Digital Commons Network^™

Lead Induced Differences In Bone Properties In Osteocalcin +/+ And −/− Female Mice, G. Yildirim, W. C. Budell, O. Berezovska, S. Yagerman, S. S. Maliath, P. Mastrokostas, S. Tommasini, T. L. Dowd

Publications and Research

Lead (Pb) toxicity is a major health problem and bone is the major reservoir. Lead is detrimental to bone, affects bone remodelingand is associated with elderly fractures. Osteocalcin (OC) affects bone remodeling, improves fracture resistance and decreases with age and in some diseases. The effect of lead in osteocalcin depleted bone is unknown and of interest. We compared bone mineral properties of control and Pb exposed (from 2 to 6 months) femora from female adult C57BL6 OC+/+ and OC−/− mice using Fourier Transform Infrared Imaging (FTIRI), Micro-computed tomography (uCT), bone biomechanical measurements and serum turnover markers (P1NP, CTX). Lead significantly …

Characterizing Cellular Injury And Inflammation With Aldob-/-Mouse Model Of Mafld, Andy Rashid

All Master's Theses

Metabolic-associated fatty liver disease (MAFLD) affects 1 in 3 people in the US and is a healthcare burden on the order of billions of dollars. MAFLD is characterized by pathological lipid accumulation in the liver, excess production of triglycerides and cholesterol, and export of LDL particles that raise serum lipid levels. These metabolic perturbations can lead to the development of liver fibrosis, chronic inflammation, and insulin resistance. Diagnosing MAFLD prior to fibrosis is crucial for successful intervention and prevention of advanced liver disease and other metabolic complications. Fructose-1Phospahte (F1P) accumulation from fructose overconsumption can drive hepatic lipogenesis and MAFLD progression. …

Demography And Habitat Associations Of The Basalt Cactus: Pediocactus Nigrispinus, Zarha Dillon-Zuppelli

All Master's Theses

Cacti are iconic, conspicuous, and important contributors to arid ecosystems. They stabilize soil and provide essential food and habitat to wildlife. Pediocactus nigrispinus is a species of cactus endemic to the Pacific Northwest and has been listed as a sensitive species due to its vulnerability to habitat loss. Pediocactus nigrispinus is being threatened by habitat fragmentation, poaching, and a changing climate. Best conservation methods for this species are poorly understood, due in part to a limited understanding of its demography and associations that may help define its occurrence.

A demographic study in Washington State was implemented in 2016 to give …

Ballistic Experiments With A Sample Of 3-D Printed Columbia Plateau Projectile Point Types, Aren Orsen

All Master's Theses

Recent advances in 3-D scanning and printing offer the means for experimental archaeologists to utilize reproductions of artifacts for analysis and interpretation. In this case study I accurately reproduce a sample of Columbia Plateau projectile points, measure their ballistic properties with an experimental approach, and test the effectiveness and function of point types representing different time periods. Eight morphologically distinct projectile points were 3-D scanned, printed, and test fired into a clay target. Velocity, kinetic energy, momentum, penetration, and wound channel size were measured. Results indicate all eight arrow mounted point types were suitable for small to medium game. Variations …

Waiting To Exhale, Abigail H. Ogle

Theses and Dissertations

We breathe as a measure of time, it keeps us alive, and fabricates the pattern of our lives. We are punctuated by “snarls,” “glitches,” or moments of irregularity – of trying to catch one's breath, having it taken away, or gasping for it. It is the punctuation of sighs, huffs, sniffs, scoffs, screams, and deep intakes that appear as glitches in the breathing system.

In our daily rhythm of breathing, the presence of the glitch, defined as potentiality, can create space for something unexpected or new to arise. Using the wind from fans and approximately 1,260 square feet of silk, …

Illusion: Immersive Experience, Tessa S. Trowbridge

Theses and Dissertations

Can society learn from art, and if so, what type of knowledge can be gained from art? It is currently understood that art and design can help humans explore, discover, and understand philosophical and imaginative topics. There is a general agreement that art can create insight and awareness in ways that logical and rational statements cannot, and from these unique interactions, humans can see the world with a new perspective (Worth, n.d.). This thesis will investigate the claim that art can inspire human imagination and allow viewers to gain insight into a surreal reality using designed, physically immersive spaces.

Immersive …

Implementation Of Enhanced Probe Data (Canbus) For Tactical Workzone And Winter Operations Management, Jairaj Desai, Rahul Suryakant Sakhare, Justin Mahlberg, Jijo K. Mathew, Howell Li, Darcy M. Bullock

JTRP Technical Reports

For over a decade, segment-based probe data has been extensively used by transportation stakeholders for monitoring mobility on Indiana roadways. However, enhanced probe data from connected vehicles includes a richer dataset that can provide more detailed real-time and after-action reviews. This enhanced data includes detailed vehicle trajectories, at 3s resolution, and “event data.” This event data is near real-time and includes hard-braking events, hard-acceleration events, weather-related data, including wiper activations and some seat belt usage data. This project developed a set of methodologies and resulting visualizations that enables the use of emerging connected vehicle data in operational decision-making on work …

Crowdsourcing/Winter Operations Dashboard Upgrade, Justin A. Mahlberg, Jairaj Desai, Haydn Malackowski, Howell Li, Jijo K. Mathew, Rahul Suryakant Sakhare, Timothy Wells, Darcy M. Bullock

JTRP Technical Reports

INDOT has recently completed the deployment of Parsons telematics-based dash-cameras, automatic vehicle locator (AVL) positions, and spreader rate monitoring across their winter operations fleet. The motivation of this study was to develop dashboards that integrate connected vehicle data into the real-time monitoring and after-action review of winter storms. Each month approximately 13 billion connected vehicle records are ingested for the state of Indiana and almost 99 billion weather data records are ingested nationwide in 15-minute intervals. This study developed techniques to utilize this connected vehicle data and weather data to monitor real-time mobility of interstates and post storm after-action assessments …

Investigating Consistency Among Bridge Inspectors Using Simulated Virtual Reality Testbed, Mohammad Jahanshahi, Shirley J. Dyke, Luis David Fernandez Vasquez, Nikkhil Vijaya Sankar, Yu-Ting Huang

JTRP Technical Reports

The current condition of US infrastructure requires a data-driven, risk-based approach to asset management. In the case of bridges, inspectors in every state visit these structures and collect data, and based on the information they report, state departments evaluate bridge conditions, predict deterioration, and make repair and retrofit decisions. However, the capacity of inspectors for defect detection might vary due to several factors, such as the inspectors’ experience or eyesight, which results in differences when reporting their results. Through the development of a virtual reality (VR)-based testbed, the variability among inspectors in examination and documentation practices in steel and concrete …

Chile, En Particular, Lilianet Brintrup Hertling

Fiction and Poetry

Chile, en particular o “gritar en chileno como [lo hacen] los piñones, el mote, los pájaros y las empanadas, tal vez como murmuraban el huemul y la razón”, de Lilianet Brintrup Hertling, es un libro que sorprenderá al lector. Sus referencias geográficas, históricas, culturales, culinarias y biográficas comienzan con la manducación: se mastican, se tragan, se degluten formando un bolo alimenticio inmediatamente descriptivo, valorativo y etopéyico.

Letter From The Editors, Raven L. Jones, Tanya Upthegrove Gregory, Alexandra M. Sánchez

Language Arts Journal of Michigan

No abstract provided.

Student Spotlight: Madelyn (Mj) S., Madelyn S.

Language Arts Journal of Michigan

No abstract provided.

University Of Richmond Magazine - Summer 2023

University of Richmond Magazine

The University of Richmond's Alumni Magazine was first published as The Alumni Bulletin in 1936 and continues to this day as the University of Richmond Magazine.

Building The Soil And The Community At Hollands Track Farm, Newdegate, Western Australia, Jamie Bowyer, Nick Kelly

Natural resources published reports

The Kelly family have been farming at Hollands Track Farm, about 18 km south-west of Newdegate, since 1965. They currently produce grains, beef, eggs and sheep. Long-term annual average rainfall is 350 mm. The Kellys were early adopters – in the 1990s – of the no-till farming system, which is now widely used in Western Australia. Around 2002 they sold the last of their sheep and moved to a continuous cropping program with increased fertiliser and chemical use. They were very good at this system, and it served them well. They really enjoy the challenge of growing good crops. Over …

Pasture Condition Guides For The Southern Rangelands, Including The Gascoyne, Murchison And Goldfields-Nullarbor, Peter-Jon A. Waddell, Philip We Thomas, Wayne J. Fletcher, Kath Ryan, Joshua E. Foster, John K. Stretch, Jim S. Addison

Bulletins 4000 -

These guides address a recognised gap in readily applicable and easily accessible information on southern rangelands pasture condition and management.

These guides provide descriptions and images for southern rangelands pastures with similar management requirements for the grazing of native pastures by livestock. Therefore, the focus is on palatability of vegetation to livestock, and the effects of livestock management and external factors on the condition of the vegetation and soils.

The first section provides an overview and map, introduces concepts and terms important to understanding arid shrubland management in general, these guides in particular, and includes an economic analysis of the …

Ccl2 Suppression In Lewis Lung Carcinoma Model Enhances Host Survival And Immune Response In The Tumor Microenvironment, Nivedita Biswas

Theses and Dissertations

CCL2, a chemokine also referred to as monocyte chemoattractant protein 1 (MCP-1) and small inducible cytokine A, is chemotactic for monocytes. CCL2-induced recruitment of CCR2+Ly6C(hi) monocytes increases vascular permeability CCR2+ endothelium aiding the escape and migration of tumor cells. CCL2 is produced by cancers of varied immunogenicity and augments tumor proliferation and metastasis. Elevated CCL2 expression by tumor cells is linked to poor prognosis.We have previously shown that two bacterially derived superantigens, Staphylococcal enterotoxin G and I (SEG/SEI) stimulate large numbers of T cells in an antigen-independent fashion and promote enhanced survival in the poorly immunogenic B16-F10 melanoma model. Conversely, …

Natural Fractals And Facial Emotion Recognition, Nathaniel Joseph Pagel

Theses and Dissertations

The psychological benefits that come from visually processing natural imagery have been widely studied. The components of natural imagery that provoke positive responses are not fully understood. This study uses a mixed design approach to identify if the acute exposure to statistical fractal imagery, of both a high-range or mid-range complexity, affects cognitive workload, physiological arousal, and gaze patterns in the recognition and identification of emotions through facial expressions. Participants were undergraduate students fulfilling a partial course requirement (N = 87). Eye-tracking metrics were used to compare exposure to fractal complexities. Participants were randomly assigned to either be exposed to …

The Interplay Between Parp-1 And Histone Modifications In Transcriptional Regulation During Development And Heat Shock Response, Gbolahan Gbenga Bamgbose

Theses and Dissertations

Poly(ADP-ribose) polymerase 1 (PARP-1), a multifunctional nuclear enzyme, plays a crucial role in transcriptional regulation through its three functional domains: the N-terminal DNA-binding domain (DBD), the automodification domain (AD), and the C-terminal domain, which includes the WGR and the catalytic domains. Despite its importance, the mechanisms directing PARP-1 to chromatin remain unclear and PARP-1’s role in development is still poorly understood. In chapter II, we interrogated the role of PARP-1 domains in PARP-1 to chromatin. We used ChIP-seq of YFP-tagged deletional isoforms of PARP-1 and a construct that lacks only the first zinc finger domain (ΔZnI). Interestingly, our findings suggest …

Acaricidal Activity Of The Orally Administered Isoxazoline Drugs (Lotilaner, Fluralaner, And Afoxolaner) In White-Footed Mice Against Larval Ticks, Emily Marie Gisi

Theses and Dissertations

Lyme disease, caused by Borrelia burgdorferi, is currently the most prevalent vector borne disease in North America. With the CDC estimating almost 500,000 new cases every year, methods are needed to control the vector, the black legged tick (Ixodes scapularis). Like other tick-borne diseases, Lyme disease is zoonotic and involves tick parasitism on rodent reservoirs in the wild. The main reservoir host of Lyme disease is the white-footed mouse (Peromyscus leucopus). This study aims to explore the effectiveness of a reservoir targeted control approach by the treatment of white-footed mice with oral isoxazoline class drugs. …

Intracranial Mast Cell Activation And Central Histaminergic Dysregulation In Food Allergy-Associated Neuropathology And Behavioral Changes, Danielle Germundson-Hermanson

Theses and Dissertations

Food allergy occurs when the immune system reacts inappropriately to an otherwise harmless food. The hypersensitivity response is known to cause physical symptoms ranging from mild gastrointestinal discomfort to life-threatening anaphylaxis. Curiously, there is growing evidence that some food-allergic individuals experience changes in mood and behavior after consuming an offending food despite not experiencing severe physical symptoms. However, the mechanism(s) through which food allergy may affect the brain and behavior has yet to be elucidated. Previously, we found that inducing non-anaphylactic cow’s milk allergy (CMA) in mice resulted in abnormal behavior, neuroinflammation, and an increased the number of brain mast …

Computational Framework For Neuro-Optics Simulation And Deep Learning Denoising, Cecilia Ling

Theses and Dissertations

The application of machine learning techniques in microscopic image restoration has shown superior performance. However, the development of such techniques has been hindered by the demand for large datasets and the lack of ground truth. To address these challenges, this study introduces a computer simulation model that accurately captures the neural anatomic volume, fluorescence light transportation within the tissue volume, and the photon collection process of microscopic imaging sensors. The primary goal of this simulation is to generate realistic image data for training and validating machine learning models. One notable aspect of this study is the incorporation of a machine …

Assessing Neuropsychological Changes Post Covid-19 Infection Using The Global Neuropsychological Assessment, Jeremy M. Raines

Theses and Dissertations

COVID-19 is characterized by a respiratory syndrome with severity ranging from mild upper respiratory tract illness to severe interstitial pneumonia and acute respiratory distress syndrome. Although physical symptoms are most common in those infected with COVID-19, patients may present with several neuropsychiatric sequelae caused by direct central nervous system infection, neuroinflammation, and/or prolonged hypoxia encephalitis. Though extent literature on COVID-19 related cognitive decline is still in its infancy, it has been suggested neurological impairment is most common in those with severe symptom presentation, requiring hospitalization and among those who have experienced hypoxic events. In the current study, sixty-two healthy controls …

Echoes Of The Zoning: Confronting Legal Realism In The Arguments For Reparations From The Atlantic Slave Trade And Modern-Day Human Trafficking, Glenys P. Spence

Fordham International Law Journal

This Article is based on the premise that modern day human trafficking, like the transatlantic slave trade, violates jus cogens norms, and thus the practice was and still is a violation of US laws under customary international law. The analysis will examine the laws that were applied to chattel slavery in England and her colonies through the lens of some seminal slavery cases to unearth the tyranny of interpretation in human trafficking reparations and liability claims under the current Supreme Court jurisprudence and the Alien Tort Statute (“ATS”). The featured cases will reveal that the same philosophies undergirding the jurisprudence …

Staphylococcal Enterotoxin I Immunotherapy Combined With Hla-Dq8 Induces Tumoricidal Activity, With Low Superantigen Toxicity, Leading To Long-Term Survival And Tumor-Specific Memory Against Established B16-F10 Melanoma In Humanized Hla-Dq8 Transgenic Mice, Nathan Velaris

Theses and Dissertations

Immunotherapies now stand at the forefront of cancer treatment as a versatile arsenal of cutting-edge tools wielded by medical professionals to combat and conquer a spectrum of formidable diseases. Most notably, immunotherapies such as immune checkpoint inhibitors, have revolutionized the field of oncology offering a promising alternative to conventional treatments like chemo and radiation therapy with significant improvements for patients in terms of quality of life and survival. Immunotherapies can be uniquely personalized to a patient's genetic and immune system profile leading to more effective treatments and durable long-lasting responses. Our research group has identified Staphylococcal enterotoxin I as a …

Integrating Technology Into Wildlife Surveys, Sally E. Yannuzzi

Theses and Dissertations

Technology is rapidly improving and being incorporated into field biology, with survey methods such as machine learning and uncrewed aircraft systems (UAS) headlining efforts. UAS paired with machine learning algorithms have been used to detect caribou, nesting waterfowl and seabirds, marine mammals, white-tailed deer, and more in over 19 studies within the last decade alone. Simultaneously, UAS and machine learning have also been implemented for infrastructure monitoring at wind energy facilities as wind energy construction and use has skyrocketed globally. As part of both pre-construction and regulatory compliance of newly constructed wind energy facilities, monitoring of impacts to wildlife is …

Solving The Cherry-Picking Problem In Legislative History Use – A Corpus-Based Approach For Empirical Intentionalist Legal Interpretation Analysis, Brett James Hashimoto, James Heilpern

Faculty Publications

The use of legislative histories under intentionalist/purposivist theories of statutory interpretation is frequently criticized because it can be easily biased (see, e.g., Scheppele, 2012). To date, corpus-based statutory interpretation has relied almost exclusively on textualist theory of legal interpretation. However, corpus linguistic methods are not necessarily bound to any one theory (e.g., Biber & Reppen, 2015). The present study analyses two legislative histories as corpora and compares them against a general corpus of English to determine if interpretative theory makes a meaningful difference in two example cases (Costello v. United States, 2012; Taniguchi v. Kan Saipan Pacific, 2012). Senses of …

Theory-Driven Approach To Developing Socially Responsible Leadership Among College Students Who Mentor: Congruence, Hannah M. Sunderman, Lindsay J. Hastings

Department of Agricultural Leadership, Education, and Communication: Faculty Publications

The Social Change Model of Leadership (SCM) is the most widely used student leadership development model in higher education. Therefore, the purpose of the current paper is to share a theory-driven approach to developing Congruence, an individual value of the SCM. We discuss the development and implementation of a two-part virtual leader development intervention focused on college students who mentor K-12 youth. Part One was a virtual, twohour content block in the fall with interactive activities. Part Two was a small-group, virtual meeting in the spring with in-depth discussions. The intervention focused on recognizing congruent leadership and considering a situation …

Effects Of Peri-Urbanization On Coastal Sage Scrub Ant Species In Baja California, Alejandro E. Mieles, Margaret A. Voss, Estelí Jiménez-Soto

School of Geosciences Faculty and Staff Publications

Increasing urbanization on the Baja California Peninsula threatens ant diversity. Reductions in ant species diminish ecosystem services provided to semiarid coastal scrub areas. Peri-urban areas in particular are at high risk of reductions in ant biodiversity due to development. To document and evaluate ant species diversity and richness in a rapidly developing area, nine sites were sampled within areas of coastal sage scrub (CSS) encircling the urban periphery of Ensenada, Baja California. Forty species and 17 genera of ants were collected, only one of which was non-native. Although the sampled area represents less than 1% of the peninsula and 3% …

Naturally Occurring Vegetation Connectivity Facilitates Ant-Mediated Coffee Berry Borer Removal, Sanya Cowal, Jonathan R. Morris, Estelí Jiménez-Soto, Stacy M. Philpott

School of Geosciences Faculty and Staff Publications

Vegetation connectivity is an essential aspect of the habitat complexity that impacts species interactions at local scales. However, agricultural intensification reduces connectivity in agroforestry systems, including coffee agroecosystems, which may hinder the movement of natural enemies and reduce the ecosystem services that they provide. Ants play an important role in regulating the coffee berry borer (CBB), which is the most damaging coffee pest. For arboreal ant communities, the connections between trees are important structures that facilitate ant mobility, resource recruitment, foraging success, and pest control ability. To better understand how connectivity impacts arboreal ants in coffee agroecosystems, we conducted an …

Sénégal: Le Changement Politique Dans L’Ère Numérique, Zane Irwin , '23

Senior Theses, Projects, and Awards

No abstract provided.