Digital Commons Network^™

Climate Adaptation Nexus Of Manjing’S Smallholder Tea Agroforestry And Livelihood Diversification Through Prospective Ecological Utilization On Highlands In The Greater Mekong Subregion In China, Yang Hongyan

Chulalongkorn University Theses and Dissertations (Chula ETD)

A holistic approach that integrates environmental and cultural aspects within the community livelihood framework is crucial for ensuring the sustainability of agroforestry to tackle climate variability. Engaging the livelihoods of smallholder ancient tea agroforestry in the Jingmai Mountain region in the Mekong River Sub-region of Yunnan Province of China, the study aimed to determine the nexus of smallholder ancient tea agroforestry and livelihood diversification through prospective utilization under the context of climate change. Desk studies, field observations, questionnaires, and in-depth interviews were employed for data collection. 239 smallholders and 10 key informants were interviewed. Descriptive statistics analysis, regression analysis, narrative …

The Development Of Novel Chimeric Antigen Receptor T Cell Targeting B7h3 For Common Solid Cancers, Thananya Inthanachai

Chulalongkorn University Theses and Dissertations (Chula ETD)

Chimeric antigen receptor (CAR-T cells) have shown a prominent success in hematologic malignancies and are being widely investigated to overcome heterogeneity and immune suppressive environment in solid tumors. B7 homolog 3 (B7H3), an overexpressed antigen across multiple cancers with restricted expression on normal tissues, serves as a potential target for CAR T cells therapy. This study, Gene Expression Profiling Interactive Analysis 2 (GEPIA 2) was used to evaluate CD276 gene upregulation and using flow cytometric staining to investigate an expression of B7H3 across various solid tumors. As a potential antigen targeting cancers, novel B7H3 CAR-T cells were developed from new …

The More Severe Adverse Effect Of Alcohol In Fc Gamma Receptor Iib Deficient (Fcgrllb-/-) Lupus Mice Than In Wild-Type Due To The More Profound Responses Against Alcohol-Induced Leaky Gut, Phatcharapon Yiengwattananon

Chulalongkorn University Theses and Dissertations (Chula ETD)

Consuming alcoholic beverages is well-known to have a part in causing inflammation and obstructing the function of the digestive system, and it may lead to leaky intestines. However, the relationship between alcohol consumption and Systemic Lupus Erythematosus (SLE) remains a subject of controversy continued. In general, alcohol can promote intestinal bacterial dysbiosis and also result in endotoxin release by Gram-negative bacteria. This stimulates many immune cells to produce inflammatory cytokines in the gut. This study focuses on the inflammatory response effect of FcgRIIb-/- mice upon loss of FcgRIIb receptors in which alcohol-induced leaky gut can occur. In 8-week-old mice lacking …

Influence Of Tidal Current On Heavy Metal Dynamics In The Chao Phraya River Estuary, Kansiri Silrat

Chulalongkorn University Theses and Dissertations (Chula ETD)

The Chao Phraya River estuary, a vital ecological and economic region in Thailand, faces significant contamination challenges due to anthropogenic activities. This study aims to investigate the influence of tidal currents on the dynamics of heavy metals (HMs) in the estuarine ecosystem, focusing on cadmium (Cd), arsenic (As), lead (Pb), copper (Cu), and zinc (Zn). A sampling was conducted over two tidal periods on April 29-30, 2021, including both surface and vertical water samples and surface sediment collected at multiple tidal currents. The results reveal notable variations in HMs concentrations influenced by tidal cycles. For water samples, cadmium concentrations ranged …

Effect Of Aprotic Solvents On The Microtensile Bond Strength Of Composite Core And Fiber-Reinforced Composite Posts, Wisarut Prawatvatchara

Chulalongkorn University Theses and Dissertations (Chula ETD)

Objective: The purpose of this study was to examine the effect of aprotic solvents, which were tetrahydrofuran, pyridine, and morpholine, compared to hydrogen peroxide on surface roughness of fiber-reinforced composite post and microtensile bond strength between fiber-reinforced composite post surfaces and the composite core. Material and methods: A total of 75 FRC posts plus, and 75 D.T. light posts were divided into 3 groups (non-thermocycling, 5,000-cycle and 10,000cycle thermocycling groups). Each group was divided into five subgroups according to the post-surface treatment: C: non-treatment group; H2O2: immersing with 35% hydrogen peroxide; THF: immersing with tetrahydrofuran; PY: immersing with pyridine; MP: …

The Production Of Encapsulated Holy Basil Oil Powder Via Different Scales Of Spray Drying Process., Chanakarn Chungmarisakul

Chulalongkorn University Theses and Dissertations (Chula ETD)

The spray drying process is widely utilized in food manufacturing and pharmaceuticals for products like seasoning powder, milk powder, and medicine. This research investigates the scale-up of the spray drying process from laboratory to commercial scale with maintaining the product characteristic. A key aspect of the study is the encapsulation technique applied to prolong the release of essential oils from holy basil, encapsulating the essential substances (liquid, suspension, or emulsion) in nanoparticle form with hot air flow. The study utilizes the Aspen program, incorporating mass and energy balance calculations for simulation. The results, assuming similar particle size, water evaporation per …

Process Design And Evaluation Of Value-Added Chemical Production From Crude Glycerol Obtained From Biodiesel Industry, Piyawan Thanahiranya

Chulalongkorn University Theses and Dissertations (Chula ETD)

Excessive glycerol, a major by-product of biodiesel industry, has been increasingly utilized as a platform chemical feedstock for production of value-added chemicals. Accordingly, this study aims to simulate the productions of propionic acid (PA), succinic acid (SA), and dihydroxyacetone (DHA) from glycerol via fermentation. For PA production, diluents and extractants as well as techniques in the back-extraction are investigated, whereas the techniques of reactive extraction and direct crystallization, as well as the use of dimethyl sulfoxide (DMSO) as an electron acceptor for SA production are investigated. Meanwhile, the effects of carbon source types and glycerol types on the DHA productivity …

Extracting High-Molecular Weight Dna From Cyanobacteria Using Promega's Wizard® Hmw Dna Extraction Kit With A Modified Protocol, Metis, Megan A. Hept, Lesley H. Greene

Chemistry & Biochemistry Faculty Publications

Extraction of high molecular weight (HMW) DNA for long read sequencing with little to no fragmentation and high purity is difficult to acquire from cyanobacterial species. Here we describe a modified method of extraction using Promega's Wizard® HMW DNA Extraction Kit to acquire high molecular weight DNA from cyanobacterial species. The protocol used in the kit is the “3.D. Isolating HMW DNA from Gram-Positive and Gram-Negative Bacteria” protocol. During a key step in the protocol, the lingering remnants of the mucilage layer of the cyanobacterial species is removed, preventing it from sticking to the DNA pellet produced. This customized modification …

Help I Posted”: Race, Power, Disciplinary Shifts, And The #Wpalistservfeministrevolution, Iris Ruiz, Brian Hendrickson, Mara Lee Grayson, Et Al.

Arts & Sciences Faculty Publications

No abstract provided.

Effects Of Prescribed Fire On Planted Oak Growth And Survival In Restored Savannas, Allison Earl

Masters Theses

Most oak savannas in the Midwestern United States have been lost to agriculture and habitat degradation. Because of their rarity and ability to support high plant and animal diversity, savannas are often a target for restoration. Oak savanna restoration frequently relies on direct planting of oak seedlings to establish the necessary tree canopy. Returning fire to the system is critical to the herbaceous component of the savanna, but managers risk damaging or killing trees if burning is introduced too soon. I studied growth and physiological responses of three oak species (Quercus alba, Q. macrocarpa, and Q. velutina …

Exploring Anterior Cruciate Ligament Tears And Athletic Identity As Predictors Of Disordered Eating Behaviors In Female Collegiate Soccer Players, Niondina M. Nyström

Masters Theses

Research has consistently established the relationship between injury occurrence and subsequent mental health concerns within the athletic population (Brown et al., 2014; NCAA, 2021). Specifically, negative mental health outcomes such as anxiety, depression, and social isolation have followed the occurrence of an anterior cruciate ligament (ACL) tear (McGinley et al., 2022; Töyrä & Bergström, 2017). Similarly, because of high levels of athletic identity (AI), the inability to participate in a sport due to injury has been associated with disordered eating (DE) (Gusfa et al., 2022). Despite this, no studies have examined disordered eating and the role of athletic identity after …

Representation Of South Asia In American Television, Zahin Zaima

Masters Theses

No abstract provided.

Exploring Polyamorous Relationship Experiences Of Lesbian, Gay, Bisexual, And Pansexual Individuals, Jiale Man

Theses and Dissertations

Polyamory is a type of relationship under the consensual non-monogamy relationship umbrella that assumes the possibility, validity, and worthwhileness of maintaining romantic, sexual, and intimate relationships with multiple people simultaneously. In Western society, the prevalence and domination of mononormativity have led to the marginalization of relationships alternative to monogamy (i.e., polyamory). As a result, individuals in polyamorous relationships continue to experience bias, stigma, and discrimination at varying levels. With a rise in public interest in CNM in the past two decades, scientists and researchers have slowly started to examine various topics related to CNM, including its prevalence, public attitudes toward …

The Effect Of Strain And Drug Combinations On Ketamine's Locomotor Activating Effects In Rats, Caroline K. Flagler

Theses and Dissertations

Rationale: Initially developed as an anesthetic, ketamine is now used to treat a variety of disorders, including treatment resistant depression (TRD). While ketamine appears to be a breakthrough therapy for TRD, it has many use-limiting side effects, including abuse liability, psychotomimetic effects, and sedation. Utilizing ketamine in combination with other medications, such as the monoaminergic antidepressant desipramine (DSP), opioid antagonist naltrexone (NTX), and the NMDA receptor partial agonist D-cycloserine (DCS) may reduce side-effects resulting from ketamine therapy.

Objectives: The goal of this project was to study ketamine’s adverse effects using locomotor activation in an open field as a behavioral correlate …

Advanced Modeling And Innovative Transcranial Magnetic Stimulation Coil Designs For The Treatment Of Neurological Disorders, Mohannad Tashli

Theses and Dissertations

Transcranial magnetic stimulation (TMS) is a safe, effective and non-invasive treatment for several mental and psychiatric disorders. TMS is an FDA approved treatment and is commonly applied to patients who do not respond to medications for the treatment of clinical depression, smoking cessation, obsessive-compulsive disorder and migraine. Recently, there has been an increase in the development of electromagnetic neuromodulation techniques targeted at enhancing the effectiveness of TMS devices for the treatment of mental diseases. In TMS stimulation, focality is an important factor which determines the specificity of the pulses induced in different brain tissues. The electromagnetic pulses must be confined …

Evaluating The Influence Of Concurrently Available Non-Drug Reinforcers On Drug Reinforcement Using Sophisticated Preclinical Models Of Substance Use Disorder, Madison M. Marcus

Theses and Dissertations

The maladaptive allocation of behavior towards cocaine and away from other concurrently available non-drug reinforcers (e.g., family, health, work, etc.) is a key characteristic of cocaine use disorder (CUD) that is embedded into multiple diagnostic criteria for CUD. Accordingly, basic research conducted in a drug-vs-food “choice” context has improved our fundamental knowledge of the behavioral and neurobiological mechanisms of drug reinforcement. However, to date, these preclinical studies have only been conducted with food as the alternative reinforcer. The extent to which other non-drug reinforcers compete with cocaine-taking behavior is unknown. The studies in this dissertation establish two sophisticated discrete-trial cocaine-vs-alternative …

Characterization And Decoding Of Speech Activity From Intracranial Signals, Pedram Zanganeh Soroush

Theses and Dissertations

Speech is the first and foremost means of human communication. Millions of people worldwide suffer from severe speech disorders due to neurological diseases such as amyotrophic lateral sclerosis (ALS), brain stem stroke, and severe paralysis. A speech neuroprosthesis that decodes speech directly from neural signals could dramatically improve life for these individuals. Recent studies have demonstrated that it is possible to decode and synthesize various aspects of acoustic speech directly from intracranial measurements of electrophysiological brain activity. For those who have completely lost the ability to speak, the objective is to synthesize acoustic speech directly from brain activity during imagined …

Modulation Of Epigenetic Regulatory Pathways As A Therapeutic Strategy In Breast Cancer, Ryan M. Finnegan

Theses and Dissertations

Anti-estrogens or aromatase inhibitors in combination with cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors are the current standard of care for estrogen receptor-positive (ER+) Her-2 negative metastatic breast cancer. In triple negative breast cancer, cytotoxic drugs and ionizing radiation are often used as standard of care. Although these therapies prolong progression-free survival, the growth-arrested state of residual tumor cells is clearly transient. Tumor cells that escape what might be considered a dormant state and regain proliferative capacity often acquire resistance to further therapies. Epigenetic regulation can modulate the effects of cancer therapeutics. Our studies are based upon the observation that …

Novel Strategies In Head And Neck Tumor Therapy; Contribution Of Senescence In Therapy Response, And Resistance Development After Cisplatin Treatment, Fereshteh Ahmadinejad

Theses and Dissertations

Therapeutic outcomes achieved in head and neck squamous cell carcinoma (HNSCC) patients by concurrent cisplatin-based chemoradiotherapy initially reflect both tumor regression and tumor stasis. However, local, and distant metastasis and disease relapse as well as cisplatin-induced resistance are common in HNSCC patients. In the current work, we demonstrate that cisplatin treatment induces senescence in both p53 wild- type HN30 and p53 mutant HN12 head and neck cancer models. We also show that tumor cells can escape from senescence both in vitro and in vivo. We further established a cisplatin-resistant cell line from HN30 parental cell line that underwent brief senescence …

An Epidemiological Synthesis Of Emerging And Re-Emerging Zoonotic Disease Threats In Cameroon, 2000-2022: A Systematic Review, Nancy B. Tahmo, Frankline Sevidzem Wirsiy, Dum-Buo Nnamdi, Marcel Tongo, James V. Lawler, M. Jana Broadhurst, Charles S. Wondji, David Brett-Major

Journal Articles: Epidemiology

INTRODUCTION: Population factors such as urbanization, socio-economic, and environmental factors are driving forces for emerging/re-emerging zoonotic diseases in Cameroon. To inform preparedness and prioritization efforts, this study mapped out epidemiological data (including prevalence) of zoonotic diseases occurring in Cameroon between 2000 and 2022 by demographic factors.

METHODS: Following the PRISMA guidelines, a protocol was registered in the PROSPERO database (CRD42022333059). Independent reviewers searched the PubMed, Embase, CINAHL, Cochrane, and Scopus databases on May 30, 2022 for relevant articles; duplicates were removed, and the titles, abstracts, and full texts were screened to identify eligible articles.

RESULTS: Out of 4142 articles identified, …

Promoting Inclusion For Students Through Service-Learning, Charlene Marie Winter

All Electronic Theses and Dissertations

The following literature review explores how service-learning can be used in an inclusive setting. How can schools use service-learning to promote diverse learning by including students of varying abilities? Studies have shown that service-learning helps students with skills such as communication, leadership, and responsibility while still getting academic standards met. Concerns arise about how to assess whether academic standards are being met. Patterns in assessment methods are shown in the research with student self-reflections being a main source for teachers to evaluate what the students learned.. Service-learning has been shown to not only meet academic standards but to develop character …

Laying Out A Space: Spectral Geographies, Fictions Of The Soul, Erin D. Yerby

Theses and Dissertations

Laying out a Space: Spectral Geographies, Fictions of the Soul, arises out of my artistic practice, and thoughts behind my current project and MFA exhibition, Spectral Geographies.

Linking the problem of the world ‘out there’ or external space, to inner experience through painting as both medium and practice, my work expresses what I call inner geographies, spaces where intimate immensities, folding inside and outside, find expression. I think of my paintings as beginning with this gesture of laying out a between-space where the intimacies of waking dreams and visions are opened by, and grow into, actual places, …

I'M Not Sure It Was A Hoopoe Or A Decanter, Ali Kaeini

Theses and Dissertations

“I’m not sure it was a Hoopoe or a Decanter” explores the experience of cultural displacement through the lens of an Iranian artist and immigrant. Drawing on ancient Iranian stories, Persian poetry, and cultural artifacts, my paintings and drawings reflect the uncertainty of the contemporary political and religious conditions in Iran, as well as the challenges faced by individuals forced to flee their homeland due to war, political instability, and social conditions. My work weaves references to ancient Iranian objects, Persian miniatures' structural forms and patterns, and Islamic architecture, using traditional and contemporary materials to create large, unconventional paintings. Through …

Roles Of Specialized Pro-Resolving Mediators And Omega-3 Polyunsaturated Fatty Acids In Periodontal Inflammation And Impact On Oral Microbiota, Chun-Teh Lee, Gena D Tribble

Faculty, Staff and Student Publications

Periodontitis is a chronic inflammatory disease induced by dysbiotic dental biofilms. Management of periodontitis is primarily anti-bacterial via mechanical removal of bacterial biofilm. The successful resolution requires wound healing and tissue regeneration, which are not always achieved with these traditional methods. The discovery of specialized pro-resolving mediators (SPMs), a class of lipid mediators that induce the resolution of inflammation and promote local tissue homeostasis, creates another option for the treatment of periodontitis and other diseases of chronic inflammation. In this mini-review, we discuss the host-modulatory effects of SPMs on periodontal tissues and changes in the taxonomic composition of the gut …

อิทธิพลของคุณลักษณะผู้ส่งสารในโฆษณาต่อพฤติกรรมผู้บริโภคตราสินค้าจากประเทศญี่ปุ่น, ณัฐนรี กิตติมงคลชัย

Chulalongkorn University Theses and Dissertations (Chula ETD)

การวิจัยเชิงสำรวจในครั้งนี้ มีวัตถุประสงค์เพื่อศึกษา 1) คุณลักษณะผู้ส่งสารในโฆษณา (ได้แก่ มิติด้านความเชี่ยวชาญ มิติด้านความน่าไว้วางใจ และมิติด้านความน่าดึงดูดใจ) และพฤติกรรมผู้บริโภคตราสินค้าจากประเทศญี่ปุ่น (ได้แก่ ทัศนคติต่อโฆษณา ทัศนคติต่อตราสินค้า และความตั้งใจซื้อของผู้บริโภค) และ 2) อิทธิพลของคุณลักษณะผู้ส่งสารในโฆษณาต่อพฤติกรรมผู้บริโภคตราสินค้าจากประเทศญี่ปุ่น โดยใช้แบบสอบถามเก็บข้อมูลผ่านช่องทางออนไลน์ จาก 1) กลุ่มตัวอย่างอายุระหว่าง 24 - 44 ปี ที่เคยซื้อและใช้งานสินค้าเครื่องปรับอากาศ Daikin ภายในช่วงเวลา 3 ปีที่ผ่านมา จำนวน 110 คน และ 1) กลุ่มตัวอย่างอายุระหว่าง 24 - 44 ปี ที่เคยซื้อและบริโภคสินค้าบะหมี่กึ่งสำเร็จรูป Nissin ภายในช่วงเวลา 3 เดือนที่ผ่านมา จำนวน 110 คน รวมทั้งหมด 220 คน ผลการวิจัยพบว่า คุณลักษณะผู้ส่งสารในโฆษณาที่เป็นผู้มีชื่อเสียงที่มีค่าเฉลี่ยรวมมากที่สุด คือ มิติด้านความน่าดึงดูดใจ ขณะที่คุณลักษณะผู้ส่งสารในโฆษณาที่เป็นตัวการ์ตูนที่มีค่าเฉลี่ยรวมมากที่สุด คือ มิติด้านความเชี่ยวชาญ นอกจากนั้น คุณลักษณะผู้ส่งสารในโฆษณาที่เป็นผู้มีชื่อเสียงที่มีอิทธิพลต่อพฤติกรรมผู้บริโภคตราสินค้าจากประเทศญี่ปุ่นมากที่สุด คือ มิติด้านความน่าดึงดูดใจ และคุณลักษณะผู้ส่งสารในโฆษณาที่เป็นตัวการ์ตูนที่มีอิทธิพลต่อพฤติกรรมผู้บริโภคตราสินค้าจากประเทศญี่ปุ่นมากที่สุด คือ มิติด้านความเชี่ยวชาญ

A Bioinformatics Approach For Evaluating Evolutionary Convergence Of Gene Family Size In Hematophagous Insects, Mbemba Ceesay

Theses, Dissertations and Culminating Projects

The act of blood-feeding can be nutritionally rewarding for blood-feeding arthropods. However, blood digestion can release pro-oxidant molecules such as heme and iron at potentially harmful levels. If left uncontrolled, this heme/iron can cause oxidative damage and eventually cell death. This has led to the evolution of various adaptations that protect blood-feeding arthropods against iron- and heme-associated damage. Here I postulate that the signature of this adaptation can be observed in patterns of gene family size. To test this hypothesis, I explore convergent evolutionary expansions and contractions of gene families in distinct lineages of hematophagous insects. Specifically, I compare the …

Copley Library Annual Report 2022-2023, Helen K. And James S. Copley Library, University Of San Diego

Copley Library Annual Reports

Message from the Dean; Favorite study destinations, Library Exhibits (Summer 2022-Summer 2023); Department of Anthropology - Hostile Terrain 94 exhibition; Comic Studies and Practices Symposium; Copley's Annual Signature Event - the Digital Initiatives Symposium; Art in the Library: A Feast for the Senses; One Book One San Diego; Winning Student Video for Promoting Renovated Library; Programming Partnerships with the USD Department of History; Candice Marie Benbow - Black History Month/Women's History Month Speaker; Research and Scholarship Recognition Reception; Research Day for Middle School - Copley's Pontem Partnership with Diocese Schools; Upward Bound Tours the Library; Information Literacy Instruction: Bringing Students …

The Future Is Now: Copyright Protection For Works Created By Artificial Intelligence, Gary Myers

Faculty Publications

Creativity was once considered a primarily, if not exclusively, human endeavor. People create art, literature, and music, while machines handle mechanical tasks, like a typewriter or camera. The world has changed, and in the current year those changes are disrupting conventional ideas about authorship and creativity. Developments in the power and robustness of artificial intelligence ( or AI) have made it possible for a wide array of creative AI-generated works to be created. Early developments, such as IBM Deep Blue's mastery of the game of chess, were still somewhat mechanical in nature, as they were based on the computer analyzing …

The Case Of The Missing Device Patents, Or: Why Device Patents Matter, Erika Lietzan, Kristina M. L. Acri, Evan Weidner

Faculty Publications

A company that earns premarket approval of its medical device is entitled to an extension of one patent claiming the device, to make up for some of the time it spent doing premarket research. Yet, surprisingly, a mere thirteen percent of those eligible for this extension (also known as patent term "restoration") ask for one. In contrast, most drug companies entitled to this same patent extension ask for one.

In this Article, we attribute the imbalance largely to differences between the two regulatory frameworks. In brief, because the FDA classifies and regulates devices based on what they do and how …

The Causation Canon, Sandra F. Sperino

Faculty Publications

It is rare to witness the birth of a canon of statutory interpretation. In the past decade, the Supreme Court created a new canon-the causation canon. When a statute uses any causal language, the Court will assume that Congress meant to require the plaintiff to establish "but-for" cause.

This Article is the first to name, recognize and discuss this new canon. The Article traces the birth of the canon, showing that the canon did not exist until 2013 and was not certain until 2020. Demonstrating how the Court constructed this new canon yields several new insights about statutory interpretation.

The …