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Decreasing Sudden Unexpected Infant Death, Carey B. Acosta, Kristal Brown, Judy E. Bowling

Nursing & Health Sciences Research Journal

Background: Sleep-related sudden unexpected infant death (SUID) is an alarming, potentially preventable event with over 3,500 annual occurrences in the United States (US). In response to sleep-related SUIDs, the American Academy of Pediatrics and National Institutes of Health advocate for safe sleep practices to promote establishment of safe sleep environments for infants through the Safe to Sleep initiative. However, research evidence shows that lack of knowledge in hospital staff and community members (parents/caregivers) and cultural barriers/biases are factors associated with the inability or resistance to adopting safe sleep practices for infants.

Methods: In 2017, internal evidence within a local …

Exploring Workplace Incivility And Bullying In Healthcare Workers In A South Florida Community Hospital, Nada Wakim, Natalie Bermudez, Claudia C. Sabogal-Rodriguez

Nursing & Health Sciences Research Journal

Introduction: Workplace incivility and bullying are concerning issues in healthcare with detrimental consequences for healthcare workers (HCW) and healthcare organizations. Organizational leaders’ recognition of incivility/bullying within healthcare organizations, and their sources, is imperative to prevent and/or address issues by creating “zero tolerance” work environments. The purpose of this cross-sectional, descriptive study was to explore HCWs’ experiences with incivility and bullying at a South Florida community hospital.

Methods: A convenience sample of HCWs at a South Florida community hospital were recruited to voluntarily complete the Nursing Incivility Scale.

Results: A sample of 325 HCWs responded to the survey. The results showed …

Letter From The Editor: Coming Together As A Resilient Workforce, Nohemi Sadule Rios

Nursing & Health Sciences Research Journal

No abstract provided.

Economics Of Artificial Intelligence In Healthcare: Diagnosis Vs. Treatment., Narendra N Khanna, Mahesh A Maindarkar, Vijay Viswanathan, Jose Fernandes E Fernandes, Sudip Paul, Mrinalini Bhagawati, Puneet Ahluwalia, Zoltan Ruzsa, Aditya Sharma, Raghu Kolluri, Inder M Singh, John R Laird, Mostafa Fatemi, Azra Alizad, Luca Saba, Vikas Agarwal, Aman Sharma, Jagjit S Teji, Mustafa Al-Maini, Vijay Rathore, Subbaram Naidu, Kiera Liblik, Amer M Johri, Monika Turk, Lopamudra Mohanty, David W Sobel, Martin Miner, Klaudija Viskovic, George Tsoulfas, Athanasios D Protogerou, George D Kitas, Mostafa M Fouda, Seemant Chaturvedi, Mannudeep K Kalra, Jasjit S Suri

Medical Education Articles

Motivation: The price of medical treatment continues to rise due to (i) an increasing population; (ii) an aging human growth; (iii) disease prevalence; (iv) a rise in the frequency of patients that utilize health care services; and (v) increase in the price. Objective: Artificial Intelligence (AI) is already well-known for its superiority in various healthcare applications, including the segmentation of lesions in images, speech recognition, smartphone personal assistants, navigation, ride-sharing apps, and many more. Our study is based on two hypotheses: (i) AI offers more economic solutions compared to conventional methods; (ii) AI treatment offers stronger economics compared to …

How Universities Use Twitter To Communicate About Mental Health, Sarah Elizabeth Polhill

Theses and Dissertations

From a sample of over three million tweets from universities in the US, we described the characteristics of universities' communication about mental health on Twitter, including common keywords, bigrams, linked resources, and hashtags, as well as the frequency of dialogic communication and mental health tweets over time, especially in the context of the COVID-19 Pandemic. This study uses data mining to collect tweets from official university Twitter accounts and selected accounts of university wellness and counseling programs. Relevant tweets were collected from a large sample using keywords and bigrams relevant to mental health from the Twitter accounts of IACS accredited …

Examining The Relationship Between Stomiiform Fish Morphology And Their Ecological Traits, Mikayla L. Twiss

All HCAS Student Capstones, Theses, and Dissertations

Trait-based ecology characterizes individuals’ functional attributes to better understand and predict their interactions with other species and their environments. Utilizing morphological traits to describe functional groups has helped group species with similar ecological niches that are not necessarily taxonomically related. Within the deep-pelagic fishes, the Order Stomiiformes exhibits high morphological and species diversity, and many species undertake diel vertical migration (DVM). While the morphology and behavior of stomiiform fishes have been extensively studied and described through taxonomic assessments, the connection between their form and function regarding their DVM types, morphotypes, and daytime depth distributions is not well known. Here, three …

December 9, 2022 Minutes, Swosu Faculty Senate

Faculty Senate Minutes

SWOSU Faculty Senate Official Minutes from the December 9, 2022 meeting.

Asecret Charting And Sensory Processing Disorder - A Tool For Parents And Teachers, Taylor Lerman

Honors Theses

When considering the results of research from this study, the reader should note this specifically applies to elementary school aged students but could be applicable outside of this study for the purpose of added ages. The cumulative ASECRET charts do not explicitly apply to that of a typical child and added disabilities to consider are discussed within the discussion section of research. Conditions left unmentioned should not be considered inapplicable, but for the purpose of this research, discussion points focus on sensory processing and conditions with higher rates of comorbidity to sensory processing compared to others. The purpose of this …

2 Years On: Loss And Grief Amidst The Covid-19 Pandemic, Eman H. Nabulsi

Psychology and Counseling Theses

This study sought to examine the variability and impact of different kinds of losses experienced during COVID-19 and how people reacted to and coped with those losses. The most common loss reported by individuals was the loss of social connection, while death-related losses were identified as the most impactful loss experienced. Results suggest that people responded in a myriad of ways, including increased cautiousness for health safety, refocusing their attention on important life matters, and finding alternative ways to connect with others. Furthermore, this study found that individual factors such as intolerance of uncertainty and perceived social support may play …

The Effects Of Survival, Pleasantness, And Storytelling Conditions On True And False Memory Recollection, Rachel Daniels

Honors Theses

The purpose of the present study was to analyze the extent to which various processing scenarios influenced participants' rates of true and false memory recollection. Participants were placed in one of three conditions, storytelling, survival, or pleasantness, and then studied a list of common nouns. They were then instructed to comment on the words in a specific manner depending on the condition to which they were randomly assigned. Following this, participants completed a math distractor task, and were then asked to complete a free recall test for the previously studied words. The results indicated that participants in the storytelling condition …

G-Rich Motifs Within Phosphorothioate-Based Antisense Oligonucleotides (Asos) Drive Activation Of Fxn Expression Through Indirect Effects, Feng Wang, Ezequiel Calvo-Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts

Faculty, Staff and Student Publications

Friedreich's ataxia is an incurable disease caused by frataxin (FXN) protein deficiency, which is mostly induced by GAA repeat expansion in intron 1 of the FXN gene. Here, we identified antisense oligonucleotides (ASOs), complementary to two regions within the first intron of FXN pre-mRNA, which could increase FXN mRNA by ∼2-fold in patient fibroblasts. The increase in FXN mRNA was confirmed by the identification of multiple overlapping FXN-activating ASOs at each region, two independent RNA quantification assays, and normalization by multiple housekeeping genes. Experiments on cells with the ASO-binding sites deleted indicate that the ASO-induced FXN activation was driven by …

Linguistic And Ontological Concept Formation: The Lion Method, Göran Goldkuhl

The Qualitative Report

Concept formation is a demanding task in social research. A methodological approach (called LION) is presented that emphasizes the clarification of concepts based on linguistic and ontological views. This method originates from a qualitative-pragmatist tradition of studies of work-practices in organizational settings and it is explicitly based on the linguistic turn and the practice turn in social research. It is also based on the articulation of seven conceptualization maxims. Its aim is to bring rigor to the conceptualizing process and clarity to resulting conceptualizations. The method is illustrated through an analysis example from service management. The concepts of “value-in-use” and …

Crossing The Gender Chasm For Productive Field Engagement, Raghunandan Reddy

The Qualitative Report

The paper aims to demonstrate that while researcher’s background could be a factor in gaining access to research participants and to the organization, other elements like trustworthiness, reflexivity, and engaged participant listening help in overcoming gender barriers in interviewing the research participants. This paper is a reflexive account of field experience as a part of doctoral research aimed at establishing that not only could gender barriers to access to research participants be overcome, but also that a gender-outsider positionality offers insights into women’s workplace experiences that are shaped through the discourses and practices of managerialism. The field experience highlighted the …

International Teaching Internship: Development Of Pre-Service Teachers’ Competences, Luthfi Auni, Teuku Zulfikar, Saiful Akmal, Alfiatunnur Alfiatunnur, Farah Dina

The Qualitative Report

Teachers’ competences should be shaped from a very early stage of their training (Mâţă, Cmeciu, & Ghiaţău, 2013). For that reason, pre-service teachers are required to get involved in teaching internships and gain professional experience from training programs and workshops. These experiences are assets for these pre-service teachers when they resume teaching positions upon graduation. The present narrative study, therefore, aims to investigate the benefits of international teaching internship, known as South-East Asian Teacher (henceforth SEA-Teacher Program) on Indonesian pre-service English teachers’ identity and competence development. There were four male and four female participants of SEA-Teacher program participated in the …

High-Resolution Cryo-Em Structure Of The Shigella Virus Sf6 Genome Delivery Tail Machine, Fenglin Li, Chun-Feng David Hou, Ruoyu Yang, Richard Whitehead, Carolyn M. Teschke, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Sf6 is a bacterial virus that infects the human pathogen Shigella flexneri. Here, we describe the cryo–electron microscopy structure of the Sf6 tail machine before DNA ejection, which we determined at a 2.7-angstrom resolution. We built de novo structures of all tail components and resolved four symmetry-mismatched interfaces. Unexpectedly, we found that the tail exists in two conformations, rotated by ~6° with respect to the capsid. The two tail conformers are identical in structure but differ solely in how the portal and head-to-tail adaptor carboxyl termini bond with the capsid at the fivefold vertex, similar to a diamond held over …

Imagining And Reimagining The Future Of Special And Inclusive Education, James M. Kauffman, Dimitris Anastasiou, Garry Hornby, Joao Lopes, Mack D. Burke, Marion Felder, Bernd Ahrbeck, Andrew Wiley

More Faculty of Arts, Humanities and Business Research

“Reimagination” is required to create a new vision of education that better serves individuals with disabilities. Imagination is a way of conceiving possibilities and probabilities. The future of special education is imagined within the limits of possibility and probability of “appropriate” education for children with special educational needs and disabilities. Education is reimagined for full inclusion without special education and an alternative reimagination of inclusive special education. Particular attention is given to the administrative structure of public education and to the training of teachers for the imagined approaches to special education. The importance of imagining special and inclusive education being …

Algorithmic Solutions To Combat Online Fake News, Xinyi Zhou

Dissertations - ALL

The unprecedented growth of new information producing, distributing, and consuming every moment on the Web has fostered the rise of ``fake news.'' Because of its detrimental effect on democracy, global economies, and public health, effectively combating online fake news has become an essential and urgent task.

This dissertation starts with making typological, theoretical, and empirical efforts to promote the public's comprehension of fake news and lay the foundation for algorithmically combating fake news. As there has been no universal definition of fake news, this dissertation discusses the definition of fake news from three dimensions: veracity, intention, and news, comparing it …

The Effects Of Holistic Modalities On Stress Reduction In Nursing Students Attending School During The Pandemic, Rachel Kamp

Honors Theses

Nursing students tend to experience high levels of stress due to the pressures and demands of nursing school, including exams, clinical, and interactions with professors and preceptors (Labrague et al., 2017). Recently, the COVID-19 Pandemic has created additional stressors. Both mind and body modalities (yoga, meditation, deep breathing etc.) and exercise modalities (running, walking, etc.) are some of many health promoting, stress reducing activities that were proven to be effective in reducing stress in nursing students prior to the pandemic. This study aims to determine if these modalities are still effective now, and how nursing faculty supports stress reduction in …

Comprehensive Identification And Expression Analyses Of The Snrk Gene Family In Casuarina Equisetifolia In Response To Salt Stress, Di Ai, Yujiao Wang, Yongcheng Wei, Jie Zhang, Jingxiang Meng, Yong Zhang

Faculty, Staff and Student Publications

Background

Sucrose nonfermenting-1 (SNF1)-related protein kinases (SnRKs) play crucial roles in plant signaling pathways and stress adaptive responses by activating protein phosphorylation pathways. However, there have been no comprehensive studies of the SnRK gene family in the widely planted salt-tolerant tree species Casuarina equisetifolia. Here, we comprehensively analyze this gene family in C. equisetifolia using genome-wide identification, characterization, and profiling of expression changes in response to salt stress.

Results

A total of 26 CeqSnRK genes were identified, which were divided into three subfamilies (SnRK1, SnRK2, and SnRK3). The intron–exon structures and protein‑motif compositions were similar within each subgroup but …

Phenol Neurolysis In People With Spinal Cord Injury: A Descriptive Study, Radha Korupolu, Aila Malik, Erin Pemberton, Argyrios Stampas, Sheng Li

Faculty, Staff and Student Publications

STUDY DESIGN: Descriptive study.

OBJECTIVES: The study's main objective was to describe the common targets of phenol neurolysis and review the safety and efficacy of the dose used for this spasticity management procedure in people with spinal cord injury (SCI).

SETTING: An acute rehabilitation hospital.

METHODS: Data from people with SCI who underwent phenol neurolysis procedures for spasticity management between April 2017 and August 2018 were included in this study. We collected demographics and phenol neurolysis procedure-related information.

RESULTS: A total of 66 people with SCI and spasticity underwent phenol neurolysis of 303 nerves over 102 encounters. During these encounters, …

Human Rabies - Texas, 2021, Dawn Blackburn, Faisal S Minhaj, Roukaya Al Hammoud, Lillian Orciari, Jael Miller, Trevor Maness, Jon Stewart, Brittany Singletary, Elvia Ledezma, Misti Ellsworth, Andrea Carlo-Angleró, Michael Niezgoda, Crystal M Gigante, Agam K Rao, Panayampalli S Satheshkumar, Gloria P Heresi, Amanda Kieffer, Ryan M Wallace

Faculty, Staff and Student Publications

In late August 2021, a boy aged 7 years was bitten by a bat while he was playing outside his apartment home in Medina County, Texas. He informed his parents; however, no rabies postexposure prophylaxis (PEP) was sought because there were no visible bite marks, and the family was unaware that contact with a bat, including in the absence of visible bite marks, might cause rabies. Approximately 2 months later, the child was hospitalized for altered mental status, seizures, and hypersalivation and ultimately received a diagnosis of rabies. Experimental therapies were attempted; however, the child died 22 days after symptom …

Efficacy Of Cabozantinib In Metastatic Mit Family Translocation Renal Cell Carcinomas, Jonathan Thouvenin, Omar Alhalabi, Maria Carlo, Lucia Carril-Ajuria, Laure Hirsch, Nieves Martinez-Chanza, Sylvie Négrier, Luca Campedel, Dylan Martini, Delphine Borchiellini, Jad Chahoud, Massimo Lodi, Philippe Barthélémy, Elshad Hasanov, Andrew W Hahn, Thierry Gil, Srinivas R Viswanathan, Ziad Bakouny, Pavlos Msaouel, Mehmet Asim Bilen, Toni K Choueiri, Laurence Albiges, Nizar M Tannir, Gabriel G Malouf

Faculty, Staff and Student Publications

Background: MiT family translocation renal cell carcinoma (TRCC) is a rare and aggressive subgroup of renal cell carcinoma harboring high expression of c-MET. While TRCC response rates to VEGF receptor tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors are limited, efficacy of cabozantinib (a VEGFR, MET, and AXL inhibitor) in this subgroup is unclear.

Methods: We performed a multicenter, retrospective, international cohort study of patients with TRCC treated with cabozantinib. The main objectives were to estimate response rate according to RECIST 1.1 and to analyze progression-free survival (PFS) and overall survival (OS).

Results: Fifty-two patients with metastatic TRCC treated in …

Inhibition Of The Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib In Loss-Of-Function Notch1-Mutant Head And Neck Cancer, Faye M Johnson, Filip Janku, Mohamed A Gouda, Hai T Tran, Jitesh D Kawedia, Debora Schmitz, Hendrik Streefkerk, J Jack Lee, Clark R Andersen, Defeng Deng, Seema Rawal, Pooja A Shah, Adel K El-Naggar, Jason M Johnson, Mitchell J Frederick

Faculty, Staff and Student Publications

BACKGROUND: PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy of the PI3K/mTOR inhibitor bimiralisib in patients with NOTCH1-mutant HNSCC.

METHODS: Patients with recurrent/metastatic NOTCH1-mutant HNSCC who had progressed during chemotherapy and immunotherapy received bimiralisib until unacceptable toxicity or progression. To assess whether NOTCH1 mutations can be detected in blood, we measured circulating tumor DNA (ctDNA). To assess activated NOTCH1 protein levels, we quantitated cleaved NOTCH1 (cl-NOTCH) by immunohistochemistry.

RESULTS: Eight patients were treated, and 6 were evaluable for response. The objective response rate was 17%. For all 8 patients, …

Our Natural World, Jennifer Mattei

Biology Faculty Publications

It’s nothing earth-shattering to say our natural world gives us everything we need to survive, from the oxygen we breathe and the clean water we drink to that apple you are enjoying with your lunch today. We all know this. However, we sometimes fail to appreciate and act on the converse—if we fail to maintain a well-functioning and resilient natural world our future is literally at risk.

What’s more, our reliance on nature goes deeper than the base physical essentials of air, water and food that are required for life. Our bodies—physically, mentally and emotionally—are healthier for their interaction with …

Evaluation Of Anti-Factor Xa Level Usage For Low Molecular Weight Heparin In A Healthcare System, Natalie Quesep, Lourdes R. Menendez, Erika Dittmar, Radhan B. Gopalani, Payal Patel, Srikanth Nagalla

Nursing & Health Sciences Research Journal

Background: Low-molecular-weight heparin (LMWH) is a commonly used anticoagulant for treatment of venous thromboembolism (VTE). Routine monitoring of therapeutic effects through anti-Xa levels is not recommended but may be beneficial in patients with altered pharmacokinetics.^1,2 Inappropriate monitoring leads to excessive testing and premature dose adjustments, compromising safety and efficacy. The purpose of this project was to assess appropriateness of monitoring LMWH anti-Xa levels and identify opportunities to optimize utilization within a community health system.

Methods: A random-sample, retrospective chart review at a multi-site hospital system was conducted over a 3-year period. Inclusion criteria were adults admitted with …

A Concept Analysis Of Moral Comfort In Nursing, Natalie Bermudez

Nursing & Health Sciences Research Journal

Introduction: Nurses are the most trusted professional group in the United States. As such, examination and exploration of concepts or phenomena, either positively or negatively affecting nurses’ ethical decision-making and moral actions, are needed. While nursing literature is abundant on moral distress and its negative impact, literature on moral comfort (a positive phenomenon) is sparsely available. The purpose of this concept analysis is to explore MC within nursing literature and other disciplines to identify moral comfort’s defining attributes, antecedents, consequences, and empirical referents.

Method: Walker and Avant’s eight-step concept analysis approach was used.

Results: Six articles were included in this …

Consistency Of Efficacy Results Across Various Clinical Measures And Statistical Methods In The Lecanemab Phase 2 Trial Of Early Alzheimer’S Disease, Shobha Dhadda, Michio Kanekiyo, David Li, Chad J Swanson, Michael Irizarry, Scott Berry, Lynn D Kramer, Donald A Berry

Faculty, Staff and Student Publications

BACKGROUND: Lecanemab (BAN2401) is a humanized IgG1 monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils) with activity at insoluble fibrils and slowed clinical decline in an 18-month phase 2 proof-of-concept study (Study 201; ClinicalTrials.gov NCT01767311) in 856 subjects with early Alzheimer's disease (AD). In this trial, subjects were randomized to five lecanemab dose regimens or placebo. The primary efficacy endpoint was change from baseline in the Alzheimer's Disease Composite Score (ADCOMS) at 12 months with Bayesian analyses. The key secondary endpoints were ADCOMS at 18 months and Clinical Dementia Rating-Sum-of-Boxes (CDR-SB) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog14) …

A General Catalyst Controlled Route To Prostaglandin F2a, Laura Cunningham, Sourabh Mishra, Leon Matthews, Stephen P Fletcher

Faculty, Staff and Student Publications

We report a general, catalyst-controlled route to prostaglandin F2_α and its analogues. The approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling reaction between a racemic bicyclic allyl chloride and alkenyl boronic esters bearing chiral alcohols to give cyclopentyl intermediates bearing 3 contiguous stereocenters. The route provides advanced intermediates in 99% ee as a single diastereoisomer in all cases examined, with the absolute stereochemistry of the cyclopentane core controlled by the ligand. Intermediates that could be used to produce prostaglandin analogues such as bimatoprost, latanoprost, fluprostenol, and cloprostenol were synthesized. The final two stereocenters were installed via Pd-catalyzed Tsuji–Trost …

2022-2023 Performance Forum (Chamber Juries) - December 9, 2022, Yu Xie, Yubin Zhang, Yoonki Lee, Sheng Yuan Kuan, Julian Rauh, Ethan Sanchez, Tyler Marvin, Matthias Ziolkowski, Jeremiah Grace

Performance Forum

No abstract provided.

Neddylated Cullin 3 Mediates The Adaptive Response To Topoisomerase 1 Inhibitors, Alice Meroni, Jan Grosser, Sumedha Agashe, Natasha Ramakrishnan, Jessica Jackson, Priyanka Verma, Laura Baranello, Alessandro Vindigni

2020-Current year OA Pubs

DNA topoisomerase 1 (TOP11) inhibitors are mainstays of anticancer therapy. These drugs trap TOP1 on DNA, stabilizing the TOP1-cleavage complex (TOP1-cc). The accumulation of TOP1-ccs perturbs DNA replication fork progression, leading to DNA breaks and cell death. By analyzing the genomic occupancy and activity of TOP1, we show that cells adapt to treatment with multiple doses of TOP1 inhibitor by promoting the degradation of TOP1-ccs, allowing cells to better tolerate subsequent doses of TOP1 inhibitor. The E3-RING Cullin 3 ligase in complex with the BTBD1 and BTBD2 adaptor proteins promotes TOP1-cc ubiquitination and subsequent proteasomal degradation. NEDDylation of Cullin 3 …