Digital Commons Network^™

Digital Preservation Of Rumah Tukang Kahar For Cultural Heritage Tourism, Aiman Mohd Rashid, Lisa Sidyawati, Nor Izura Tukiman, Norhida Mohd Suaib, Mohd Farid Mohd Ariff

ARSNET

The paper focuses on exploring the virtual collaboration process in the digital preservation project of Rumah Tukang Kahar, a traditional Malay house in Negeri Sembilan, Malaysia, as a form of cultural heritage tourism. The purpose of the project is to develop an augmented reality interface through mobile app, website, and pamphlets with AR markers, to virtually and physically boost Malaysia heritage tourism economy. This paper describes a year-long virtual collaboration process between multidisciplinary and transnational researchers with various expertise between Malaysia and Indonesia under the Indonesia-Malaysia Research Consortium (I'MRC) initiatives. The paper reflects on the design and product development process …

Experiential Time In Some Modern Poetry, Aaron Lercher

Contemporary Aesthetics (Journal Archive)

Experiential or lived time (A-series time) can be many things. Gertrude Stein claims, in her 1935 Narration lectures, that experiential time is a plenum: all experiential time is full of vivid experience, if one is alert to perceive it. Stein, however, then poses a problem of narration that seems to obstruct poetic access to this vivid plenum. Bernadette Mayer and Lisa Jarnot take up Stein’s challenge with time-defined and time-filling poetic writing processes. Much like children, these processes can come to have their own experiential times.

Amelia Lapeña-Bonifacio, Ma. Amihan Bonifacio-Ramolete

Perspectives in the Arts and Humanities Asia

Excerpt: Amelia Lapeña-Bonifacio, National Artist for Theater and professor emerita of the University of the Philippines Diliman, passed away on 29 December 2020 at the age of ninety. Born on 4 April 1930 in Binondo, Manila, she was the sixth child of Gregorio Bañez Lapeña and Paz Mercado Lirag. At an early age, she watched the senakulo with her family as well as the sarsuwela and komedya with her mother. While in high school, she had the chance to read her older siblings’ books, such as Gone with the Wind and plays by Shakespeare, and eventually became literary editor of …

How To Rewrite A Tagalog Novel Into An English Classic: Danton Remoto’S English Translation Of Lope K. Santos’S Banaag At Sikat, Chris Cañete Rodriguez Kelly

Perspectives in the Arts and Humanities Asia

To appeal to a contemporary global readership, Danton Remoto in his English translation of Lope K. Santos’s Banaag at Sikat omits much of the original’s political passages. Such an approach to translation, however, hollows out elements of the original. Following the work of Annette Damayanti Lienau and Akshya Saxena, this essay understands colonial and vernacular languages as dialectically interdependent. It argues that Remoto’s abridgement of Banaag at Sikat is produced not by a refusal to translate the Tagalog of the original, but a refusal to translate the coconstitutive difference between English and Tagalog, which inheres precisely in the excessive political …

Review Of Nusantara: Heidi Shamsuddin. Nusantara: A Sea Of Tales. Singapore: Penguin Books, 2021. 223 Pages., Jay Jomar F. Quintos

Perspectives in the Arts and Humanities Asia

Excerpt: In the introduction to the book Nusantara: A Sea of Tales, writer Heidi Shamsuddin loosely defines “Nusantara” as an umbrella term for “countries sharing the Austronesian language such as Malaysia, Indonesia, Brunei, Philippines, Timor Leste, Madagascar, Oceania, as well as countries where Austronesian minorities are present such as Singapore, Thailand, Vietnam, and Taiwan” (2). The premise of this definition compels us to imagine the topology and formation of archipelagos and islands that make up the Austronesian world. When the book collects and surveys stories and then maps out the points and turns where they intersect, it turns out to …

“I, Began, To, Die, And, I, Began, To, Grow”: Incarnational Theopoetics In The Poetry Of José Garcia Villa, Nathan Timothy Chan

Perspectives in the Arts and Humanities Asia

Although critics have observed that Villa’s poems use religious language and imagery, this has not been sufficiently explored. The article interprets the first set of seven comma poems that Villa published in 1948 as exemplifying his incarnational theopoetics in both form and content. In these poems, God or Christ is poetically, yet sometimes illogically, enmeshed with the created order. God assumes a body—not only the body of Man, but also the bodies of animals, machineries, and objects. This portrayal of God as embodied allows a deeper understanding of not only what Villa’s conception of God is, but also how his …

Ang Parolang Ginto Ng Sambayanang Pilipino: Isang Munting Parangal Kay Bienvenido L. Lumbera (1932-2021), Nicanor G. Tiongson

Perspectives in the Arts and Humanities Asia

Excerpt: Sa tribyut na ito, nais kong balikan ang sa aking pakiwari’y naging mahahalagang ambag ni Bien Lumbera sa pagpapaunlad at pagpapayaman ng ating wika, kultura, at bansa—una, bilang guro; pangalawa, bilang iskolar, kritiko, at artista; at pangatlo, bilang tao.

Kewarganegaraan Inklusif: Menempatkan Model Budaya Disabilitas Dalam Teori Multikultural Liberal Will Kymlicka, Hanandhia Lindsy Rustam, Lg. Saraswati Putri

Multikultura

Tulisan ini bertujuan untuk menggambarkan cultural model of disability atau model budaya disabilitas dalam teori multikultural liberal Will Kymlicka. Status kewarganegaraan disabilitas seringkali masih diturunkan menjadi kewarganegaraan pasif atau parsial yang patut dikasihani dan mendapat perhatian paternalistik. Kemunculan advokasi disabilitas sebagai hak kelompok dan bukan hak individu baru-baru ini menuntut kita untuk mengevaluasi secara lebih menyeluruh konsepsi disabilitas sebagai sebuah kelompok non-etnis namun bersifat budaya yang menegosiasikan tempat mereka di wilayah negara. Model budaya disabilitas inilah yang sejalan dengan tujuan teori multikultural liberal Will Kymlicka yang menyatakan bahwa masyarakat yang beragam membutuhkan lebih dari sekedar akses yang setara dan hak-hak …

Prinsip Harmoni (Héxié) Pada Penokohan Li Yunxiang Dalam Film Ne Zha Reborn (Xīnshén Bǎng: Nǎ Zhā Chóngshēng) Karya Zhao Ji, Chika Asri Oktaviyanti, Adi Kristina Wulandari, Rahadjeng Pulungsari Hadi

Multikultura

Film New Gods: Ne Zha Reborn (Xīnshén bǎng: Nǎ zhā chóngshēng新神榜：哪吒重生) adalah film animasi fantasi yang dirilis pada 12 Februari 2021, disutradarai Zhao Ji (赵霁). Film ini menceritakan tokoh Li Yunxiang yang merupakan sosok kelahiran kembali Ne Zha di masa modern dalam melawan musuhnya yaitu Klan Naga Laut Timur. Ne Zha adalah salah satu dewa dalam mitologi Cina yang ceritanya terdapat dalam novel zaman Dinasti Ming (1368-1644) berjudul Investiture of The Gods (Fēng shén yǎnyì封神演義). Penelitian ini bertujuan membaca representasi prinsip Harmoni (Héxié和谐) dalam konsep Yin-Yang melalui karakterisasi tokoh Li Yunxiang. Metode yang digunakan dalam penelitian adalah metode kualitatif. Hasil …

Longitudinal Associations Of Dietary Fiber Intake With Glycated Hemoglobin And Estimated Insulin Sensitivity In Adults With And Without Type 1 Diabetes, Arpita Basu, Andrew Hooyman, Leigh Ann Richardson, Amy C. Alman, Janet K. Snell-Bergeon

Physical Therapy Faculty Articles and Research

Dietary fiber, an essential bioactive compound in plant-based diets, is of public health concern based on habitual low intakes in the general population. Not much data are available on how habitual dietary fiber is associated with glycemic control in type 1 diabetes (T1D) as well as in prediabetes and normoglycemic adults. To address this gap, we conducted a six-year longitudinal analysis of an original cohort in adults with and without T1D (n = 1255; T1D: n = 563; non-diabetes mellitus (non-DM): n = 692). Dietary data were collected from a validated food frequency questionnaire, biochemical measures were obtained after an …

The Use Of Audio Visual Media In Learning To Listen To The Pulau Si Mardan Theater Performance In Tanjungbalai City At Sisingamangaraja Tanjungbalai High School, Anastasia Hotmauli Sinaga, Johan Amir, Janri S. Simanungkalit

Jurnal Pendidikan dan Pembelajaran

The aim of the research is to describe the effectiveness of using audio-visual media in learning listen to Mardan Island theater performances at Sisingamangaraja Tanjung Balai High School, as well as explaining the components that support the effectiveness of using audio-visual media in learning to listen to Mardan Island theater performances. This research method uses descriptive qualitative research methods. The results of the research found the language and literature learning process using audio-visual media and the components contained in this media can increase the effectiveness of increasing student literacy in explaining and analyzing story themes, story content and moral messages.

The Effect Of Using Rolling Quiz Box Media To Improve The Critical Thinking Ability Of Grade 3 Students At Madrasah Ibtidaiyah, Cindy Novita Sari, Rora Rizky Wandini

Jurnal Pendidikan dan Pembelajaran

This research aims to determine the effect of using Rolling Quiz Box media to improve students' critical thinking skills. The method in this research uses quantitative research of the Quasi Experiment type with a One Group Pretest-Posttest design. In this study, there are two study groups, namely the control class and the experimental class. At the beginning of the research, a pretest was given to see the students' initial understanding, and a posttest was given after the treatment for the control class teaching without media and the experimental class teaching using Rolling Quiz Box media. Clustered random sampling was utilized …

Volume 122, Number 1 - Tuesday, October 31st 2023, Saint Mary's College Of California

The Collegian

No abstract provided.

Constitutive Interleukin-7 Cytokine Signaling Enhances The Persistence Of Epstein-Barr Virus-Specific T-Cells, Sandhya Sharma, Tim Sauer, Bilal A Omer, Thomas Shum, Lisa A Rollins, Cliona M Rooney

Faculty, Staff and Students Publications

The efficacy of therapeutic T-cells is limited by a lack of positive signals and excess inhibitory signaling in tumor microenvironments. We previously showed that a constitutively active IL7 receptor (C7R) enhanced the persistence, expansion, and anti-tumor activity of T-cells expressing chimeric antigen receptors (CARs), and C7R-modified GD2.CAR T-cells are currently undergoing clinical trials. To determine if the C7R could also enhance the activity of T-cells recognizing tumors via their native T-cell receptors (TCRs), we evaluated its effects in Epstein–Barr virus (EBV)-specific T-cells (EBVSTs) that have produced clinical benefits in patients with EBV-associated malignancies. EBVSTs were generated by stimulation of peripheral …

Toll-Like Receptor 4 And Cd11b Expressed On Microglia Coordinate Eradication Of Candida Albicans Cerebral Mycosis, Yifan Wu, Shuqi Du, Lynn H Bimler, Kelsey E Mauk, Léa Lortal, Nessim Kichik, James S Griffiths, Radim Osicka, Lizhen Song, Katherine Polsky, Lydia Kasper, Peter Sebo, Jill Weatherhead, J Morgan Knight, Farrah Kheradmand, Hui Zheng, Jonathan P Richardson, Bernhard Hube, Julian R Naglik, David B Corry

Faculty, Staff and Students Publications

The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of brain anti-Candida immunity remains unknown. We show that C. albicans enters the mouse brain from the blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) and candidalysin. Saps disrupt tight junction proteins of the blood-brain barrier (BBB) to permit fungal brain invasion. Saps also hydrolyze amyloid precursor protein (APP) into amyloid β (Aβ)-like peptides that bind to Toll-like receptor 4 (TLR4) and promote fungal killing in vitro while candidalysin engages the integrin CD11b (Mac-1) on microglia. …

A Small-Molecule Inhibitor Of Topbp1 Exerts Anti-Myc Activity And Synergy With Parp Inhibitors, Fang-Tsyr Lin, Kang Liu, Lidija A Wilhelms Garan, Helena Folly-Kossi, Yongcheng Song, Shwu-Jiuan Lin, Weei-Chin Lin

Faculty, Staff and Students Publications

We have previously identified TopBP1 (topoisomerase IIβ-binding protein 1) as a promising target for cancer therapy, given its role in the convergence of Rb, PI(3)K/Akt, and p53 pathways. Based on this, we conducted a large-scale molecular docking screening to identify a small-molecule inhibitor that specifically targets the BRCT7/8 domains of TopBP1, which we have named 5D4. Our studies show that 5D4 inhibits TopBP1 interactions with E2F1, mutant p53, and Cancerous Inhibitor of Protein Phosphatase 2A. This leads to the activation of E2F1-mediated apoptosis and the inhibition of mutant p53 gain of function. In addition, 5D4 disrupts the interaction of TopBP1 …

Hyperpolarization-Activated Cyclic Nucleotide-Gated Cation Channel 3 Promotes Hcc Development In A Female-Biased Manner, Yueqi Zhang, Xinhui Liu, Kairui Sun, Yue Luo, Jack Yang, Aimin Li, Matti Kiupel, Stefanie Fenske, Martin Biel, Qing-Sheng Mi, Hongbing Wang, Hua Xiao

Dermatology Articles

Sex differences in hepatocellular carcinoma (HCC) development are regulated by sex and non-sex chromosomes, sex hormones, and environmental factors. We previously reported that Ncoa5(+/-) mice develop HCC in a male-biased manner. Here we show that NCOA5 expression is reduced in male patient HCCs while the expression of an NCOA5-interacting tumor suppressor, TIP30, is lower in female HCCs. Tip30 heterozygous deletion does not change HCC incidence in Ncoa5(+/-) male mice but dramatically increases HCC incidence in Ncoa5(+/-) female mice, accompanied by hepatic hyperpolarization-activated cyclic nucleotide-gated cation channel 3 (HCN3) overexpression. HCN3 overexpression cooperates with MYC to promote mouse HCC development, whereas …

Some Are More Equal Than Others: U.S. Supreme Court Clerkships, Tracey E. George, G. Mitu Gulati, Albert H. Yoon

Vanderbilt Law School Faculty Publications

The most elite and scarce of all U.S. legal credentials is serving as a Justice on the U.S. Supreme Court. A close second is clerking for a Justice. A Court clerkship is a prize as well as a ticket to future success. Rich accounts of the experience fill bookshelves and journal pages. Yet the public lacks a clear story about who wins this clerkship lottery. Original analysis of forty years of clerkships tells that story. New datasets detail clerks’ paths from college to the Court to careers. Research shows that Court clerkships favor educational pedigree and status over pure achievement. …

Exemplary Centre And "Terra Incognita"; Excursions, Diplomacy, And Appropriation Of Colonial Knowledge In Belu, Timor, Hans Hägerdal

Wacana, Journal of the Humanities of Indonesia

The article analyses early European knowledge about Belu, a historical region in Central Timor which, although “belonging” mostly to the Dutch colonial sphere, still had a position of cultural-ritual centrality on a Timor-wide level. Before the mid-nineteenth century, the region was, from a Dutch point of view, largely unknown in terms of political hierarchies, social structure, and economic opportunities. However, three officially commissioned authors, A.G. Brouwer, W.L. Rogge, and H.J. Grijzen, wrote extensive reports about Belu in 1849, 1865, and 1904, in which they attempted to understand local society and the opportunities they offered the colonial state. The article explores …

The Archive Of Faces And The Archive Of Plaster; Reading Anthropological Facial Plaster-Casts Taken From Living Individuals From The Former Netherlands East Indies, Laetitia Lai

Wacana, Journal of the Humanities of Indonesia

This article introduces two interconnected approaches to provenance research on anthropological facial plaster-casts taken from living individuals. It focuses on three series of facial casts taken by Dutch anthropologist Johannes Pieter Kleiweg de Zwaan (1875-1971) in the Netherlands East Indies in 1907 and 1910. It suggests that “reading” the facial casts as an archive of faces and an archive of plaster has the potential to reveal information systematically left out in their object biographies. Through this reading process, the colonial networks of control and power asymmetries which made the plaster-casting possible are examined. It seeks out additional information to bring …

Tgf-Β1 In Aplysia: Role In Long-Term Changes In The Excitability Of Sensory Neurons And Distribution Of Tβr-Ii-Like Immunoreactivity, Muhammad S Khan, Eun Kim, Quentin Le Hingrat, Adam Kleinman, Alessandro Ferrari, Jose C Sammartino, Elena Percivalle, Cuiling Xu, Shaohua Huang, Thomas W Kenniston, Irene Cassaniti, Fausto Baldanti, Ivona Pandrea, Andrea Gambotto, Cristian Apetrei

Faculty, Staff and Student Publications

The study provides important insights into the immunogenicity and efficacy of a tetravalent protein subunit vaccine candidate against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The vaccine induced both humoral and cellular immune responses in nonhuman primates with controlled SIVagm infection and was able to generate Omicron variant-specific antibodies without specifically vaccinating with Omicron. These findings suggest that the tetravalent composition of the vaccine candidate could provide broad protection against multiple SARS-CoV-2 variants while minimizing the risk of immune escape and the emergence of new variants. Additionally, the use of rhesus macaques with controlled SIVsab infection may better represent vaccine …

Diet And The Role It Plays In Cognition, Ryan S. Lavrisa

Honors College Theses

The Food and Agricultural Organization of the United Nations have calculated the effects of animal agriculture and factory farming to be responsible for generating 14.5-16.5% of global greenhouse gas emissions as well as using 70% of all agricultural land to sustain itself. Plant-based diets such as veganism and vegetarianism have been on the rise as many seek to find diets that mitigate the animal suffering and environmental impact for which animal agriculture is responsible. With the rise of these diets, it is important to understand the cognitive effects adhering to such diets can have on the body and mind, as …

The Influence Of Obesity On Outcomes With Immune Checkpoint Blockade: Clinical Evidence And Potential Biological Mechanisms, Andrew W Hahn, Neha Venkatesh, Pavlos Msaouel, Jennifer L Mcquade

Faculty, Staff and Student Publications

Immune checkpoint blockade (ICB) is a mainstay of treatment for advanced cancer, yet tumor response and host toxicity are heterogenous in those patients who receive ICB. There is growing interest in understanding how host factors interact with tumor intrinsic properties and the tumor microenvironment to influence the therapeutic index with ICB. Obesity, defined by body mass index, is a host factor associated with improved outcomes in select cancers when treated with ICB. While the biological mechanism for this obesity paradox is not fully understood, pre-clinical and translational studies suggest obesity may potentially impact tumor metabolism, inflammation, and angiogenesis. Herein, we …

Sdc1 And Itga2 As Novel Prognostic Biomarkers For Pdac Related To Ipmn, Chuan-Long Zhang, Qian Shen, Fu-Dong Liu, Fan Yang, Meng-Qi Gao, Xiao-Chen Jiang, Yi Li, Xi-Yuan Zhang, Ge-Er En, Xue Pan, Bo Pang

Faculty, Staff and Student Publications

The existing biomarkers are insufficient for predicting the prognosis of pancreatic ductal adenocarcinoma (PDAC). Intraductal papillary mucinous neoplasm (IPMN) is a precursor to PDAC; therefore, identifying biomarkers from differentially expressed genes (DEGs) of PDAC and IPMN is a new and reliable strategy for predicting the prognosis of PDAC. In this study, four datasets were downloaded from the Gene Expression Omnibus database and standardized using the R package 'limma.' A total of 51 IPMN and 81 PDAC samples were analyzed, and 341 DEGs in PDAC and IPMN were identified; DEGs were involved in the extracellular matrix and tumor microenvironment. An acceptable …

Anthocyanins: Molecular Aspects On Their Neuroprotective Activity, César A Zaa, Álvaro J Marcelo, Zhiqiang An, José L Medina-Franco, Marco A Velasco-Velázquez

Faculty, Staff and Student Publications

Anthocyanins are a type of flavonoids that give plants and fruits their vibrant colors. They are known for their potent antioxidant properties and have been linked to various health benefits. Upon consumption, anthocyanins are quickly absorbed and can penetrate the blood-brain barrier (BBB). Research based on population studies suggests that including anthocyanin-rich sources in the diet lower the risk of neurodegenerative diseases. Anthocyanins exhibit neuroprotective effects that could potentially alleviate symptoms associated with such diseases. In this review, we compiled and discussed a large body of evidence supporting the neuroprotective role of anthocyanins. Our examination encompasses human studies, animal models, …

How Can A Divided Self Be The Same Person: Who Is The Real Me?, Philosopher's Discussion Group

The Philosopher's Stone

• How Can A Divided Self Be The Same Person: Who is The Real Me?

Evaluating The Utility Of S100a8/A9 As A Non-Invasive Biomarker, Leah Mellett

Arts & Sciences Graduate Student Theses and Dissertations

Biomarkers, a portmanteau of “biological markers”, are clinically relevant observations that can accurately and reproducibly indicate or predict patient outcomes. These objective measurements have vast clinical utility as they can aid clinicians with diagnoses, provide information about patient prognoses, and monitor changes in patient health statuses. While the discovery of several biomarkers are attributed to differential expression or concentration of genes or proteins within blood samples, biomarkers can be alternatively found in other bodily fluids or tissues depending on the associated condition. Recently, advances in urine proteomics have allowed for the identification of urine biomarkers that may eliminate the drawbacks …

Class Notes

DePaul Magazine

DePaul alumni share news about their promotions, career moves, weddings, birth announcements, other accomplishments and more with the DePaul community.

Exercise Mediates Myokine Release And Tumor Suppression In Prostate Cancer Independent Of Androgen Signaling, Jin-Soo Kim, Dennis R. Taaffe, Daniel A. Galvão, Fred Saad, Robert U. Newton

Research outputs 2022 to 2026

A prominent toxicity of androgen suppression in patients with prostate cancer (PCa) is loss of skeletal muscle. Exercise may induce tumor suppression through the endocrinal function of skeletal muscle; however, this is currently unknown. In this review, we summarize our work demonstrating the acute and chronic myokine response to exercise and the tumor-suppressive effect of circulatory milieu alteration in PCa patients. © Lippincott Williams & Wilkins.

Contextual Role Of Architectural Background Images In Digital Comics, Anissa Febrina, Muhammad Heru Arie Edytia, Zia Faizurrahmany El Faridy

ARSNET

This research aims to determine the role of architectural background images in digital comics and their proportional contribution to the overall reading interest. Digital comics are a form of media with sequential panels of images that project two-dimensional scenes positioned in a certain context. The context is presented in the background and is used as a story-building element in the comics. The study is interested in identifying important criteria of the architectural background as part of the digital comics narrative and measuring its relevance. This research uses the quantitative comparative method, with non-probability purposive sampling of 15 respondents. This research …