Digital Commons Network^™

Antidiabetic Potential Of Vitex Mombassae Fruits Extract In Streptozotocin-Nicotinamide Induced Diabetic Wistar Rat Model, Mussa B. Mbegeze, Joan J.E. Munissi, Flora Stephano, Ramadhani S.O. Nondo, Stephen S. Nyandoro

Tanzania Journal of Science

Besides changes in life styles and improper dietary patterns, the rapidly increasing burden of diabetes mellitus type 2 is correlated with antidiabetic agents currently in clinical use, which are costly, less effective, and present undesirable side effects. Natural products from plants are promising alternative sources for developing more effective and cost friendly antidiabetic agents. This study therefore investigated the antidiabetic potential of Vitex mombassae fruits extract (VMFE) in streptozotocin-nicotinamide induced diabetic Wistar rat model. Oral acute toxicity test was conducted in male Wistar rat using up and down method by following OECD Guideline 423 (2002). No clinical signs of toxicity …

Phytochemical Constituents Of Cissus Oliveri Growing In Pwani Region, Tanzania, Fadhili S. Estomini, Stephen I. Nnungu, Amelia S. Buriyo

Tanzania Journal of Science

Cissus oliveri (Engl.) Gilg ex Engl. is among the plant species of the family Vitaceae widely used in traditional medicine for management of different ailments. This study aimed at assessing the phytochemicals of C. oliveri parts in order to provide scientific validation for its use as a therapeutic agent. Qualitative analysis of water and ethanolic extracts was conducted by using standard methods and the results revealed that all the parts possess alkaloids, flavonoids, phenols and tannins. Similarly, glycosides and saponins were only present in leaf and root. Quantitative analysis performed by gravimetric and spectrophotometric methods showed that all parts contain …

Association Of Residual Feed Intake To Metrics Of Tanganyika Shorthorn Zebu Cattle In Maswa And Misungwi Districts, Tanzania, Godfrey L. Chasama, Fred D. Chibwana, Aloyce S. Hepelwa, Jestina V. Katandukila

Tanzania Journal of Science

Increasing competition for feed resources and greenhouse gases pollution have been compelling beef production systems to operate at higher feed utilization. These challenges imply the need to breed cattle for Residual Feed Intake (RFI) to lower feeding costs and enteric methane production per output. To explore relevant indicator traits of RFI, this study investigated the association of RFI to Tanganyika Shorthorn Zebu (TSZ) cattle metrics from the Misungwi and Maswa Districts of Tanzania, where Tarime and Sukuma ecotypes are common. A correlation study involving the fattening of twenty-eight TSZ bulls was conducted at Tanzania Livestock Research Institute -Mabuki. From the …

Digitisation Of Classical Exercise Practices With Stack: Management Of Large Mathematics Classes In Higher Education Institutions, Idrissa S. Amour, Fatuma Simba, Septimi Kitta, Abdi T. Abdalla

Tanzania Journal of Science

Management of large classes’ tutorials is a known problem in Mathematics. Engineering mathematics classes enrol around 1000 students at the University of Dar es Salaam. For effective learning, each tutorial session should register not more than 40 students. This requires at least 25 sessions of tutorials per week, which may not be feasible due to both scarce human resources and venues. In this work, we developed online Mathematics exercises based on the System for Teaching and Assessment using Computer Algebra Kernel (STACK). About 300 STACK questions in linear algebra, calculus, complex numbers, and numerical analysis were constructed for weekly tutorials …

Irf1 Regulates Self-Renewal And Stress Responsiveness To Support Hematopoietic Stem Cell Maintenance, Alexandra J S Rundberg Nilsson, Hongxu Xian, Shabnam Shalapour, Jörg Cammenga, Michael Karin

Faculty, Staff and Student Publications

Hematopoietic stem cells (HSCs) are tightly controlled to maintain a balance between blood cell production and self-renewal. While inflammation-related signaling is a critical regulator of HSC activity, the underlying mechanisms and the precise functions of specific factors under steady-state and stress conditions remain incompletely understood. We investigated the role of interferon regulatory factor 1 (IRF1), a transcription factor that is affected by multiple inflammatory stimuli, in HSC regulation. Our findings demonstrate that the loss of IRF1 from mouse HSCs significantly impairs self-renewal, increases stress-induced proliferation, and confers resistance to apoptosis. In addition, given the frequent abnormal expression of IRF1 in …

Leucine Supplementation Exacerbates Morbidity In Male But Not Female Mice With Colorectal Cancer-Induced Cachexia, Eleanor R. Schrems, Wesley S. Haynie, Richard A. Perry Jr., Francielly Morena, Ana Regina Cabrera, Megan E. Rosa-Caldwell, Nicholas P. Greene, Tyrone A. Washington

Health, Human Performance and Recreation Faculty Publications and Presentations

Cancer cachexia (CC) is a multifactorial wasting syndrome characterized by a significant loss in lean and/or fat mass and represents a leading cause of mortality in cancer patients. Nutraceutical treatments have been proposed as a potential treatment strategy to mitigate cachexia-induced muscle wasting. However, contradictory findings warrant further investigation. The purpose of this study was to determine the effects of leucine supplementation on skeletal muscle in male and female Apc^Min/+ mice (APC). APC mice and their wild-type (WT) littermates were given normal drinking water or 1.5% leucine-supplemented water (n = 4–10/group/sex). We measured the gene expression of regulators of …

Neuroprotective Agents With Therapeutic Potential For Covid-19, César A Zaa, Clara Espitia, Karen L Reyes-Barrera, Zhiqiang An, Marco A Velasco-Velázquez

Faculty, Staff and Student Publications

COVID-19 patients can exhibit a wide range of clinical manifestations affecting various organs and systems. Neurological symptoms have been reported in COVID-19 patients, both during the acute phase of the illness and in cases of long-term COVID. Moderate symptoms include ageusia, anosmia, altered mental status, and cognitive impairment, and in more severe cases can manifest as ischemic cerebrovascular disease and encephalitis. In this narrative review, we delve into the reported neurological symptoms associated with COVID-19, as well as the underlying mechanisms contributing to them. These mechanisms include direct damage to neurons, inflammation, oxidative stress, and protein misfolding. We further investigate …

Simian Immunodeficiency Virus-Infected Rhesus Macaques With Aids Co-Develop Cardiovascular Pathology And Encephalitis, Kevin S. White, Joshua A. Walker, John Wang, Patrick Autissier, Andrew D. Miller, Nadia N. Abuelezan, Rachel Burrack, Qingsheng Li, Woong-Ki Kim, Kenneth C. Williams

Nebraska Center for Virology: Faculty Publications

Despite effective antiretroviral therapy, HIV co-morbidities remain where central nervous system (CNS) neurocognitive disorders and cardiovascular disease (CVD)-pathology that are linked with myeloid activation are most prevalent. Comorbidities such as neurocogntive dysfunction and cardiovascular disease (CVD) remain prevalent among people living with HIV. We sought to investigate if cardiac pathology (inflammation, fibrosis, cardiomyocyte damage) and CNS pathology (encephalitis) develop together during simian immunodeficiency virus (SIV) infection and if their co-development is linked with monocyte/ macrophage activation. We used a cohort of SIV-infected rhesus macaques with rapid AIDS and demonstrated that SIV encephalitis (SIVE) and CVD pathology occur together more frequently …

Faculty Feed: October 27th, 2023, College Of Arts & Sciences

News, Magazines and Reports

Student and faculty accomplishments for the previous week.

Arms Control And Deterrence In The Age Of Cross-Domain Coercion, Damon Coletta

Space and Defense

For deterrence, now, first seek arms control. The old relationship linking deterrence, defense, and arms control served U.S. policy makers for decades during the Cold War. It was manifest through the Spirit of Geneva (1955) and the Reykjavik Summit (1986). Much later, during the rise of cross-domain coercion and following Russia’s annexation of Crimea, the same idea reemerged in NATO’s Warsaw Communique (2016).

Medical School Watercooler Newsletter - October 26, 2023, Lindsey Lyle

Watercooler Newsletter

This is the October 26, 2023 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents Include:

• Faculty Development to host November events
• MCI welcomes USA students for National Chemistry Week
• Medical students present urology research at state conference
• Tobacco Exposed: Join the Conversation

Spartan Daily, October 26, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 29

October 26. 2023, Csusb

Coyote Chronicle (1984-)

No abstract provided.

The Indiana Statesman, October 26, 2023, Indiana State University

Student Newspaper

ISU’s SMIFC conference brings crowd; Leadershop offers lesson in conflict management; Q and A with mayoral candidate Sakbun

October 26, 2023, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Vista: October 26, 2023, University Of San Diego

USD Vista (1965-)

No abstract provided.

Intimate Partner Violence, Socioeconomic Status, And The Media, Christianna Victoria Page

Theses and Dissertations

News media’s communication of social issues can create societal pushes for policy change. This is true regarding femicide and violence against women. How news media communicate demographics such as socioeconomic status (SES) of intimate partner femicide (IPF) victims in a digital space is underexplored. This study is a thematic analysis analyzing how digital news articles communicate the SES of IPF victims. The sample for this study was taken from a population of digital news articles about IPF sources from ten major U.S.-based online news sites and analyzed 50 digital articles for news media’s communication of SES of victims. Results from …

Levetiracetam Ameliorates Epileptogenesis By Modulating The Adenosinergic Pathway In A Kindling Model Of Epilepsy In Mice, Muhammad Jamal, Muhammad Azam, Salman Ali Khan, Zaheer Ul-Haq, Shabana Usman Simjee

Turkish Journal of Medical Sciences

Background: Levetiracetam (LEV) has been found to have an antihyperalgesic effect via acting on the adenosine system. However, the effects of LEV on the modulation of the adenosine system in the brain have not been elucidated in the prevention of seizures and epilepsy. The present study aimed to explore the possible LEV mechanisms of action in the adenosine signaling systems in an animal model of epilepsy. Methodology: A docking study was initially performed to determine the possible interaction of LEV with adenosine A1 receptors (A1Rs) and equilibrative nucleoside transporters-1 (ENT1). The experimental study was divided into an acute seizure test …

Should Valgus-Impacted Proximal Humerus Fractures Necessarily Be Operated On? Radiological Versus Functional Results, Muhli̇k Akyürek, Emre Koraman, Yusuf İyeti̇n, Mehmet Akan

Turkish Journal of Medical Sciences

Background/aim: Impacted valgus proximal humerus fracture has been known to be challenging in terms of treatment and outcomes since it was defined. Moreover, it is a type of fracture that is difficult to treat. In addition, exact limits have not yet been determined regarding which parameters affect patients? functional and reported outcomes. The purpose of this study was to compare the radiological results of patients with impacted valgus proximal humerus fractures treated conservatively and surgically and to evaluate the effect of these radiological parameters on functional outcomes. Materials and methods: A total of 79 patients who were treated between 2015 …

Investigating The Physiological Role Of S199a And S199d Mutants Of Phf6 Protein In T-Cell Acute Lymphoblastic Leukemia, Gökçe Erdoğan, Osman Ni̇dai̇ Özeş, Osman Alphan Küpesi̇z, Şükran Burçak Yoldaş

Turkish Journal of Medical Sciences

Background/aim: T-cell acute lymphoblastic leukemia (T-ALL) is a form of leukemia characterized by the proliferation of immature T lymphocytes. NOTCH1 is one of the most frequently mutated genes in T-ALL. NOTCH1 expression in T-cell development depends on plant homeodomain finger protein 6 (PHF6), which plays a tumor suppressor role in T-ALL. Several studies have shown that PHF6 expression is essential for NOTCH1 expression. Therefore, whether posttranslational modification of PHF6 plays a role in the regulation of NOTCH1 expression and T-ALL cell line proliferation was investigated herein. Materials and methods: The amino acid sequence of PHF6 was analyzed and it was …

Cupressus Arizonica: An Emerging Aeroallergen For East Mediterranean Children, Hi̇lal Ünsal, Ümi̇t Murat Şahi̇ner, Özge Uysal Soyer, Bülent Eni̇s Şekerel

Turkish Journal of Medical Sciences

Background/aim: Cupressus sempervirens is a tree native to the Mediterranean region. We aimed to investigate the frequency of sensitization/allergy to Cupressus arizonica pollen, which is not native to Anatolia. Materials and methods: Patients aged 5?18 years who underwent respiratory allergy screening in Türkiye?s largest referral center over a 1-year period were reviewed retrospectively for a diagnostic study of Cupressus allergy. Results: Of 246 patients, 207 (67.6% male) with a median age of 11.7 (IQR 9.2?15) years were found to be aeroallergen-sensitive and C. arizonica (32%) was the second most common sensitivity after grass pollen (83.6%). In the C. arizonica-sensitive subgroup, …

Effects Of Vitrification Solution Supplemented With Platelet-Rich Plasma In Rat Ovarian Tissue Cryopreservation, Ayli̇n Gökhan, Türker Çavuşoğlu, Kubi̇lay Doğan Kiliç, Cansin Şi̇ri̇n, Canberk Tomruk, Gürkan Yi̇ği̇ttürk, Oytun Erbaş, Eser Sözmen, Meral Baka

Turkish Journal of Medical Sciences

Background/aim: The subject of this study was to investigate the utility of platelet-rich plasma (PRP) in the cryopreservation process to reduce cryodamage and increase tissue viability. Materials and methods: Twenty-one female Wistar rats were randomly allocated to three groups. In Group 1 (G1), rats were not subjected to vitrification (n = 7). Group 2 (G2) was the vitrification group in which PRP was added to the basic vitrification solution (n = 7). Group 3 (G3) was the vitrification group in which fetal bovine serum was added to the basic vitrification solution (n = 7). Warmed tissues were evaluated with histochemical …

Evaluation Of Syringin?S Neuroprotective Effect In A Model Of Neonatal Hypoxic-Ischemic Brain Injury, Ezgi̇ Yangin Ergon, Asli Çeli̇k, Ayşe Gülden Di̇ni̇z Ünlü, Rüya Çolak, Senem Alkan Özdemi̇r, Şebnem Çalkavur, Osman Yilmaz

Turkish Journal of Medical Sciences

Background/aim: A significant cause of mortality and morbidity in the neonatal era is hypoxic-ischemic encephalopathy (HIE). This study examined the histopathological analysis and neuroprotective impact of syringin (SYR) in an experimental HIE rat model. Material and methods: On the 7th postnatal day, 24 Wistar albino rats were evaluated in 3 groups using the HIE model under gas anesthesia. In the experiment, Group A received 10 mg/kg SYR plus dimethyl sulfoxide (DMSO), Group B received DMSO only, and Group C served as a sham group. Immunohistochemical techniques were used to assess apoptotic cell measurement and proinflammatory cytokines (TNF-? and IL-1ß primary …

Comparison Of The Effect Of Postweaning Social Isolation, Enriched Environment, And Exercise Training On Learning And Memory Functions In Rats, Hati̇ce Eki̇nalan Kayhan, Ni̇lsel Okudan, Muaz Belvi̇ranli

Turkish Journal of Medical Sciences

Background/aim: To assess the effects of postweaning social isolation, an enriched environment, and exercise training on learning and memory functions in rats, as well as their relation with the brain-derived neurotrophic factor (BDNF) and nerve growth factor (NGF) concentrations in the hippocampus. Materials and methods: Randomly assigned into 4 groups were 35 female postweaning rats (25 day old), as the control (C), social isolation (SI), enriched environment (EE), and exercise training (E) groups. The SI and the EE groups were housed under their specific conditions and the E and the C groups were housed under standard conditions for 6 weeks. …

Unraveling The Impact Of Primary Immunodeficiency Disorders On The Microbiota Of Dental Caries In Children Through 16s Rrna Gene-Based Metagenomic Analysis, Bushra Al-Kebsi̇, Gökhan Kars, Hazal Özer, Şükrü Nai̇l Güner

Turkish Journal of Medical Sciences

Background/aim: Dental caries is a frequently occurring and multifactorial chronic disease in children resulting from the interaction of cariogenic bacteria and host susceptibility. The aim of this study was to elucidate the impacts of primary immunodeficiency disorders (PIDs) on microbiota of dental caries in children by 16S rRNA gene-based metagenomic analysis. Materials and methods: Enrolled in this study were 15 children with primary PID with caries (PID group) and 15 healthy children with caries as a control (CG). The DMFT index, saliva flow rate, and buffering capacity of each participant were assessed before the metagenomic analyses were conducted. For taxonomic …

First Approximation Of Population Distributions On The International Space Station, Justin St. P. Walsh, Rao Hamza Ali, Alice C. Gorman, Amir Kanan Kashefi

Art Faculty Articles and Research

This paper presents an analysis of data derived from thousands of publicly available photographs showing life on the International Space Station (ISS) between 2000 and 2020. Our analysis uses crew and locational information from the photographs’ metadata to identify the distribution of different population groups—by gender, nationality, and space agency affiliation—across modules of the ISS, for the first time. Given the significance of the ISS as the most intensively inhabited space habitat to date, an international cooperative initiative involving 26 countries and five space agencies, and one of the most expensive building projects ever undertaken by humans, developing an understanding …

Tripartite Motif Protein 6 Promotes Hepatocellular Carcinoma Progression Via Multiple Pathways, Yifeng Zhang, Lin Yuan, Shanshan Cui, Song Wu

Turkish Journal of Medical Sciences

Background/aim: Hepatocellular carcinoma (HCC) ranks among the most prevalent malignancies worldwide and the third leading cause of cancer-related death. The TRIM (tripartite motif-containing) protein family members had been reported to be involved in carcinogenesis and tumor progression. Here we aimed to explore the expression profile of TRIM6 in HCC and investigate its clinical significance as well as underlying mechanisms. Materials and methods: We retrospectively enrolled 138 HCC patients that underwent surgical resection in our hospital and tested protein expression level of TRIM6 through immunohistochemical staining. The correlation between TRIM6 and patients? characteristics was assessed by Chi-square test. Log-rank test and …

Rna-Based Translation Activators For Targeted Gene Upregulation, Yang Cao, Huachun Liu, Shannon S Lu, Krysten A Jones, Anitha P Govind, Okunola Jeyifous, Christine Q Simmons, Negar Tabatabaei, William N Green, Jimmy L Holder, Soroush Tahmasebi, Alfred L George, Bryan C Dickinson

Duncan NRI Faculty and Staff Publications

Technologies capable of programmable translation activation offer strategies to develop therapeutics for diseases caused by insufficient gene expression. Here, we present "translation-activating RNAs" (taRNAs), a bifunctional RNA-based molecular technology that binds to a specific mRNA of interest and directly upregulates its translation. taRNAs are constructed from a variety of viral or mammalian RNA internal ribosome entry sites (IRESs) and upregulate translation for a suite of target mRNAs. We minimize the taRNA scaffold to 94 nucleotides, identify two translation initiation factor proteins responsible for taRNA activity, and validate the technology by amplifying SYNGAP1 expression, a haploinsufficiency disease target, in patient-derived cells. …

Oregon State Ranking Assessment For Preble's Shrew (Sorex Preblei), Misty Nelson

Institute for Natural Resources Publications

Oregon State Ranking Assessment for Preble's shrew (Sorex preblei) by the Oregon Biodiversity Information Center, following NatureServe 2023 methodology.

Oregon State Rank Assessment For Black-Tailed Jackrabbit (Lepus Californicus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for black-tailed jackrabbit (Lepus californicus) using NatureServe methodology, 2023.