Digital Commons Network^™

Single Low-Dose Targeted Bevacizumab Infusion In Adult Patients With Steroid-Refractory Radiation Necrosis Of The Brain: A Phase Ii Open-Label Prospective Clinical Trial, Shervin R. Dashti, Robert J. Kadner, Bradley S. Folley, Jason P. Sheehan, Dong Y. Han, Richard J. Kryscio, Mary B. Carter, Lisa B. E. Shields, Brian M. Plato, Renato V. La Rocca, Aaron C. Spalding, Tom L. Yao, Justin F. Fraser

Sanders-Brown Center on Aging Faculty Publications

OBJECTIVE There is an unmet need for safe and rapidly effective therapies for refractory brain radiation necrosis (RN). The aim of this prospective single-arm phase II trial was to evaluate the safety and efficacy of a single low-dose targeted bevacizumab infusion after blood-brain barrier disruption (BBBD) in adult patients with steroid-refractory brain RN.

METHODS Ten adults with steroid-refractory, imaging-confirmed brain RN were enrolled between November 2016 and January 2018 and followed for 12 months after treatment. Bevacizumab 2.5 mg/kg was administered as a one-time targeted intra-arterial infusion immediately after BBBD. Primary outcomes included safety and > 25% decrease in lesion volume. …

Evaluation Of Practice Patterns And Outcomes After Implementing Smart For Pancreatic Cancer, Eric Schaff, Parag J. Parikh, Pin Li, Rupen Shah, Gazala Khan, Farzan Siddiqui, Benjamin Movsas, David Kwon

Radiation Oncology Meeting Abstracts

Purpose/Objective(s): Stereotactic MRI-guided adaptive radiation therapy (SMART) enables safe dose escalation for locally advanced, borderline resectable, and medically inoperable pancreatic cancer and has shown favorable toxicity and survival outcomes. In late 2018, our institution commissioned SMART for these patients, making it available to all patient referrals. We wanted to review changes in our patient population and differences in clinical outcomes for patients before and after the implementation of SMART.

Materials/Methods: In this IRB approved analysis, we retrospectively reviewed 167 consecutive patients from 2015-2021 with locally advanced, borderline resectable, or medically unresectable pancreatic cancer who were treated with radiation therapy. Chemoradiation …

Medical Imaging Utilization Trends In Radiation Oncology Over The Past Decade, S. Quirk, M. Roumeliotis, L. Van Dyke, K. Martell, L. Barbera, W. L. Smith, Kundan Thind

Radiation Oncology Meeting Abstracts

Purpose/Objective(s): We quantify the increase in use of pre-treatment imaging and verification imaging in radiation oncology over the past decade. We also quantify the trend towards hypofractionation, which has partially led to increased imaging.

Materials/Methods: The pre-treatment and verification imaging data used are from a single, tertiary, university-affiliated cancer center. Pre-treatment imaging was defined as magnetic resonance imaging (MRI), positron emission tomography (PET) and four-dimensional computed tomography (4DCT). Verification imaging was defined as cone-beam computed tomography (CBCT). All treatment approved plans were included from 2012 to 2021. Data extraction was performed using custom scripts interfacing with the treatment planning system …

The Impact Of Implementing Hypofractionation Prescription Regimens And Modernizing Delivery Technique On Treatment Resources In Breast Radiotherapy, S. Quirk, Kundan Thind, L. Van Dyke, K. Long, T. Phan, P. Grendarova, K. Martell, W. L. Smith, L. Barbera, M. Roumeliotis

Radiation Oncology Meeting Abstracts

Purpose/Objective(s): To determine the change in treatment resources due to the implementation of hypofractionated prescription regimen.

Materials/Methods: All patients between January 1, 2012 and December 31, 2021 receiving curative intent breast radiotherapy at a tertiary cancer center were included. Plan and patient data were extracted from the patient database with the treatment planning system and direct database query. Treatment plan categorization was completed using data elements to include only curative intent. Treatment plans for seroma boost or supraclavicular irradiation were excluded to ensure this analysis did not double-count regional nodal irradiation contribution or confound boost with hypofractionation. Treatment delivery time …

Egestion Rates Of Microplastic Fibres In Fish Scaled To In Situ Concentration And Fish Density, Loren Hou, Rachel Mcneish, Timothy Hoellein

Biology: Faculty Publications and Other Works

Microplastics (particles <5 >mm) are commonly found in aquatic organisms across taxonomic groups and ecosystems. However, the egestion rate of microplastics from aquatic organisms and how egestion rates compare to other rates of microplastic movement in the environment are sparsely documented.We fed microplastic fibres to round gobies (Neogobius melanostomus), an abundant, invasive species in the Laurentian Great Lakes. We conducted two trials where round gobies were fed microplastic-containing food either a single time (1 day) or every day over 7 days.There was no difference in microplastic egestion rates from the 1 day or 7 day feeding trials, suggesting no impact of …

Role Of Tet Dioxygenases In The Regulation Of Both Normal And Pathological Hematopoiesis, Kanak Joshi, Lei Zhang, Peter Breslin S.J, Ameet R. Kini, Jiwang Zhang

Biology: Faculty Publications and Other Works

The family of ten-eleven translocation dioxygenases (TETs) consists of TET1, TET2, and TET3. Although all TETs are expressed in hematopoietic tissues, only TET2 is commonly found to be mutated in age-related clonal hematopoiesis and hematopoietic malignancies. TET2 mutation causes abnormal epigenetic landscape changes and results in multiple stages of lineage commitment/differentiation defects as well as genetic instability in hematopoietic stem/progenitor cells (HSPCs). TET2 mutations are founder mutations (first hits) in approximately 40–50% of cases of TET2-mutant (TET2MT) hematopoietic malignancies and are later hits in the remaining cases. In both situations, TET2MT collaborates with co-occurring mutations to promote malignant transformation. In …

被折疊的詞史段落 : 康熙末至乾隆初的浙西詞派與浙西詞壇, Shuiyun Chen

嶺南學報 Lingnan Journal of Chinese Studies

從康熙末到乾隆初這一段時間，在以往的詞史叙述中往往被忽略掉了，而這一時段正是浙西詞派影響擴大、厲鶚在詞壇地位逐漸上升的時期。朱彝尊退出詞壇之後，柯煜、杜詔、樓儼等接續其思想，或刊刻南宋詞籍，或參與詞書修纂，或組織詩詞唱和，在京師和江南壯大了浙派的聲勢，在浙西桐鄉、平湖、海寧、海鹽、錢塘等地更出現了浙派第二、三代傳人，這時徐逢吉、吳焯、厲鶚逐漸嶄露頭角，先後在杭州、揚州、天津組織了多次詩詞唱和，成爲浙西詞壇的主盟者，厲鶚在乾隆初更以其清婉深秀的風格引領一時風尚，得到了南北詞壇的一致推崇。

The period from the Late Kangxi to the Early Qianlong Period of Qing has often been omitted in the narratives of the history of ci. However, this is the period when the Western Zhejiang School’s influence expanded and Li E’s 厲鶚 fame rose in the ci circle. After Zhu Yizun’s 朱彝尊 withdrawal from the circle, Ke Yu 柯煜, Du Zhao 杜詔, and Lou Yan 樓儼 continued his thoughts by publishing collections of ci of the Southern Song dynasty and organizing ci recitations, which strengthened the Zhejiang School’s influence in Beijing and Jiangnan. There even appeared a second or …

康邸 : 桐城派的一個文學空間, Dangqian Ye

嶺南學報 Lingnan Journal of Chinese Studies

乾隆朝永恩襲爵康親王二十餘年間，劉大櫆及其門下弟子與康邸師友僚吏優遊園林，詩文酬唱，盛極一時。康邸成爲前期桐城派的重要文學空間，永恩、徐琰、甘運源、朱孝純等一批康邸文人被列入桐城派，康邸的桐城情結在父子之間傳承延續。以永恩爲代表的一批旗籍文人身份高貴卻清貧勤儉、情趣高雅，與劉大櫆、姚鼐人生理想與處世風格若合符契，讓長期漂泊北京、偃蹇坎坷的劉、姚得到物質上的支持、精神上的鼓勵與身份上的尊重，幫助桐城派在早期艱難發展中找到一條新路。

Liu Dakui 劉大櫆 and his disciples befriended Yong’en 永恩, Prince Kang and his fellows in the latter’s twenty years of holding the hereditary title during the reign of Emperor Qianlong of Qing. They held various literary activities in Prince Kang’s Mansion which became literary space for the early stage of the Tongcheng School 桐城派.Men of letters associated to Prince Kang’s Mansion such as Yong’en, Xu Yan 徐琰, Gan Yunyan 甘運源, Zhu Xiaochun 朱孝純 were also considered members of the Tongcheng School, and the bond passed down to its next generation. Yong’en was a representative of the Manchurian bannermen of …

中國古代音樂文學的創作模式, Jian-Hua Zhang

嶺南學報 Lingnan Journal of Chinese Studies

中國古代音樂文學的創作模式主要有“以樂從辭”“選辭配樂”“由樂定辭”三種。“以樂從辭”的創作機理是“聲依永，律和聲”，這與“由樂定辭”的創作機理正好相反，“由樂定辭”的創作機理乃是“永依聲”。“選辭配樂”的創作機理是選既成之辭配入既成之曲，既有對辭的“拼湊分割”，亦有對曲的“填實虚聲”。“元狩、元鼎”與“開元、天寶”是三種創作模式轉折的兩個關鍵的時間節點，伴隨創作模式之變更，辭樂關係也隨之發生一定的微妙變動。

Yi yue cong ci 以樂從辭 (lit., to compose the melody according to the lyrics), xuan ci pei yue 選辭配樂 (lit., to select an existing lyrics to match an existing melody), and you yue ding ci 由樂定辭 (lit., to write the lyrics according to the melody) are the three major creative modes of classical Chinese musical literature. Yi yue cong ci’s mechanism is sheng yi yong, lü he sheng 聲依永, 律和聲 (the sound relies on the singing, and pitch-pipes harmonize sound), while you yue ding ci’s mechanism is the opposite yong yi sheng 永依聲 (the singing relies on …

以夏變夷 : 晚明“天下全圖”的域外知識來源與製圖觀, Yawei Liu

嶺南學報 Lingnan Journal of Chinese Studies

曹君義《天下九邊分野人跡路程全圖》爲晚明出現的一種複合型“世界地圖”，它以變形南、北美洲大陸爲海島的繪圖方式爲特徵，雖吸收部分西學地理内容，但該圖並非受利瑪竇地圖直接影響。本文通過比對圖中美、歐、非洲的圖像特徵與文字内容，認爲其參考自傳教士艾儒略的《萬國全圖》，而另一種以諸多小島表現域外國家的製圖方式（如梁輈《乾坤萬國全圖古今人物事跡》），則受利瑪竇地圖影響。因此，依照域外知識來源，可將明清流傳的含有職方國與《山海經》神話之國的世界地圖分爲三類：九邊型全圖、四海五洲型全圖、四海島夷型全圖。這些結合中西地理知識、帶有想象色彩的早期世界地圖，反映了晚明地理製圖由關注“九邊”到“以夏變夷”的一種觀念變化。

Cao Junyi’s 曹君義 Tianxia jiubian fenye renji lucheng quantu 天下九邊分野人跡路程全圖 (Complete Map of the Allotted Fields, Human Traces, and Routes within and without the Nine Borders under Heaven) is a composite “world map” in the late Ming dynasty. This map followed Chinese cartographic tradition to place China in the center and represented Southern and Northern Americas as islands. Although it absorbed some knowledge about Western geography, it was not directly influenced by the map made by Matteo Ricci. This article provides comparisons of the map’s visual representations and texts about Americas, Europe, and Africa, and concludes that its major …

Exploring Risk Factors Of Alzheimer’S Disease Using Mouse Models, Xian Han

Theses and Dissertations (ETD)

Mouse models of Alzheimer’s disease (AD) that accurately recapitulate pathology and molecular changes are crucial for understanding disease mechanisms and subsequent therapeutic development. We examined five commonly used mouse models of AD (5xFAD, J20, APPNL-F, APPNL-G-F, Tau P301S) and compared their whole- and phosphoproteomes with human AD (the integration of three published datasets) to study whether they can mimic protein/RNA expression discrepancies, molecular changes, and enriched pathways found in human AD cases. The mouse models especially 5xFAD and APPNL-G-F show proteomic signatures similar to human AD but lack human-specific AD progressions, such as dysregulation of synaptic pathways and networks. Integration …

Character First: Defining And Methodizing Character Depth, Jeff Mason

Criterion: A Journal of Literary Criticism

This paper explores the definition of "depth" in characters and provides a radical new definition, supplemented by an applicable model. By looking into significant literary theory, contemporary works of story, and even elements of mathematics, this paper advances our understanding of characters and how they create meaning in stories.

Large Event Public Protection Plan With Juneau Ironman Case Study, Christopher E. Phinney

Student Projects for Graduate Degrees

Due to the increase in large public events being targeted by lone wolf terrorists since September 11, 2001, large sporting events are being categorized by United States Department of Homeland Security as soft targets for potential attacks. (Martin, 2016) The Ironman Group identified Juneau, Alaska, as a premier site for conducting an Ironman Event in August 2022 and is expected to be repeated through 2024. The Juneau fire and police departments have limited resources to support an event of this magnitude. Due to past malicious incidents that have taken place during large public events, the Juneau Ironman event raised concerns …

Marriage And Relationships In Art Spiegelman’S Maus: The Erasure Of The Female Experience, Gretchen K. Picklesimer Kinney

Criterion: A Journal of Literary Criticism

In this paper, the author explores how Vladek’s focus on money, control, and independence creates an imbalance of power in his romantic relationships with Luica, Anja, and Mala. She explores Vladek’s motivations for continuing (or not continuing) these relationships, and how Vladek tries to maintain power and control. She analyzes how Vladek ignores the perspectives and experiences of these women to create his own biased narrative of the relationships.

Impact Of The 2016 American College Of Surgeons Guideline Revision On Overlapping Lumbar Fusion Cases At A Large Academic Medical Center, Ali S. Farooqi, Austin J. Borja, Rashad Jabarkheel, Gregory Glauser, Krista Strouz, Scott Mcclintock, Neil R. Malhotra

Mathematics Faculty Publications

OBJECTIVE: The American College of Surgeons (ACS) u pdated its guidelines on overlapping surgery in 2016. The objective was to examine differences in postoperative outcomes after overlapping surgery either pre-ACS guide-line revision or post-guideline revision, in a coarsened exact matching sample. -METHODS: A total of 3327 consecutive adult patients u ndergoing single-level posterior lumbar fusion from 2013 to 2019 were retrospectively analyzed. Patients were separated into a pre-ACS guideline revision cohort (surgery before April 2016) or a post-guideline revision cohort (surgery after October 2016) for comparison. The primary outcomes were proportion of cases performed with any degree of overlap, and …

Pedagogies And Practices Of Teaching Girlhood Studies, Emily R. Aguiló-Pérez, Jacqueline Reid-Walsh

English Faculty Publications

Girlhood Studies, as an academic discipline, is continually growing. Since some educational institutions include girls’ studies as part of a special curriculum, an academic program, a certificate course, a minor, or as part of Women’s Studies or Gender Studies, Girlhood Studies has a presence in academia although at this stage rarely in an autonomous department. This interest in the pedagogies and practices of teaching Girlhood Studies is an important aspect of its growth as a field of study not only at the university level but also in other academic settings and outside of them, be they workshops, special programs for …

Temporary Staffing In Long-Term Care Facilities In Tennessee, Tennessee. Comptroller Of The Treasury.

Office of Research and Education Accountability

No abstract provided.

Machine Learning-Based Methods For The Segmentation Of Scanning Electron Microscopy Images Of Fine-Grained Shale Samples, Binqian Yin

Earth & Environmental Sciences Dissertations - Archive

The segmentation of scanning electron microscopy (SEM) images is critical yet time-consuming for geological studies, as it will need to differentiate the boundaries for different mineral objects to facilitate subsequent analyses, such as porosity calculation. Recently, machine learning methods, especially convolutional neural networks (CNNs), have been explored to segment SEM images for fine-grained shale samples. However, existing methods fail to address two critical issues in the segmentation of shale rock images---insufficient labeled data and imbalanced objects. To this end, this dissertation has proposed a machine learning pipeline that consists of supervised, semi-supervised, and active learning stages to reduce manual efforts …

The Layer That Did Not Swim Away: Broadband Acoustic Discrimination And Characterization Of Ocean Stratification, Elizabeth Reed-Weidner

Doctoral Dissertations

Ocean stratification plays a critical role in many oceanographic processes. The magnitude of mixing between stable water masses is regulated, in part, by the intensity of stratification. As such, stratification modulates the vertical transport of heat and many important dissolved constituents in the water column, influencing such processes as ocean ventilation, and ocean heat and carbon uptake. As human induced climate change alters oceanic stratification a thorough understanding of its distribution and variability is critical in the study of the world’s oceans. However, traditional methods are limited in terms of spatial context and rapid, near-synoptic observational methods, such as those …

‘Unapologetically Vernacular’: A Study Of The Composing Process Of Youth Writing And Performing Slam And Spoken Word Poetry, Dennis Magliozzi

Doctoral Dissertations

The purpose of this study is to examine the creative process and cultural resources youth poets use to generate poetry and inspire their own written material. This study is guided by the following two central research questions: In what ways do youth create their own poetry? In what ways do youth use cultural resources to inspire and develop their poetic work? This is a qualitative study that relies on three focal participants and utilizes Arts Based Educational Research (ABER) as a research strategy. After reviewing the data from participants, the following predominant themes present themselves for discussion: First, Process is …

Synthetic Approaches Towards [4]Triangulene., Md Al Faruk

Doctoral Dissertations

The [n]triangulenes (n = number of rings on a side) are a triangle-shaped class of polycyclic aromatic compounds that have been of interest for almost 100 years. Triangulenes are expected to be high-spin species with unusual electronic structures and with potential applications in molecular electronics. The first examples of simple triangulenes have been synthesized very recently by reactions on a surface and were characterized by scanning electron microscopy. Our research group has reported the solution phase synthesis and polymerization of [3]triangulene. This thesis describes approaches toward an efficient scalable synthesis of the little-known [4]triangulene ring system. Our synthetic plan, which …

A Strong-Qcd Regime Measurement Of The Proton’S Spin Structure, David Ruth

Doctoral Dissertations

The theory of the strong force, Quantum Chromodynamics (QCD) remains one of the mostimportant ways to understand the fundamental properties of ordinary matter. However, at low momentum transfer Q2, in the regime where the strong force becomes extremely strong, our understanding of QCD for ordinary nucleons becomes hazy. Several cutting edge theories such as Chiral Perturbation Theory (χPT) and Lattice QCD have provided valuable predictions in this regime, but Lattice QCD has not yet extended predictions of many important quantities to this kinematic region, and Chiral Perturbation Theory has faced several important disagreements with experimental data for the neutron over …

Multi-Level Characterization Of Plasticity, Fracture, And Phase Transformation In Metals With Hexagonal Close-Packed Structure, Evgenii Vasilev

Doctoral Dissertations

In this thesis, contributions to characterization of plasticity, fracture, and phase transformation in metals with hexagonal close-packed structure are presented. First, the structure-properties correlations are established for Mg-1.3Zn-0.4Ca-0.4Mn and Mg-1.5Nd alloys. Next, the role of microstructural features such as gran/twin boundaries in the development of damage and fracture in magnesium is discussed. Then, a structure metric for quantitative assessment of fracture is developed and validated on magnesium and titanium alloys. Experimental studies on plasticity are followed by crystal plasticity modelling of Taylor impact test on zirconium to correlate experimental and predicted evolution of microstructure and shape change. Finally, a phase …

Ionospheric O+ And H+ Outflow During Geomagnetic Storms, Niloufar Nowrouzi

Doctoral Dissertations

A geomagnetic storm begins when solar wind carrying southward IMF Bz impinges upon the Earth’s magnetosphere. There are two major structures that can cause a geomagnetic storm: streaminteraction regions (SIRs) and coronal mass ejections (CMEs). The two types of structures differ in the strength of the magnetic field and the time length of southward Bz, and so the effects on the magnetosphere are different. One result of the energy input from the solar wind is ionospheric outflow. Because of solar wind-magnetosphere-ionosphere coupling, ionospheric ions can become a significant source for the magnetosphere during geomagnetic storms. In this thesis, I performed …

Advanced Electronics And Post-Processing Algorithm For The Sontrac 3d Neutron Spectrometer, George Suarez

Doctoral Dissertations

The second-generation SONTRAC instrument is being designed by UNH and NASA to detect solar neutrons, a game-changing observation for understanding particle acceleration at the Sun. The new instrument targets small satellites with highly constrained size, mass, and power; bringing a new set of challenges to the design of the instrument electronics. SONTRAC uses silicon photomultiplier detectors to image neutron scattered proton tracks in a scintillating fiber bundle. Individual detector readout provides the best performance, but is not achievable within the size, mass and power constrains for a small satellite. To overcome this problem, we explored detectors configured in strips to …

Disordered Cathode Electrode Materials For Aqueous Zinc Ion Batteries And The Effect Of Conditioned Electrolytes In Cycling Performances, Saewon Kim

Doctoral Dissertations

Electrochemical energy storage is essential to free various electronic devices from electric wiring. Besides the prominent lithium-ion batteries, next-generation batteries using zinc ions as charge carriers in aqueous electrolytes have risen as attractive alternatives due to their superior safety, environmental-friendliness, low cost, and excellent theoretical performance. However, high-performance cathode materials to accommodate the capacity and cyclability of zinc-ion storage have been lacking because of the strong electrostatic interaction between multivalent Zn-ions and host cathode materials. This study suggests a few varieties of vanadium oxide derivatives with large interlayer spaces, excellent structural stability, and finely tuned structural properties. Alkali-intercalated vanadates (MVOs) …

Elastic Electron Scattering From Mirror Nuclei 3he And 3h., Leiqaa Kurbany

Doctoral Dissertations

The primary aim of my work is the extraction of the elastic cross-sections from data collected in Jefferson Lab Hall A experiment E12-11-112, which measured inclusive elastic scattering from the mirror nuclei 3He and 3H at low momentum transfer. I determined the ratio of the 3He and 3H cross-sections since it cancels many of the systematic uncertainties that enter the absolute cross-section extraction, and it reduced fractional uncertainty to 1.85%. By going to low energy and forward angle, the effect of the magnetic form factor Fm(Q2) can be minimized, which allows for an extraction of the charge form factor Fch(Q2) …

Autonomous Teaming Of Multileader System - Robust Cluster Formation Approach, Maryam N. Naleini

Electrical Engineering Dissertations - Archive

The cluster consensus problem of Multileader MAS Is considered and the clustering problem of interconnected multileader systems is formulated as a disturbance attenuation problem. For the first time, it's proved that the multileader MAS can reach cluster consensus without limiting the communication between the clusters. The combination of Small Gain Theorem and H8 optimization has been designed in the graphical differential game platform to prove the stability for the system. At the end, an online off-policy reinforcement learning algorithm is developed to find the solution to the H8 optimal problem of multileader MAS with completely unknown systems.

Community Engagement Newsletter, December 2022, University Of Northern Iowa. Office Of Community Engagement.

Community Engagement Newsletter

Contents:

--- Engaged UNI: Fortepan Iowa
--- Faculty/Staff Engagement
--- UNI Engaged Podcast
--- Events
--- In Other News

Primed And Cued: Long-Term Acoustic Telemetry Links Interannual And Seasonal Variations In Freshwater Flows To The Spawning Migrations Of Common Snook In The Florida Everglades, Jordan A. Massie, Rolando O. Santos, Ryan J. Rezek, W. Ryan James, Natasha M. Viadero, Ross E. Boucek, David A. Blewett, Alexis A. Trotter, Philip W. Stevens, Jennifer S. Rehage

Marine Science

Background: Spawning migrations are a widespread phenomenon among fishes, often occurring in response to environmental conditions prompting movement into reproductive habitats (migratory cues). However, for many species, individual fish may choose not to migrate, and research suggests that conditions preceding the spawning season (migratory primers) may influence this decision. Few studies have provided empirical descriptions of these prior conditions, partly due to a lack of long-term data allowing for robust multi-year comparisons. To investigate how primers and cues interact to shape the spawning migrations of coastal fishes, we use acoustic telemetry data from Common Snook (Centropomus undecimalis) in Everglades National …