Digital Commons Network^™

Gibbs Process Distinguishes Survival And Reveals Contact-Inhibition Genes In Glioblastoma Multiforme, Afrooz Jahedi, Gayatri Kumar, Lavanya Kannan, Tarjani Agarwal, Jason Huse, Krishna Bhat, Kasthuri Kannan

Faculty, Staff and Student Publications

Tumor growth is a spatiotemporal birth-and-death process with loss of heterotypic contact-inhibition of locomotion (CIL) of tumor cells promoting invasion and metastasis. Therefore, representing tumor cells as two-dimensional points, we can expect the tumor tissues in histology slides to reflect realizations of spatial birth-and-death process which can be mathematically modeled to reveal molecular mechanisms of CIL, provided the mathematics models the inhibitory interactions. Gibbs process as an inhibitory point process is a natural choice since it is an equilibrium process of the spatial birth-and-death process. That is if the tumor cells maintain homotypic contact inhibition, the spatial distributions of tumor …

C4b-Binding Protein Inhibits Particulate- And Crystalline-Induced Nlrp3 Inflammasome Activation, Damien Bierschenk, Nikolina Papac-Milicevic, Ian P Bresch, Valentina Kovacic, Serena Bettoni, Mateusz Dziedzic, Rick A Wetsel, Susanne Eschenburg, Christoph J Binder, Anna M Blom, Ben C King

Faculty, Staff and Student Publications

Dysregulated NLRP3 inflammasome activation drives a wide variety of diseases, while endogenous inhibition of this pathway is poorly characterised. The serum protein C4b-binding protein (C4BP) is a well-established inhibitor of complement with emerging functions as an endogenously expressed inhibitor of the NLRP3 inflammasome signalling pathway. Here, we identified that C4BP purified from human plasma is an inhibitor of crystalline- (monosodium urate, MSU) and particulate-induced (silica) NLRP3 inflammasome activation. Using a C4BP mutant panel, we identified that C4BP bound these particles

Blockade Of Mglur5 In Astrocytes Derived From Human Ipscs Modulates Astrocytic Function And Increases Phagocytosis, Izabella B Q De Lima, Pablo L Cardozo, Julia S Fahel, Juliana P S Lacerda, Aline S Miranda, Antônio L Teixeira, Fabiola M Ribeiro

Faculty, Staff and Student Publications

TNF-α is essential for induction and maintenance of inflammatory responses and its dysregulation is associated with susceptibility to various pathogens that infect the central nervous system. Activation of both microglia and astrocytes leads to TNF-α production, which in turn triggers further activation of these cells. Astrocytes have been implicated in the pathophysiology of a wide range of neurodegenerative diseases with either harmful or protective roles, as these cells are capable of secreting several inflammatory factors and also promote synapse elimination and remodeling. These responses are possible because they sense their surroundings via several receptors, including the metabotropic glutamate receptor 5 …

Wnt Signaling In Liver Regeneration, Disease, And Cancer, Gengyi Zou, Jae-Il Park

Faculty, Staff and Student Publications

The liver exhibits the highest recovery rate from acute injuries. However, in chronic liver disease, the long-term loss of hepatocytes often leads to adverse consequences such as fibrosis, cirrhosis, and liver cancer. The Wnt signaling plays a pivotal role in both liver regeneration and tumorigenesis. Therefore, manipulating the Wnt signaling has become an attractive approach to treating liver disease, including cancer. Nonetheless, given the crucial roles of Wnt signaling in physiological processes, blocking Wnt signaling can also cause several adverse effects. Recent studies have identified cancer-specific regulators of Wnt signaling, which would overcome the limitation of Wnt signaling target approaches. …

Gankyrin-Mediated Interaction Between Cancer Cells And Tumor-Associated Macrophages Facilitates Prostate Cancer Progression And Androgen Deprivation Therapy Resistance, Guang Peng, Chao Wang, Hongru Wang, Min Qu, Keqin Dong, Yongwei Yu, Yuquan Jiang, Sishun Gan, Xu Gao

Faculty, Staff and Student Publications

Increasing evidence reveals that the interaction between tumor cells and tumor-associated macrophages (TAMs) facilitates the progression of prostate cancer, but the related mechanisms remained unclear. This study determined how gankyrin, a component of the 19S regulatory complex of the 26S proteasome, regulates the progression and androgen deprivation therapy (ADT) resistance of prostate cancer through tumor cell-TAM interactions.

Protein Translation Paradox: Implications In Translational Regulation Of Aging, Harper S Kim, Andrew M Pickering

Faculty, Staff and Student Publications

Protein translation is an essential cellular process playing key roles in growth and development. Protein translation declines over the course of age in multiple animal species, including nematodes, fruit flies, mice, rats, and even humans. In all these species, protein translation transiently peaks in early adulthood with a subsequent drop over the course of age. Conversely, lifelong reductions in protein translation have been found to extend lifespan and healthspan in multiple animal models. These findings raise the protein synthesis paradox: age-related declines in protein synthesis should be detrimental, but life-long reductions in protein translation paradoxically slow down aging and prolong …

Evaluation Of Scrub Typhus Surveillance, Alwar District, Rajasthan, India, July-August 2020, Surendra M Prajapati, Kanica Kaushal, Simmi Tiwari, Ajit Shewale, Tushar Nale, Tanzin Dikid

Faculty, Staff and Student Publications

INTRODUCTION: Scrub typhus is one of the most underreported and fatal illnesses accounting for 23% of all febrile illness. Rajasthan reported cases during 2018-2019 in state reporting system but did not report any case to central Integrated Disease Surveillance Programme (IDSP) unit. We evaluated the Scrub typhus surveillance system in Alwar district, Rajasthan, with the objective of describing and evaluating the system and providing evidence-based recommendations to identify gaps.

MATERIAL AND METHODS: In cross-sectional study, we reviewed records and conducted key informant interviews at district- and block-level health facilities. Using US Centers for Disease Control guidelines, we evaluated the system …

Multi-Faceted Role Of Lrp1 In The Immune System, Olga Sizova, Lisa St John, Qing Ma, Jeffrey J Molldrem

Faculty, Staff and Student Publications

Graft versus host disease (GVHD) represents the major complication after allogeneic hematopoietic stem cell transplantation (Allo-SCT). GVHD-prone patients rely on GVHD prophylaxis (e.g. methotrexate) and generalized anti-GVHD medical regimen (glucocorticoids). New anti-GVHD therapy strategies are being constantly explored, however there is an urgent need to improve current treatment, since GVHD-related mortality reaches 22% within 5 years in patients with chronic GVHD. This review is an attempt to describe a very well-known receptor in lipoprotein studies - the low-density lipoprotein receptor related protein 1 (LRP1) - in a new light, as a potential therapeutic target for GVHD prevention and treatment. Our …

Crmm 4500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Tennessee Wildlife Special Edition, 2023-2024 Fishing Regulations, Tennessee. Wildlife Resources Agency.

Hunting and Fishing Regulations

No abstract provided.

Tennessee Wildlife 2023-2024 Hunting & Trapping Regulations, Tennessee. Wildlife Resources Agency.

Hunting and Fishing Regulations

No abstract provided.

Annual Wild Turkey Status Report 2022, Tennessee. Wildlife Resources Agency.

Turkey Management

No abstract provided.

Jrsm 3900: Visual Media (Syllabus), Ruoxu Wang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction to and application of principles of visual communication, including typography, color and organization for print and digital media using Adobe Creative Cloud.

Crmm 6500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Crmm 4500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Jrsm 3900: Visual Media (Syllabus), Ruoxu Wang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction to and application of principles of visual communication, including typography, color and organization for print and digital media using Adobe Creative Cloud.

Crmm 6500: Web Publish L: Html/Css (Syllabus), Jin Yang

Journalism and Strategic Media Syllabi Archive

Course Description: Introduction of web design software and web design concept; basic knowledge of web markup language html and cascading style sheets (CSS); overview of WordPress as content management system (CMS); development of website projects incorporating multimedia elements.

Sermon By Elias Jefferson Jones, Compiled By Ella Costillo Bennett, 1915.

Documents

Sermon, "Elias Jefferson Jones Preaches His First Sermon in Darktown", by Elias Jefferson Jones, compiled by Ella Costillo Bennett, 23 typed pages, 1915.

"Sidetreks", The Commercial Appeal's Weekend Living, Issue 3, 1981?

Publications

Booklet, "Sidetreks: Weekend Trips From...The Commercial Appeal's Weekend Living", Issue 3, 1981?

"This third offering, like the others, is designed to provide minivacations for area residents. There are 10 new treks in this book. Each trip can make an easy three-day weekend, with most designed for a Saturday and Sunday getaway. Most call for less than a half-day's driving. The areas recommended are rich in history, scenic beauty and places to have a good time and enjoy recreation and entertainment."

"Sidetreks", The Commercial Appeal's Weekend Living, Issue 2, 1980?

Publications

Booklet, "Sidetreks: Weekend Trips From...The Commercial Appeal's Weekend Living", Issue 2, 1980?

"This new offering, like the first, is designed to provide mini-vacations for area residents. There are seven new treks in this book, with three retained for the first, because of their wide popularity. Most of the trips call for less than a half-day's driving. The areas recommended are rich in history and others are just good places to go to have a good time and enjoy recreation and entertainment."

"Sidetreks", The Commercial Appeal's Weekend Living, Issue 4, 1982

Publications

Booklet, "Sidetreks: Weekend Trips From...The Commercial Appeal's Weekend Living", Issue 4, 1982

"Each year for three years, The Commercial Appeal has produced a Sidetreks book - collections of short trips taken from the newspaper's Weekend Living Section. In those years, more than 10,000 copies have been sold. Now, in 1982, comes Sidetreks 4. This offering, like the others, is designed to provide minivacations for area residents. Of the 10 trips included in Sidetreks 4, each provides a leisurely three-day weekend trip. Most are designed for a Saturday and Sunday getaway and average five to six hours driving time."

Does Administration Of Prehospital Plasma Improve Survival Rates In Injured Adults At Risk For Hemorrhagic Shock?, Carly Belko

PCOM Physician Assistant Studies Student Scholarship

Objective: The objective of this selective EBM review is to determine whether administration of prehospital plasma will improve survival rates in injured adults at risk for hemorrhagic shock.

Study Design: A systematic review of two randomized controlled trials (RCT) and one retrospective cohort study

Data Sources: All three studies were identified using PubMed and selected based on their ability to answer the clinical question while including patient-oriented outcomes (POEMs). All articles were peer-reviewed, published in English, and published on or after 2011.

Outcomes Measured: The outcomes addressed were survival rates, calculated using mortality rates based on if the patient was …

Robinson Crusoe Crusades Against Traditional Ideas Of Heroism, Sabrina Hess

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Together With Tosha Newsletter, January 2023, Tennessee. Department Of Labor & Workforce Development.

TOSHA Newsletter

No abstract provided.

Controlled Substance Monitoring Database; 2023 Report To The 113th Tennessee General Assembly, Tennessee. Department Of Health.

Controlled Substance Monitoring Database Annual Report

No abstract provided.

Voice Quality Assessment In Cases Of Vocal Fold Gaps After Single Growth Factor Injection, Amr Roushdyel Badrawy, Asmaa Abdel Hamid, Israa Eltaweel, Azza Abdel Aziz Azzam

Journal of Medicine in Scientific Research

In severe vocal fold (VF) lesions, deposits of disorganized, thick collagen bundles and little hyaluronic acid (HA) are deposited in the superficial layer of lamina propria (SLP). These changes lead to severe dysphonia and aspiration, which could be complicated by fatal pneumonia. Unfortunately, no specific treatment has been recognized due to unpredictable VF regeneration. Current progress in regenerative medicine has allowed the development of tissue engineering techniques using cells, scaffolds, and growth factors (GFs). Extrinsic GFs application could help in the induction of the regenerative process. The work aims to assess the voice quality after a single GF injection of …

Teen Appeal, Memphis, 02.05, 1999

Documents

Issue 2:5 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on February 23, 1999.

Teen Appeal, Memphis, 02.08, 1999

Documents

Issue 2:8 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on May 25, 1999.

Teen Appeal, Memphis, 02.06, 1999

Documents

Issue 2:6 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on April 5, 1999.

Teen Appeal, Memphis, 02.03, 1998

Documents

Issue 2:3 of the “Teen Appeal” published by the University of Memphis Journalism Department and Commercial Appeal, Memphis, Tennessee, on December 8, 1998.