Digital Commons Network^™

Oregon State Rank Assessment For Gold Beach Pocket Gopher (Thomomys Mazama Helleri), Misty Nelson

Institute for Natural Resources Publications

Oregon state conservation status assessment for Gold Beach pocket gopher (Thomomys mazama helleri) using NatureServe methodology, 2023.

Linking Individual Behavior With Physiology To Understand Complex Life Histories, Doreen Cabrera

Theses and Dissertations

Life history strategies encompass a suite of co-evolved traits crucial for ensuring an individual's fitness, often evolving from trade-offs between traits competing for the same resources. Adult male crayfish in the Cambaridae family undergo seasonal morphological changes linked to reproductive status, a process called cyclic dimorphism. In this dissertation, we attempt to understand how cyclic dimorphism evolved in non-native northern crayfish (Faxonius virilis). First, in Chapter 1, we review empirical studies that have assessed animal personality across developmental periods. The results show that personality traits tend to be stable within life stages but not across developmental events. In Chapter 2, …

Robotic Arm Controlling Strategy For Fiber-Optic Assessment Of Myofascial Pain, Yuyao Li

Electrical and Systems Engineering Undergraduate Student Research

Myofascial pain is a prevalent condition characterized by chronic musculoskeletal discomfort, often requiring precise diagnostic tools for effective assessment. This project focuses on developing an advanced robotic arm control system to facilitate fiber-optic evaluation of myofascial pain. By leveraging Python-based programming, the robotic arm’s functionality was significantly enhanced, transitioning from single-joint control via a proprietary app to parallel joint control through keyboard commands. This advancement streamlines operation, reducing assessment time and improving workflow efficiency.

Key contributions include establishing a robust communication protocol between the robotic arm and external hardware, optimizing system performance through collaboration with Dobot Factory technical support, and …

Inclisiran: Where Are We On Safety, Efficacy, And Clinical Effectiveness Of Sirna Therapies For Prevention?, Christie M Ballantyne, Abdul Mannan Khan Minhas, Carl E Orringer

Faculty, Staff and Students Publications

No abstract provided.

Circulating Senescent Myeloid Cells Infiltrate The Brain And Cause Neurodegeneration In Histiocytic Disorders, C Matthias Wilk, Flurin Cathomas, Orsolya Török, Jessica Le Berichel, Matthew D Park, Camille Bigenwald, George R Heaton, Pauline Hamon, Leanna Troncoso, Brooks P Scull, Diana Dangoor, Aymeric Silvin, Ryan Fleischmann, Meriem Belabed, Howard Lin, Elias Merad Taouli, Steffen Boettcher, Long Li, Antonio Aubry, Markus G Manz, Julia K Kofler, Zhenyu Yue, Sergio A Lira, Florent Ginhoux, John F Crary, Kenneth L Mcclain, Jennifer L Picarsic, Scott J Russo, Carl E Allen, Miriam Merad

Faculty, Staff and Students Publications

Neurodegenerative diseases (ND) are characterized by progressive loss of neuronal function. Mechanisms of ND pathogenesis are incompletely understood, hampering the development of effective therapies. Langerhans cell histiocytosis (LCH) is an inflammatory neoplastic disorder caused by hematopoietic progenitors expressing mitogen-activated protein kinase (MAPK)-activating mutations that differentiate into senescent myeloid cells that drive lesion formation. Some individuals with LCH subsequently develop progressive and incurable neurodegeneration (LCH-ND). Here, we showed that LCH-ND was caused by myeloid cells that were clonal with peripheral LCH cells. Circulating BRAFV600E

Coastal Wetland Restoration Through The Lens Of Odum's Theory Of Ecosystem Development, Friedrich W. Keppeler, Annette S. Engel, Linda M. Hooper-Bùi, Paola C. López-Duarte, Charles W. Martin, Jill A. Olin, Katelyn J. Lamb, Michael J. Polito, Nancy N. Rabalais, Brian J. Roberts, Erick M. Swenson, Olaf P. Jensen

Michigan Tech Publications

Advancing ecological restoration assessments requires a more detailed consideration of species interactions and ecosystem processes. Most restoration projects rely on a few metrics not always directly linked with ecological theory. Here, we used Odum's theory of ecosystem development to assess and compare the ecosystem structure and services of created marshes (4–6 years old) with preexisting, reference marshes in a brackish water region of the Mississippi River Delta. We built ecosystem models for created and reference marshes that integrated large datasets of stomach contents, stable isotopes, and taxa abundances. Despite strong resemblance in community structure, created marshes were at an earlier …

Protective Effects Of Safranal On Kidney Tissue In A Rat Model Of Distant Ischemiareperfusion Injury With Infrarenal Aortic Occlusion, Mehmet Tort, Hülya Sevi̇l, Fehi̇m Can Sevi̇l, Neci̇p Beci̇t, Uğur Aksu, Zülfükar Kadi̇r Saritaş, Hasan Hüseyi̇n Demi̇rel, Azi̇z Bülbül, Zehra Yaşar, Merve Beci̇t Kizilkaya, Hazen Saritaş

Turkish Journal of Medical Sciences

Background/aim: Ischemia-reperfusion (IR) injury to a part of the body can cause damage to distant organs such as the kidney and heart. This study investigated the protective effects of safranal against IR-induced renal injury. Materials and methods: Used in this study were 24 Wistar Albino male rats, which were divided into 3 equal and randomised groups. The sham group underwent laparotomy only. In the IR group, the infrarenal aorta was clamped for 1 h, and then reperfused for 2 h. In the IR-safranal group, safranal was administered 30 min before the procedure and IR injury was induced in the same …

Effects Of Acetylsalicylic Acid And Ultrasound Elastography On Testicular Torsion In Rats, Ezgi̇ Gün Soytürk, Ünal Biçakci, Serdar Aslan, Tolga Güvenç, Meltem Neci̇be Ceyhan Bi̇lgi̇ci̇

Turkish Journal of Medical Sciences

Background/aim: To investigate the effects of acetylsalicylic acid (ASA) and the use of ultrasound elastography on testicular torsion. Materials and methods: Herein, 6 equal groups of rats were formed (n: 48): control group, sham group, torsion/detorsion (T/D)-1 h group, T/D-1 h + ASA group, T/D-8 h group, and T/D-8 h + ASA group. Testicular torsion was created by rotating the left testis 720° clockwise. At 30 min before torsion, 100 mg/kg of ASA was injected intraperitoneally. Elastography was performed at 8 and 24 h. After orchiectomy, specimens were collected for histopathological evaluation. Results: When comparing the left testicular volume (LV) …

Oncogenic Kras Drives Lipofibrogenesis To Promote Angiogenesis And Colon Cancer Progression, Wen-Hao Hsu, Kyle A Labella, Yiyun Lin, Ping Xu, Rumi Lee, Cheng-En Hsieh, Lei Yang, Ashley Zhou, Jonathan M Blecher, Chang-Jiun Wu, Kangyu Lin, Xiaoying Shang, Shan Jiang, Denise J Spring, Yan Xia, Peiwen Chen, John Paul Shen, Scott Kopetz, Ronald A Depinho

Faculty, Staff and Student Publications

Oncogenic KRAS (KRAS*) contributes to many cancer hallmarks. In colorectal cancer, KRAS* suppresses antitumor immunity to promote tumor invasion and metastasis. Here, we uncovered that KRAS* transforms the phenotype of carcinoma-associated fibroblasts (CAF) into lipid-laden CAFs, promoting angiogenesis and tumor progression. Mechanistically, KRAS* activates the transcription factor CP2 (TFCP2) that upregulates the expression of the proadipogenic factors BMP4 and WNT5B, triggering the transformation of CAFs into lipid-rich CAFs. These lipid-rich CAFs, in turn, produce VEGFA to spur angiogenesis. In KRAS*-driven colorectal cancer mouse models, genetic or pharmacologic neutralization of TFCP2 reduced lipid-rich CAFs, lessened tumor angiogenesis, and improved overall survival. …

Formate Supplementation Enhances Antitumor Cd8+ T-Cell Fitness And Efficacy Of Pd-1 Blockade, Jared H Rowe, Ilaria Elia, Osmaan Shahid, Emily F Gaudiano, Natalia E Sifnugel, Sheila Johnson, Amy G Reynolds, Megan E Fung, Shakchhi Joshi, Martin W Lafleur, Joon Seok Park, Kristen E Pauken, Joshua D Rabinowitz, Gordon J Freeman, Marcia C Haigis, Arlene H Sharpe

Faculty, Staff and Student Publications

UNLABELLED: The tumor microenvironment (TME) restricts antitumor CD8+ T-cell function and immunotherapy responses. Cancer cells compromise the metabolic fitness of CD8+ T cells within the TME, but the mechanisms are largely unknown. Here we demonstrate that one-carbon (1C) metabolism is enhanced in T cells in an antigen-specific manner. Therapeutic supplementation of 1C metabolism using formate enhances CD8+ T-cell fitness and antitumor efficacy of PD-1 blockade in B16-OVA tumors. Formate supplementation drives transcriptional alterations in CD8+ T-cell metabolism and increases gene signatures for cellular proliferation and activation. Combined formate and anti-PD-1 therapy increases tumor-infiltrating CD8+ T cells, which are essential for …

Protective Effects Of Swimming Exercises And Metformin On Cardiac And Aortic Damage Caused By A High-Fat Diet In Obese Rats With Type 2 Diabetes, By Regulating The Bcl2/Bax Signaling Pathway, Ebru Özüdoğru, Emrah Atay, Mehtap Savran, Hali̇l Aşci, Özlem Özmen, Şenay Topsakal

Turkish Journal of Medical Sciences

Background/aim: Due to the increasing mortality and morbidity rates in diabetes mellitus (DM), which is one of the biggest health problems of our age, many treatment modalities are still being tried. The positive effects of metformin (MET) and physical exercise (EXE) on the pathophysiology of diabetes are well known. In this study, it was aimed to detail these positive effects of MET and EXE in combination on the basis of inflammation, apoptosis mechanisms, and endogen nesfatin-1 (NES-1) synthesis. Materials and methods: Twenty-seven type 2 DM (DM-2) male Wistar Albino rats were divided into 4 groups, as the high-fat diet (HFD), …

What Is The Impact Of Intraperitoneal Surfactant Administration Against Postoperative Intraabdominal Adhesion Formation? An Experimental Study, Şehmus Pala, Tuncay Kuloğlu, Remzi̇ Atilgan, Zehra Sema Özkan, Serhat Hançer

Turkish Journal of Medical Sciences

Background/Aim: Surfactant is a surface-active substance that, in addition to its detergent effect, also has effects that reduce inflammation and fibrosis. Because of these effects, it was aimed herein to investigate the effect of intraperitoneal surfactant application on preventing postoperative peritoneal adhesion formation in a uterine horn adhesion model. Materials and methods: Twenty-one Wistar albino rats were randomly divided into 3 groups (G1-G3), as follows: G1 (n = 7): control group. The abdomen was opened and then closed; G2 (n = 7): adhesion group. The abdomen was opened. Then, a 2-cm linear incision was made over the right uterine horn, …

Xtx101, A Tumor-Activated, Fc-Enhanced Anti-Ctla-4 Monoclonal Antibody, Demonstrates Tumor-Growth Inhibition And Tumor-Selective Pharmacodynamics In Mouse Models Of Cancer, Kurt A. Jenkins, Miso Park, Magali Pederzoli-Ribeil, Ugur Eskiocak, Parker Johnson, Wilson Guzman, Megan Mclaughlin, Deborah Moore-Lai, Caitlin O'Toole, Zhen Liu, Benjamin Nicholson, Veronica Flesch, Huawei Qiu, Tim Clackson, Ronan C. O'Hagan, Ulrich Rodeck, Margaret Karow, Jennifer O'Neil, John C. Williams

Department of Dermatology and Cutaneous Biology Faculty Papers

INTRODUCTION: The clinical benefit of the anti-CTLA-4 monoclonal antibody (mAb) ipilimumab has been well established but limited by immune-related adverse events, especially when ipilimumab is used in combination with anti-PD-(L)1 mAb therapy. To overcome these limitations, we have developed XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 mAb.

METHODS: XTX101 consists of an anti-human CTLA-4 mAb covalently linked to masking peptides that block the complementarity-determining regions, thereby minimizing the mAb binding to CTLA-4. The masking peptides are designed to be released by proteases that are typically dysregulated within the tumor microenvironment (TME), resulting in activation of XTX101 intratumorally. Mutations within the Fc region …

A Patterned Human Primitive Heart Organoid Model Generated By Pluripotent Stem Cell Self-Organization, Brett Volmert, Chao Zhou, Et Al.

2020-Current year OA Pubs

Pluripotent stem cell-derived organoids can recapitulate significant features of organ development in vitro. We hypothesized that creating human heart organoids by mimicking aspects of in utero gestation (e.g., addition of metabolic and hormonal factors) would lead to higher physiological and anatomical relevance. We find that heart organoids produced using this self-organization-driven developmental induction strategy are remarkably similar transcriptionally and morphologically to age-matched human embryonic hearts. We also show that they recapitulate several aspects of cardiac development, including large atrial and ventricular chambers, proepicardial organ formation, and retinoic acid-mediated anterior-posterior patterning, mimicking the developmental processes found in the post-heart tube stage …

Nitric Oxide Is Required For Lung Alveolarization Revealed By Deficiency Of Argininosuccinate Lyase, Zixue Jin, Ming-Ming Jiang, Brendan Lee

Faculty, Staff and Students Publications

Inhaled nitric oxide (NO) therapy has been reported to improve lung growth in premature newborns. However, the underlying mechanisms by which NO regulates lung development remain largely unclear. NO is enzymatically produced by three isoforms of nitric oxide synthase (NOS) enzymes. NOS knockout mice are useful tools to investigate NO function in the lung. Each single NOS knockout mouse does not show obvious lung alveolar phenotype, likely due to compensatory mechanisms. While mice lacking all three NOS isoforms display impaired lung alveolarization, implicating NO plays a pivotal role in lung alveolarization. Argininosuccinate lyase (ASL) is the only mammalian enzyme capable …

Mapping The Unseen: Harnessing Indigenous Knowledge Through Participatory Mapping To Address Displacement And Housing Challenges In Post Invasion Iraq, Sana Murrani

School of Art, Design and Architecture

Post-invasion Iraq has been grappling with high rates of internal displacement and severe housing shortages for the past 20years, largely fuelled by violence, genocide and political instability. The intricacy of these interrelated challenges necessitates contextually informed, innovative and participatory approaches to effect change. This paper proposes the use of participatory mapping as a creative tool to tap into the indigenous knowledge and wayfinding skills of Iraqis, fostering a deeper understanding of the lived realities that can contribute to the design of effective policies for managing displacement and housing issues. The rising trend of internal displacement and the subsequent housing shortages, …

Index To Volumes 31 And 32, 2003-2004, Bird Observer

Bird Observer

No abstract provided.

About The Cover: Golden Eagle, William E. Davis Jr.

Bird Observer

No abstract provided.

Putting Pen To Bird: Stalking The Wily Logcock With Bic And Word Processor, Mark Lynch

Bird Observer

No abstract provided.

Banding Northern Saw-Whet Owls In The Blackstone River Valley, Kathy Clayton

Bird Observer

No abstract provided.

Rare Marsh Birds In The North Pool, Plum Island - Spring And Summer 2004, Tom Wetmore

Bird Observer

No abstract provided.

Invasive Alien Plants: The Role Of Birds In Their Spread And The Threat To Bird Habitat, Peter C. Alden

Bird Observer

No abstract provided.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.

About Books, Mark Lynch

Bird Observer

No abstract provided.

Peregrine Falcons In Massachusetts In 2004, Thomas W. French

Bird Observer

No abstract provided.

Gleanings From The Journal Of William Brewster: Journey To Lake Umbagog, Robert H. Stymeist

Bird Observer

No abstract provided.

About The Cover: Common Loon, William E. Davis Jr.

Bird Observer

No abstract provided.

Nesting Wilson's Storm-Petrels In Antarctica, Brooke Stevens

Bird Observer

No abstract provided.

Eighth Annual Report Of The Massachusetts Avian Records Committee, Marjorie Rines

Bird Observer

No abstract provided.

Field Notes, J. Thomas Brownrigg, Michael F. Mcwade

Bird Observer

No abstract provided.