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The Oncolytic Herpes Simplex Virus Type-1 (Hsv-1) Vaccine Strain Vc2 Causes Intratumor Infiltration Of Functionally Active T Cells And Inhibition Of Tumor Metastasis And Pro-Tumor Genes Vegf And Pdl1 Expression In The 4t1/Balb/C Mouse Model Of Stage Four Breast Cancer, Rafiq Nabi, Farhana Musarrat, Jose Cesar Jose, Ingeborg M. Langohr, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

Introduction: Oncolytic viruses (OVs) provide new modalities for cancer therapy either alone or in combination with synergistic immunotherapies and/or chemotherapeutics. Engineered Herpes Simplex Virus Type-1 (HSV-1) has shown strong promise for the treatment of various cancers in experimental animal models as well as in human patients, with some virus strains licensed to treat human melanoma and gliomas. In the present study we evaluated the efficacy of mutant HSV-1 (VC2) in a late stage, highly metastatic 4T1 murine syngeneic. Method: VC2 was constructed VC2 using double red recombination technology. For in-vivo efficacy we utilized a late stage 4T1 syngeneic and immunocompetent …

Energetic Budget Of Diploid And Triploid Eastern Oysters During A Summer Die-Off, Sarah Bodenstein, Sandra M. Casas, Terrence R. Tiersch, Jerome F. La Peyre

Faculty Publications

Triploid oysters are widely used in off-bottom aquaculture of eastern oysters, Crassostrea virginica. However, farmers of the Gulf of Mexico (GoM) and Atlantic coast estuaries have observed unresolved, late-spring die-offs of triploid oysters, threatening the sustainability of triploid aquaculture. To investigate this, the physiological processes underlying oyster growth (e.g., feeding, respiration) and mortality of one-year-old diploid and triploid oysters were compared in early summer following an uptick in mortality. It was predicted that higher triploid mortality was the result of energetic imbalances (increased metabolic demands and decreased feeding behavior). Oyster clearance rates, percentage of time valves were open, absorption efficiency, …

Sodium Propionate Or Sodium Butyrate Promotes Fatty Acid Oxidation In Hepg2 Cells Under Oxidative Stress, Kristina J. Cook, Ann Coulter, Michael Keenan, Frank Greenway, Jack N. Losso

Faculty Publications

The beneficial effects of sodium butyrate (NaB) and sodium propionate (NaP) on fatty acid oxidation (FAO) genes and production of proinflammatory cytokines related to nonalcoholic fatty liver disease (NAFLD) were evaluated using HepG2 human liver hepatocellular carcinoma cells exposed to palmitate/oleate or lipopolysaccharides (LPSs) as a model. The results showed that NaP or NaB was able to promote FAO, regulate lipolysis, and reduce reactive oxygen species production by significantly increasing the mRNA expression of peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α), peroxisome proliferator-activated receptor alpha (PPARα), adipose triglyceride lipase (ATGL), carnitine palmitoyltransferase 1 alpha (CPT1α), fibroblast growth factor 21 …

Novel Liquor-Based Hot Sauce: Physicochemical Attributes, Volatile Compounds, Sensory Evaluation, Consumer Perception, Emotions, And Purchase Intent, Ricardo S. Aleman, Jhunior A. Marcía, Ismael Montero-Fernández, Joan King, Shirin Kazemzadeh Pournaki, Roberta Targino Hoskin, Marvin Moncada

Faculty Publications

Hot sauces are popular peppery condiments used to add flavor and sensory excitement to gastronomical preparations. While hot sauce occupies a retail category well over a century old, a novel production method using liquor as the base preservative rather than traditional vinegar is now commercially available, and its uniqueness begs study. Hot sauces produced with tequila, rum, vodka, and bourbon were compared to traditional vinegar-based hot sauces concerning physicochemical properties, volatile compounds, microbiological quality, sensory scores, emotions, and purchase intent (PI). Under accelerated conditions, pH, titratable acidity (TA), water activity (Aw), viscosity, and color were analyzed weekly for 20 weeks, …

Serum Mannan-Binding Lectin-Associated Serine Proteases In Early Pregnancy For Gestational Diabetes In Chinese Pregnant Women, Ming Gao, Jing Li, Rui Zhang, Ninghua Li, Weiqin Li, Shuang Zhang, Peng Wang, Hui Wang, Zhongze Fang, Zhijie Yu, Gang Hu, Junhong Leng, Xilin Yang

Population and Public Health Science Faculty Publications

Aims: This study aimed to explore associations of mannan-binding lectin-associated serine protease (MASP) levels in early pregnancy with gestational diabetes mellitus (GDM). We also examined interactions of MASPs and deoxycholic acid (DCA)/glycoursodeoxycholic acid (GUDCA) for the GDM risk and whether the interactive effects if any on the GDM risk were mediated via lysophosphatidylcholine (LPC) 18:0. Materials and methods: A 1:1 case-control study (n = 414) nested in a prospective cohort of pregnant women was conducted in Tianjin, China. Binary conditional logistic regressions were performed to examine associations of MASPs with the GDM risk. Additive interaction measures were used to examine …

The Rise Of Native Lordships At Pashash, A.D. 200–600, North Highlands Of Ancash, Peru, George F. Lau, Milton Luján Dávila, Jacob L. Bongers, David Chicoine

Faculty Publications

This article examines the rise of native, segmentary lordships in the highlands of north-central Peru. It reports on new excavations and mapping at the seat of a prehispanic polity, Pashash (Recuay culture), a large hilltop center that developed after the collapse of Chavín civilization. Fieldwork revealed monumental constructions and two special activity contexts radiocarbon-dated to ca. a.d. 200–400: an offering area in a large palatial compound and a room-complex with chambers closed off and sealed with feasting refuse. Multiple lines of evidence help reconstruct a regional picture for the establishment of wealthy local elites. Cultural innovations explicitly link new leaders …

Briquetage And Brine: Living And Working At The Classic Maya Salt Works Of Ek Way Nal, Belize, Heather Mckillop, E. Cory Sills

Faculty Publications

Systematic flotation survey and spatial analysis of artifacts at the submerged salt work of Ek Way Nal reveal evidence of a residence, salt kitchens, and additional activities. Ek Way Nal is one of 110 salt works associated with a Late to Terminal Classic (A.D. 600-900) salt industry known as the Paynes Creek Salt Works. Wooden posts that form the walls of 10 buildings are remarkably preserved in a peat bog below the sea floor providing an opportunity to examine surface artifacts in relation to buildings. Numerous salt kitchens have been located at the Paynes Creek Salt Works by evidence of …

L2 Perception Of The S-Aspirated Phone In Spanish, Raúl A. Gamboa

Electronic Theses and Dissertations

This dissertation deals with the perception of the aspirated coda /s/ by Spanish L2 learners. Second language research, with some exceptions, focuses on whether L1English–L2 Spanish learners can perceive the aspirated variant, showing that only advanced learners with time spent in s-weakening regions succeed at the task. L2 studies about s-aspiration have yet to investigate the perception of the aspirated coda /s/ in different environments across actual phrases and sentences. This study focuses on the intelligibility of pairs of ambiguous phrases and sentences perceptually differentiated only by the aspirated coda /s/. Additionally, it investigates the prosodic stress´ influence on the …

Ground Level: Poems, Margaret Graber

Electronic Theses and Dissertations

“Ground Level” is a full-length poetry collection situated at the intersection of ecopoetics and psychology, where the theme of “grounding” one’s self continually emerges in the midst of personal geographical changes and experiences of collective social trauma during a period of prolonged immersion in the natural world. By exploring through an array of poetic forms, structures, and experimentations including golden shovels, contrapuntals, haikus, an abecedarian, a sestina, grounding exercises, poems featuring 20th century children’s television host Fred Rogers, and a sonnet crown which also explores queerness in the 21st century Southeast, the speaker engages with a number of different methods …

Effects And Mechanisms Of Cognitive Impairment During Vigorous-Intensity Exercise, Myungjin Jung

Electronic Theses and Dissertations

Recent research indicates that vigorous-intensity exercise concurrent with a prefrontal cortex (PFC)-dependent cognitive task can temporarily deactivate the PFC, leading to impaired cognition. Shifting attentional focus from a cognitive task to exercise or vice versa during exercise may also affect cognitive performance. However, the underlying mechanisms of this effect remain unclear. Therefore, this dissertation aimed to evaluate whether changes in attention and PFC oxygenation mediate cognitive impairment during vigorous-intensity exercise. Seventy-five young healthy adults (37 males, 38 females; 20.3 ± 1.6 years) completed three visits. The initial visit consisted of a max cycle test to measure VO2max via indirect calorimetry. …

Dear God The Light, Suado Abdirahman Sheikhhassan

Electronic Theses and Dissertations

This creative thesis contains original poetry by Suado Sheikhassan.

"No Redemption In Nonfiction": Portfolio Reflection On The Queer, Anticapitalist Directions Of Creative Nonfiction, Bethany Fitts

Electronic Theses and Dissertations

I reflect on the current state of my artistic practice and discuss rapidly changing documentary methods in the 21st century as they relate to broader evolutions in the creative nonfiction genre. I then discuss these methods alongside my experimental short-doc Gameplay.

Impact Of Flow Conditions On Graphene-Coated Soil And Geotextile Materials, Brennan Power

Electronic Theses and Dissertations

Levees are fundamental infrastructures for reducing and mitigating flood risk during extreme weather events. Unfortunately, levees do not eliminate flood risk entirely due to floods potentially exceeding a levee’s capacity. Graphene has become a significant material for enhancing the mechanical properties of materials such as concrete and soil. The focus of this study was to determine methods to coat two materials commonly used in levee sites, sand and geotextile, with graphene to determine the stability of the coating on the materials under different flow conditions simulating real-life scenarios such as wet and dry periods. These graphene-coated materials could then be …

Design, Synthesis, And Application Of Indolizine-Donor Containing Fluorophores For Near-Infrared And Shortwave-Infrared Biological Imaging, William E. Meador

Electronic Theses and Dissertations

Low energy light in the near infrared (NIR, 700 – 1000 nm), shortwave infrared (SWIR, 1000 – 1700 nm), and extended SWIR (ESWIR, 1700 – 2700 nm) has numerous important applications including fluorescence biological imaging, secure display technologies, and photodetectors. While inorganic materials have dominated each of these spectral regions, organic molecules that absorb and emit light in these regions are being heavily researched due to their high degree of molecular tunability via structure-function relationships, cheap production due to the avoidance of precious metals, ease of manufacturing through solution processability, and operation under physiological and ambient conditions. This dissertation illustrates …

Regulatory Frameworks For Smart Mobility: Current U.S. Regulation Of Connected And Automated Vehicles And The Road Ahead, Olivia Dworkin, Jorge Ortiz, Nicholas Xenakis

Journal of Law and Mobility

On June 7, 2023, Senator Gary Peters from Michigan gave an interview about autonomous vehicle technology where he stated that: “From a competitive standpoint, there’s no question that it is absolutely essential that this technology get developed here and deployed here in the United States. We’re facing significant international competition from other countries that understand that autonomy represents not only the future of mobility, but it drives other technologies in a significant way.” Just last year, Senator Peters and eleven of his colleagues had also written a letter to Secretary of Transportation Pete Buttigieg that: “The federal government has the …

Whitewashing The Fourth Amendment, Daniel S. Harawa

Faculty Articles

A conventional critical race critique of the Supreme Court and its Fourth Amendment jurisprudence is that it erases race. Scholars argue that by erasing race, the Court has crafted doctrine that is oblivious to people of color’s lived experiences with policing in America. This Article complicates this critique by asking whether it is solely the Court that is doing the erasing. It explores how race was — or more accurately, was not — litigated in seminal Fourth Amendment cases scholars have targeted for attack: Florida v. Bostick, Illinois v. Wardlow, and United States v. Drayton. As the Article shows, race …

The Price Of Fairness, Christopher Buccafusco, Daniel J. Hemel, Eric Talley

Faculty Articles

The COVID-19 pandemic led to acute supply shortages across the country as well as concerns over price increases amid surging demand. In the process, it reawakened a debate about whether and how to regulate “price gouging” — a controversy that continues as inflation has accelerated even as the pandemic abates. Animating this debate is a longstanding conflict between laissez-faire economics, which champions price fluctuations as a means to allocate scarce goods, and perceived norms of consumer fairness, which are thought to cut strongly against sharp price hikes amid shortages. This Article provides a new, empirically grounded perspective on the price …

A Preliminary Assessment Of The Spawning Potential Ratio Of Five Target Species Of The Coastal Gillnet Fishery In Guyana And Suriname, Tomas Willems, Elford Liverpool, Michael Hiwat

Gulf and Caribbean Research

Data—limited stock assessment methods have the potential to positively impact livelihoods of fishermen around the world by providing management recommendations that aim to optimize sustainable yields from fisheries. Some years ago, a novel length— based (LB) method was developed for the assessment of spawning potential ratio (SPR), a measure of the reproductive capacity of fish stocks. We applied the LB—SPR method to 5 important target species of the coastal gillnet fishery in Guyana and Suriname. Nebris microps (Smalleye Croaker; 32% SPR) and Macrodon ancylodon (King Weakfish; 34% SPR) had the highest spawning potential, but remained below the 40% target level …

A Fiduciary Theory Of Progressive Prosecution, Bruce A. Green, Rebecca Roiphe

Faculty Scholarship

Progressive prosecutors differ from their more traditional counterparts primarily in the way in which they make decisions. They tend to bind their discretion by announcing categorical policies rather than making fact-based decisions case by case. This Article catalogs the unusual degree of pushback progressive prosecutors have encountered from the public, legislatures, courts, police, and their own subordinate prosecutors. Drawing on fiduciary theory, it explains this reaction as a response to progressive prosecutors’ abdication of their fiduciary role. As a public fiduciary, prosecutors are entrusted with protecting the public’s abstract interest in justice, and an integral part of this role is …

Il-33 Mediates Pseudomonas Induced Airway Fibrogenesis And Is Associated With Clad, Mudassir M Banday, Sangeetha B Rao, Shruthi Shankar, Mudasir A Khanday, Jon Finan, Edward O'Neill, Antonio Coppolino, Andreas Seyfang, Archit Kumar, Daniel E Rinewalt, Hilary J Goldberg, Ann Woolley, Hari Reddy Mallidi, Gary Visner, Amit Gaggar, Kapil N Patel, Nirmal S Sharma

Faculty, Staff and Student Publications

BACKGROUND: Long term outcomes of lung transplantation are impacted by the occurrence of chronic lung allograft dysfunction (CLAD). Recent evidence suggests a role for the lung microbiome in the occurrence of CLAD, but the exact mechanisms are not well defined. We hypothesize that the lung microbiome inhibits epithelial autophagic clearance of pro-fibrotic proteins in an IL-33 dependent manner, thereby augmenting fibrogenesis and risk for CLAD.

METHODS: Autopsy derived CLAD and non-CLAD lungs were collected. IL-33, P62 and LC3 immunofluorescence was performed and assessed using confocal microscopy. Pseudomonas aeruginosa (PsA), Streptococcus Pneumoniae (SP), Prevotella Melaninogenica (PM), recombinant IL-33 or PsA-lipopolysaccharide was …

Better Policy Interventions Through Intersectionality, Elizabeth R. Cole, Lauren E. Duncan

Psychology: Faculty Publications

Deployment of intersectionality frameworks in policy design and implementation is a way to ensure that the means and goals of interventions are congruent with target populations’ understanding of their circumstances, their desired outcomes, and their empowerment. In this paper, we examine the ways concepts from psychology have been used to inform interventions and policies, and we use an intersectional lens to suggest improvements to these interventions to be more inclusive in their impact. We review three social policy interventions that were developed based on social psychological research: (1) sexual assault prevention programs based on bystander interventions; (2) so-called “wise schooling” …

Needs Salt, Joshua Lang

Dance (MFA) Theses

Researcher Joshua Lang investigates the development of the Eden narrative in western culture. Near the beginning of the book of Genesis, the Eden narrative provides a lens to culturally significant elements of early Hebrew culture. Genesis illustrates early Hebrew culture’s relationship with the natural world, sex, sin, judgment, and death. Similarly, John Milton’s retelling of the narrative in Paradise Lost divulges information about the culture that Milton lived in, as well as a great deal about the author himself. Milton’s blindness, and his opinions on heteronormative marriage, Protestantism, sin, judgment, and death are evident in the text. In Paradise Lost …

Dancing Through Loss, Tracy Vogt

Dance (MFA) Theses

This thesis project aims to examine and interrogate the embodiment of grief through the comparison of western concert dance works choreographed by Antony Tudor, Martha Graham, Alvin Ailey, Bill T. Jones, Anna Halprin, and Camille A. Brown. This research will culminate in a choreographic work reflecting and responding to my own personal journey with grief and loss while also incorporating and integrating the process of the choreographers studied.

Erosion: Landscape Reveals Us, John Alexander Mcbride

Dance (MFA) Theses

This thesis explores the connective tissue between the land on which we stand and the body we inhabit. Through the lens of climate change and erosion, this research unveils the lasting effects of severe and traumatic weather patterns on the psychology and physiology of those who continue to endure them. How bodies (capitalistic bodies, collective bodies, and our personal bodies) treat the land and each other affects us all—we are all part of the eroding ecosystem, linked together by the soil beneath our feet. The soil that has been scorched and stolen, mined and massacred. The soil that is fertile …

Rapid-Throughput Analysis Of 1,4-Dioxane In Plants By Centrifugal Sampling And Phytoforensic Analysis For Site Delineation And Assessing Enhanced Rhizodegradation, Anthony Eberechukwu Oha

Masters Theses

"Owing to its broad use and environmental persistence, 1,4-dioxane (dioxane) poses a notable threat to public health and is recalcitrant to traditional remedial systems. Dioxane moves readily in an aqueous environment and is an emerging contaminant in drinking water, surface water, groundwater, and wastewater. The extent of dioxane in the biosphere is also difficult to delineate, particularly in the subsurface. Phytoremediation has demonstrated the potential for dioxane groundwater remediation. Recent findings indicate that plant-microbial symbiosis may be more advantageous for limiting potential transport and transfer into plant tissues and the atmosphere. Bioaugmentation of the rhizosphere paired with soil amendments has …

Individual Behavioral And Neurobiological Markers Associated With Vulnerable To Ethanol Use Phenotype, Hannah Elizabeth Manning

Honors Theses and Capstones

Alcohol use disorder is a chronic, relapsing brain condition that affects 29.5 million Americans. The disease is characterized by loss of control over drinking, continued use of alcohol in the face of negative consequences, and the experience of withdrawal symptoms. While there are several forms of treatment available for alcohol use disorder, 95% of patients experience at least one relapse during recovery. Currently, the high tendency to relapse remains the major challenge standing in the way of successful treatment for alcohol use disorder. Research is continuing to be conducted into the behavioral and neural mechanisms underlying relapse into alcohol use, …

Taxonomic Classification Of Viral And Bacterial Dna Following 2021 Avian Mass Mortality Event, Tessa Baillargeon

Honors Theses and Capstones

From May through July 2021, an unusual mortality event occurred along the eastern coast and Midwest of the United States. Thousands of birds, mostly from the order Passeriformes, were part of the die-off including blue jays (Cyanocitta cristata), common grackles (Quiscalus quiscula), European starlings (Sturnus vulgaris), American robins (Turdus migratorius). Clinical signs included crusted eyes, swollen conjunctiva, otitis, seizures, and ataxia.

The New Hampshire Veterinary Diagnostic Laboratory (NHVDL) received over 100 affected birds from various collaborators throughout the United States including Washington DC, NJ, CT, MD, and OH. Given the timing and geologic …

Investigating The Relationship Between Sea Ice Extent And Erignathus Barbatus Breeding Phenology In The Alaskan Arctic, Rachel E. Lewis

Honors Theses and Capstones

No abstract provided.

Developing Honey Bee Diagnostics At The New Hampshire Veterinary Diagnostics Lab: Successes And Challenges, Mary Feranda

Honors Theses and Capstones

No abstract provided.

Individual Behavioral And Neurobiological Markers Associated With A Vulnerable To Ethanol Use Phenotype, Kelsey M. Alimandi

Honors Theses and Capstones

Alcohol use disorder (AUD) is a chronic relapsing brain condition that is characterized by excessive alcohol consumption, continued use when faced with negative consequences, and a negative emotional state associated with withdrawals (anxiety, irritability, depression). The main challenge to treating AUD is preventing relapse. The purpose of this study was to use a prolonged-exposure model to allow rats to self-administer ethanol to determine the brain regions active during relapse events. The rats performed multiple behavioral tests such as economic demand, negative consequences, and an elevated plus maze. These tests determined how hard rats were willing to work for an ethanol …