Digital Commons Network^™

A Nation That Rebuilds Its Soils Rebuild Itself- An Engineer's Perspective, Karen L. Johnson, Neil D. Gray, Wendy Stone, Bryce F.J. Kelly, Mark F. Fitzsimons, Cathy Clarke, Lynsay Blake, Stephen Chivasa, Florence Mtambanengwe, Paul Mapfumo, Andy Baker, Sabrina Beckmann, Lena Dominelli, Andrew L. Neal, Tariro Gwandu

School of Geography, Earth and Environmental Sciences

Nations can build and rebuild degraded soils to help address climate change and potentially improve the nutritional content of food if we change policies that allow the addition of safe mineral and organic wastes to soil. We present a framework that facilitates the transition from intensive conventional to more regenerative farming practices by considering soil’s natural cycle. Our paper is presented in three parts. Firstly, we consider that ’soil is living’; just like humans, the soil biome needs a balanced diet of macro and micronutrients as well as a nurturing environment. We simplify the soil science and take a systems …

2022-2023 Nursing Undergraduate Student Handbook, Morehead State University. Nursing Department.

Nursing Department Publications Archive

2022-2023 Undergraduate Student Handbook of the Department of Nursing at Morehead State University.

Associations Between Eight Earth Observation-Derived Climate Variables And Enteropathogen Infection: An Independent Participant Data Meta-Analysis Of Surveillance Studies With Broad Spectrum Nucleic Acid Diagnostics, Josh M. Colston, Benjamin F. Zaithcik, Hamada S. Badr, Eleanor Burnett, Syed Asad Ali, Ajit Rayamajhi, Syed M. Satter, Daniel Eibach, Ralf Krumkamp, M Imran Nisar, Anita K. M. Zaidi, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Diarrheal disease, still a major cause of childhood illness, is caused by numerous, diverse infectious microorganisms, which are differentially sensitive to environmental conditions. Enteropathogen‐specific impacts of climate remain underexplored. Results from 15 studies that diagnosed enteropathogens in 64,788 stool samples from 20,760 children in 19 countries were combined. Infection status for 10 common enteropathogens—adenovirus, astrovirus, norovirus, rotavirus, sapovirus, Campylobacter, ETEC, Shigella, Cryptosporidium and Giardia—was matched by date with hydrometeorological variables from a global Earth observation dataset—precipitation and runoff volume, humidity, soil moisture, solar radiation, air pressure, temperature, and wind speed. Models were fitted for each pathogen, accounting …

Measurement Of The Inclusive And Differential T T¯ Γ Cross Sections In The Dilepton Channel And Effective Field Theory Interpretation In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek

Research Outputs: 2025-Present

The production cross section of a top quark pair in association with a photon is measured in proton-proton collisions in the decay channel with two oppositely charged leptons (e^±μ^∓, e⁺e⁻, or μ⁺μ⁻). The measurement is performed using 138 fb⁻¹ of proton-proton collision data recorded by the CMS experiment at s = 13 TeV during the 2016–2018 data-taking period of the CERN LHC. A fiducial phase space is defined such that photons radiated by initial-state particles, top quarks, or any of their decay products are included. An inclusive …

Analysis Of The Cp Structure Of The Yukawa Coupling Between The Higgs Boson And Τ Leptons In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek, H. Rejeb Sfar

Research Outputs: 2025-Present

The first measurement of the CP structure of the Yukawa coupling between the Higgs boson and τ leptons is presented. The measurement is based on data collected in proton-proton collisions at s = 13 TeV by the CMS detector at the LHC, corresponding to an integrated luminosity of 137 fb⁻¹. The analysis uses the angular correlation between the decay planes of τ leptons produced in Higgs boson decays. The effective mixing angle between CP-even and CP-odd τ Yukawa couplings is found to be −1 ± 19°, compared to an expected value of 0 ± 21° at the 68.3% …

Seasonality Of Children's Height And Weight And Their Contribution To Accelerated Summer Weight Gain, Jennette P Moreno, Salma Musaad, Hafza Dadabhoy, Tom Baranowski, Stephanie J Crowley, Debbe Thompson, Tzuan A Chen, Craig A Johnston

Children’s Nutrition Research Center Staff Publications

No abstract provided.

Practices Of Vitamin D Supplementation Leading To Vitamin D Toxicity: Experience From A Low-Middle Income Country, Siraj Muneer, Imran Siddiqui, Hafsa Majid, Nawazish Zehra, Lena Jafri, Aysha Habib

Department of Pathology and Laboratory Medicine

Introduction: The trend of prescribing VD preparations for nonspecific body aches and self-medication has increased significantly. The importance of vitamin D toxicity (VDT) has been underestimated and under recognized. This study was done to determine the frequency toxicity (>150 ng/ml) in subjects for 25-hydroxyvitamin D (25OHD) and evaluate the vitamin D (VD) supplements used by these subjects.
Methodology: This descriptive cross-sectional study was conducted at the Section of Chemical Pathology, Aga Khan University Hospital Karachi from April 2020 to March 2021. Subjects with 25OHD toxicity were contacted and information related to history of calcium and VD supplementation were collected. …

Search For Supersymmetry In Final States With Two Or Three Soft Leptons And Missing Transverse Momentum In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, M. Spanring, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek, H. Rejeb Sfar

Research Outputs: 2025-Present

A search for supersymmetry in events with two or three low-momentum leptons and missing transverse momentum is performed. The search uses proton-proton collisions at s = 13 TeV collected in the three-year period 2016–2018 by the CMS experiment at the LHC and corresponding to an integrated luminosity of up to 137 fb⁻¹. The data are found to be in agreement with expectations from standard model processes. The results are interpreted in terms of electroweakino and top squark pair production with a small mass difference between the produced supersymmetric particles and the lightest neutralino. For the electroweakino interpretation, two …

Measurements Of The Associated Production Of A W Boson And A Charm Quark In Proton–Proton Collisions At √S=8tev, Cms Collaboration, A. Tumasyan, W. Adam, T. Bergauer, M. Dragicevic, J. Erö, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, T. Madlener, I. Mikulec, F. M. Pitters, N. Rad, J. Schieck, R. Schöfbeck, M. Spanring, S. Templ, W. Waltenberger, C. E. Wulz, M. Zarucki, V. Chekhovsky, A. Litomin, V. Makarenko, J. Suarez Gonzalez, M. R. Darwish, E. A. De Wolf, D. Di Croce, T. Janssen

Research Outputs: 2025-Present

Measurements of the associated production of a W boson and a charm (c) quark in proton–proton collisions at a centre-of-mass energy of 8TeV are reported. The analysis uses a data sample corresponding to a total integrated luminosity of 19.7fb-1 collected by the CMS detector at the LHC. The W bosons are identified through their leptonic decays to an electron or a muon, and a neutrino. Charm quark jets are selected using distinctive signatures of charm hadron decays. The product of the cross section and branching fraction σ(pp → W + c + X) B(W → ℓν) , where ℓ= e …

Inclusive And Differential Cross Section Measurements Of Single Top Quark Production In Association With A Z Boson In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello

Research Outputs: 2025-Present

Inclusive and differential cross sections of single top quark production in association with a Z boson are measured in proton-proton collisions at a center-of-mass energy of 13 TeV with a data sample corresponding to an integrated luminosity of 138 fb⁻¹ recorded by the CMS experiment. Events are selected based on the presence of three leptons, electrons or muons, associated with leptonic Z boson and top quark decays. The measurement yields an inclusive cross section of 87.9−7.3+7.5(stat)−6.0+7.3(syst) fb for a dilepton invariant mass greater than 30 GeV, in agreement with standard model (SM) calculations and represents the most precise determination …

Search For Heavy Resonances Decaying To Zz Or Zw And Axion-Like Particles Mediating Nonresonant Zz Or Zh Production At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek

Research Outputs: 2025-Present

A search has been performed for heavy resonances decaying to ZZ or ZW and for axion-like particles (ALPs) mediating nonresonant ZZ or ZH production, in final states with two charged leptons (ℓ = e, μ) produced by the decay of a Z boson, and two quarks produced by the decay of a Z, W, or Higgs boson H. The analysis is sensitive to resonances with masses in the range 450 to 2000 GeV. Two categories are defined corresponding to the merged or resolved reconstruction of the hadronically decaying boson. The search is based on data collected during 2016–2018 by the …

Search For Higgsinos Decaying To Two Higgs Bosons And Missing Transverse Momentum In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek

Research Outputs: 2025-Present

Results are presented from a search for physics beyond the standard model in proton-proton collisions at s = 13 TeV in channels with two Higgs bosons, each decaying via the process H → bb ¯ , and large missing transverse momentum. The search uses a data sample corresponding to an integrated luminosity of 137 fb⁻¹ collected by the CMS experiment at the CERN LHC. The search is motivated by models of supersymmetry that predict the production of neutralinos, the neutral partners of the electroweak gauge and Higgs bosons. The observed event yields in the signal regions are found to …

Measurement And Qcd Analysis Of Double-Differential Inclusive Jet Cross Sections In Proton-Proton Collisions At √S = 13 Tev, The Cms Collaboration, A. Tumasyan, W. Adam, J. W. Andrejkovic, T. Bergauer, S. Chatterjee, K. Damanakis, M. Dragicevic, A. Escalante Del Valle, R. Frühwirth, M. Jeitler, N. Krammer, L. Lechner, D. Liko, I. Mikulec, P. Paulitsch, F. M. Pitters, J. Schieck, R. Schöfbeck, D. Schwarz, S. Templ, W. Waltenberger, C. E. Wulz, V. Chekhovsky, A. Litomin, V. Makarenko, M. R. Darwish, E. A. De Wolf, T. Janssen, T. Kello, A. Lelek

Research Outputs: 2025-Present

A measurement of the inclusive jet production in proton-proton collisions at the LHC at s = 13 TeV is presented. The double-differential cross sections are measured as a function of the jet transverse momentum p_T and the absolute jet rapidity |y|. The anti-k_T clustering algorithm is used with distance parameter of 0.4 (0.7) in a phase space region with jet p_T from 97 GeV up to 3.1 TeV and |y| < 2.0. Data collected with the CMS detector are used, corresponding to an integrated luminosity of 36.3 fb⁻¹ (33.5 fb⁻¹). The measurement is used in a comprehensive QCD analysis at next-to-next-to-leading order, which results in significant improvement in the accuracy of the …

Impact And Coping Strategies Among Vulnerable Groups: An Urban-Rural Resilience Trajectory Of The Covid-19 Pandemic, Rizki Fillali, Ana Rosidha Tamyis, Sulton Mawardi, Hening Wikan Sawiji

Masyarakat: Jurnal Sosiologi

The COVID-19 pandemic has had profound effects on the livelihoods of vulnerable groups. Previous studies have indicated that vulnerable groups in urban areas suffer more economic impacts than their counterparts in rural areas, largely due to mobility restrictions, social and physical distancing measures, and pre-pandemic vulnerabilities, exacerbating the challenges that urban groups face to survive. This article examines variations in the impacts and coping strategies of vulnerable groups in selected urban and rural areas in Indonesia during the COVID-19 pandemic, and determines how these impacts and coping strategies have shaped the trajectory of community resilience. The article argues that although …

Social And Virtual Segregation: A Study Of Gated Communities In Yogyakarta, Kuskridho Ambardi, Odam Asdi Artosa, Novi Paramita Dewi, Kurniawan Yanto Yuliarso

Masyarakat: Jurnal Sosiologi

The problem of social segregation gains new relevance as digital technology has now become the core of people’s lives and work. Unfortunately, this factor is often neglected in studies of social segregation. Previous studies have only taken note of social and spatial segregation. This study aims to fill a conceptual gap by raising the virtual dimension within socio-spatial segregation. This research finds that virtual segregation has strengthened segregationist tendencies that follow the growth of luxurious housing complexes and gated communities. Furthermore, this study also asserts that deregulation policies in housing and the commercial development of telecommunication infrastructure are factors that …

Learning To Be Gay: Narrative Socialization Of Young Indonesian Homosexuals, Amika Wardana

Masyarakat: Jurnal Sosiologi

The increasing religious conservatism within Indonesian society has propelled the growth of hatred and vigilantism targeting sexual minorities—which are seen as committing an unforgiven sin—especially towards LGBTs (Lesbian, Gay, Bisexual and Transgender). This study addresses the processes that these minorities experience in order to express their sexual identities and forge social relationships with fellow same-sex queers. In specific, this study focuses on the ways young gays begin to understand and develop their sexual identity amidst a largely hostile social environment. By utilizing social media, these young gays have built digital communities for socialising with fellow gay people, as well as …

Systematic Review With Meta-Analysis: Safety And Effectiveness Of Combining Biologics And Small Molecules In Inflammatory Bowel Disease, Quazim A Alayo, Osama Altayar, Matthew A Ciorba, Deborah Thomas, Parakkal Deepak, Et Al.

2020-Current year OA Pubs

BACKGROUND: Combining biologics and small molecules could potentially overcome the plateau of drug efficacy in inflammatory bowel disease (IBD). We conducted a systematic review and meta-analysis to assess the safety and effectiveness of dual biologic therapy (DBT), or small molecule combined with a biologic therapy (SBT) in IBD patients.

METHODS: We searched MEDLINE, EMBASE, Scopus, Web of Science, Cochrane Database of Systematic Reviews, and Clinical trials.gov until November 3, 2020, including studies with 2 or more IBD patients on DBT or SBT. Main outcome was safety assessed as pooled rates of adverse events (AEs) and serious AEs (SAEs) for each …

Coronavirus Disease 2019 (Covid-19) Vaccine Breakthrough Infections Among Healthcare Personnel, December 2020-April 2021, Katelin B Nickel, Victoria J Fraser, Hilary M Babcock, Jennie H Kwon, Cdc Prevention Epicenters Program

2020-Current year OA Pubs

Coronavirus disease 2019 (COVID-19) vaccine effectiveness in the early months of vaccine availability was high among healthcare personnel (HCP) at 88.3% for 2-doses. Among those testing positive for severe acute respiratory coronavirus virus 2 (SARS-CoV-2), those with breakthrough infection after vaccination were more likely to have had a non-work-related SARS-CoV-2 exposure compared to unvaccinated HCP.

Lack Of Pathogen Identification Influencing Antibiotic De-Escalation In Hospital-Acquired Pneumonia, Matthew C Bittmann, Scott T Micek, Marin H Kollef

2020-Current year OA Pubs

No abstract provided.

Child Dietary Patterns In Homo Sapiens Evolution: A Systematic Review, Lora L Iannotti, Emmanuel A Gyimah, Miranda Reid, Melissa Chapnick, Mary Kate Cartmill, Chessa K Lutter, Charles Hilton, Theresa E Gildner, Elizabeth A Quinn

2020-Current year OA Pubs

Dietary patterns spanning millennia could inform contemporary public health nutrition. Children are largely absent from evidence describing diets throughout human evolution, despite prevalent malnutrition today signaling a potential genome-environment divergence. This systematic review aimed to identify dietary patterns of children ages 6 months to 10 years consumed before the widespread adoption of agriculture. Metrics of mention frequency (counts of food types reported) and food groups (globally standardized categories) were applied to: compare diets across subsistence modes [gatherer-hunter-fisher (GHF), early agriculture (EA) groups]; examine diet quality and diversity; and characterize differences by life course phase and environmental context defined using Köppen-Geiger …

All-Cause And In-Hospital Mortality After Aspirin Use In Patients Hospitalized With Covid-19: A Systematic Review And Meta-Analysis, Nischit Baral, Joshua D Mitchell, Pramod K Savarapu, Maxwell Akanbi, Bandana Acharya, Soumya Kambalapalli, Amith Seri, Krishna P Bashyal, Arvind Kunadi, Niranjan Ojha, Annabelle Santos Volgman, Tripti Gupta, Timir K Paul

2020-Current year OA Pubs

BACKGROUND: With the results of the largest randomized controlled trial (RECOVERY) and the most extensive retrospective cohort study on coronavirus disease 2019 (COVID-19) recently published, we performed a meta-analysis on the association of aspirin with mortality of COVID-19. We aimed to investigate the role of aspirin in COVID-19 hospitalizations.

MATERIALS AND METHODS: We searched PubMed, EMBASE and Cochrane databases for studies from 1 January 2020 until 20 July 2022, that compared aspirin versus non-aspirin use in hospitalized COVID-19 patients. We excluded case reports, review articles and studies on non-hospitalized COVID-19 infections. We used the inverse variance method and random effects …

Psychiatric Comorbidity And Psychosocial Stressors Among People Initiating Hiv Care In Cameroon, Angela M. Parcesepe, Lindsey M. Filiatreau, Peter Vanes Ebasone, Anastase Dzudie, Brian W. Pence, Milton Wainberg, Marcel Yotebieng, Kathryn Anastos, Eric Pefura-Yone, Denis Nsame, Rogers Ajeh, Denis Nash

2020-Current year OA Pubs

BACKGROUND: Psychiatric comorbidity, the presence of two or more mental health disorders, has been associated with suboptimal HIV treatment outcomes. Little is known about the prevalence of psychiatric comorbidity among people with HIV (PWH) in sub-Saharan Africa.

METHODS: We conducted interviews with PWH initiating HIV care in Cameroon between June 2019 and March 2020. Depression, anxiety, post-traumatic stress disorder (PTSD), and harmful drinking were dichotomized to represent those with and without symptoms of each. Psychiatric comorbidity was defined as having symptoms of two or more disorders assessed. Moderate or severe household hunger, high anticipatory HIV-related stigma, low social support, and …

Antibodies In Healthcare Personnel Following Severe Acute Respiratory Syndrome Coronavirus Virus 2 (Sars-Cov-2) Infection, Rachel E Bosserman, Christopher W Farnsworth, Caroline A O'Neil, Candice Cass, Daniel Park, Claire Ballman, Meghan A Wallace, Emily Struttmann, Henry Stewart, Olivia Arter, Kate Peacock, Victoria J Fraser, Philip J Budge, Margaret A Olsen, Carey-Ann D Burnham, Hilary M Babcock, Jennie H Kwon, Cdc Prevention Epicenters

2020-Current year OA Pubs

In a prospective cohort of healthcare personnel (HCP), we measured severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) nucleocapsid IgG antibodies after SARS-CoV-2 infection. Among 79 HCP, 68 (86%) were seropositive 14-28 days after their positive PCR test, and 54 (77%) of 70 were seropositive at the 70-180-day follow-up. Many seropositive HCP (95%) experienced an antibody decline by the second visit.

Creation Of Philadelphia Chromosome By Crispr/Cas9-Mediated Double Cleavages On Bcr And Abl1 Genes As A Model For Initial Event In Leukemogenesis, Minori Tamai, Kenji Kamimoto, Kohei Omachi, Et Al.

2020-Current year OA Pubs

The Philadelphia (Ph) chromosome was the first translocation identified in leukemia. It is supposed to be generated by aberrant ligation between two DNA double-strand breaks (DSBs) at the BCR gene located on chromosome 9q34 and the ABL1 gene located on chromosome 22q11. Thus, mimicking the initiation process of translocation, we induced CRISPR/Cas9-mediated DSBs simultaneously at the breakpoints of the BCR and ABL1 genes in a granulocyte-macrophage colony-stimulating factor (GM-CSF) dependent human leukemia cell line. After transfection of two single guide RNAs (sgRNAs) targeting intron 13 of the BCR gene and intron 1 of the ABL1 gene, a factor-independent subline was …

Estimation Of Intrafamilial Dna Contamination In Family Trio Genome Sequencing Using Deviation From Mendelian Inheritance, Christopher J Yoon, Brian Wiley, Malachi Griffith, Obi L Griffith, Et Al.

2020-Current year OA Pubs

With the increasing number of sequencing projects involving families, quality control tools optimized for family genome sequencing are needed. However, accurately quantifying contamination in a DNA mixture is particularly difficult when genetically related family members are the sources. We developed TrioMix, a maximum likelihood estimation (MLE) framework based on Mendel's law of inheritance, to quantify DNA mixture between family members in genome sequencing data of parent-offspring trios. TrioMix can accurately deconvolute any intrafamilial DNA contamination, including parent-offspring, sibling-sibling, parent-parent, and even multiple familial sources. In addition, TrioMix can be applied to detect genomic abnormalities that deviate from Mendelian inheritance patterns, …

Detection Of Emerging Neurodegeneration Using Bayesian Linear Mixed-Effect Modeling, Yann Cobigo, Richard J Perrin, Et Al.

2020-Current year OA Pubs

Early detection of neurodegeneration, and prediction of when neurodegenerative diseases will lead to symptoms, are critical for developing and initiating disease modifying treatments for these disorders. While each neurodegenerative disease has a typical pattern of early changes in the brain, these disorders are heterogeneous, and early manifestations can vary greatly across people. Methods for detecting emerging neurodegeneration in any part of the brain are therefore needed. Prior publications have described the use of Bayesian linear mixed-effects (BLME) modeling for characterizing the trajectory of change across the brain in healthy controls and patients with neurodegenerative disease. Here, we use an extension …

Edge-Centric Analysis Of Stroke Patients: An Alternative Approach For Biomarkers Of Lesion Recovery, Sebastian Idesis, Joshua Faskowitz, Richard F Betzel, Maurizio Corbetta, Olaf Sporns, Gustavo Deco

2020-Current year OA Pubs

Most neuroimaging studies of post-stroke recovery rely on analyses derived from standard node-centric functional connectivity to map the distributed effects in stroke patients. Here, given the importance of nonlocal and diffuse damage, we use an edge-centric approach to functional connectivity in order to provide an alternative description of the effects of this disorder. These techniques allow for the rendering of metrics such as normalized entropy, which describes the diversity of edge communities at each node. Moreover, the approach enables the identification of high amplitude co-fluctuations in fMRI time series. We found that normalized entropy is associated with stroke lesion severity …

Neonatal Motor Functional Connectivity And Motor Outcomes At Age Two Years In Very Preterm Children With And Without High-Grade Brain Injury, Peppar E P Cyr, Rachel E Lean, Jeanette K Kenley, Sydney Kaplan, Dominique E Meyer, Jeffery J Neil, Dimitrios Alexopoulos, Rebecca G Brady, Joshua S Shimony, Thomas L Rodebaugh, Cynthia E Rogers, Christopher D Smyser

2020-Current year OA Pubs

Preterm-born children have high rates of motor impairments, but mechanisms for early identification remain limited. We hypothesized that neonatal motor system functional connectivity (FC) would relate to motor outcomes at age two years; currently, this relationship is not yet well-described in very preterm (VPT; born <32 weeks' gestation) infants with and without brain injury. We recruited 107 VPT infants - including 55 with brain injury (grade III-IV intraventricular hemorrhage, cystic periventricular leukomalacia, post-hemorrhagic hydrocephalus) - and collected FC data at/near term-equivalent age (35-45 weeks postmenstrual age). Correlation coefficients were used to calculate the FC between bilateral motor and visual cortices and thalami. At two years corrected-age, motor outcomes were assessed with the Bayley Scales of Infant and Toddler Development, 3rd edition. Multiple imputation was used to estimate missing data, and regression models related FC measures to motor outcomes. Within the brain-injured group only, interhemispheric motor cortex FC was positively related to gross motor outcomes. Thalamocortical and visual FC were not related to motor scores. This suggests neonatal alterations in motor system FC may provide prognostic information about impairments in children with brain injury.

Inferring The Dynamical Effects Of Stroke Lesions Through Whole-Brain Modeling, Sebastian Idesis, Chiara Favaretto, Nicholas V Metcalf, Joseph C Griffis, Gordon L Shulman, Maurizio Corbetta, Gustavo Deco

2020-Current year OA Pubs

Understanding the effect of focal lesions (stroke) on brain structure-function traditionally relies on behavioral analyses and correlation with neuroimaging data. Here we use structural disconnection maps from individual lesions to derive a causal mechanistic generative whole-brain model able to explain both functional connectivity alterations and behavioral deficits induced by stroke. As compared to other models that use only the local lesion information, the similarity to the empirical fMRI connectivity increases when the widespread structural disconnection information is considered. The presented model classifies behavioral impairment severity with higher accuracy than other types of information (e.g.: functional connectivity). We assessed topological measures …

Cost And Value In Contemporary Heart Failure Clinical Guidance Documents, John W. Ostrominski, Sameer Hirji, Ankeet S. Bhatt, Javed Butler, Mona Fiuzat, Gregg C. Fonarow, Paul A. Heidenreich, James L. Januzzi, Carolyn S. P. Lam, Thomas M. Maddox, Christopher M. O'Connor, Muthiah Vaduganathan

2020-Current year OA Pubs

OBJECTIVES: This study sought to evaluate the frequency and nature of cost/value statements in contemporary heart failure (HF) clinical guidance documents (CGDs).

BACKGROUND: In an era of rising health care costs and expanding therapeutic options, there is an increasing need for formal consideration of cost and value in the development of HF CGDs.

METHODS: HF CGDs published by major professional cardiovascular organizations between January 2010 and February 2021 were reviewed for the inclusion of cost/value statements.

RESULTS: Overall, 33 documents were identified, including 5 (15%) appropriate use criteria, 7 (21%) clinical practice guidelines, and 21 (64%) expert consensus documents. Most …