Digital Commons Network^™

Population-Based Screening Of Newborns: Findings From The Nbs Expansion Study (Part One), Amy Brower, Michael Watson, Et Al

2020-Current year OA Pubs

Each year, through population-based newborn screening (NBS), 1 in 294 newborns is identified with a condition leading to early treatment and, in some cases, life-saving interventions. Rapid advancements in genomic technologies to screen, diagnose, and treat newborns promise to significantly expand the number of diseases and individuals impacted by NBS. However, expansion of NBS occurs slowly in the United States (US) and almost always occurs condition by condition and state by state with the goal of screening for all conditions on a federally recommended uniform panel. The Newborn Screening Translational Research Network (NBSTRN) conducted the NBS Expansion Study to describe …

It's About The Patients: Practical Antibiotic Stewardship In Outpatient Settings In The United States, Alpesh N Amin, E Patchen Dellinger, Glenn Harnett, Bryan D Kraft, Kerry L Laplante, Frank Lovecchio, James A Mckinnell, Glenn Tillotson, Salisia Valentine

2020-Current year OA Pubs

Antibiotic-resistant pathogens cause over 35,000 preventable deaths in the United States every year, and multiple strategies could decrease morbidity and mortality. As antibiotic stewardship requirements are being deployed for the outpatient setting, community providers are facing systematic challenges in implementing stewardship programs. Given that the vast majority of antibiotics are prescribed in the outpatient setting, there are endless opportunities to make a smart and informed choice when prescribing and to move the needle on antibiotic stewardship. Antibiotic stewardship in the community, or "smart prescribing" as we suggest, should factor in antibiotic efficacy, safety, local resistance rates, and overall cost, in …

A Recombinant Murine-Like Rotavirus With Nano-Luciferase Expression Reveals Tissue Tropism, Replication Dynamics, And Virus Transmission, Yinxing Zhu, Liliana Sánchez-Tacuba, Gaopeng Hou, Takahiro Kawagishi, Ningguo Feng, Harry B Greenberg, Siyuan Ding

2020-Current year OA Pubs

Rotaviruses (RVs) are one of the main causes of severe gastroenteritis, diarrhea, and death in children and young animals. While suckling mice prove to be highly useful small animal models of RV infection and pathogenesis, direct visualization tools are lacking to track the temporal dynamics of RV replication and transmissibility

Bsl2-Compliant Lethal Mouse Model Of Sars-Cov-2 And Variants Of Concern To Evaluate Therapeutics Targeting The Spike Protein, Mohanraj Manangeeswaran, Derek D C Ireland, Seth G Thacker, Ha-Na Lee, Logan Kelley-Baker, Aaron P Lewkowicz, Paul W Rothlauf, Marjorie Cornejo Pontelli, Louis-Marie Bloyet, Michael A Eckhaus, Mirian I Mendoza, Sean Whelan, Daniela Verthelyi

2020-Current year OA Pubs

Since first reported in 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is rapidly acquiring mutations, particularly in the spike protein, that can modulate pathogenicity, transmission and antibody evasion leading to successive waves of COVID19 infections despite an unprecedented mass vaccination necessitating continuous adaptation of therapeutics. Small animal models can facilitate understanding host-pathogen interactions, target selection for therapeutic drugs, and vaccine development, but availability and cost of studies in BSL3 facilities hinder progress. To generate a BSL2-compatible

At-Home Blood Collection And Stabilization In High Temperature Climates Using Home Rna, Lauren G Brown, Amanda J Haack, Dakota S Kennedy, Karen N Adams, Jennifer E Stolarczuk, Meg G Takezawa, Erwin Berthier, Sanitta Thongpang, Fang Yun Lim, Damien Chaussabel, Mathieu Garand, Ashleigh B Theberge

2020-Current year OA Pubs

Expanding whole blood sample collection for transcriptome analysis beyond traditional phlebotomy clinics will open new frontiers for remote immune research and telemedicine. Determining the stability of RNA in blood samples exposed to high ambient temperatures (>30°C) is necessary for deploying home-sampling in settings with elevated temperatures (e.g., studying physiological response to natural disasters that occur in warm locations or in the summer). Recently, we have developed

Patient Clinical Documentation In Telehealth Environment: Are We Collecting Appropriate And Sufficient Information For Best Practice?, Shannon H. Houser, Cathy A. Flite, Susan L. Foster, Thomas J. Hunt, Angela Morey, Miland N. Palmer, Jennifer Peterson, Roberta Damez Pope, Linda Sorensen

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, the use of telehealth for patient visits grew rapidly and served an important role as a valuable and necessary resource. Although clinical documentation is critical for telehealth patient visits, there is limited information about how healthcare facilities manage telehealth patient visit documentation, technology used for telehealth visits, and challenges encountered with telehealth patient visit documentation. This study aimed to assess the use of telehealth during the pandemic, the quality of clinical documentation in telehealth practice and to identify challenges and issues encountered with telehealth patient visits in order to develop a strategy for best practices …

Expression Variation Of Ogg1 And Hprt Gene And Dna Damage In Arsenic Exposed Industrial Workers, Zertashia Akram, Ishrat Mahjabeen, Muhammad Umair, Muhammad Fahim, Mahmood Akhter Kayani, Lulu Fatima, Malik Waqar Ahmad, Sarwat Jahan, Tayyaba Afsar, Ali Almajwal, Nawaf W. Alruwaili, Iftikhar Ali Khawar, Suhail Razak

2020-Current year OA Pubs

Arsenic exposure alters redox balance, induces DNA damage, and deregulates many genes. OGG1 gene involved in base repair mechanism, for excision of 8-oxoguanine (8-oxoG) from DNA formed as a result of accumulation of ROS in cell. HPRT gene encode transferase enzymes involved in purine recycling mechanism. The main focus of the study was to evaluate the expression variation in HPRT, OGG1 gene expression, and DNA damage of industrial workers. Blood samples of 300 occupational workers were collected from welding, brick kiln, furniture, pesticide, and paint industry (n = 60/industry) to evaluate the expression variation in HPRT, OGG1 gene expression, and …

Chronic Neuropsychiatric Sequelae Of Sars-Cov-2: Protocol And Methods From The Alzheimer's Association Global Consortium, Gabriel A De Erausquin, Carlos Cruchaga, Igor Zwir, Et Al

2020-Current year OA Pubs

Introduction: Coronavirus disease 2019 (COVID-19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID-19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID-19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity …

Tourette Syndrome Research Highlights From 2021, Andreas Hartmann, Per Andrén, Cyril Atkinson-Clement, Virginie Czernecki, Cécile Delorme, Nanette Marinette Debes, Natalia Szejko, Keisuke Ueda, Kevin J. Black

2020-Current year OA Pubs

We summarize selected research reports from 2021 relevant to Tourette syndrome that the authors consider most important or interesting. The authors welcome article suggestions and thoughtful feedback from readers.

Investing In Late-Life Brain Capital, Walter D Dawson, Eric J Lenze, Et Al.

2020-Current year OA Pubs

Within many societies and cultures around the world, older adults are too often undervalued and underappreciated. This exacerbates many key challenges that older adults may face. It also undermines the many positive aspects of late life that are of tremendous value at both an individual and societal level. We propose a new approach to elevate health and well-being in late life by optimizing late-life Brain Capital. This form of capital prioritizes brain skills and brain health in a brain economy, which the challenges and opportunities of the 21st-century demands. This approach incorporates investing in late-life Brain Capital, developing initiatives focused …

Plasma Neurofilament Light Chain Levels Are Elevated In Children And Young Adults With Wolfram Syndrome, Sarah A Eisenstein, Raveena S Boodram, Courtney L Sutphen, Heather M Lugar, Brian A Gordon, Bess A Marshall, Fumihiko Urano, Anne M Fagan, Tamara Hershey

2020-Current year OA Pubs

Wolfram syndrome is a rare disease caused by pathogenic variants in the

Association Between Recent Overdose And Chronic Pain Among Individuals In Treatment For Opioid Use Disorder, Sarah M. Hartz, Robert C. Culverhouse, Carrie M. Mintz, Matthew S. Ellis, Zachary A. Kasper, Patricia Cavazos-Rehg, Richard A. Grucza, Laura J. Bierut, Theodore J. Cicero

2020-Current year OA Pubs

Chronic pain increases risk for opioid overdose among individuals with opioid use disorder. The purpose of this study is to evaluate the relationship between recent overdose and whether or not chronic pain is active. 3,577 individuals in treatment for opioid use disorder in 2017 or 2018 were surveyed regarding recent overdoses and chronic pain. Demographics from the 2017 Treatment Episode Data Set, which includes all U.S. facilities licensed or certified to provide substance use care, were used to evaluate the generalizability of the sample. χ2 tests and logistic regression models were used to compare associations between recent overdoses and chronic …

ข้อสังเกตทางกฎหมายว่าด้วยการใช้ซอฟต์แวร์ปิดกั้นโฆษณา, ณัฐปคัลภ์ จวติช

Chulalongkorn University Theses and Dissertations (Chula ETD)

เอกัตศึกษานี้มุ่งศึกษาประเด็นทางกฎหมายต่าง ๆ ที่เกี่ยวข้องกับการใช้ซอฟต์แวร์ปิดกั้นโฆษณาผ่านมุมมองของผู้มีส่วนได้เสียต่าง ๆ ในระบบกฎหมายต่างประเทศ ได้แก่ 1. ประเด็นสิทธิทางรัฐธรรมนูญ 2. ประเด็นกฎหมายการแข่งทางการค้าและการกระทำอันไม่เป็นธรรมทางการค้า 3. ประเด็นด้านกฎหมายลิขสิทธิ์ และ 4. ประเด็นด้านกฎหมายละเมิด เพื่อที่จะนำมาศึกษาเปรียบเทียบการปรับใช้กับระบบกฎหมายไทย จากกรณีศึกษาต่าง ๆ ที่เกิดขึ้นในระบบกฎหมายต่างประเทศได้แก่ กฎหมายสารบัญญัติและคำพิพากษาของศาลสามารถจำแนกการคุ้มครองผู้มีส่วนได้เสียเป็นสองฝ่ายคือ ฝ่ายที่หนึ่ง มุ่งคุ้มครองผู้บริโภค ได้แก่ประเทศสหรัฐอเมริกาซึ่งมีรัฐบัญญัติ Communications Decency Act (47 U.S.C. § 230) กำหนดความคุ้มกันความรับผิดทางแพ่งให้แก่ผู้พัฒนาหรือผู้ใช้งานซึ่งใช้เครื่องมือทางเทคนิคในการปิดกั้นสิ่งที่เห็นว่าไม่พึงประสงค์ ในขณะที่สหพันธ์สาธารณรัฐเยอรมนี แม้ไม่ได้มีกฎหมายสารบัญญัติที่เกี่ยวข้องโดยตรง แต่ก็ปรากฏว่าศาลสูงสุดแห่งสหพันธ์ฯ ได้ปรับใช้สิทธิทางรัฐธรรมนูญมามีผลกระทบต่อกฎหมายเอกชนโดยอ้อมและชั่งน้ำหนักระหว่างประโยชน์ของมหาชนและประโยชน์ของเอกชน ดังนั้น แม้ศาลจะยอมรับว่ารูปแบบการทำธุรกิจของผู้พัฒนาซอฟต์แวร์ปิดกั้นโฆษณาจะส่งผลกระทบในทางลบต่อรายได้ของผู้ประกอบธุรกิจสื่อสิ่งพิมพ์ออนไลน์ก็ตาม แต่เสรีภาพในเสพสื่อของผู้บริโภคย่อมมีน้ำหนักมากกว่าประกอบกับเป็นการส่งเสริมการแข่งขันในตลาดโฆษณาออนไลน์และลักษณะการทำงานของซอฟต์แวร์ฯ ไม่ได้เป็นการเข้าไปทำซ้ำหรือดัดแปลงชุดคำสั่งบนเว็บไซต์จึงไม่เป็นการกระทำละเมิดลิขสิทธิ์ ในขณะที่ฝ่ายที่สอง มุ่งคุ้มครองผู้ประกอบธุรกิจ ได้แก่ สาธารณรัฐประชาชนจีนซึ่งแม้ไม่ได้มีกฎหมายสารบัญญัติที่เกี่ยวข้องเช่นเดียวกัน แต่ศาลได้วินิจฉัยแตกต่างออกไปว่าลักษณะการทำงานของซอฟต์แวร์ปิดกั้นโฆษณาเป็นการขัดต่อจริยธรรมทางธุรกิจและส่งผลกระทบต่อโครงสร้างตลาดของผู้ประกอบธุรกิจซึ่งต้องพึ่งพารายได้จากการโฆษณา เพื่อที่จะให้เกิดความชัดเจนกับความชอบด้วยกฎหมายของการใช้ซอฟต์แวร์ปิดกั้นโฆษณาในระบบกฎหมายไทย ผู้เขียนจึงเสนอแนะว่า 1. ควรที่จะเลือกใช้แนวทางของฝ่ายที่หนึ่ง โดยสำนักงานคณะกรรมการการแข่งขันทางการค้าอาจเลือกที่จะออกประกาศโดยการกำหนดเงื่อนไขต่าง ๆ แก่ผู้พัฒนาซอฟต์แวร์ปิดกั้นโฆษณา 2. บัญญัติให้การทำซ้ำหรือดัดแปลงแก้ไขชุดคำสั่งซึ่งเกิดขึ้นในหน่วยความจำชั่วคราวของคอมพิวเตอร์ไม่ถือว่าเป็นการกระทำละเมิดลิขสิทธิ์ในงานโปรแกรมคอมพิวเตอร์

Clinical Evaluation Of Bioactive Resin Based Pits & Fissures Sealants Versus Conventional Resin Based Pits & Fissures Sealants In Caries Susceptible Fissures In Permanent Molars: A Randomized Controlled Study, Mohamed Fouad Haridy, Alaa Abdelsalam, Heba Hamza, Mohamed Riad, Omar Shalan

Dentistry

No abstract provided.

Fracture Resistance Of Root Canal-Treated Molars Restored With Ceramic Overlays With/Without Different Resin Composite Base Materials: An In Vitro Study, Hend Sayed Ahmed, Mohamed Fouad Haridy, Shehabeldin Saber, Mohamed Kataia, Edger Schafer

Dentistry

No abstract provided.

Influence Of Different Combinations Of Cad-Cam Crown And Customized Abutment Materials On The Force Absorption Capacity In Implant Supported Restorations – In Vitro Study, Ahmed Sabet

Dentistry

Objectives: To evaluate the force absorption capacity of implant supported restorations utilizing different CAD-CAM materials for the fabrication of crowns and customized abutments. Methods: 80 titanium inserts were scanned to design customized abutments and crowns. The specimens were divided into four groups (n = 20/material): (Z): zirconia, (P): PEEK, (V): VITA Enamic, and (E): IPS e.max. Each group was subdivided into two subgroups according to customized abutment material: (Z) zirconia, and (P) for PEEK. For the assessment of force absorption, all specimens were loaded in a universal testing machine, applied loads curves were collected from the machine’s software, and resulting …

Cbct Evaluation Of Modified Mini-Implant Aided Trans-Palatal Arch On Maxillary Molar Distalization, Islam Tarek Abbas Hassan Ahmed Prof, Islam Ghorab, Hatem Saifeldin

Dentistry

No abstract provided.

Deep Profiling Of Multiple Ischemic Lesions In A Large, Multi-Center Cohort: Frequency, Spatial Distribution, And Associations To Clinical Characteristics, Anna K Bonkhoff, Laura Heitsch, Chia-Ling Phuah, Et Al.

2020-Current year OA Pubs

BACKGROUND PURPOSE: A substantial number of patients with acute ischemic stroke (AIS) experience multiple acute lesions (MAL). We here aimed to scrutinize MAL in a large radiologically deep-phenotyped cohort.

MATERIALS AND METHODS: Analyses relied upon imaging and clinical data from the international MRI-GENIE study. Imaging data comprised both Fluid-attenuated inversion recovery (FLAIR) for white matter hyperintensity (WMH) burden estimation and diffusion-weighted imaging (DWI) sequences for the assessment of acute stroke lesions. The initial step featured the systematic evaluation of occurrences of MAL within one and several vascular supply territories. Associations between MAL and important imaging and clinical characteristics were subsequently …

Enhancing Neuroimaging Genetics Through Meta-Analysis For Tourette Syndrome (Enigma-Ts): A Worldwide Platform For Collaboration, Peristera Paschou, Emily D Bihun, Tamara Hershey, Jonathan M Koller, Kevin J. Black, Et Al.

2020-Current year OA Pubs

Tourette syndrome (TS) is characterized by multiple motor and vocal tics, and high-comorbidity rates with other neuropsychiatric disorders. Obsessive compulsive disorder (OCD), attention deficit hyperactivity disorder (ADHD), autism spectrum disorders (ASDs), major depressive disorder (MDD), and anxiety disorders (AXDs) are among the most prevalent TS comorbidities. To date, studies on TS brain structure and function have been limited in size with efforts mostly fragmented. This leads to low-statistical power, discordant results due to differences in approaches, and hinders the ability to stratify patients according to clinical parameters and investigate comorbidity patterns. Here, we present the scientific premise, perspectives, and key …

The Most Suitable Types Of Obturator For Stomatognathic System Rehabilitation After Maxillofacial Surgery: A Systematic Review, Riezky Rhamdani, Irfan Dammar

Journal of Dentomaxillofacial Science

No abstract provided.

Second Molar Scissor Bite Correction In Class Ii Malocclusion Using Miniscrew And Cross-Elastic, Citra L. Yuwono, Retno Widayati

Journal of Dentomaxillofacial Science

No abstract provided.

Correlation Of Depression, Anxiety And Stress Symptoms With Xerostomia Symptoms Among Medical And Dentistry Students In Pre-Clinical And Clinical Phase, Qushay U. Malinta, Anandha W. Yustika, Rasmidar Samad

Journal of Dentomaxillofacial Science

No abstract provided.

The Relationship Between Malocclusion, Bruxism, Clicking Sound And Hypertonus Of Masseter Muscle In Austism Spectrum Disorders, Lisda Damayanti, Calvin Atherton, Erna Kurnikasari, Inne S. Sasmita

Journal of Dentomaxillofacial Science

No abstract provided.

Periodontitis Correlated With Increased Esr And Platelet Counts In Indonesians With Type 2 Diabetes Mellitus, Hendri Susanto, Frank Abbas

Journal of Dentomaxillofacial Science

No abstract provided.

The Effect Of Administration Of Siamese Catfish (Pangasius Hypophthalmus) Extract On Fibroblast Cells After Tooth Extraction In Wistar Rats, Veny Larasati, Trisnawaty, Angelina N. Ricardo

Journal of Dentomaxillofacial Science

No abstract provided.

Antibacterial Activity Of Bangle Rhizome Essential Oil (Zingiber Montanum) Against Streptococcus Mutans, Devina Rs. Pardosi, Cicih B. Purnamasari, Swandari Paramita, Lilies A. Astuti, Masyhudi, Enos T. Arung

Journal of Dentomaxillofacial Science

No abstract provided.

Bioactive Potential Of Edel Cocoa Bean (Theobroma Cacao L) From Kedaton Jember: Cytotoxicity And Antioxidants Evaluation, Rina Sutjiati, Leliana S. Devi, Dwi Prijatmoko, Herniyati, Rudy Joealijanto, Erna Sulistyani, Bilqis P. Safitri, Nihla Fitriyani

Journal of Dentomaxillofacial Science

No abstract provided.

Socio-Demographic Relationship With The Prevalence Of Dental Caries And Fissure Sealants In Pediatric Patients At The Dental Hospital Department Of Pediatric Dentistry Baiturrahmah University, Sri P. Utami, Niatul Umami

Journal of Dentomaxillofacial Science

No abstract provided.

Antibacterial Effectivity Of Coffee Bean Extract And Instant Coffee (Spray Drying) Against Porphyromonas Gingivalis, Tantin Ermawati, Nazilaturrohmah, Achmad Gunadi, Dessy Rachmawaty

Journal of Dentomaxillofacial Science

No abstract provided.

Idiopathic Osteosclerosis Of The Jaws On Panoramic Radiograpic Analysis In Indonesian Sub-Population, Irfan Sugianto, Barunawaty Yunus, Fadhlil Ua. Rahman, Muliaty Yunus, Dwi P. Wulansari, Muhammad F. Hidayat

Journal of Dentomaxillofacial Science

No abstract provided.