Digital Commons Network^™

Svm-Do: Identification Of Tumor-Discriminating Mrna Signatures Via Support Vectormachines Supported By Disease Ontology, Mustafa Erhan Özer, Pemra Özbek Sarica, Kazim Yalçin Arğa

Turkish Journal of Biology

Background/aim: The complicated nature of tumor formation makes it difficult to identify discriminatory genes. Recently, transcriptome-based supervised classification methods using support vector machines (SVMs) have become popular in this field. However, the inclusion of less significant variables in the construction of classification models can lead to misclassification. To improve model performance, feature selection methods such as enrichment analysis can be used to extract useful variable sets. The detection of genes that can discriminate between normal and tumor samples in the association of cancer and disease remains an area of limited information. We therefore aimed to discover novel and practical sets …

Physicochemical Differences Between Camelid Single-Domain Antibodies And Mammalian Antibodies, Nazli Eda Eski̇er, Doğa Eski̇er, Esi̇n Fi̇ruzan, Si̇bel Kalyoncu

Turkish Journal of Biology

Background/aim: In recent years, single-domain antibodies, also known as nanobodies, have emerged as an alternative to full immunoglobulin Gs (IgGs), due to their various advantages including increased solubility, faster clearance, and cheaper production. Nanobodies are generally derived from the variable domain of the camelid heavy-chain-only immunoglobulin Gs (hcIgGs). Due to the high sequence homology between variable heavy chains of camelids (VHHs) and humans (VHs), hcIgGs are ideal candidates for nanobody development. However, further examination is needed to understand the structural differences between VHs and VHHs. This analysis is essential for nanobody engineering to mitigate potential immunogenicity while preserving stability, functionality, …

Epilepsy Networks And Their Surgical Relevance, Kevin Hines, Chengyuan Wu

Department of Neurosurgery Faculty Papers

Surgical epilepsy is a rapidly evolved field. As the understanding and concepts of epilepsy shift towards a network disorder, surgical outcomes may shed light on numerous components of these systems. This review documents the evolution of the understanding of epilepsy networks and examines the data generated by resective, ablative, neuromodulation, and invasive monitoring surgeries in epilepsy patients. As these network tools are better integrated into epilepsy practice, they may eventually inform surgical decisions and improve clinical outcomes.

Oregon State Rank Assessment For Pit Roach (Hesperoleucus Mitrulus), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for pit roach (Hesperoleucus mitrulus) using NatureServe methodology, 2023.

Infernal Symbioses: Reading Dante’S Inferno In The Chthulucene, Rawitawan Sophonpanich

Journal of Letters

This article explores the possibility of foregrounding Dante’s Inferno from the epic La Divina Commedia in this day and age of environmental crises. This catastrophic state has androgenic origins and has been labeled by climate scientists as the “Anthropocene” – a new geological era marked by the ways in which humanity has irrevocably altered the earth system. Nevertheless, Donna Haraway has voiced her opposition against this classification, postulating that it contains too much nihilistic and pessimistic connotations that function to discourage humans from doing the work necessary to alleviate the crises. Haraway therefore proposes “Chthulucene” to denote the temporally and …

Comparative Conceptual Metaphors In Thai Politics: A Case Study Before The Elections In 2001, 2007, And 2023, Theewara Saengin

Journal of Letters

The changes in Thailand’s electoral system over a period of more than 20 years have influenced the use of language that reflects the perspectives of people in Thai society. This article aims to (1) study Thai political metaphors before the 2023 elections in political analysis articles in the ThaiRath online newspaper between October 1 and December 31, 2022, and (2) compare Thai political metaphors before the 2023 elections with those in 2001 and 2007 using a conceptual metaphor framework for comparing one thing to another through a process of mapping meaning from a source domain to a target domain, as …

Glp1 Receptor Agonists-Effects Beyond Obesity And Diabetes, Sydney S Wilbon, Mikhail G Kolonin

Faculty, Staff and Student Publications

Glucagon-like peptide-1 receptor agonists (GLP1RA) have been transformative for patients and clinicians in treating type-2 diabetes and obesity. Drugs of this class, the bioavailability of which is continuously improving, enable weight loss and control blood glucose with minimal unwanted side effects. Since adopting GLP1RA for treating metabolic diseases, animal and clinical studies have revealed their beneficial effects on several other pathologies, including cardiovascular diseases, neurodegeneration, kidney disease, and cancer. A notable commonality between these diseases is their association with older age. Clinical trials and preclinical data suggest that GLP1RA may improve outcomes in these aging-related diseases. Some of the benefits …

Amondys 45 (Casimersen), A Novel Antisense Phosphorodiamidate Morpholino Oligomer: Clinical Considerations For Treatment In Duchenne Muscular Dystrophy, Megan E. Vasterling, Rebecca J. Maitski, Brice A. Davis, Julie E. Barnes, Rucha A. Kelkar, Rachel J. Klapper, Hirni Patel, Shahab Ahmadzadeh, Sahar Shekoohi, Alan D. Kaye, Giustino Varrassi

School of Medicine Faculty Publications

AMONDYS 45 (casimersen) is an antisense oligonucleotide therapy used to treat Duchenne muscular dystrophy (DMD), a rare genetic disorder characterized by a mutation in the DMD gene. Symptoms include progressive muscle weakness, respiratory and cardiac complications, and premature death. Casimersen targets a specific mutation in the DMD gene that results in the absence of dystrophin protein, a key structural component of muscle fibers. While there is currently no cure for DMD, exon-skipping therapy works by restoring the reading frame of the mutated gene, allowing the production of a partially functional dystrophin protein. Clinical trials of casimersen have shown promising results …

Evolution Of Primate Vocal Repertoires: Vocal Systems As Embodied Capital For Mediating Within-Group Conflict, Eric Schniter, Mateo Peñaherrera-Aguirre

ESI Working Papers

Life history traits constrain investments in costly neural and somatic embodied capital, potentially shaping the evolution of primate vocal communication systems. This study integrates life history theory with the social complexity hypothesis to test a sequential pathway from longevity to social dynamics to vocal repertoire size, using updated vocal repertoire data for McComb & Semple’s (2005) set of 42 non-human primate species, alongside measures of group size and within-group conflict. We compiled data on vocal repertoire size, within-group conflict, group size, endocranial volume, and maximum longevity, analysing these via Phylogenetic Sequential Canonical Cascade Model and ancestral character reconstructions. …

Long-Term Variations In The Salinity Off The Egyptian Mediterranean Coast, Ebtessam E. Mohamed, Amna S. Dabbous, Hussein I. Maiyza, Tarek M. El-Geziry

Blue Economy

The variability in seawater salinity, an indicator of the global hydrological cycle, is crucial in basin-scale circulation and so many dynamical processes from basin to global scale. Salinity is significant for marine science because fluctuations in salinity can affect physical processes such as climate change, ocean current variations, and water mass formation. From a biological perspective, variations in salinity may pose a threat to marine animals and disrupt their normal functioning. In this study, the long-term variability of salinity in the photic zone (0-200 m) of the Egyptian Mediterranean Sea is examined using an extended data set from 1950 to …

Blue Economic Potency Of Marine Invertebrates For Bio-Drug Discovery, Hassan A.H. Ibrahim, Hanan M. Abdelnaby, Samia S. Abouelkheir, Hamdy A. Abo-Taleb, Nermeen A. El Sersy

Blue Economy

In terms of focus, promising results obtained from extensive investigations showed that the biodiversity of marine invertebrates has been documented. This poses the marine ecosystem as a hopeful resource in the discovery of novel compounds, with an ideal starting point in scaffolding additional screening of marine natural products (MNPs), especially to face the rise in the burden of diseases and treatment failure. A wide range of antimicrobial, antiviral, anticancer, anti-inflammatory, antiparasitic, neuroprotective, analgesic, antimalarial and other agents of marine origin have been pursued in the control and management of diseases. In the current review, we will focus on figuring out …

Benign Acute Childhood Myositis In A Pediatric Patient Post Influenza B Infection, Michael C. Huzior, Brendan P. Chernicki, Lisa Nguyen, Bobby Kumar

HPD Articles

Benign acute childhood myositis (BACM) is a mild and self-limited sudden onset of lower extremity pain during or following recovery from a viral illness. It is characterized by difficulty walking due to severe bilateral calf pain, which usually resolves in three days. It is typically appreciated during times of large influenza outbreaks and epidemics. The most severe complication can be rhabdomyolysis without proper treatment and can lead to renal damage and potential renal failure. There are limited reported cases of BACM and therefore no clear guidelines in the treatment or management of the condition. This case is unique in the …

Prolonged Antibiotic Use In A Preclinical Model Of Gulf War Chronic Multisymptom-Illness Causes Renal Fibrosis-Like Pathology Via Increased Micro-Rna 21-Induced Pten Inhibition That Is Correlated With Low Host, Ayushi Trivedi, Dipro Bose, Punnag Saha, Subhajit Roy, Madhura More, Jonathan Skupsky, Nancy G. Klimas, Saurabh Chatterjee

HPD Articles

Gulf War (GW) veterans show gastrointestinal disturbances and gut dysbiosis. Prolonged antibiotic treatments commonly employed in veterans, especially the use of fluoroquinolones and aminoglycosides, have also been associated with dysbiosis. This study investigates the effect of prolonged antibiotic exposure on risks of adverse renal pathology and its association with gut bacterial species abundance in underlying GWI and aims to uncover the molecular mechanisms leading to possible renal dysfunction with aging. Using a GWI mouse model, administration of a prolonged antibiotic regimen involving neomycin and enrofloxacin treatment for 5 months showed an exacerbated renal inflammation with increased NF-κB activation and pro-inflammatory …

In An Animal’S Shoes: Facing Animal Suffering As A Difficulty Of Reality, Konstantin Deininger

Between the Species

This paper examines the challenges posed by confronting the topic of animal suffering in animal husbandry. The predominant positions within animal ethics mainly focus on the moral status of humans and animals, arguing that killing farm animals is morally wrong due to specifiable intrinsic properties that grant farm animals significant moral status. Such positions are derived from a detached perspective that advocates for rational consistency. This paper opposes this detached perspective. By drawing on Cora Diamond’s concept of a difficulty of reality, it contends that facing animal suffering, including changing one’s habits and attitudes towards this suffering, is instead best …

Tinea Capitis Treated With Homoeopathic Medicine Pulsatilla Nigricans: A Case Report, Khushboo Garg, Divya Bansal, Aayush Mittal

Indian Journal of Research in Homoeopathy

Introduction: Tinea infection is a common complaint encountered in day-to-day practice with increasing incidence, especially in countries such as India over the past decade. Tinea capitis is predominantly a disease of prepubertal children characterised by lesions of variable morphology on the scalp associated with itching, erythema, signs of inflammation and hair loss. Prompt recognition and treatment are necessary to prevent its spread due to its contagious nature, associated hair loss and the resultant psychological impact on social life. Individualised homoeopathic treatment has a significant scope in treating and combating such conditions cost-effectively through the totality of symptoms.

Case Summary …

Research Highlights, Shweta Singh, Gurpreet Singh

Indian Journal of Research in Homoeopathy

Research Highlights

Description Of Sivalhippus (Equidae: Perissodactyla) From The Late Miocene Siwalik Sub-Group Of Pakistan, Muhammad Tahir Waseem, Ayesha Iqbal, Sania Zubaid, Abdul Majid Khan, Muhammad Ammar

Journal of Bioresource Management

New fossil mandible as well as isolated upper and lower dentitions of the late Miocene Hipparionine species, have been discovered from a locality of Chakwal, Punjab, Pakistan. By using morphometric and morphologic analysis, we have deduced that these specimens belong to Sivalhippus theobaldi. The body size of this species was intermediate between Sivalhippus perimensis and Hipparion antilopinum while its hypsodonty indicates that this species was a grazer to a larger extent which existed in mosaic of woodland and grassland in the Latest Miocene. However, the comparison with the recent horse (Equus caballus) mandible indicates some differences in …

Antifungal Activity Of Homoeopathic Medicines Towards Alternaria Solani Of Solanum Lycopersicum Plant – An In Vitro Study And On-Farm Trial, Akkilla Suya, Vettrivel Arul, Rajamanickam Kandasamy

Indian Journal of Research in Homoeopathy

Background: The overuse of pesticides has damaged biodiversity, raising concerns about the potential for genetic mutations in humans and other organisms caused by pesticide residues in food. The recent research has demonstrated that homoeopathic medicines can act as fertilisers for plant nourishment.

Objectives: The study aimed to evaluate the antifungal activity of homoeopathic medicines in vitro and on-farm trials.

Methods: The impact of homoeopathic medicines, Sulphur 30C, Ocimum basilicum 30C and Cuprum metallicum 30C, on inhibiting the mycelial growth of Alternaria solani was studied in-vitro using Agar well-diffusion assay. In an on-farm trial using Solanum lycopersicum (PKM-1 …

Balancing Act: A Neutrosophic Approach To Human Rights And Values In Varied Societal Contexts, Fernando Castro Sánchez, Kleber Eduardo Carrión León, Paul Orlando Piray Rodríguez, José Sergio Puig Espinosa

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Approaches To Environmental Law And Policy, Santiago Fernando Fiallos Bonilla, Diego Fernando Coka Flores, Janneth Ximena Iglesias Quintana, Víctor Raúl Reátegui Paredes

Neutrosophic Sets and Systems

No abstract provided.

Application Of Neutrosophic Correlation In The Identification Of Deficiencies In Animal Protection, Teresa De Jesús Molina Guitérrez, Mesías Elías Machado Maliza, Milena Álvarez Tapia, Noel Moreno Lemus

Neutrosophic Sets and Systems

No abstract provided.

Ethics In Medical Research And Experimentation, Carlos Castañeda Guillot, Icler Sisalema Aguilar, Alex Valencia Herrera, Wilder Fabio Ramos Palacios

Neutrosophic Sets and Systems

No abstract provided.

Neutrosophic Sets And Systems {Special Issue: Neutrosophic Advancements And Their Impact On Research In Latin America}, Vol. 62, 2023, Florentin Smarandache, Mohamed Abdel-Basset, Maikel Leyva Vazquez, Said Broumi

Neutrosophic Sets and Systems

No abstract provided.

Social Media Utilization Of Public Benefit Organizations During The Covid-19 Pandemic, Piotr Szamrowski, Marian Oliński

European Management Studies

Purpose: The main purpose of the research was twofold. First, it was to assess the impact of the COVID-19 pandemic on the publishing activity of Polish public benefit organizations on Facebook. Second, to determine the impact of content published in a crisis situation on the public reaction. Design/methodology/approach: During the investigation, the financial reports of public benefit organizations were analyzed. Farther the basic parameters of the organization’s Facebook profile and the content published on Facebook were analyzed (1025 organizations were covered by the research). From the reports, financial data of organizations has been collected. Both in 2020 and in 2021, …

Hepatoprotective Effect Of Berberis Lycium In Αlpha-Naphthylisothiocyanate Induced Cholestatic Mouse Models, Shamaila Bashir, Hassan Hameed, Nida Irshad, Aqsa Ashraf, Muhammad Faizan, Saiyada Fatima Maida Halim, Hafiz M. Mazhar Asjad, Andleeb Batool, Imran Sohail

Journal of Bioresource Management

Cholestasis is characterized by the obstruction of bile flow from hepatocytes to the intestine. It results in accumulation of bile acids in the liver, which cause oxidative stress, inflammation, apoptosis, fibrosis, and cirrhosis. Till now, the treatment options against cholestasis are limited. Therefore, there is an utmost requirement to develop and evaluate the drugs with potential anti-cholestatic effects. In the current study, the drug-induced cholestasis mouse models were generated via oral administration of α-naphthylisothiocyanate (ANIT). The mice were placed into three groups of six animals each. Group I was the control group and was given saline. The cholestasis model Group …

Comprehensive Assessment Of Economic, Productive, Phenotypic, And Morphometric Traits In Azikheli Buffalo Breed Of Northern Pakistan, Nadar Khan, Bakhtawara Bibi, Tariq Ahmad, Salman Khan, Aamir Khan, Muhammad Ibrahim

Journal of Bioresource Management

The study was conducted to illuminate the phenotypic, morphometric, and productive characteristics of the Azikheli buffalo breed. One thousand two hundred pure Azikheli buffaloes (male: female) were randomly selected from the main hub of the Azikheli buffalo breed in Swat (Azikhel). The data were analyzed for comparison and frequency distribution. Phenotypic characteristic of the female buffalo shows that more than 73 % of the body color was golden yellowish. In contrast, in males, this value was 83 %, followed by white-albino and grayish colors. The shape of horns were semi sickle and grayish in color. Morphometric parameters of the breed …

Evaluating Microbial Contamination Of Bakeries, Wheat Flour In Ghaemshahr, Iran, Reyhaneh Gouran, Nazanin Khakipour

Journal of Bioresource Management

Although flour is regarded as a safe product from the perspective of microbiology due to its low water activity, it can be a suitable environment for the growth of microorganisms if suitable conditions are provided for their growth and reproduction. The objective of this study was to examine the microbial quality of 82 % and 78 % flours distributed in 5 bakeries in the city of Ghaemshahr. The evaluation of the results of the physicochemical tests on the samples revealed that sample No.5's moisture content (82 % of the flour sample from the bakery E) was significantly higher than other …

Ethnobotanical Study Of Antihemorrhagic Plants In The Skikda Region (North East Of Algeria), Nabila Souilah, Hamdi Bendif, Abdelkrim Benaradj, Abdelouaheb Belaid, Scherazad Mekious

Journal of Bioresource Management

Our survey was carried out at the level of 17 Municipalities of the Province of Skikda. Questionnaire sheets were distributed to 55 herbalists and 350 locale population (informants). The processing of survey data with the local population shows us that women (52 %) have more knowledge of phytotherapy compared to men (48 %) with a fairly high level of education. For the herbalists, we found that most are men (85.45 %) aged between 31-40 years (29.09 %) and 41-50 years (25.45 %), and with level of university study (36.36 %). On the other hand, 52.73 % of herbalists said they …

Tourism And Visitor Management In Protected Areas Post-Pandemic: The English Context, Denise Hewlett, Richard Gunton, Debra Gray, Ainara Terradillos, Sheela Agarwal, Natalia Lavrushkina, Danny Byrne

Plymouth Business School

Protected areas comprise of some of the most precious and sensitive habitats on the planet. However, many of these areas are also used as major tourism and leisure destinations. Managed well, these areas can safeguard biodiversity conservation with multiple positive benefits to local populations and economies. Yet, where not carefully planned and managed, there has long been recognition of the possibility of negative impacts on natural environments and social consequences for local communities. This chapter considers such impacts experienced in Dorset, UK, post the peak of the COVID-19 pandemic. It reviews how effective some of the most commonly used tools …

Llms And Crisis Epistemology: The Business Of Making Old Crises Seem New, Mich Ciurria

Critical Humanities

Large Language Models (LLMs) like ChatGPT have set in motion a series of crises. These include disruptions to the labor force, education, and democracy. Some people believe that rich technocratic ‘saviors’ should solve these crises. Naomi Klein, however, argues that this is a neoliberal fantasy. Tech CEOs will not solve AI-related crises because they have a vested interest in perpetuating disaster capitalism and the social inequalities that keep wages low. Who, then, can solve the AI crisis? I submit that the answer is: oppressed groups with experiential and intergenerational knowledge of crises. To oppressed folks, technological crises are not new, …