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Articles 20551 - 20580 of 24900
Full-Text Articles in Entire DC Network
Evaluation Of Growth Performance, Energy Utilization, And Carcass Trait Responses Of Finishing Lambs Administered Zeranol, Emily Nold
Schultz-Werth Award Papers
The objective of this research was to determine the influence of implanting heavy wether lambs with 12 mg zeranol (1 pellet Ralgro, Merck Animal Health. Madison, NJ) 59 d before harvest. Average daily gain (ADG), feed efficiency, and carcass merit were evaluated. Polpypay and crossbred wethers (n = 32 total) were equally divided into two treatment groups within a randomized complete block design. Sixteen pens were used resulting in 8 replicate pens per treatment. Wethers were fed a finishing diet consisting of cracked corn, soybean meal and soybean hulls ad libitum for 59 d. Lambs had access to clean water …
Kidney Stones And Energy Drinks: A Literature Review, Donovan D. Bentz
Kidney Stones And Energy Drinks: A Literature Review, Donovan D. Bentz
Schultz-Werth Award Papers
Kidney stones are common, painful, and expensive to treat. Several factors play a role in the development of stones, particularly the consumption of sugars such as fructose. As such, the consumption of sugary energy drinks contributes to the development of kidney stones. However, there is a lack of understanding behind the mechanism of kidney stone development and the role energy drinks play in stone development. This review analyzes the mechanism of kidney stone development and the effect energy drink consumption has on stone development. Here, we also detail the dietary roles calcium, oxalate, ascorbic acid, and animal protein have on …
Murderess Row: Selling Morals To 1920s America, Rachel Goldsmith
Murderess Row: Selling Morals To 1920s America, Rachel Goldsmith
Schultz-Werth Award Papers
Genevieve Forbes-Herrick gave her thoughts on Maurine Watkins’ new play “Chicago” in the October 16th, 1927, edition of the Chicago Tribune. Forbes-Herrick requested that the management reserve a block of seats for a few local women who “tarried on the fourth floor of the building at Dearborn Street and Austin Avenue long enough to get themselves into a play”. In Forbes-Herrick’s opinion, Beulah Annan should have been given an aisle seat for her incredible beauty, inspiring the character named Roxie. The next best seat should have gone to the incredibly stylish Belva Gaertner to witness the characterization of Velma. Moonshine …
A Mor Antagonist With High Potency And Antagonist Efficacy Among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-Hydroxy)Phenylmorphans, Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice
A Mor Antagonist With High Potency And Antagonist Efficacy Among Diastereomeric C9-Alkyl-Substituted N-Phenethyl-5-(3-Hydroxy)Phenylmorphans, Dana R. Chambers, Agnieszka Sulima, Dan Luo, Thomas E. Prisinzano, Arthur E. Jacobson, Kenner C. Rice
Pharmaceutical Sciences Faculty Publications
The 5-(3-hydroxy)phenylmorphan structural class of compounds are unlike the classical morphinans, 4,5-epoxymorphinans, and 6,7-benzomorphans, in that they have an equatorially oriented aromatic ring rather than the axial orientation of that ring found in the classical opioids. This modified and simplified opioid-like structure has been shown to retain antinociceptive activity, depending on its stereochemistry and substituents, and some of them have been found to be much more potent than morphine. A simple C9-hydroxy-5-(3-hydroxy)phenylmorphan enantiomer was found to be about 500 times more potent than morphine in vivo. We have previously examined C9-alkenyl and hydroxyalkyl substituents in the N-phenethyl-5-(3-hydroxy)phenylmorphan class of compounds. …
“Life And Death, Blessing And Cursing” New Context For “Skin Of Blackness”: In The Book Of Mormon, T. J. Uriona
“Life And Death, Blessing And Cursing” New Context For “Skin Of Blackness”: In The Book Of Mormon, T. J. Uriona
BYU Studies
For many readers of the Book of Mormon, 2 Nephi 5 can prove rather challenging. Not only does this chapter contain the actualization of a curse and the apparent genesis of an outgroup, but it also states that “the Lord God did cause a skin of blackness to come upon” this group because of their iniquity (2 Ne. 5:21). Given the prevalence of racial thought in society today, this passage has been interpreted as a hurtful reference to a phenotypic change in skin color brought on by a divine curse, leading many researchers to propose alternatives to a purely racialized …
The Indivisible System: Modeling The Metal-Pterin-Dithiolene System In Molybdenum And Tungsten Cofactors, Cassandra Gates
The Indivisible System: Modeling The Metal-Pterin-Dithiolene System In Molybdenum And Tungsten Cofactors, Cassandra Gates
Bryn Mawr College Dissertations and Theses
Mo and W enzymes are ubiquitous in living organisms and crucial for sustaining life. Mo and W enzyme variety is diverse, but they contain a highly conserved aspect of functionality in these enzymes, the pyranopterin-dithiolene (PDT) ligand. A total of eight possible electron redox equivalents occurs between the metal center and PDT, making the molybdenum cofactor (Moco) and the tungsten cofactor (Tuco) the most redox rich cofactors in all of biology. This research focuses on the development of new pterin-dithiolene synthetic modeling systems for Moco. The knowledge gained from the characterization of these compounds is applied to the enzymes, furthering …
Basic Concepts Of Radiation Biology, Ans Baeyens, Ana Margarida Abrantes, Vidhula Ahire, Elizabeth A. Ainsbury, Sarah Baatout, Bjorn Baselet, Maria Filomena Botelho, Tom Boterberg, Francois Chevalier, Fabiana Da Pieve, Wendy Delbart, Nina Frederike Jeppesen Edin, Cristian Fernandez-Palomo, Lorain Geenen, Alexandros G. Georgakilas, Nathalie Heynickx, Aidan D. Meade, Anna Jelinek Michaelidesova, Dhruti Mistry, Alegría Montoro, Carmel Mothersill, Ana Salomé Pires, Judith Reindl, Giuseppe Schettino, Yehoshua Socol, Vinodh Kumar Selvaraj, Peter Sminia, Koen Vermeulen, Guillaume Vogin, Anthony Waked, Anne Sophie Wozny
Basic Concepts Of Radiation Biology, Ans Baeyens, Ana Margarida Abrantes, Vidhula Ahire, Elizabeth A. Ainsbury, Sarah Baatout, Bjorn Baselet, Maria Filomena Botelho, Tom Boterberg, Francois Chevalier, Fabiana Da Pieve, Wendy Delbart, Nina Frederike Jeppesen Edin, Cristian Fernandez-Palomo, Lorain Geenen, Alexandros G. Georgakilas, Nathalie Heynickx, Aidan D. Meade, Anna Jelinek Michaelidesova, Dhruti Mistry, Alegría Montoro, Carmel Mothersill, Ana Salomé Pires, Judith Reindl, Giuseppe Schettino, Yehoshua Socol, Vinodh Kumar Selvaraj, Peter Sminia, Koen Vermeulen, Guillaume Vogin, Anthony Waked, Anne Sophie Wozny
Books/Book Chapters
Radiation biology is the study of the effects of ionizing radiation on biological tissues and living organisms. It combines radiation physics and biology. The purpose of this chapter is to introduce the terminology and basic concepts of radiobiology to create a better understanding of the ionizing radiation interactions with a living organism. This chapter firstly describes the different types of radiation, the sources, and the radiation interactions with matter. The basic concepts of radioactivity and its applications are also included. Ionizing radiation causes significant physical and chemical modifications, which eventually lead to biological effects in the exposed tissue or organism. …
Skin Deep: Racial Categorization In Herman Melville’S Moby-Dick, Devasha Solomon
Skin Deep: Racial Categorization In Herman Melville’S Moby-Dick, Devasha Solomon
Senior Honors and Award-Winning Theses
This thesis engages skin as a site of racialization and changeability in Herman Melville’s 1851 novel Moby-Dick. Throughout the novel, Ishmael close reads the skins of those around him to fit his vision of the narrative. Lots of skins are sewn together to create a single white skin. He classifies characters into neat categories in an attempt to destroy their ambiguity, but Ishmael himself contains and develops racial ambiguities that he fears. Melville’s narrator fails to force all of his characters into his story because of the counterstories fundamentally engrained in the skins he attempts to violate.
The Faidherbe Statue And Memory Making In Saint-Louis-Du-Sénégal, 1887–2020, Kalala J. Ngalamulume
The Faidherbe Statue And Memory Making In Saint-Louis-Du-Sénégal, 1887–2020, Kalala J. Ngalamulume
History Faculty Research and Scholarship
No abstract provided.
"No Safe Place": Applying The Transactional Stress And Coping Model To Active Warfare, Cindy Sousa, Guido Veronese
"No Safe Place": Applying The Transactional Stress And Coping Model To Active Warfare, Cindy Sousa, Guido Veronese
Graduate School of Social Work and Social Research Faculty Research and Scholarship
No abstract provided.
A Label-Free Fiber Ring Laser Biosensor For Ultrahigh Sensitivity Detection Of Salmonella Typhimurium, Shi Qiu, Bin Liu, Yuankui Leng, Edward Fox, Xian Zhou, Binbin Yan, Xinzhu Sang, Long Long, Xingdao He, Jinhui Yuan, Gerald Farrell, Qiang Wu
A Label-Free Fiber Ring Laser Biosensor For Ultrahigh Sensitivity Detection Of Salmonella Typhimurium, Shi Qiu, Bin Liu, Yuankui Leng, Edward Fox, Xian Zhou, Binbin Yan, Xinzhu Sang, Long Long, Xingdao He, Jinhui Yuan, Gerald Farrell, Qiang Wu
Articles
The rapid detection of low concentrations of Salmonella Typhimurium (S. Typhimurium) is an essential preventive measure for food safety and prevention of foodborne illness. The study presented in this paper addresses this critical issue by proposing a single mode-tapered seven core-single mode (STSS) fiber ring laser (FRL) biosensor for S. Typhimurium detection. The experimental results show that the specific detection time of S. Typhimurium is less than 20 min and the wavelength shift can achieve -0.906 nm for an S. Typhimurium solution (10 cells/mL). Furthermore, at a lower concentration of 1 cell/mL applied to the biosensor, a result of -0.183 …
Isolation And Identification Of Chlorate-Reducing Hafnia Sp. From Milk, William P. Mccarthy, Meghana Srinivas, Martin Danaher, Christine O'Connor, Tom F. O'Callaghan, Douwe Van Sinderen, John Kenny, John T. Tobin
Isolation And Identification Of Chlorate-Reducing Hafnia Sp. From Milk, William P. Mccarthy, Meghana Srinivas, Martin Danaher, Christine O'Connor, Tom F. O'Callaghan, Douwe Van Sinderen, John Kenny, John T. Tobin
Articles
Chlorate has become a concern in the food and beverage sector, related to chlorine sanitizers in industrial food production and water treatment. It is of particular concern to regulatory bodies due to the negative health effects of chlorate exposure. This study investigated the fate of chlorate in raw milk and isolated bacterial strains of interest responsible for chlorate breakdown. Unpasteurized milk was demonstrated to have a chlorate-reducing capacity, breaking down enriched chlorate to undetectable levels in 11 days. Further enrichment and isolation using conditions specific to chlorate-reducing bacteria successfully isolated three distinct strains of Hafnia paralvei . Chlorate-reducing bacteria were …
Old Joe, Ron Bland
Old Joe, Ron Bland
Mighty Pen Project Anthology & Archive
In Vietnam, an old elephant wanders an abandoned plantation, striking wonder and sadness in a young Army helicopter gunner.
Articles, stories, and other compositions in this archive were written by participants in the Mighty Pen Project. The program, developed by author David L. Robbins, and in partnership with Virginia Commonwealth University and the Virginia War Memorial in Richmond, Virginia, offers veterans and their family members a customized twelve-week writing class, free of charge. The program encourages, supports, and assists participants in sharing their stories and experiences of military experience so both writer and audience may benefit.
Using 3-Dimensional Mapping To Determine The Possibility Of Structural Control On Development Of The Upper Ordovician Lexington Limestone, Central Kentucky, U.S.A., Sean Davis
Theses and Dissertations--Earth and Environmental Sciences
The upper Lexington Limestone of Late Ordovician age has been interpreted to represent a structurally controlled, complex, facies mosaic. This facies mosaic has historically been interpreted to be a carbonate buildup of shoal complexes with interbedded shale units with intertonguing facies. Due to relatively recent advances in geographic-information-systems (GIS) mapping technologies, it is possible to generate three-dimensional (3-D) compatible maps to offer insight to the complexities of the upper Lexington Limestone and to determine if structural control affected the distribution of members. The resulting two-dimensional (2-D) and 3-D maps show that basement faults likely exerted a significant influence on facies …
Rooted: Metaphors And Judicial Philosophy In Artis V. District Of Columbia, Richard L. Heppner Jr.
Rooted: Metaphors And Judicial Philosophy In Artis V. District Of Columbia, Richard L. Heppner Jr.
Law Faculty Publications
This article examines how the metaphors in judicial opinions reveal judicial theories of lawmaking and judicial philosophies, through a close reading of Justice Ginsburg’s majority opinion and Justice Gorsuch’s dissenting opinion in the Artis v. District of Columbia, 138 S. Ct. 594 (2018).
Artis was about what the phrase “shall be tolled” means in the federal supplemental jurisdiction statute, 28 U.S.C. §1367. Does a state-law claim’s statute of limitations pause or continue to run while the claim is in federal court? In holding that Congress used “stop the clock” tolling, an “off-the-shelf” legal device that pauses statute of limitations, …
From Newark’S Little Italy To Congress: How The Italian American Values Of Family, Pride, And Hard Work Influenced Congressman Peter Rodino’S Legislation, Francesca Simone
From Newark’S Little Italy To Congress: How The Italian American Values Of Family, Pride, And Hard Work Influenced Congressman Peter Rodino’S Legislation, Francesca Simone
Student Works
No abstract provided.
External Funding Bulletin, January - June 2023, Uno Office Of Research And Creative Activity
External Funding Bulletin, January - June 2023, Uno Office Of Research And Creative Activity
Sponsored Programs Bulletins
No abstract provided.
Murine Tbk1 Is Required By Flt3+ Leukemia Stem Cells Yet Dispensable In Homeostatic Hematopoiesis, Austin Runde
Murine Tbk1 Is Required By Flt3+ Leukemia Stem Cells Yet Dispensable In Homeostatic Hematopoiesis, Austin Runde
Master's Theses
The TANK-binding kinase 1 (TBK1) is a cytoplasmic, serine/threonine kinase and a critical activator of the innate immune system. Reports have implicated TBK1 as a promoter of multiple cancer types. Acute myeloid leukemia (AML) is a cancer arising from the hematopoietic stem/progenitor cells (HSPCs). Although ~70% of AML patients achieve complete remission with chemotherapy, at least half will relapse due to the failure to eradicate leukemia stem cells (LSCs). As our previous data indicate the TLR-TAK1/TICAM-1 axes regulate LSCs, we suspect TBK1 also regulates LSCs. To study TBK1 in AML, we generated tamoxifen-inducible, Tbk1-knockout (Tbk1NULL) mice and Tbk1NULL MLL-AF9+ mouse …
Technical Analyses On The Materials From 2011-2017 Fieldwork At La 20,000 La Cienega, New Mexico, Heather Trigg, Anya Gruber, Ana Opishinski, Clint Lindsay, Katherine Albert
Technical Analyses On The Materials From 2011-2017 Fieldwork At La 20,000 La Cienega, New Mexico, Heather Trigg, Anya Gruber, Ana Opishinski, Clint Lindsay, Katherine Albert
Andrew Fiske Memorial Center for Archaeological Research Publications
LA 20,000 is a 17th -century site associated with Spanish colonizers. It is the largest, most complex of the few 17th -century Spanish ranches in New Mexico that have thus far been excavated. Located 12 miles southwest of Santa Fe (Figure 1.1), the site is owned by the nonprofit living history museum El Rancho de las Golondrinas although structures associated with the ranch are also located on adjacent property to the north and to the south of the core of the site. Dendrochronology and material culture suggest the ranch was established by 1629 and destroyed in 1680 during the Pueblo …
Preliminary Report Of The Hasp 2022 Field Season: Geophysics, Coring, And Excavations At Neðri-Ás, Kálfsstaðir, Hlíð, Hrafnhóll, Hvammur, Reykir, And Víðines, In Hjaltadalur With An Appendix By Magnús Á. Sigurgeirsson, Guðný Zoëga, John M. Steinberg
Preliminary Report Of The Hasp 2022 Field Season: Geophysics, Coring, And Excavations At Neðri-Ás, Kálfsstaðir, Hlíð, Hrafnhóll, Hvammur, Reykir, And Víðines, In Hjaltadalur With An Appendix By Magnús Á. Sigurgeirsson, Guðný Zoëga, John M. Steinberg
Andrew Fiske Memorial Center for Archaeological Research Publications
This report outlines the 2022 work at Neðri Ás, Kálfsstaðir, Hlíð (formally called both Hrappsstaðir and Hrafnsstaðir), Hrafnhóll, Hvammur, Reykir, and Víðines (including Grófarstekkur) in Hjaltadal as part of the Hjaltadalur Archaeological Survey Project (HASP). This is the second year of a scheduled three-year project. The purpose of the project is to outline the settlement sequence and regional development in Hólar and around Hjaltadal and compare them with similar studies that have been carried out in Skagafjörður. The eight farms investigated in 2022 all seem to have been established well before the Hekla 1104 (H1104) tephra fell. Neðri Ás, Kálfsstaðir, …
Cheap Speech And The Gordian Knot Of Defamation Reform, Lyrissa Barnett Lidsky
Cheap Speech And The Gordian Knot Of Defamation Reform, Lyrissa Barnett Lidsky
UF Law Faculty Publications
This article addresses the complex past and uncertain future of defamation law in order to evaluate complaints lodged against it by critics, including—most notably—U.S. Supreme Court Justices Clarence Thomas and Neil Gorsuch. The article describes how statutory and constitutional reforms have altered the legal landscape of defamation law over the past half-century and explains why the common law has played a less prominent role. The article then assesses the criticisms of Justices Thomas and Gorsuch, finding them to rest on flawed understandings of how today’s defamation law operates. After identifying barriers to reform, the article offers a prescription to modernize …
Authorbots, Derek E. Bambauer, Mihai Surdeanu
Authorbots, Derek E. Bambauer, Mihai Surdeanu
UF Law Faculty Publications
ChatGPT has exploded into the popular consciousness in recent months, and the hype and concerns about the program have only grown louder with the release of GPT-4, a more powerful version of the software. Its deployment, including with applications such as Microsoft Office, has raised questions about whether the developers or distributors of code that includes ChatGPT, or similar generative pre-trained transformers, could face liability for tort claims such as defamation or false light. One important potential barrier to these claims is the immunity con-ferred by 47 U.S.C. § 230, popularly known as “Section 230.” In this Essay, we make …
Bottom-Rung Appeals, Merritt E. Mcalister
Bottom-Rung Appeals, Merritt E. Mcalister
UF Law Faculty Publications
There are haves and have-nots in the federal appellate courts, and the haves get more attention. For decades the courts have used a triage regime where they distribute judicial attention selectively: some appeals receive a lot of judicial attention, some appeals receive barely any. What this work unearths is that this triage system produces demonstrably unequal results depending on the circuit handling the appeal and whether the appellant has counsel or not. Together, these two factors produce dramatic disparities: in one circuit, for example, an unrepresented appellant receives, on average, a decision less than a tenth the length of a …
On Fires, Floods, And Federalism, Andrew Hammond
On Fires, Floods, And Federalism, Andrew Hammond
UF Law Faculty Publications
In the United States, law condemns poor people to their fates in states. Where Americans live continues to dictate whether they can access cash, food, and medical assistance. What’s more, immigrants, territorial residents, and tribal members encounter deteriorated corners of the American welfare state. Nonetheless, despite repeated retrenchment efforts, this patchwork of programs has proven remarkably resilient. Yet, the ability of the United States to meet its people’s most basic needs now faces an unprecedented challenge: climate change. As extreme weather events like wildfires and hurricanes become more frequent and more intense, these climate-fueled disasters will displace and impoverish more …
Deconstructing Employment Contract Law, Rachel Arnow-Richman, J.H. Verkerke
Deconstructing Employment Contract Law, Rachel Arnow-Richman, J.H. Verkerke
UF Law Faculty Publications
Employment contract law is an antiquated, ill-fitting, incoherent mess. But no one seems inclined to fix this problem. Employment law scholars, skeptical of employees’ ability to bargain, tend to disregard contract law and advocate for just-cause and other legislative reforms to eliminate at-will employment. And contracts scholars largely ignore employment cases—viewing them, with some justification, as part of a peculiar, specialized body of law wholly divorced from general contract jurisprudence. As a result of this undesirable employment law exceptionalism, courts lack the tools needed to resolve recurring disputes.
This Article offers a new, comprehensive historical account that exposes the formalistic …
The End Of Balancing? Text, History & Tradition In First Amendment Speech Cases After Bruen, Clay Calvert, Mary-Rose Papandrea
The End Of Balancing? Text, History & Tradition In First Amendment Speech Cases After Bruen, Clay Calvert, Mary-Rose Papandrea
UF Law Faculty Publications
This Article examines the potential impact on First Amendment free-speech jurisprudence of the U.S. Supreme Court’s increasing reliance on text, history, and tradition in 2022 decisions such as New York State Rifle & Pistol Association v. Bruen. In Bruen, the Court embraced a new test for examining Second Amendment cases. It concentrates on whether there is a historical tradition of regulating the conduct in question, and it eliminates any use of constitutionally common means-end standards of review such as strict and intermediate scrutiny. Those two scrutiny standards often guide the Court’s free-speech decisions. The Bruen majority, however, asserted that its …
Negligent Ai Speech: Some Thoughts About Duty, Jane R. Bambauer
Negligent Ai Speech: Some Thoughts About Duty, Jane R. Bambauer
UF Law Faculty Publications
Careless speech has always existed on a very large scale. When people talk, they often give bad advice or wrong information, and occasionally this leads the listener to act in a way that causes physical harm. The scale was made more visible by the public Internet as the musings and conversations of billions of participants became accessible and searchable to all. This dynamic produced a set of tort and free speech principles that we have debated and adjusted to over the last three decades.
AI speech systems bring a new dynamic. Unlike the disaggregated production of misinformation in the Internet …
Witness Hide-And-Seek: Why Federal Prosecutors Should Record Pretrial Interviews, Christina Frohock, Jeffrey E. Marcus
Witness Hide-And-Seek: Why Federal Prosecutors Should Record Pretrial Interviews, Christina Frohock, Jeffrey E. Marcus
Articles
This Article pays long-overdue attention to a federal appellate court's warning against "playing hide-and-seek" with witnesses. Specifically, prosecutors should record interviews. While courtroom cameras dominate the topic of judicial transparency, cameras can play a critical role in a sleepier corner of criminal proceedings: pretrial witness interviews. The Article first tracks the history of open judicial proceedings as a tradition of our Anglo- American jurisprudence. Next, the Article identifies the normative thread running through that history. Fairness may suffer when cameras transform public proceedings into publicized proceedings. Finally, the Article argues that this same issue of fairness applies to pretrial witness …
A Study Of Explainable Real-Time Object Detection And Human-Ai Teaming Interactions In Virtual Environments, Joseph Schwalb
A Study Of Explainable Real-Time Object Detection And Human-Ai Teaming Interactions In Virtual Environments, Joseph Schwalb
Theses
The exponential nature by which Artificially Intelligent (AI) models grow enables evermore complex tasks to be achieved. Since these tasks tend to augment human capability, interacting with these models presents a unique way to commission assistive automation. The introduction of Explainable AI (XAI) enables AI stakeholders to converse with models, understand model reasonings, and comprehend biases while considering reliability requirements. The introduction of this Explainable capability in Human-AI teams presents a unique approach to addressing the complexities behind Human-Computer Interactions. Our application of Explainable AI for Intelligent Systems to augment decision-making is poised to shine a light on the challenges, …
The Ambassador Program: Improving Functional Community Participation For Individuals With Intellectual And Developmental Disabilities, Kathryn Elizabeth College
The Ambassador Program: Improving Functional Community Participation For Individuals With Intellectual And Developmental Disabilities, Kathryn Elizabeth College
Occupational Therapy Capstones
This scholarly project aims to create more functional engagement opportunities for individuals with intellectual and developmental disabilities (ID/DD) in a community setting. Individuals with ID/DD experience a multitude of barriers when attempting to become active members of the community and engage in meaningful opportunities and social interactions (Doerpinghaus et al., 2022; Trembath et al., 2010). These barriers can include a lack of individualized support, low self-esteem, difficulty finding valuable volunteer experiences, and a prejudice in community settings (Milot et al., 2020; Trembath et al., 2010).