Digital Commons Network^™

Evaluation Of Metaverse Integration Of Freight Fluidity Measurement Alternatives Using Fuzzy Dombi Edas Model, Muhammet Deveci, Ilgin Gokasar, Oscar Castillo, Tugrul Daim

Engineering and Technology Management Faculty Publications and Presentations

Developments in transportation systems, changes in consumerism trends, and conditions such as COVID-19 have increased both the demand and the load on freight transportation. Since various companies are transporting goods all over the world to evaluate the sustainability, speed, and resiliency of freight transportation systems, data and freight fluidity measurement systems are needed. In this study, an integrated decision-making model is proposed to advantage prioritize the freight fluidity measurement alternatives. The proposed model is composed of two main stages. In the first stage, the Dombi norms based Logarithmic Methodology of Additive Weights (LMAW) is used to find the weights of …

Missed Opportunities To Improve Food Security For Pregnant People: A Qualitative Study Of Prenatal Care Settings In Northern New England During The Covid-19 Pandemic, Chelsey R. Canavan, Tiffany D’Cruze, Meaghan A. Kennedy, Kayla E. Hatchell, Maureen Boardman, Arvind Suresh, Daisy Goodman, Alka Dev

Dartmouth Scholarship

Background: Food insecurity during pregnancy has important implications for maternal and newborn health. There is increasing commitment to screening for social needs within health care settings. However, little is known about current screening processes or the capacity for prenatal care clinics to address food insecurity among their patients. We aimed to assess barriers and facilitators prenatal care clinics face in addressing food insecurity among pregnant people and to identify opportunities to improve food security among this population. Methods: We conducted a qualitative study among prenatal care clinics in New Hampshire and Vermont. Staff and clinicians engaged in food security screening …

Immune Profiles And Dna Methylation Alterations Related With Non-Muscle-Invasive Bladder Cancer Outcomes, Ji Qing Chen, Lucas A. Salas, John K. Wiencke, Devin C. Koestler, Annette M. Molinaro, Angeline S. Andrew, John D. Seigne, Margaret R. Karagas, Karl T. Kelsey, Brock C. Christensen

Dartmouth Scholarship

Background: Non-muscle-invasive bladder cancer (NMIBC) patients receive frequent monitoring because ≥ 70% will have recurrent disease. However, screening is invasive, expensive, and associated with significant morbidity making bladder cancer the most expensive cancer to treat per capita. There is an urgent need to expand the understanding of markers related to recurrence and survival outcomes of NMIBC. Methods and results: We used the Illumina HumanMethylationEPIC array to measure peripheral blood DNA methylation profiles of NMIBC patients (N = 603) enrolled in a population-based cohort study in New Hampshire and applied cell type deconvolution to estimate immune cell-type proportions. Using Cox proportional …

Diurnal Rnapii-Tethered Chromatin Interactions Are Associated With Rhythmic Gene Expression In Rice, Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson Mcclung, Guoliang Li, Xingwang Li

Dartmouth Scholarship

Background: The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms of gene expression. However, the dynamics of diurnal 3D genome architecture and their potential functions underlying the rhythmic gene expression remain unclear. Results: Here, we reveal the genome-wide rhythmic occupancy of RNA polymerase II (RNAPII), which precedes mRNA accumulation by approximately 2 h. Rhythmic RNAPII binding dynamically correlates with RNAPII-mediated chromatin architecture remodeling at the genomic level of chromatin interactions, spatial clusters, and chromatin connectivity maps, which are associated with the circadian rhythm of gene expression. Rhythmically expressed genes within the same peak phases …

Lung Function And Atherosclerosis: A Cross-Sectional Study Of Multimorbidity In Rural Uganda, Rebecca F. Gilbert, Cody Cichowitz, Prossy Bibangambah, June Ho Kim, Linda C. Hemphill, Isabelle T. Yang, Ruth N. Sentongo, Bernard Kakuhikire, David C. Christiani, Alexander C. Tsai, Samson Okello, Mark J. Siedner, Crystal M. North

Dartmouth Scholarship

Background: Chronic obstructive pulmonary disease (COPD) is a leading cause of global mortality. In high-income settings, the presence of cardiovascular disease among people with COPD increases mortality and complicates longitudinal disease management. An estimated 26 million people are living with COPD in sub-Saharan Africa, where risk factors for co-occurring pulmonary and cardiovascular disease may differ from high-income settings but remain uncharacterized. As non-communicable diseases have become the leading cause of death in sub-Saharan Africa, defining multimorbidity in this setting is critical to inform the required scale-up of existing healthcare infrastructure. Methods: We measured lung function and carotid intima media thickness …

Gene–Gene Interaction Of Ahrwith And Within The Wntcascade Affects Susceptibility To Lung Cancer, Albert Rosenberger, Nils Muttray, Rayjean J. Hung, David C. Christiani, Neil E. Caporaso, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Guillermo Fernández-Tardón, Gad Rennert, John K. Field, Michael P.A. Davies, Triantafillos Liloglou, Lambertus A. Kiemeney, Philip Lazarus, Bernadette Wendel, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Eric J. Duell, Susanne M. Arnold, Gary E. Goodman, Chu Chen, Jennifer A. Doherty

Dartmouth Scholarship

Background: Aberrant Wnt signalling, regulating cell development and stemness, influences the development of many cancer types. The Aryl hydrocarbon receptor (AhR) mediates tumorigenesis of environmental pollutants. Complex interaction patterns of genes assigned to AhR/Wnt-signalling were recently associated with lung cancer susceptibility. Aim: To assess the association and predictive ability of AhR/Wnt-genes with lung cancer in cases and controls of European descent. Methods: Odds ratios (OR) were estimated for genomic variants assigned to the Wnt agonist and the antagonistic genes DKK2, DKK3, DKK4, FRZB, SFRP4 and Axin2. Logistic regression models with variable selection were trained, validated and tested to predict lung …

I Am Hiq—A Novel Pair Of Accuracy Indices For Imputed Genotypes, Albert Rosenberger, Viola Tozzi, Heike Bickeböller, Rayjean J. Hung, David C. Christiani, Neil E. Caporaso, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Melinda C. Aldrich, Adonina Tardon, Guillermo Fernández-Tardón, Gad Rennert, John K. Field, Mike Davies, Triantafillos Liloglou, Lambertus A. Kiemeney, Philip Lazarus, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Eric J. Duell, Susanne M. Arnold, Hans Brunnström, Olle Melander, Gary E. Goodman

Dartmouth Scholarship

Background: Imputation of untyped markers is a standard tool in genome-wide association studies to close the gap between directly genotyped and other known DNA variants. However, high accuracy with which genotypes are imputed is fundamental. Several accuracy measures have been proposed and some are implemented in imputation software, unfortunately diversely across platforms. In the present paper, we introduce Iam hiQ, an independent pair of accuracy measures that can be applied to dosage files, the output of all imputation software. Iam (imputation accuracy measure) quantifies the average amount of individual-specific versus population-specific genotype information in a linear manner. hiQ (heterogeneity in …

Enhanced Cell Deconvolution Of Peripheral Blood Using Dna Methylation For High-Resolution Immune Profiling, Lucas A. Salas, Ze Zhang, Devin C. Koestler, Rondi A. Butler, Helen M. Hansen, Annette M. Molinaro, John K. Wiencke, Karl T. Kelsey, Brock C. Christensen

Dartmouth Scholarship

DNA methylation microarrays can be employed to interrogate cell-type composition in complex tissues. Here, we expand reference-based deconvolution of blood DNA methylation to include 12 leukocyte subtypes (neutrophils, eosinophils, basophils, monocytes, naïve and memory B cells, naïve and memory CD4 + and CD8 + T cells, natural killer, and T regulatory cells). Including derived variables, our method provides 56 immune profile variables. The IDOL (IDentifying Optimal Libraries) algorithm was used to identify libraries for deconvolution of DNA methylation data for current and previous platforms. The accuracy of deconvolution estimates obtained using our enhanced libraries was validated using artificial mixtures and …

A Problem At Any Age: A Case Report Of Congenital Malrotation With Bowel Ischemia In An 84-Year-Old, Marisa E. Schwab, Sage P. Kramer, Aya Bashi, Taehyun P. Chung, Claudia M. Mueller

Dartmouth Scholarship

Background: Malrotation with bowel ischemia is classically thought of as a disease of infants. However, the true prevalence of malrotation in both the pediatric and adult population is unknown due to the unclear number of asymptomatic patients. Case presentation: A previously healthy 84-year-old man with no prior abdominal surgeries presented with an acute abdomen and was found on CT to have small bowel located in the right hemiabdomen and an abnormal SMA-SMV relationship suggestive of intestinal malrotation, as well as pneumatosis intestinalis. He underwent an exploratory laparotomy, where he was found to have a paraduodenal space which did not contain …

Volatile Organic Compound Profiling To Explore Primary Graft Dysfunction After Lung Transplantation, Pierre Hugues Stefanuto, Rosalba Romano, Christiaan A. Rees, Mavra Nasir, Louit Thakuria, Andre Simon, Anna K. Reed, Nandor Marczin, Jane E. Hill

Dartmouth Scholarship

Primary graft dysfunction (PGD) is a major determinant of morbidity and mortality following lung transplantation. Delineating basic mechanisms and molecular signatures of PGD remain a fundamental challenge. This pilot study examines if the pulmonary volatile organic compound (VOC) spectrum relate to PGD and postoperative outcomes. The VOC profiles of 58 bronchoalveolar lavage fluid (BALF) and blind bronchial aspirate samples from 35 transplant patients were extracted using solid-phase-microextraction and analyzed with comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry. The support vector machine algorithm was used to identify VOCs that could differentiate patients with severe from lower grade PGD. Using …

Evolution Of The Repression Mechanisms In Circadian Clocks, Jonathan Tyler, Yining Lu, Jay Dunlap, Daniel B. Forger

Dartmouth Scholarship

Background: Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback varies widely between lower and higher organisms. Results: Here, we study repression mechanisms in the cyanobacterial and eukaryotic clocks through mathematical modeling and systems analysis. We find a common mathematical model that describes the mechanism by which organisms generate rhythms; however, transcription’s role in this has diverged. In cyanobacteria, protein sequestration and phosphorylation generate and regulate rhythms while transcription regulation keeps proteins in proper stoichiometric balance. …

Association Between Chiropractic Care And Use Of Prescription Opioids Among Older Medicare Beneficiaries With Spinal Pain: A Retrospective Observational Study, James M. Whedon, Sarah Uptmor, Andrew W.J. Toler, Serena Bezdjian, Todd A. Mackenzie, Louis A. Kazal

Dartmouth Scholarship

Background: The burden of spinal pain can be aggravated by the hazards of opioid analgesics, which are still widely prescribed for spinal pain despite evidence-based clinical guidelines that identify non-pharmacological therapies as the preferred first-line approach. Previous studies have found that chiropractic care is associated with decreased use of opioids, but have not focused on older Medicare beneficiaries, a vulnerable population with high rates of co-morbidity and polypharmacy. The purpose of this investigation was to evaluate the association between chiropractic utilization and use of prescription opioids among older adults with spinal pain. Methods: We conducted a retrospective observational study in …

Chesapeake Governance Study: Report Of 2021 Decision Maker Interview Results, D.G. Webster

Dartmouth Scholarship

This report describes the aggregate results from a series of interviews conducted with decision makers involved in governance of the Chesapeake Watershed. Interviews began in June and ended in December of 2021. Information collected will be combined with other data to create and then test a computer model to predict likely policy changes under a range of future scenarios. It is part of a larger project funded by the National Science Foundation called Modeling the Dynamics of Human and Estuarine Systems with Regulatory Feedbacks (Award #2009248). Using the Chesapeake Bay as an example, this project will combine the policy model …

Raps Sheet, December 2022, Retirement Association Of Portland State

RAPS Sheet: Monthly Newsletter

No abstract provided.

Work And Family Pathways And Their Associations With Health For Young Women In Korea, Yujin Kim, Hyeyoung Woo, Sinn Won Han

Sociology Faculty Publications and Presentations

The aim of this study is two-fold: to discern patterns in pathways of work and family transitions among young women (aged 24–39 years) whose decisions and behaviors toward labor force participation, marriage, and parenthood are considerably shaped by social constraints and gender norms; and to examine whether and to what extent work and family pathways are associated with later health. Using data from a longitudinal survey based on a large sample of adult women in Korea (N = 2418), we identified eight dominant pathways of employment, marriage, and parenthood among young women and found that educational attainment and family values …

Applying A Mt. Mazama Volcanic Ash Treatment As A Trail Accessibility Improvement, Charles Riley, Ashton Greer, Matthew D. Sleep

TREC Final Reports

A procedure has been developed for implementing a topically applied Mt. Mazama volcanic ash trail surface amendment for improving trail firmness and stability. This project involved implementation of previously conducted Mt. Mazama volcanic research by applying a Mazama Ash and Portland Cement solution over a 0.2-mile section of the Geo Trail at the Oregon Institute of Technology Klamath Falls campus. Testing was performed to verify ideal Ash-to-Cement-to-Water ratios. A procedure was developed and applied for batching and mixing the dry materials on-site, spreading and integrating the dry material with the existing trail surface, and wetting and compacting the surface. After …

Enabling Decision-Making In Battery Electric Bus Deployment Through Interactive Visualization, Xiaoyue Cathy Liu, Gabrielius Kudirka, Biao Kuang, Yirong Zhou, Jianlin Chen

TREC Final Reports

The transit industry is rapidly transitioning to battery-electric fleets because of the direct environmental and financial benefits they could offer, such as zero emissions, less noise, and lower maintenance costs. Yet the unique spatiotemporal characteristics associated with transit system charging requirements, as well as various objectives when prioritizing the fleet electrification, requires the system operators and/or decision-makers to fully understand the status of the transit system and energy/power system in order to make informed deployment decisions. A recently completed NITC project, No. 1222 titled An Electric Bus Deployment Framework for Improved Air Quality and Transit Operational Efficiency, developed a bi-objective …

Data From: Machine Learning Predictions Of Electricity Capacity, Marcus Harris, Elizabeth Kirby, Ameeta Agrawal, Rhitabrat Pokharel, Francis Puyleart, Martin Zwick

Complex Systems Faculty Datasets

This research applies machine learning methods to build predictive models of Net Load Imbalance for the Resource Sufficiency Flexible Ramping Requirement in the Western Energy Imbalance Market. Several methods are used in this research, including Reconstructability Analysis, developed in the systems community, and more well-known methods such as Bayesian Networks, Support Vector Regression, and Neural Networks. The aims of the research are to identify predictive variables and obtain a new stand-alone model that improves prediction accuracy and reduces the INC (ability to increase generation) and DEC (ability to decrease generation) Resource Sufficiency Requirements for Western Energy Imbalance Market participants. This …

Resurfacing A Trail In Oregon Using Volcanic Ash, Charles Riley, Ashton Greer

TREC Project Briefs

In the latest instance of taking research to practice, researchers at Oregon Tech have completed a pilot section of trail using a NITC-developed sustainable paving method. A quarter-mile section of the Klamath Geo Trail, just east and up the hill from the Oregon Tech Klamath Falls campus, has been successfully resurfaced using volcanic ash from Mount Mazama.

Climate Justice And Racial And Gender Equity: Creating And Promoting Featured Collections, Sherry Buchanan

Library Faculty and Staff Publications and Presentations

PDXScholar, the repository for Portland State University, showcases three main collections that are automatically curated based on filters – tags that collect and display the content: Climate Justice, Racial and Gender Equity, and COVID-19. In this presentation, I will give an overview of our featured collections, their development and promotion, including the criteria for inclusion, technical aspects, and impact. The Digital Commons automated collection tool and system configuration will be briefly explained.

Sequencing And Functional Characterization Of A Latrodectus Geometricus Defensin, Lg-Defensin, Jacklyn Victoria Thompson

Electronic Theses and Dissertations

Defensins are small, cysteine-rich, immune related proteins described to be the most widespread family of invertebrate antimicrobial peptides. Presently, there is limited information regarding spider defensins. In this study, a new defensin peptide was described in Latrodectus geometricus, Lg-defensin. The full open reading frame was resolved using RACE and de novo assembly, followed by a bioinformatical analysis and phylogenetic alignment to determine conserved sequence patterns and structural similarities to other defensins. Next, the functionality of Lg-defensin was determined using in vitro RNA interference to assess what impact silencing had on the spider’s ability to control a gram-positive and gram-negative bacterial …

"Now, Then, Then:" An Original Composition And Examination Of The Influence Of Blues, Bluegrass, And Rock In Western Concert Music, David Klock

Electronic Theses and Dissertations

This thesis examines four pieces by three composers and one creative team, focusing on connections to bluegrass, blues, and rock music in each. The pieces are Raphael by Bryce Dessner, Cognitive Consonance II: Westering by Christopher Trapani, Bog Bodies and other Macabre Miniatures by Nicolas Lell Benavides, and “Three Dots and a Dash” by Punch Brothers. Each of these works uses distinct instrumentations, but every ensemble includes guitar in some fashion. This examination informs the original composition entitled Now, Then, Then, scored for violin, cello, electric guitar, and marimba. In this original composition, Klock uses devices found within these …

Religion And Spirituality As A Coping Mechanism For Racial Microaggressions: A Literature Review, Ashia Anderson

Electronic Theses and Dissertations

Racial discrimination is still very prevalent in the United States. People of color continue to face racism despite efforts to eradicate it. Sometimes it comes in a more subtle form known as a microaggression which can be an everyday occurrence for many people (Lewis & Neville, 2015). This is a unique stressor in that it targets an aspect of an individual that cannot be changed, and it requires the individual to decide to either confront their offender or handle it in a different manner. The goal of this paper is to perform a literature review to investigate if African Americans …

Differentiate Metasploit Framework Attacks From Others, Gina Liu Ajero

Electronic Theses and Dissertations

Metasploit Framework is a very popular collection of penetration testing tools. From auxiliaries such as network scanners and mappers to exploits and payloads, Metasploit Framework offers a plethera of apparatuses to implement all the stages of a penetration test. There are two versions: both a free open-source community version and a commercial professional version called Metasploit Pro. The free version, Metasploit Framework, is heavily used by cyber crimininals to carry out illegal activities to gain unauthorized access to targets.

In this paper, I conduct experiments in a virtual environment to discover whether attacks originated from Metasploit Framework are marked with …

Surviving The Seventies: How Ten East Texan Women Labored For Their Families, Emily B. Smith

Electronic Theses and Dissertations

The 1970s were a period of political and social turmoil. Many women left the domestic sphere and entered public life to work, seek higher education, and pursue a career. Yet many factors worked against them. They entered a workforce that treated them poorly or went to a university with limited degrees for women. The seventies were also a time of social, cultural, and political upheaval marked by a deep recession in which quality jobs were harder to find and layoffs were common. This oral history project seeks to document the experiences of East Texan women during this tumultuous period. And …

The Cost Of Survival For Insulin-Dependent Diabetics, Nikol Nesterenko

UC Law Journal

Insulin, an injectable drug discovered about 100 years ago that now costs less than $5 to manufacture, is currently sold between $300 and $500 in the United States. The continuously growing price forces many insulin-dependent diabetics to forego their lifesaving medication, which can result in death. Although insulin manufacturers are a significant cause of insulin unaffordability in this country, pharmacy benefit managers (PBMs), such as CVS Caremark, OptumRx, and Express Scripts, are essential in the insulin market and pressure insulin manufacturers to provide higher rebates, leading to higher prices for consumers.

Some states have addressed this issue by passing legislation …

The Practice Of Dry Needling In Physical Therapy, Sarah A. Robertson

University Honors Theses

This thesis is a systematic review that discusses the current state of the treatment modality of "Dry Needling" in the field of physical therapy. To do this, current studies of the patient outcomes associated with Dry Needling are analyzed and discussed, as well as legislation at both the state and national levels.

Social Media Impact On Small Brick And Mortar Businesses, David N. Bowles

University Honors Theses

This thesis examines the implementation of various strategies and goals for small to medium brick-and-mortar enterprises regarding their use of social media. Drawing from primary data collection with small brick-and-mortar businesses within the greater metro area of Portland, Oregon, the value of social media is the ability of an organization to create a sense of value for their consumers while promoting positive relations and enhancing the consumer's ability to interact with an organization on a more personal level. Focusing on the implementation of various strategies and promotional efforts to increase the success of these small businesses and align their organizational …

Intersectionality Pertaining To The Disproportionate Rates Of Black Women In Prisons And Jails, Mackenzie Heller

University Honors Theses

The incarceration rates of Black women in America surpass even all other demographics. Yet, Black women are often not on the news when discussing prison rates in the United States. Rather we see Black men, Hispanic men, and so forth. While these people do make up large portions of the prison system they are seeing a decline in their incarceration rates. Black women are often pushed to the sidelines when discussing matters that can be seen as central to their livelihoods.

This thesis addresses the intersectionality that only Black women experience and how that affects their imprisonment rates and experiences …

Working Outside The Binary: Experiences Of Nonbinary Employees In The Workforce, Mordeky C. Dullum

University Honors Theses

Transgender issues in the workplace have only recently become a focus in research, and it is still new and understudied. Even less studied is the demographic of gender expansive individuals including nonbinary and gender non-conforming individuals. This qualitative study aims to explore and highlight workplace experiences for nonbinary people, with a particular focus on younger nonbinary people who experience less employment stability in more public facing jobs. Thirteen participants engaged in interviews where they were asked to describe their experiences dealing with discrimination, harassment and transphobia in the workplace, in addition to sharing their ideas for practical solutions or changes …