Digital Commons Network^™

Bernd Jager Tribute, Scott D. Churchill

Duquesne Studies in Phenomenology

No abstract provided.

Theorizing, Journeying, Dwelling, Bernd Jager

Duquesne Studies in Phenomenology

No abstract provided.

Body, House, And City: The Intertwinings Of Embodiment, Inhabitation And Civilization, Bernd Jager

Duquesne Studies in Phenomenology

No abstract provided.

About Desire And Satisfaction, Bernd Jager

Duquesne Studies in Phenomenology

No abstract provided.

From The Homestead To The City: Two Fundamental Concepts Of Education, Bernd Jager

Duquesne Studies in Phenomenology

No abstract provided.

Of Masks And Marks, Therapists And Masters, Bernd Jager

Duquesne Studies in Phenomenology

No abstract provided.

Approved Courses 12-5-23, Angela Brock

Individual Course Committee (ICC)

No abstract provided.

Deletion Of Vβ3, Cheng Ye, Sadie A Clements, Weihong Gu, Aron M Geurts, Clayton E Mathews, David V. Serreze, Yi-Guang Chen, John P Driver

Faculty Research 2023

In both humans and NOD mice, type 1 diabetes (T1D) develops from the autoimmune destruction of pancreatic beta cells by T cells. Interactions between both helper CD4

Spinoza And Enlightened Pleasures, Charlie Huenemann

Communication Studies and Philosophy Faculty Publications

Spinoza recognizes that worldly pleasures are not contrary to the life of the philosophical sage, but such pursuits must be carefully directed. He distinguishes between a joy that affects only some parts of the body (titillatio) and joy that extends through the body as a whole (hilaritas or "cheerfulness"). Titillation can be excessive, since it can blind us to our other needs. But cheerfulness cannot be excessive, since the whole body is improved at once. In his account of cheerfulness, Spinoza can be understood to be describing the life of a liefhebber, which is the Dutch …

Is Your Computer Lying? Ai And Deception, Noreen L. Herzfeld

Reuter Professorship of Science and Religion Publications

Recent developments in AI, especially the spectacular success of Large Language models, have instigated renewed questioning of what remains distinctively human. As AI stands poised to take over more and more human tasks, what is left that distinguishes humans? One way we might identify a humanlike intelligence would be when we detect it telling lies. Yet AIs lack both the intention and the motivation to truly tell lies, instead producing merely bullshit. With neither emotions, embodiment, nor the social awareness that leads to a theory of mind, AIs lack the internal referents on which to judge truth or falsity. When …

A Proposed Financing Framework For Smes: Exploring The Case Of Ṣukūk, Mahmoud G. Zakzouk, Ahmed A. El-Masry, M. Kabir Hassan, Abdelrahman Yousri Abdelrahman

Journal of King Abdulaziz University: Islamic Economics

The purpose of this study is to explore the purported role(s) of employing Ṣukūk as a source of finance in the field of SMEs. This study contributes to the growing stream of SME financing studies by examining "why" and "how" Ṣukūk can be institutionalised as an additional innovative source. The study proposes an empirically-informed SME financing framework using Ṣukūk. To illustrate this, a qualitative approach is adopted using semi-structured interviews and publicly published secondary materials. Distinct from the previous literature and efforts, this study reveals the powerful role of Ṣukūk in financing SMEs, especially in the Organisation of Islamic Cooperation …

Gardner-Webb Class Travels To Cataloochee Valley To Study Elk Behavior, Office Of University Communications

Gardner-Webb NewsCenter Archive

Gardner-Webb University students in Biology 315 (animal physiology) recently made a trip to Cataloochee Valley in Great Smoky Mountains National Park, where they viewed elk in their natural habitat. Assistant Professor of biology Jay Zimmer teaches the class and noted that the fall of the year is one of the best times to study elk behavior.

Issues In Robot Law And Policy, A. Michael Froomkin

Books and Book Chapters

No abstract provided.

Gag Grouper (Mycteroperca Microlepis) Neurocranium, Sierra Potts, David Kerstetter

All Scans: Kerstetter Fisheries and Avian Ecology 3D Scan Series

10 cm neurocranium from Gag Grouper, Mycteroperca microlepis, collected from Snapper Mike's on 05/11/2023 by Sierra Potts

Oregon State Rank Assessment For Bonneville Redside Shiner (Richardsonius Balteatus Hydrophlox), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Bonnevile redside shiner (Richardsonius balteatus hydrophlox) using NatureServe methodology, 2023.

Spartan Daily, December 5, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 161, Issue 43

Addressing Resource Constraints For Alzheimer’S Dementia Patients And Caregivers In The Global South: An Interdisciplinary Approach, Zaheen Rashed '24

Student Research

There are two main focuses of this paper: to address the care that AD patients in countries with few healthcare resources receive and to explore the experiences of familial caregivers who care for these patients. This thesis will investigate issues including access to the education required to administer informed care, who is ultimately responsible for caring for AD patients in countries with few health facilities, and the lack of resources that is apparent in countries that do not have AD specialists or clinics. This paper will pinpoint the root issue in treating AD patients globally to serve as the first …

Expression Of The Vesicular Gaba Transporter Within Neuromedin S+ Neurons Sustains Behavioral Circadian Rhythms, Ivana L. Bussi, Alexandra F. Neitz, Raymond E. A. Sanchez, Leandro P. Casiraghi, Michael Moldavan, Divya Kunda, Charles N. Allen, Jennifer A. Evans, Horacio O. De La Iglesia

Biomedical Sciences Faculty Research and Publications

The suprachiasmatic nucleus (SCN) of the hypothalamus is the site of a central circadian clock that orchestrates overt rhythms of physiology and behavior. Circadian timekeeping requires intercellular communication among SCN neurons, and multiple signaling pathways contribute to SCN network coupling. Gamma-aminobutyric acid (GABA) is produced by virtually all SCN neurons, and previous work demonstrates that this transmitter regulates coupling in the adult SCN but is not essential for the nucleus to sustain overt circadian rhythms. Here, we show that the deletion of the gene that codes for the GABA vesicular transporter Vgat from neuromedin-S (NMS)⁺ neurons—a subset of neurons …

Michael Ridenour 399 Art Portfolio, Michael Ridenour

Professional Practices (ART 399)

A plethora of my artwork is based on imaginary animals and their role in reality or fantasy. I utilize pencil and charcoal to add depth and feeling to the piece whether it is colored or monochromatic. To make the drawings, I first gather some ideas from creatures from mythology or the virtual landscape and add some features of my own design. This passion for capturing creatures, real or fictional, can utilize their unusual adaptations from a scientific point of view as a way to merge two of my interests. I have always been fascinated by animals, especially mythical ones or …

Where Is The Evidence That Laboratory Animal Use Is Falling?, Andrew N. Rowan

WellBeing News

Advocates tend to believe that laboratory animal use is increasing, but reports from several countries indicate that such a belief is off-target.

Programs Agenda 12-5-23, Angela Brock

Programs Committee (PC)

No abstract provided.

Approved Programs 12-5-23, Angela Brock

Programs Committee (PC)

No abstract provided.

Teresa Hill Art 399 Portfolio, Teresa Hill

Professional Practices (ART 399)

Aside from the aesthetics of cartoons and video games that I was attracted to in childhood; other influences that often guide where works would go are personal experiences, our connection with nature and others, the development of the imagination, and the human eye. The pieces made from that influence contain something tied back to others, whether it is the use of various warm/cool hues, the use of nature and flowers, colorful clothing on figures, or hands and legs being slightly longer than the rest of a figure’s proportions. Artists like Yayoi Kusama, Bonnie Seeman, and Hayao Miyazaki have also impacted …

Resolution Of The Tetrabothrius Jagerskioeldi Cryptic Species Complex Among Holarctic Alcidae (Charadriiformes): Cestodes Among Fraterculinae—Exploring Marine Diversity, Host Range, And Dynamic Oceanography In The Greater North Pacific, Eric P. Hoberg, Kaylen Marie Soudachanh, Svetlana K. Bondarenko

MANTER: Journal of Parasite Biodiversity

In the biosphere, limits for diversity among species, communities, and biomes are revealed through intensive and extensive field-based inventory and assembly of voucher specimens and associated informatics examined in a phylogenetic, historical, ecological, and biogeographic arena. Archival resources for specimens and information contribute to a cumulative view of faunal structure and assembly under a comparative umbrella. Ultimately, species definitions, and inclusive partitions among populations and lineages, are fundamental in articulating hypotheses that examine interactions about evolution, the nature of organisms, and the condition of environments across space and time. We conclude our proposals establishing species limits for tapeworms of the …

Amateur Status Was A Dominant Issue In The Early Days Of Spo, John W. Lundin

Works by Local Authors

In the late 1800s, professional sports attracted high-stakes gambling. The potential for bribery and extortion led to a general sense that paid athletes were corruptible and competitions untrustworthy. While betting on amateur events was common, a deep divide emerged between "pure" amateurs, who were said to compete for the love of the sport, and professionals, who competed for money in the form of cash prizes or other remuneration. This prejudice even extended to coaches who had been professionals, who were believed to be too tainted to coach amateurs. The distinction often boiled down to so-called gentleman-athletes, who had private fortunes, …

Polymerization Of Acrylamide N-Methylene Lactic And Glycolic Acid, Sevara Khazratkulova, Nodira Zokirova, Busora Mukhamedova, Basant Lal, Orifjon Khamidov, Elyor Berdimurodov, Guloy Alieva, Ahmad Hosseini-Bandegharaei, Nizomiddin Aliev

Baghdad Science Journal

In this research work, the novel polymer base on acrylamide N-methylene lactic and glycolic acid was synthesized and its structural performances were identified by the IR, 1H NMR and 13C NMR spectroscopic investigations. The influencing factors and kinetics of polymerization, viscosity performance were studied and quantum chemical calculations were used to identify the correlation between the structure and properties. It was determined that the polymerization rate of the examined monomers in an aqueous solution, in the presence of DAA, adheres to the standard rules for radical polymerization of acrylamide monomers in solution. An investigation into the pH solution's impact on …

Antiseizure Effects Of Peganum Harmala L. And Lavandula Angustifolia, Zahra Rahimian, Seyedhassan Sadrian, Mina Shahisavandi, Hadi Aligholi, Mohammad M. Zarshenas, Alireza Abyar, Zahra Zeraatpisheh, Ali A. Asadi-Pooya

Department of Neurology Faculty Papers

Peganum harmala L. and Lavandula angustifolia are two traditional herbs with probable antiseizure effects. This study evaluated the effects of these two herbal extracts on pentylenetetrazol- (PTZ-) induced seizures in mice. We prepared hydroalcoholic extracts using P. harmala seeds and the aerial parts of L. angustifolia and then randomly divided 190 mice into 19 groups. Normal saline (10 mg/kg), diazepam (2 mg/kg), P. harmala (2.5, 5, 10, 15, 30, 45, and 60 mg/kg), and L. angustifolia (200, 400, 600, and 800 mg/kg) were intraperitoneally (IP) administrated 30 min before an IP administration of PTZ (90 mg/kg). Animals were observed for …

Inhibition Of Neurogenic Inflammatory Pathways Associated With The Reduction In Discogenic Back Pain, Jose A. Canseco, Hannah A. Levy, Brian A. Karamian, Olivia Blaber, Michael Chang, Neil Patel, John G. Curran, Alan S. Hilibrand, Gregory D. Schroeder, Alex R. Vaccaro, Dessislava Z. Markova, David E. Surrey, Christopher K. Kepler

Rothman Institute Papers

STUDY DESIGN: Retrospective cohort study.

PURPOSE: This study aimed to determine whether the initiation of anti-calcitonin gene-related peptide (CGRP inhibitor) medication therapy for migraines was also associated with improvements in back/neck pain, mobility, and function in a patient population with comorbid degenerative spinal disease and migraine.

OVERVIEW OF LITERATURE: CGRP upregulates pro-inflammatory cytokines such as tumor necrosis factor-α, interleukin-6, brain-derived neurotrophic factor, and nerve growth factor in spinal spondylotic disease, which results in disc degeneration and sensitization of nociceptive neurons. Although CGRP inhibitors can quell neurogenic inflammation in migraines, their off-site efficacy as a therapeutic target for discogenic back/neck pain …

Association Between Viral Infections And Glioma Risk: A Two-Sample Bidirectional Mendelian Randomization Analysis, Sheng Zhong, Wenzhuo Yang, Zhiyun Zhang, Yangyiran Xie, Lin Pan, Jiaxin Ren, Fei Ren, Yifan Li, Haoqun Xie, Hongyu Chen, Davy Deng, Jie Lu, Hui Li, Bo Wu, Youqi Chen, Fei Peng, Vinay K Puduvalli, Ke Sai, Yunqian Li, Ye Cheng, Yonggao Mou

Faculty, Staff and Student Publications

Background: Glioma is one of the leading types of brain tumor, but few etiologic factors of primary glioma have been identified. Previous observational research has shown an association between viral infection and glioma risk. In this study, we used Mendelian randomization (MR) analysis to explore the direction and magnitude of the causal relationship between viral infection and glioma.

Methods: We conducted a two-sample bidirectional MR analysis using genome-wide association study (GWAS) data. Summary statistics data of glioma were collected from the largest meta-analysis GWAS, involving 12,488 cases and 18,169 controls. Single-nucleotide polymorphisms (SNPs) associated with exposures were used as instrumental …

Acss2 Gene Variants Determine Kidney Disease Risk By Controlling De Novo Lipogenesis In Kidney Tubules, Dhanunjay Mukhi, Lingzhi Li, Hongbo Liu, Tomohito Doke, Lakshmi P Kolligundla, Eunji Ha, Konstantin Kloetzer, Amin Abedini, Sarmistha Mukherjee, Junnan Wu, Poonam Dhillon, Hailong Hu, Dongyin Guan, Katsuhiko Funai, Kahealani Uehara, Paul M Titchenell, Joseph A Baur, Kathryn E Wellen, Katalin Susztak

Faculty, Staff and Students Publications

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis remains elusive, hindering the development of novel therapeutics. In this study, we used kidney-specific expression of quantitative traits and single-nucleus open chromatin analysis to show that genetic variants linked to kidney dysfunction on chromosome 20 target the acyl-CoA synthetase short-chain family 2 (ACSS2). By generating ACSS2-KO mice, we demonstrated their protection from kidney fibrosis in multiple disease models. Our analysis of primary tubular cells revealed that ACSS2 regulated de novo lipogenesis (DNL), causing NADPH depletion and increasing ROS levels, ultimately leading to NLRP3-dependent pyroptosis. Additionally, we discovered …