The Heart, Todd R Heallen, James F Martin

The Texas Heart Institute Journal

No abstract provided.

Association Between Whole Blood-Derived Mitochondrial Dna Copy Number, Low-Density Lipoprotein Cholesterol, And Cardiovascular Disease Risk, Xue Liu, Xianbang Sun, Yuankai Zhang, Wenqing Jiang, Meng Lai, Kerri L Wiggins, Laura M Raffield, Lawrence F Bielak, Wei Zhao, Achilleas Pitsillides, Jeffrey Haessler, Yinan Zheng, Thomas W Blackwell, Jie Yao, Xiuqing Guo, Yong Qian, Bharat Thyagarajan, Nathan Pankratz, Stephen S Rich, Kent D Taylor, Patricia A Peyser, Susan R Heckbert, Sudha Seshadri, Eric Boerwinkle, Megan L Grove, Nicholas B Larson, Jennifer A Smith, Ramachandran S Vasan, Annette L Fitzpatrick, Myriam Fornage, Jun Ding, April P Carson, Goncalo Abecasis, Josée Dupuis, Alexander Reiner, Charles Kooperberg, Lifang Hou, Bruce M Psaty, James G Wilson, Daniel Levy, Jerome I Rotter, Joshua C Bis, Claudia L Satizabal, Dan E Arking, Chunyu Liu

Faculty, Staff and Student Publications

Background The relationship between mitochondrial DNA copy number (mtDNA CN) and cardiovascular disease remains elusive. Methods and Results We performed cross-sectional and prospective association analyses of blood-derived mtDNA CN and cardiovascular disease outcomes in 27 316 participants in 8 cohorts of multiple racial and ethnic groups with whole-genome sequencing. We also performed Mendelian randomization to explore causal relationships of mtDNA CN with coronary heart disease (CHD) and cardiometabolic risk factors (obesity, diabetes, hypertension, and hyperlipidemia).

Endogenous Renal Adiponectin Drives Gluconeogenesis Through Enhancing Pyruvate And Fatty Acid Utilization, Toshiharu Onodera, May-Yun Wang, Joseph M Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S Balzer, Dae-Seok Kim, Xuenan Sun, Yu A An, Bianca C Field, Charlotte Lee, Ei-Ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M Kusminski, Ruth Gordillo, Laurent Gautron, Denise K Marciano, Ming Chang Hu, Shawn C Burgess, Katalin Susztak, Orson W Moe, Philipp E Scherer

Faculty, Staff and Student Publications

Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is unknown. We assessed the impact of renal adiponectin by utilizing male inducible kidney tubular cell-specific adiponectin overexpression or knockout mice. Kidney-specific adiponectin overexpression induces a doubling of phosphoenolpyruvate carboxylase expression and enhanced pyruvate-mediated glucose production, tricarboxylic acid cycle intermediates and an upregulation of fatty acid oxidation (FAO). Inhibition of FAO reduces the adiponectin-induced enhancement of glucose production, highlighting the role of FAO in the induction …

Oncolytic Virus M1 Functions As A Bifunctional Checkpoint Inhibitor To Enhance The Antitumor Activity Of Dc Vaccine, Jia Dan, Jing Cai, Yingqian Zhong, Chaoqun Wang, Shanyu Huang, Ying Zeng, Zhen Fan, Cuiying Xu, Linyi Hu, Jiayu Zhang, Jun Hu, Ying Liu, Xingwen Su, Wenbo Zhu, Guangmei Yan, Jiankai Liang, Yuan Lin

Faculty, Staff and Student Publications

Although promising, dendritic cell (DC) vaccines still provide limited clinical benefits, mainly due to the immunosuppressive tumor microenvironment (TME) and the lack of tumor-associated antigens (TAAs). Oncolytic virus therapy is an ideal strategy to overcome immunosuppression and expose TAAs; therefore, they may work synergistically with DC vaccines. In this study, we demonstrate that oncolytic virus M1 (OVM) can enhance the antitumor effects of DC vaccines across diverse syngeneic mouse tumor models by increasing the infiltration of CD8+ effector T cells in the TME. Mechanically, we show that tumor cells counteract DC vaccines through the SIRPα-CD47 immune checkpoint, while OVM can …

Impairment Of Serine Transport Across The Blood-Brain Barrier By Deletion Of Slc38a5 Causes Developmental Delay And Motor Dysfunction, Inna Radzishevsky, Maali Odeh, Oded Bodner, Salman Zubedat, Lihi Shaulov, Maxim Litvak, Kayoko Esaki, Takeo Yoshikawa, Bella Agranovich, Wen-Hong Li, Alex Radzishevsky, Eyal Gottlieb, Avi Avital, Herman Wolosker

Faculty, Staff and Student Publications

Brain L-serine is critical for neurodevelopment and is thought to be synthesized solely from glucose. In contrast, we found that the influx of L-serine across the blood-brain barrier (BBB) is essential for brain development. We identified the endothelial Slc38a5, previously thought to be a glutamine transporter, as an L-serine transporter expressed at the BBB in early postnatal life. Young Slc38a5 knockout (KO) mice exhibit developmental alterations and a decrease in brain L-serine and D-serine, without changes in serum or liver amino acids. Slc38a5-KO brains exhibit accumulation of neurotoxic deoxysphingolipids, synaptic and mitochondrial abnormalities, and decreased neurogenesis at the dentate gyrus. …

Macrocephaly And Developmental Delay Caused By Missense Variants In Rab5c, Klaas Koop, Weimin Yuan, Federico Tessadori, Wilmer R Rodriguez-Polanco, Jeremy Grubbs, Bo Zhang, Matt Osmond, Gail Graham, Sarah Sawyer, Erin Conboy, Francesco Vetrini, Kayla Treat, Rafal Płoski, Victor Murcia Pienkowski, Anna Kłosowska, Elizabeth Fieg, Joel Krier, Coralie Mallebranche, Ziegler Alban, Kimberly A Aldinger, Deborah Ritter, Ellen Macnamara, Bonnie Sullivan, John Herriges, Joseph T Alaimo, Catherine Helbig, Colin A Ellis, Clare Van Eyk, Jozef Gecz, Daniel Farrugia, Ikeoluwa Osei-Owusu, Lesley Adès, Marie-Jose Van Den Boogaard, Sabine Fuchs, Jeroen Bakker, Karen Duran, Zachary D Dawson, Anika Lindsey, Huiyan Huang, Dustin Baldridge, Gary A Silverman, Barth D Grant, David Raizen, Undiagnosed Diseases Network, Gijs Van Haaften, Stephen C Pak, Holger Rehmann, Tim Schedl, Peter Van Hasselt

Faculty, Staff and Students Publications

Rab GTPases are important regulators of intracellular vesicular trafficking. RAB5C is a member of the Rab GTPase family that plays an important role in the endocytic pathway, membrane protein recycling and signaling. Here we report on 12 individuals with nine different heterozygous de novo variants in RAB5C. All but one patient with missense variants (n = 9) exhibited macrocephaly, combined with mild-to-moderate developmental delay. Patients with loss of function variants (n = 2) had an apparently more severe clinical phenotype with refractory epilepsy and intellectual disability but a normal head circumference. Four missense variants were investigated experimentally. In vitro biochemical …

Orthostatic Hypotension, Hypertension Treatment, And Cardiovascular Disease: An Individual Participant Meta-Analysis, Stephen P Juraschek, Jiun-Ruey Hu, Jennifer L Cluett, Anthony M Ishak, Carol Mita, Lewis A Lipsitz, Lawrence J Appel, Nigel S Beckett, Ruth L Coleman, William C Cushman, Barry R Davis, Greg Grandits, Rury R Holman, Edgar R Miller, Ruth Peters, Jan A Staessen, Addison A Taylor, Lutgarde Thijs, Jackson T Wright, Kenneth J Mukamal

Faculty, Staff and Students Publications

IMPORTANCE: There are ongoing concerns about the benefits of intensive vs standard blood pressure (BP) treatment among adults with orthostatic hypotension or standing hypotension.

OBJECTIVE: To determine the effect of a lower BP treatment goal or active therapy vs a standard BP treatment goal or placebo on cardiovascular disease (CVD) or all-cause mortality in strata of baseline orthostatic hypotension or baseline standing hypotension.

DATA SOURCES: Individual participant data meta-analysis based on a systematic review of MEDLINE, EMBASE, and CENTRAL databases through May 13, 2022.

STUDY SELECTION: Randomized trials of BP pharmacologic treatment (more intensive BP goal or active agent) with …

The George-Anne Inkwell Edition, Georgia Southern University

The Inkwell

No abstract provided.

Molecular And Sequencing Study And Identification Of Novel Sem-Type In Beta-Hemolytic Streptococci Involving The Upper Respiratory Tract In Iran, Sina Moghaddam, Samad Lotfollahzadeh, Taghi Zahraei Salehi, Ali Hassanpour, Hamid Tavanaei Manesh, Iraj Ashrafi Tamai

Faculty, Staff and Students Publications

BACKGROUND: Beta-hemolytic streptococci involving the upper respiratory tract cause strangles and strangles-like diseases in horses and cause severe economic damage to the equestrian club each year. Therefore, careful epidemiological study of these bacteria, evaluation of phylogenetic connections and SeM-typing can be useful to determine the source and epidemiological characteristics of the disease outbreak. Isolates were analyzed using molecular and phylogenetic methods and to determine antibiotic resistance pattern in Iranian isolates. Molecular and phylogenetic methods were used to evaluate Iranian streptococcal isolates, and the similarity of the Iranian SeM-97 sequence with other alleles was assessed using the Neighbor-joining method with the …

Regulation Of Postnatal Cardiomyocyte Maturation By An Rna Splicing Regulator Rbfox1, Jijun Huang, Josh Z Lee, Christoph D Rau, Arash Pezhouman, Tomohiro Yokota, Hiromi Miwa, Matthew Feldman, Tsz Kin Kong, Ziyue Yang, Woan Ting Tay, Ivan Pushkarsky, Kyungsoo Kim, Shan S Parikh, Shreya Udani, Boon Seng Soh, Chen Gao, Linsey Stiles, Orian S Shirihai, Bjorn C Knollmann, Reza Ardehali, Dino Di Carlo, Yibin Wang

Faculty, Staff and Students Publications

No abstract provided.

The —Ick Of It: Phalluses, Swords, And Character Development In “Beowulf ” And “Morte D’Arthur”, Rachel E. Savini

International Journal of Undergraduate Research and Creative Activities

This essay explores the quintessential accessory to any male warrior in medieval literature. The swords that belong to Grendel’s Mother in the medieval epic poem “Beowulf ”and King Arthur in the “Morte d’Arthur” are used as metaphors and symbols to illuminate specific motivations fueling medieval English representations of masculinity. Grendel’s Mother’s sword underscores anxieties of Hrothgar’s people in “Beowulf”—namely, that of procreation and the subversion of traditional gender roles. Its destruction is key to understanding the disdain that the Danes hold against Grendel’s Mother as an aberrant model of loyalty. King Arthur’s, thrown into a lake and seemingly cleansed of …

The Beard Conceals And Reveals: Covert Hair In Fourteenth-Century Chivalric Romance, Kelsi Roth

International Journal of Undergraduate Research and Creative Activities

What do beards indicate beyond physical aspects of sex? What do literary representations of beards and hair suggest in terms of masculinity? In the character portraits from Geoffrey Chaucer’s The Canterbury Tales, male hair and beards are used by the characters to keep their secrets and portray who they want other characters to see while the author uses beards and hair to reveal the hypocrisy of this to the reader. Inversely, in “Sir Gawain and the Green Knight,” hair is used for concealment; in this poem it is used to conceal Bertilak de Hautdesert’s true identity as the Green Knight. …

“With Middal Smal And Wel Ymake”: Objectification And Power In Medieval English Love Songs, Allison D. Jones

International Journal of Undergraduate Research and Creative Activities

Through reading sets of medieval love songs one can notice trends that are connected to the conventions of fin’amor or courtly love. Troubadours, medieval French poets, would compose and sing songs that reflect the trends of courtly love during the time period. Within the lyrics of these songs there are two main trends when it comes to the objectification of the female beloved. First, they spend a great deal of time in describing the physicality of the beloved, but make no inferences or connections to her interior life—going so far as to animalize her. Even when those beautiful features may …

Identifying Errors In The Ethical Narrativity Thesis, Winston Meier

International Journal of Undergraduate Research and Creative Activities

A self-narrative ensures continuity for a conscious subject, in that the subject empathizes with the protagonist of both their remembered past and anticipated future. The ethical narrativity thesis (ENT) posits that such a narrative (or life-story) is requisite for agency and an ordered experience. Opponents of the ENT argue that one can inhabit an episodic (non-narrative) temporal schema and qualify as a rational agent. In this paper, I argue that narrative selfhood encourages cognitive distortions and inhibits a thorough etiological understanding of one’s past. I maintain that episodicity is the optimal form of self-constitution for rational, ethical decision-making.

Sympathia Aesthetica: On The Possible Significance Of Intersubjective Cognitive Uniformity In The Critical-Era Philosophy Of Immanuel Kant, Riley Andrew Pike

International Journal of Undergraduate Research and Creative Activities

No abstract provided.

Can Contractualism And Consequentialism Be Used Together In A Two-Stage Model?, Daisy O’Connor

International Journal of Undergraduate Research and Creative Activities

Contractualism and consequentialism, two of the most prominent theories in contemporary morality, are often perceived to be in opposition to each other. This essay will propose a novel two-stage system for moral decision-making which combines the two. I will explain how this model retains the strengths of contractualism and consequentialism, whilst resolving many of the problems with the theories as they stand alone.

Ekphrasis In Ecocriticism: Auden’S “Musée Des Beaux Arts” And Bruegel’S “Landscape With The Fall Of Icarus”, Chloe N. Young

International Journal of Undergraduate Research and Creative Activities

If ekphrasisis a literary description of a visual work of art, and ecocriticism uses literature to study nature and ecological concerns, how do the two mix? The ekphrastic poem “Musée des Beaux Arts” by W.H. Auden not only expands the understanding of the genre but also broadens the understanding of nature. Auden’s poem is quintessentially ekphrastic, yet it has never been examined in terms of how it is both informed by and informs an eco-critical reading. Auden and Pieter Bruegel, the painter of “Landscape with the Fall of Icarus” upon which Auden based his poem, express nature through the imagery …

“We’Ll Cook Him Up In A Stew”: Stepmothers And Primogeniture In The Brothers Grimm’S The Juniper Tree, Kymberlin Bush

International Journal of Undergraduate Research and Creative Activities

What larger social concern could the continued popularity of the nineteenth-century cannibal stepmother narrative in twenty-first century crime and news reporting be indicating? In this paper, I compare a fictional episode of cannibalism in the non-canonical Brothers Grimms’ tale, “The Juniper Tree,” with the true story of the 2010 murder and subsequent dismemberment of Zahra Baker in Hickory, North Carolina to consider the larger cultural implications of cannibalistic stepmothers. In doing so I argue that, despite the half-hearted attempt by mainstream animation studios to try to create semi-Feminist adaptations of the canonical fairy tales collected by the Brothers Grimm, Hans …

What's At Stake: Is It A Vampire Or A Virus?, Kaitlin M. Schneider

International Journal of Undergraduate Research and Creative Activities

Vampires have been discussed for millennia, appearing in folklore throughout various cultures. From the Egyptians and the Chinese to the Slavs, there have been numerous iterations of these bloodsucking fiends, but do their characteristics have any basis in fact, perhaps predicated upon misunderstandings of certain diseases?Using medical journals to discern plausible diseases for obscure and typical vampire traits, this paper functions on two levels. On one hand, it offers a repository of medical information for researchers who may want to delve further into the interdisciplinary field of pathology and folklore, especially where vampires of Western culture are concerned. On the …

Gender-Neutral Language In Christian Universities, Adi F. Mcnally

International Journal of Undergraduate Research and Creative Activities

Award for Best Conference Paper2018 Northwest Undergraduate Conference in the HumanitiesThis paper provides brief summation of the methods transphobia are embodied through language and what the logical, moral, and business implications would be for a Christian University. In this paper, Adi McNally (who uses they/them pronouns) explores whether there is both scientific and theological weight behind transphobic and gendered language choices. They connect the Sapir-Whorf hypothesis of linguistic relativity to discussions around epicene pronouns and English grammatical development. Their argument explores writings from Doctors Lawrence Mayer and Paul McHugh, and its impact on traditionally conservative Christian thought. Further, they discuss …

Salvation Or Damnation, And Where Ethics Fits In To All That, Sophie Zepf

International Journal of Undergraduate Research and Creative Activities

Ignazio Silone’s novel Bread and Wine explores the complex nature of ethical decision-making in the context of Fascist Italy, a world in which lofty concerns of moral conduct seem the fodder of fools and idealists. Silone uses his central character, firebrand and part-time philosopher Pietro Spina, to plunge his readers into one man’s quest for goodness within the debauchery and despair of war-torn Italy. Pietro’s moral development through the context of his adventures illustrates the challenge of crafting any sound ethical code, and the ease with which one might be lost to cynicism or indifference. The road marks of Pietro’s …

The Social Epistemology Of Anthropology: Insights From Judgment Aggregation, Dagan Douglas

International Journal of Undergraduate Research and Creative Activities

Anthropological writings have, at times, been vague in the approach used to gather evidence of cultural and social beliefs of the peoples studied, and the method of representing the data to the reading public. This paper employs the theory of judgment aggregation in critiquing anthropological theory and practice. It will be structured in three parts: first, I will present the theory of judgment aggregation as constructed by Christian List and Philip Pettit; second, I will sketch some epistemological methods used by anthropologists, and assess their attitude toward the notions of judgment aggregation and group agency; and finally, I will apply …

Applications Of Medico-Legal Entomology: Using Insects For Forensic And Environmental Investigations, Denise Gemmellaro

Sustainability Seminar Series

Forensic entomology is the application of entomology (the study of insects and arthropods) to forensic investigations. Medico-legal entomology focuses on those groups of insects that are attracted to decomposing organic matter. Dr. Gemmellaro’s work is mainly focused on medico-legal entomology. Once a dead body is exposed to the elements, insects will shortly locate the body and will colonize it by laying eggs on it; one of the major groups of colonizers is the true fly family of blow flies (Diptera: Calliphoridae). Blow fly females need a decomposing body to lay their eggs; the eggs will hatch into maggots and the …

Best Of The Medical Muse

Medical Muse

No abstract provided.

Land Education And Young People Working Toward Salamander: Collective Well-Being In Response To Bioindicators Of Socioenvironmental Justice, Rachael Arens, Ricardo Martinez

Democracy & Education

Our planet is facing many environmental challenges, including climate change, loss of biodiversity and habitat, and pollution, while many of our populations are also experiencing marginalization due to poverty, race, gender, language, ability, and environmental injustices. Environmental hazards and policies often impact those in society who are most at-risk, creating a need for an environmental education (EE) movement that encourages students to challenge and regain control of a system that impacts them. Teachers can implement a reflection tool known as the SALAMANDER Collective Well-Being in Response to Bioindicators of Socioenvironmental Justice Framework to prompt students and other educators to place …

Concerned But Confused: University Students' Knowledge And Perceptions Of Climate Change, And How They Plan To Address It In Their Future Personal And Professional Lives., Miranda Kistner, Jeremy Jiménez

The SUNY Journal of the Scholarship of Engagement: JoSE

This article explores university students’ knowledge and concern level towards climate change, as well as potential roles they see themselves playing as teachers in a world increasingly affected by its impacts. A survey of 135 university students was conducted at SUNY Cortland, a medium-size state university in Upstate New York. Results show that these university students (among them pre-service teachers) are highly concerned about the potential impacts of climate change, especially for future generations. While they demonstrate some accurate knowledge of climate change, many hold many misconceptions about its causes and consequences. In articulating how they can or do respond …

Understanding Functional Benefits Of Isoleucine And Arginine On Poultry Performance And Health., Roshan Adhikari, Jason T. Lee, Keith Haydon

Proceedings of the Arkansas Nutrition Conference

Poultry industry is rapidly moving towards utilizing the best ingredients to precisely feed the birds for better performance, welfare, health, and profitability. One of the practices that evolved over time with research is better optimization of amino acid utilization in the diets thus changing the crude protein landscape. Historically, if we compare the modern diets to diets from 1980, significant changes are visible in the use of unbound or crystalline amino acids leading to reduced levels of CP and reduced unutilized nitrogen in the diets. Multiple feed-grade amino acids are available in a cost-effective manner in poultry diets. Multiple research …

Illinois Masonic Hospital News, 1960 June, Advocate Aurora Health

Historical Documents - Combined

Illinois Masonic Hospital, Chicago, IL: Informational publication about the Illinois Masonic Hospital. This issue has a feature on the newly revised program of Physical Medicine, including the new Occupational Therapy department and many of the equipment used there. It also has photographs from the graduation ceremony of the nursing school and other hospital updates.

Provenance And Significance Of The Molded Frog Lamp: An Art Historical Analysis, Lucas Laroche

Art and Art History Faculty and Student Publications (Open Access)

Come discover the fascinating story behind the “Molded Frog Lamp” housed by The University of Mississippi Museum as my research paper explores its provenance, historical context, artistic and cultural significance, as well as methods of creation.

Trna Dysregulation In Neurodevelopmental And Neurodegenerative Diseases., Robert W. Burgess, Erik Storkebaum

Faculty Research 2023

Transfer RNAs (tRNAs) decode messenger RNA codons to peptides at the ribosome. The nuclear genome contains many tRNA genes for each amino acid and even each anticodon. Recent evidence indicates that expression of these tRNAs in neurons is regulated, and they are not functionally redundant. When specific tRNA genes are nonfunctional, this results in an imbalance between codon demand and tRNA availability. Furthermore, tRNAs are spliced, processed, and posttranscriptionally modified. Defects in these processes lead to neurological disorders. Finally, mutations in the aminoacyl tRNA synthetases (aaRSs) also lead to disease. Recessive mutations in several aaRSs cause syndromic disorders, while dominant …