Digital Commons Network^™

50 Years And Counting, Scott Ripley, Jeremy Gasowski, David Vogt

UNH Today Archive

No abstract provided.

Tackling The Challenge, Keith Testa

UNH Today Archive

No abstract provided.

Introduction, Li Chen Sim, Jonathan Fulton

All Works

This chapter sets the stage for the key themes found throughout this volume, first by framing the Gulf regional order within the context of a shift in international order. US signaling of a reduced role in the Gulf is leading policymakers both in the Gulf and beyond to recalibrate their thinking on regional affairs. It then builds upon literature on ‘Asianization’ to explain how and why the issue of Gulf order is increasingly a concern for policymakers in the Asian countries analyzed in this book. Finally, it provides a brief overview of each chapter.

Recurrent Switch 2 Domain Rac2 Mutations In Intravascular Large B-Cell Lymphoma, Rohan Kodgule, Jie Chen, Pooja Khonde, Joshua Robinson, Amy D'Albora, Lisa Cook, Catrina C Fronick, Robert Fulton, Sridhar Nonavinkere Srivatsan, Patrick J Cimino, Eric J Duncavage

2020-Current year OA Pubs

No abstract provided.

Stat3 Gain-Of-Function Mutations Connect Leukemia With Autoimmune Disease By Pathological Nkg2dhi Cd8+ T Cell Dysregulation And Accumulation, Etienne Masle-Farquhar, Megan A Cooper, Tiphanie P Vogel, Et Al.

2020-Current year OA Pubs

The association between cancer and autoimmune disease is unexplained, exemplified by T cell large granular lymphocytic leukemia (T-LGL) where gain-of-function (GOF) somatic STAT3 mutations correlate with co-existing autoimmunity. To investigate whether these mutations are the cause or consequence of CD8

Rapid Astrocyte-Dependent Facilitation Amplifies Multi-Vesicular Release In Hippocampal Synapse, Jongyun Myeong, Vitaly A Klyachko

2020-Current year OA Pubs

Synaptic facilitation is a major form of short-term plasticity typically driven by an increase in residual presynaptic calcium. Using near-total internal reflection fluorescence (near-TIRF) imaging of single vesicle release in cultured hippocampal synapses, we demonstrate a distinctive, release-dependent form of facilitation in which probability of vesicle release is higher following a successful glutamate release event than following a failure. This phenomenon has an onset of ≤500 ms and lasts several seconds, resulting in clusters of successful release events. The release-dependent facilitation requires neuronal contact with astrocytes and astrocytic glutamate uptake by EAAT1. It is not observed in neurons grown alone …

Use Of An Interactive Obesity Treatment Approach In Individuals With Severe Mental Illness: Feasibility, Acceptability, And Proposed Engagement Criteria, Ginger Nicol, Madeline Jansen, Rita Haddad, Amanda Ricchio, Michael D Yingling, Julia A Schweiger, Katie Keenoy, Bradley A Evanoff, John W Newcomer

2020-Current year OA Pubs

BACKGROUND: Digital and mobile health interventions are increasingly being used to support healthy lifestyle change, including in certain high-risk populations such as those with severe mental illnesses (SMIs). Life expectancy in this population lags 15 years behind counterparts in the general population, primarily due to obesity-related health conditions.

OBJECTIVE: We tested the feasibility and usability of a 12-week interactive obesity treatment approach (iOTA) to adults with chronic SMIs (depression, bipolar disorder and schizophrenia spectrum disorder) receiving treatment in community settings. The iOTA incorporates short message service (SMS) text messages to supplement monthly in-person health coaching.

METHODS: Factors hypothesized to be …

Topics And Sentiment Surrounding Vaping On Twitter And Reddit During The 2019 E-Cigarette And Vaping Use-Associated Lung Injury Outbreak: Comparative Study, Dezhi Wu, Erin Kasson, Avineet Kumar Singh, Yang Ren, Nina Kaiser, Ming Huang, Patricia A Cavazos-Rehg

2020-Current year OA Pubs

BACKGROUND: Vaping or e-cigarette use has become dramatically more popular in the United States in recent years. e-Cigarette and vaping use-associated lung injury (EVALI) cases caused an increase in hospitalizations and deaths in 2019, and many instances were later linked to unregulated products. Previous literature has leveraged social media data for surveillance of health topics. Individuals are willing to share mental health experiences and other personal stories on social media platforms where they feel a sense of community, reduced stigma, and empowerment.

OBJECTIVE: This study aimed to compare vaping-related content on 2 popular social media platforms (ie, Twitter and Reddit) …

Condensates Formed By Prion-Like Low-Complexity Domains Have Small-World Network Structures And Interfaces Defined By Expanded Conformations, Mina Farag, Samuel R Cohen, Wade M Borcherds, Anne Bremer, Tanja Mittag, Rohit V Pappu

2020-Current year OA Pubs

Biomolecular condensates form via coupled associative and segregative phase transitions of multivalent associative macromolecules. Phase separation coupled to percolation is one example of such transitions. Here, we characterize molecular and mesoscale structural descriptions of condensates formed by intrinsically disordered prion-like low complexity domains (PLCDs). These systems conform to sticker-and-spacers architectures. Stickers are cohesive motifs that drive associative interactions through reversible crosslinking and spacers affect the cooperativity of crosslinking and overall macromolecular solubility. Our computations reproduce experimentally measured sequence-specific phase behaviors of PLCDs. Within simulated condensates, networks of reversible inter-sticker crosslinks organize PLCDs into small-world topologies. The overall dimensions of PLCDs …

Tissue Registration And Exploration User Interfaces In Support Of A Human Reference Atlas, Katy Börner, Andreas Bueckle, Bruce W Herr 2nd, Leonard E Cross, Ellen M Quardokus, Elizabeth G Record, Yingnan Ju, Jonathan C Silverstein, Kristen M Browne, Sanjay Jain, Clive H Wasserfall, Marda L Jorgensen, Jeffrey M Spraggins, N Heath Patterson, Griffin M Weber

2020-Current year OA Pubs

Seventeen international consortia are collaborating on a human reference atlas (HRA), a comprehensive, high-resolution, three-dimensional atlas of all the cells in the healthy human body. Laboratories around the world are collecting tissue specimens from donors varying in sex, age, ethnicity, and body mass index. However, harmonizing tissue data across 25 organs and more than 15 bulk and spatial single-cell assay types poses challenges. Here, we present software tools and user interfaces developed to spatially and semantically annotate ("register") and explore the tissue data and the evolving HRA. A key part of these tools is a common coordinate framework, providing standard …

Hospitality Students Win Savannah Tlc Scholarships, Georgia Southern University

College of Business: News & Publications

• Hospitality Students Win Savannah TLC Scholarships

Comparison Between Supervised And Unsupervised Learning For Autonomous Delamination Detection Using Impact Echo, Faezeh Jafari, Sattar Dorafshan

Civil Engineering Faculty Publications

Impact echo (IE) is a non-destructive evaluation method commonly used to detect subsurface delamination in reinforced concrete bridge decks. Existing analysis methods are based on frequency domain which can lead to inaccurate assessments of reinforced concrete bridge decks since they do not consider features of the IE signals in the time domain. The authors propose a new method for IE classification by combining features in the time and the frequency domains. The features used in this study included normalized peak values, energy, power, time of peaks, and signal lengths that were extracted from IE signals after they are preprocessed. We …

Gata1 Controls Numbers Of Hematopoietic Progenitors And Their Response To Autoimmune Neuroinflammation, Daniel Hwang, Larissa Ishikawa, Maryam S. Seyedsadr, Elisabeth R. Mari, Ezgi Kasimoglu, Ziver Sahin, Alexandra Boehm, Soohwa Jang, Javad Rasouli, Courtney Vaccaro, Michael Gonzalez, Hakon Hakonarson, Mohamad Rostami, Guang-Xian Zhang, Bogoljub Ciric

Department of Neurology Faculty Papers

GATA-binding factor 1 (GATA1) is a transcription factor that governs the development and function of multiple hematopoietic cell lineages. GATA1 is expressed in hematopoietic stem and progenitor cells (HSPCs) and is essential for erythroid lineage commitment; however, whether it plays a role in hematopoietic stem cell (HSC) biology and the development of myeloid cells, and what that role might be, remains unclear. We initially set out to test the role of eosinophils in experimental autoimmune encephalomyelitis (EAE), a model of central nervous system autoimmunity, using mice lacking a double GATA-site (ΔdblGATA), which lacks eosinophils due to the deletion of the …

Short Song Lyrics (Xiaoling) In The Song Dynasty : “I’Ve No Heart To Love Another” : A Pair Of Anonymous Poems In Dialog, Maija Samei

How to Read Chinese Poetry Podcast

This episode introduces us to the genre of the song lyric using two anonymous poems that present a male and female speaker in dialog. The episode discusses the origins of the genre during the Tang dynasty, its formal characteristics, and its connection to female voice and feminine themes.

Pum1 Mediates The Posttranscriptional Regulation Of Human Fetal Hemoglobin, Yuncheng Man, Amma Owusu-Ansah, Omar Y. Mian, Umut A. Gurkan, Anton A. Komar, Merlin Nithya Gnanapragasam

Faculty Scholarship

The fetal-to-adult hemoglobin switching at about the time of birth involves a shift in expression from γ-globin to β-globin in erythroid cells. Effective re-expression of fetal γ-globin can ameliorate sickle cell anemia and β-thalassemia. Despite the physiological and clinical relevance of this switch, its posttranscriptional regulation is poorly understood. Here, we identify Pumilo 1 (PUM1), an RNA-binding protein with no previously reported functions in erythropoiesis, as a direct posttranscriptional regulator of β-globin switching. PUM1, whose expression is regulated by the erythroid master transcription factor erythroid Krüppel-like factor (EKLF/KLF1), peaks during erythroid differentiation, binds γ-globin messenger RNA (mRNA), and reduces γ-globin …

Parametric Structural Optimization Of A Wheel Using The Flex Representation Method, Gregory John Vernon

Theses and Dissertations

The use of the finite element method within an optimization workflow is fraught with challenges that limit the automation of such workflows. These challenges are inherent to the traditional finite element formulations which are heavily dependent on a manual meshing process that introduces variability that is challenging to account for within an automated workflow. The recently developed flex representation method (FRM) provides a salient solution to the manual meshing process without sacrificing solution accuracy. In response to the development of FRM a global automotive company requested a study to explore the applicability of FRM to one of their sizing-optimization problems: …

Biofilm Characterization And The Potential Role Of Edna In Horizontal Gene Transfer In Hospital And Meat Isolates Of Staphylococcus Aureus And Their Biofilms, Ashley Lynne Ball

Theses and Dissertations

Staphylococcus aureus is a pathogen responsible for a wide variety of life-threatening diseases such as bacteremia, endocarditis, and pneumoniae. S. aureus has been a major concern in recent years due to the rampant spread of antibiotic resistance. The ability of S. aureus to form biofilms aids in the spread of antibiotic resistance as biofilms are a known hotspot for horizontal gene transfer. Biofilms also protect cells from host immune responses and antibiotics, making these infections very difficult to treat. The matrix of S. aureus biofilms can be made of polysaccharides, protein, and DNA. In these studies, we sought to elucidate …

Methemoglobin Formation Via Nitric Oxide And Comparison Of Methemoglobin, Deoxyhemoglobin, And Ferrous Nitrosyl Hemoglobin As Potential Mri Contrast Agents, Roya Ayati

Theses and Dissertations

Gadolinium-based contrast agents (GBCAs) are in widespread use to enhance magnetic resonance angiography images for evaluating vascular pathology. However, there are safety concerns and limitations regarding the use of GBCAs. It has been shown that the magnetic resonance imaging (MRI) signal intensity (T1-weighted images) in some of the brain's tissues is higher for patients who had multiple exposures to GBCAs compared to patients who had never had exposure to GBCAs. This implies that GBCAs are not sufficiently removed from body such that GBCAs may potentially have long-term effects on the human body. These potential safety concerns have led to an …

Evaluating Equitable Access To Nutrition In Utah, Emma Stucki

Theses and Dissertations

One of the more recent topics in transportation policy making and project prioritization in DOT's across the United States is how to improve quality of life. This quality of life focus is an intersection of public health and transportation and has many different branches including traffic safety, pollution, active transportation, equity, and accessibility to resources. The topic among these that seems to receive the least attention is equitable access to resources. However, with the proven impact that equitable access to resources has on physical and emotional well-being, as well as economic opportunity it is important to ensure that all populations, …

Shimunov V. Carias

All Decisions

ERAP Case.

Side-Channel Attacks And Countermeasures For The Mk-3 Authenticated Encryption Scheme, Peter Fabinski

Theses

In the field of cryptography, the focus is often placed on security in a mathematical or information-theoretic sense; for example, cipher security is typically evaluated by the difficulty of deducing the plaintext from the ciphertext without knowledge of the key. However, once these cryptographic schemes are implemented in electronic devices, another class of attack presents itself. Side-channel attacks take advantage of the side effects of performing a computation, such as power consumption or electromagnetic emissions, to extract information outside of normal means. In particular, these side-channels can reveal parts of the internal state of a computation. This is important because …

Sugar Freed, Sarah Gaygen

Theses

Sugar Freed is a 2D digitally animated short film about a little girl named Molly, who gets fed up with her mother, a dentist, and ends up in a candy world ruled by evil gummy bears. Sugar Freed’s message evolved over time from a simple warning against sugar, to a child gaining an understanding of why her mother’s lessons are necessary, stemming from parts of my own childhood. The purpose of this film was to see if I could find the right balance between time management and quality control to produce an animated short that was well over four-minutes long, …

Effect Of Plasma Treatment On Soil Degradation Of A Biodegradable Mulch Film, Swapnil Bhattacharya

Theses

Biodegradable Mulch Films (BMFs) offer a sustainable alternative to traditional non-degradable PE mulch films. However, their slow rate of biodegradation can lead to plastics accumulation in the soil. In this study, a commercially available BMF based on polybutylene adipate co-terephthalate (PBAT) and polylactic acid (PLA) is examined. Here the effects of gliding arc plasma treatment on the bulk and surface properties, as well as its soil degradation behavior, is studied. An increase in surface oxygen containing species and hydrophilicity was observed following plasma treatment. Only a small hydrophobic recovery was noted over 30 days. No changes in the bulk polymer …

A Program Evaluation Of The Project Roomkey In Santa Clara, San Francisco, And Alameda Counties, Louella Sevegan

Master's Projects

During the early months of 2020, the rapid spread of SARS-CoV-2 (COVID-19) had a significant impact on the homeless population. The U.S. Department of Housing and Urban Development, Office of Community Planning and Development defines a homeless person as someone who "lacks a fixed, regular, and adequate nighttime residence" (Henry, et al., 2020, page 2). According to a report conducted by Culhane et al. (2020), the homeless population has a higher chance of being infected by COVID-19 than the general population. Issues such as inadequate access to sanitation or proper hygiene, and the inability to isolate, especially in a congregate …

Department Of Safety And Homeland Security, December 2022, Tennessee. Comptroller Of The Treasury.

Performance Audit Reports

No abstract provided.

Department Of Children's Services, December 2022, Tennessee. Comptroller Of The Treasury.

Performance Audit Reports

No abstract provided.

Computer Clinical Decision Support That Automates Personalized Clinical Care: A Challenging But Needed Healthcare Delivery Strategy, Alan H Morris, Christopher Horvat, Brian Stagg, David W Grainger, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank O Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Mary Suchyta, James E Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R Duncan Hiten, Douglas F Willson, Jerry J Zimmerman, Vinay Nadkarni, Adrienne G Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang Hoe Lee, Bennett P Deboisblanc, Frederick Alan Moore, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, Willard H Dere, Alan Crandall, Julio Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Brian W Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Michael R Pinsky, Brent James, Donald M Berwick

Faculty, Staff and Student Publications

How to deliver best care in various clinical settings remains a vexing problem. All pertinent healthcare-related questions have not, cannot, and will not be addressable with costly time- and resource-consuming controlled clinical trials. At present, evidence-based guidelines can address only a small fraction of the types of care that clinicians deliver. Furthermore, underserved areas rarely can access state-of-the-art evidence-based guidelines in real-time, and often lack the wherewithal to implement advanced guidelines. Care providers in such settings frequently do not have sufficient training to undertake advanced guideline implementation. Nevertheless, in advanced modern healthcare delivery environments, use of eActions (validated clinical decision …

Hypermethylation Of Nc886 In Hpv-Positive Oropharyngeal Cancer And Its Clinical Implications: An Epigenome-Wide Association Study, Yifan Xu, Ziqiao Wang, Peng Wei, Richa Gairola, Karl T Kelsey, Andrew G Sikora, Guojun Li, Jian Gu

Faculty, Staff and Student Publications

The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased rapidly in the United States, driven by rising human papillomavirus (HPV) infections in the U.S. population. HPV-positive OPSCC patients have a better prognosis than HPV-negative patients. To gain insights into the unique biology of HPV(+) OPSCC that may contribute to its clinical behaviors, we performed a multi-stage epigenome-wide methylation profiling of leukocyte and tumor DNA in OPSCC patients and compared the methylation levels of CpG sites between HPV(+) and HPV(-) OPSCC patients. We identified and validated a significantly differentially methylated region (DMR) of 1,355 bp encompassing non-coding RNA 886 ( …

Association Of Fabry Disease With Hearing Loss, Tinnitus, And Sudden Hearing Loss: A Nationwide Population-Based Study, Yen-Fu Cheng, Sudha Xirasagar Mbbs., Ph.D., Chin-Shyan Chen, Dau-Ming Niu, Herng-Ching Lin

Publications

Hearing loss and the related otologic manifestations are receiving increased scrutiny as significant causes of morbidity in Fabry disease. However, the relative risks of auditory deficits among patients with Fabry disease relative to the general population without a diagnosis of Fabry disease have not been studied. This study aims to explore the associations between Fabry disease and hearing-related manifestations using a nationwide population-based dataset. We identified study patients for this cross-sectional study from the 2015−2017 claims databases of the Taiwan Longitudinal Health Insurance Database 2005. We first identified 2312 patients aged over 20 years with a diagnosis of Fabry disease. …

The Dangers Of Nyc Non-Union Construction Work, Laura T. Bratton

Capstones

Just last week, two construction workers were killed in the span of a few days on sites in the Bronx and Brooklyn.

According to data from the Laborers International Union of North America, there were 19 construction worker deaths in New York City this year - bringing the catastrophic number back up to its pre-pandemic levels.

New York State’s Department of Labor finds that at least 15 of this year’s deaths occurred on non-union sites. According to a recent report by the New York Committee on Occupational Safety and Health (NYCOSH), construction workers made up 19% of worker deaths but …

---

Go to article