Digital Commons Network^™

Assessment Of Quechers Extraction Protocol For The Lc-Ms/Ms Detection Of Emerging Fentanyl Analogs In Biological Specimens For Clinical And Forensic Purposes, Kylea M. Morris

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drug abuse within the United States is a dynamic and pervasive issue that affects the quality and life expectancy of our society. One of the major drug classes that are constantly utilized is opioids. Opioids are prescribed for pain management in patients suffering from cancer and other medical illnesses. Long-term use of opioids could lead to tolerance in humans, which poses a risk of reaching fatal overdose levels. Unfortunately, opioids are abused recreationally, and in some instances, individuals are unaware of the presence of dangerous synthetic drugs like fentanyl, hidden in materials such as heroin, cocaine, oxycodone, and methamphetamine. Recent …

Investigating The Marketing Language Among Online Retailers Of Violin Strings To Determine The Implied Aesthetic, Kira Kay Browning

Graduate Theses, Dissertations, and Problem Reports (ETD)

The aim of this research is to determine if language in the advertising of violin strings is acting as an exclusionary tool in favor of a Western art music “sound” produced by “classical” violinists. It posits that the marketing of strings to violinists is a topic laden with unacknowledged biases and values of musicians within Western art music. The aesthetic values attached to playing Western art music for the violin in the United States are passed on through pedagogic practice and acculturation of language. Product descriptions for strings in the United States employ language which adheres to these cultural values …

Evaluation Of A Comprehensive Diabetes Mellitus Protocol At A Rural, Federally Qualified Health Center In Southern West Virginia, Hannah D. Davis

Graduate Theses, Dissertations, and Problem Reports (ETD)

Background: Diabetes mellitus is a chronic disease that affects nearly 34 million Americans. In rural Appalachia, the population is affected disproportionately at a rate of 14% compared to the national average of 10%. Diabetes is a lifelong, chronic condition managed best by a multidisciplinary team-based approach to achieve optimal disease control. Best practices in the care of diabetes support the use of evidenced based care protocols and leveraging technology to decrease the burden of disease. Type 2 diabetes mellitus (T2DM) is the most common type, making it the focal population for evaluation.

Purpose: The purpose of this project was to …

Development And Testing Of A Biochar Combustor For A Stirling Engine, Kyle Bryant Vickery

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nonrenewable resources persist as a necessity for perpetuating the current technology and standards of living maintained throughout the world. Biochar is an alternative and renewable fuel source that constitutes the potential to provide energy comparable to coal. Designing and fabricating components that can efficiently harness biochar’s energy to power machinery would demonstrate a successful renewable energy source. The scope of this research is to explain the feasible design, fabrication, and results of technology involving the burning of biochar and transference of hot combustion products for the purpose of powering a Stirling Engine. This design consists of a solid fuel burner, …

Bone Marrow Stroma-Induced Transcriptome Signatures Of Multiple Myeloma As Modulated By Junb, Jasleen Kaur Gandhi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The bone marrow (BM) microenvironment acts as a breeding ground for drug resistance in multiple myeloma (MM). The interaction with bone marrow stromal cells (BMSCs) confer environment-mediated drug resistance (EMDR) to multiple myeloma. We investigated BM stroma-induced transcriptome signatures of MM cells through a sophisticated analysis of gene expression. In particular, we defined transcription program modulated by JunB, an emerging regulator of MM pathogenesis and a member of the transcription factor superfamily activator protein 1 (AP-1), in response to BM stimulation. The data and results lay down a foundation for future studies to illustrate the regulatory role of JunB in …

Post-Processing Precise Point Positioning Solutions With Parameter Optimization, Maria A. Gonzalez Castaneda

Graduate Theses, Dissertations, and Problem Reports (ETD)

Precise Point Positioning (PPP) technique can offer position solutions with centimeter-level accuracy by fusing precise satellite orbits and clocks with un-differenced, dual-frequency, pseudo-range, and carrier-phase observables. PPP presents a compelling alternative to Differential Global Positioning Systems, with the benefit that it only requires a single receiver and does not require simultaneous observations from many stations, making it appealing for ongoing research on hydro-graphic survey applications. The National Oceanic and Atmospheric Administration has been working on a buoy system tracked with a Global Positioning Systems receiver and Inertial Measurement Unit sensor using the PPP technique. In the interest of obtaining accurate …

Three Essays In Healthcare Economics And Policy Analysis, Tuyen Pham

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation research consists of three essays on healthcare economics and policy analysis. Chapter 1 investigates and explains the failure of a proposition on limiting dialysis clinic profits in California in 2018. The proposition would have required dialysis clinics to issue refunds to patients or their payers for revenue that exceeds 115% of the direct cost of treatment. In this chapter, a conceptual framework of how voters weigh costs and benefits is developed and two different empirical approaches, simple OLS and Double Post LASSO, are employed to identify key determinants of the voting outcome. The empirical results suggest that counties …

Three Essays In Public Economics, Joylynn Michelle Pruitt

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation presents three chapters related to each other in their application to public economics. In the study of how utility-maximizing or goal-seeking units achieve economic outcomes, this dissertation presents results for a diverse range of agents including prosecutors and liberal arts colleges. Co-authored with Dr. Bryan McCannon of West Virginia University, the first chapter examines an interesting feature of prosecutor elections, where the pool of potential challengers to an incumbent comes primarily from subordinates within the office. We develop a signaling model that analyzes whether entry into the political race by a subordinate provides voters with useful information. In …

Psychosocial Influences On And Behavioral Characteristics Of Young Adult Food Addiction, Rachel A. Wattick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction. Research on food addiction has increased in recent years, but there are few studies focusing on college-attending young adults, who may be at risk of developing food addiction due to the stress of the college environment. Additionally, causes and characteristics of food addiction are under-explored.

Aim. This dissertation aims to 1) determine the impact of adverse childhood experiences (ACEs) and other early life influences on the development of food addiction in college-attending young adults and 2) determine the psychosocial and behavioral characteristics of young adults with food addiction.

Methods. A sequential explanatory mixed-methods design was used for aims 1 …

Electrochemical And Mass Spectrometry Methods For Identification Of Gunshot Residues (Gsr) In Forensic Investigations, Kourtney A. Dalzell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gun violence continues to be one of most significant challenges straining the USA society causing thousands of human lives lost every year. In 2020 alone, firearm-related incidents including homicide, accidents, and suicides, reached a staggering number of over 43,000.^1,2 With the increase in these types of incidents, several service areas in crime laboratories are heavily impacted by the number of cases run on a yearly basis. These include firearm examinations, gunshot residue (GSR) analysis, bullet hole identification, and shooting distance determination, which are crucial to support a criminal investigation and, overall, the justice system in our country. These areas …

Development Of Methane Emissions Model To Assess Fuel Recovery Potential At Gas Well Sites Using On Site Compression, Nicholas G. Lindenfeldar

Graduate Theses, Dissertations, and Problem Reports (ETD)

The US natural gas production and consumption has increased 85.5% since 2005 primarily due to the unconventional production methods of horizontal drilling and hydraulic fracturing. Natural gas used as a fuel has a lower greenhouse gas (GHG) footprint than coal and petroleum due to lower Carbon Dioxide (CO₂) emissions when combusted. However, the “greener” benefit to natural gas may be consumed by leaks in production and transmission systems. Methane (CH₄), the primary hydrocarbon in natural gas, has an estimated Global Warming Potential (GWP) of 28-36 over 100 years, meaning it can absorb 28-36 more energy than …

Theoretical Investigation Of Sofc/Soec Degradation Mechanisms And Mitigations, Fuming Jiang

Graduate Theses, Dissertations, and Problem Reports (ETD)

America has a rapid growth in the development of renewable power generation in the twenty-first century. Hydrogen energy especially is the major topic in development of renewable power generation because it has the ability to provide for energy in transportation, combined heat and power generation and energy storage systems with little or no impact on the global ecosystem. Electrolysis and fuel cell technology for hydrogen energy storage has brought interest to the researchers worldwide.

Solid oxide electrolysis cells (SOECs) and Solid oxide fuel cells (SOFCs) are promising hydrogen energy technologies that can utilize chemical energy to produce and store electricity. …

Using Drones To Evaluate Revegetation Success On Natural Gas Pipelines, Anthony Nelson Mesa

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Appalachian region of the United States has significant growth in the production of natural gas. Developing the infrastructure required for this resource creates significant disturbances across the landscape, as both well pads and transportation pipelines must be created in this mountainous terrain. Midstream infrastructure, which includes pipeline rights-of-way and associated infrastructure, can cause significant environmental degradation, especially in the form of sedimentation. The introduction of this non-point source pollutant can be detrimental to freshwater ecosystems found throughout this region. This ecological risk has necessitated the enactment of regulations related to midstream infrastructure development. Weekly, inspectors travel afoot along pipeline …

Genetic Analysis And Telemetry Study Of Migration Habits Of The Endangered Atlantic Sturgeon, Cassia Marie Busch

Graduate Theses, Dissertations, and Problem Reports (ETD)

Atlantic sturgeon are a long-lived anadromous fish that ranged from Labrador, Canada to Florida, US. Due to overharvest in the late 1800’s and 1900’s, Atlantic sturgeon populations across the coast experienced a dramatic population crash. Recovery of this species has faced challenges due to anthropogenic threats, such as vessel strikes, bycatch, and habitat degradation. In 2012, Atlantic sturgeon were added to the United States Endangered Species Act (ESA). Under the ESA, populations were listed as five distinct population segments (DPS), reflecting their geographic arrangement and genetic structure: Gulf of Maine DPS (threatened), New York Bight DPS (endangered), Chesapeake DPS (endangered), …

Uav Path Planning And Multi-Modal Localization For Mapping In A Subterranean Environment, Kieren Yoshiki Samarakoon

Graduate Theses, Dissertations, and Problem Reports (ETD)

The use of Unmanned Aerial Vehicles (UAVs), especially quadcopters, have become popular in academia and industry due to their small size and maneuverability. These UAVs can be programmed to autonomously execute missions that are usually difficult and risky for humans, such as subterranean exploration, infrastructure surveying, and even disaster response. However, inaccessible and remote environments pose a challenge in terms of navigation as they often lack access to Global Navigation Satellite System (GNSS) connections and lack features. To address these challenges, UAVs are equipped with multiple sensors to acquire different types of data. These include range, acceleration, and even images, …

Short-Term International Sport For Development And Peace Programs: A Retrospective Analysis And Critique Informed By Stakeholders’ Perspectives In A Two-Year Follow-Up, Adam Hansell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Sport for Development and Peace (SDP) programs are a popular approach to promoting positive development throughout the world, spanning health, education, peace, and social issues. However, scholars have identified critical shortcomings of SDP work, including the potential to reinforce neoliberalist tendencies and values imposition from the Global North to the Global South. Deporte y Cambio Social was a short-term SDP program established through partnership between American and Mexican constituent groups with aims to empower girls and women through soccer. Through six semi-structured, two-year retrospective interviews, the purpose of the present study was to explore cross-cultural understandings of power and intercultural …

A Domain Adaptation Approach For Segmenting Cell Instances In Microscopy Data, Matthew R. Keaton

Graduate Theses, Dissertations, and Problem Reports (ETD)

Automated cellular instance segmentation is a process that has been utilized for accelerating biological research since before the deep learning era, and recent advancements have produced higher quality results with less effort from the biologist. Most current endeavors focus on completely cutting the researcher out of the picture by generating highly generalized models. However, these models invariably fail when faced with novel data and effectively opt to miss out on the full capabilities of deep learning in pursuit of this goal. In our work, we demonstrate how, with even a minimal amount of annotated data, dominant approaches in this space …

Advanced Process Modeling And Optimization Of Amine-Based Carbon Capture Process, Paul Jide Terhemba Akula

Graduate Theses, Dissertations, and Problem Reports (ETD)

With the rise of carbondioxide (CO2) concentration in the atmosphere to more than 400 parts per million (ppm), research efforts have been focused on achieving net-zero carbon emission technologies. Post-combustion CO2 capture (PCC) is a key strategy in reducing CO2 emissions. Amine-based CO2 capture is the baseline technology for retrofitting existing power stations. However, the integration of amine-based PCC technology with power plants to reduce greenhouse gas emissions incurs a high energy penalty, decreasing a powerplant’s efficiency by about 23 percentage points. Understanding the capture plant dynamics plays an important role in its technical and economic performance. Rigorous models are …

Development Of An Innovative Co-Treatment Technology For Produced Water And Blowdown Water: A Regional Approach Of Water Management For Energy Production, Golnoosh Khajouei

Graduate Theses, Dissertations, and Problem Reports (ETD)

Freshwater use for power generation represents the second-largest water use globally. In the United States, freshwater withdrawals for thermoelectric power accounted for 38% of the total freshwater withdrawals for all uses in 2010. Cooling systems are the most water-intensive part of the thermoelectric generation process. For instance, one 300 MW power generator required about 20,000 m³/h circulating cooling water. The cooling operation discharges a large volume of wastewater in the form of blowdown water (10-20% of the consumed water) that requires treatment for reuse or surface discharge. Produced water (PW), the fluid which returns to the surface from …

Using Landsat-Based Phenology Metrics, Terrain Variables, And Machine Learning For Mapping And Probabilistic Prediction Of Forest Community Types In West Virginia, Faith M. Hartley

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study investigates the mapping of forest community types for the entire state of West Virginia, USA using Global Land Analysis and Discovery (GLAD) Phenology Metrics analysis ready data (ARD) derived from the Landsat time series and digital terrain variables derived from a digital terrain model (DTM). Both classifications and probabilistic predictions were made using random forest (RF) machine learning (ML) and training data derived from ground plots provided by the West Virginia Natural Heritage Program (WVNHP). The primary goal of this study is to explore the use of globally consistent ARD data for operational forest type mapping over a …

A Workflow For Unconventional Reservoirs Optimization Using Supervised Machine Learning In Conjunction With Orthorhombic Elasticity Modeling, Aymen Ab Ali Alhemdi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Due to the anisotropy and heterogeneous nature of unconventional reservoirs like shale, a comprehensive parametric study to optimize hydraulic fracture treatment for such reservoirs is a tough challenge, especially when natural fractures are present. Most of the current frac simulators do not consider the anisotropy of rock elasticity in the shales. Besides, using the fracture simulation linked with reservoir simulation for the parametric study to understand the impact of multiple different design parameters on fracture propagation and production is time expensive and low efficient. The study proposes a workflow including a new orthorhombic (OB) rock algorithm to interpret geomechanical properties …

Development Of An Entry-Scale Modeling Methodology To Provide Ground Reaction Curves For Longwall Gateroad Support Evaluation, Haochen Zhao

Graduate Theses, Dissertations, and Problem Reports (ETD)

Longwall gateroad entries are generally subjected to severe mining-induced stress changes and deformations; they are prone to large roof falls, floor heaves, and rib sloughing. The standing support system in underground mines needs to be carefully designed to compensate for the mining-induced deformation of the surrounding rock mass and consecutively protect the integrity of gateroad entries. Local geology, together with mining-induced stress redistribution, influences the ground response and plays a major role in the performance of a standing support design. In the US, Support Technology Optimization Program (STOP) and its Ground Reaction Curve (GRC) design criteria have been applied to …

Development And Verification Of Flight Data Informed Performance Estimation And Prediction Simulation Tool For Small Electrical Multi-Rotor Uav, Nicholas Scott Borelle

Graduate Theses, Dissertations, and Problem Reports (ETD)

While small scale multi-rotor aircraft are becoming an increasingly large market with applications emerging every day, their ability to have both a high endurance/long range and a high speed/performance flight is severely limited. This leads to uncertainty in mission planning and aircraft design, specifically when deciding mission length and available on-board energy. Uncertainty like this leads to an increased chance of failure to complete the mission, and a failure to recover the aircraft. Considering that these aircraft are used by everyone from hobbyists to commercial companies to military personnel, the applications and missions being flown carry importance and a serious …

Cytotoxic Effects Of Potential Irrigants For Endodontic Surgery, Kaiying Haggard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Purpose: The aim of this study is to investigate if hypochlorous acid (Vashe and Endocyn), Ozone, sodium hypochlorite (0.5% NaOCl), chlorhexidine (0.12% CHX), and MTAD can be used as a disinfectant for endodontic surgery without causing bone tissue toxicity by comparing their cytotoxic effects to saline on osteoblasts in vitro.

Methods: Human Fetal Osteoblast Cells (hFOB 1.19, ATCC CRL-11372) were used. The cells viability after 10-minute exposure of Vashe, Endocyn, Ozone, NaOCl (0.5%), CHX (0.12%), MTAD, and saline at concentrations of 10, 30, 60, 90 % volume ratio were measured using CCK8 analysis and the absorbance were measured at 450 …

Microwave-Assisted Carbon Nanotube Growth From Methane On Surface Catalyst Exsolving Perovskite Oxide, Angela M. Deibel

Graduate Theses, Dissertations, and Problem Reports (ETD)

The novel method of using a perovskite exsolution catalyst, strontium titanium nickel oxide (STNO), proved capable of simultaneously producing carbon nanotubes (CNTs) and CO_x-free hydrogen during methane decomposition under microwave irradiation. An optimization of common perovskite materials was conducted for microwave-responsiveness with the results reported in this study. Out of the materials screened, strontium titanium nickel oxide (STNO) was the best candidate to achieve an acceptable methane conversion rate as well as a decent responsiveness to microwave. STNO was further optimized through Ni content, reduction dwell time, and reduction temperature to produce the best methane conversion and CNT …

A Combinatorial 5-Htr Expression Pattern Within The Ventral Projection Neurons Of The D. Melanogaster Olfactory Circuit., Mohd Freezely Ezzani Bin Mazri

Graduate Theses, Dissertations, and Problem Reports (ETD)

Neuromodulation allows neurons within a circuit to respond to stimuli from the environment according to the correct ecological value, context, and internal state of the animal. Serotonin (5-HT) is a neuromodulator that can generate different outcomes based on its target’s serotonin receptor (5-HTR) expression by affecting secondary messenger cascades. Within the Drosophila olfactory system, ventral projections neurons (vPN) express all five insect 5-HTR that project into two olfactory processing regions, the antennal lobe (AL) and the lateral horn (LH). The significance of this 5-HTR expression is unknown. In this study, I theorized the patterns of 5-HTR expression of vPNs. I …

Face Recognition With Attention Mechanisms, Qiangchang Wang

Graduate Theses, Dissertations, and Problem Reports (ETD)

Face recognition has been widely used in people’s daily lives due to its contactless process and high accuracy. Existing works can be divided into two categories: global and local approaches. The mainstream global approaches usually extract features on whole faces. However, global faces tend to suffer from dramatic appearance changes under the scenarios of large pose variations, heavy occlusions, and so on. On the other hand, since some local patches may remain similar, they can play an important role in such scenarios. Existing local approaches mainly rely on cropping local patches around facial landmarks and then extracting corresponding local representations. …

An Examination Of Career Orientation Courses And College Students' Career Decision Self-Efficacy, Logan R. Mayhew

Graduate Theses, Dissertations, and Problem Reports (ETD)

Career development is an ongoing concern for college administrators as the modern knowledge era generates new and fluctuating jobs. College students are more anxious than in previous decades about starting their careers and making vocational decisions. Building career decision self-efficacy in students results in greater feelings of confidence and increases demonstration of career-related behaviors. Students in three online career courses at West Virginia University were assessed for gains in career decision self-efficacy in comparison with a control group after participation in the courses and compared on the basis of gender. Results of a mixed ANOVA indicated a significant increase in …

Development Of Capillary Vibrating Sharp-Edge Spray Ionization For Improving Continuous Flow Mass Spectrometry Analysis, Chong Li

Graduate Theses, Dissertations, and Problem Reports (ETD)

Capillary Vibrating Sharp-Edge Spray Ionization (cVSSI) is new ionization technique developed in the year of 2018. This ionization technique has attractive features such as simplicity, compactness, ease of manipulation, low costs, compatible with continuous flow, etc. However, the development of high performance cVSSI for mass spectrometry analysis is a process that needs unremitting optimizations. In this dissertation, I demonstrate the development of cVSSI for improving continuous flow mass spectrometry analysis. The chapter 2 focuses on improving the ionization efficiency of cVSSI through reducing the droplet size. Three strategies were tested to reduce the droplet size of VSSI. The most effective …

What Is The Perceived Self-Efficacy Of Defined Job Competencies For West Virginia University Extension Faculty?, Lacey Dawn Seckman

Graduate Theses, Dissertations, and Problem Reports (ETD)

The central mission of the Extension Service is to diffuse knowledge and resources developed by teaching and research experts at land grant universities to clientele within local communities (Cummings, et al., 2015; Hall & Broyles, 2016; Seevers & Graham, 2012). Making sure faculty are prepared to carry out their roles in all aspects to serve their clientele is key to quality Extension programs. Extension faculty can come from various backgrounds, interests, and expertise, all of which are influencers of self-efficacy. Having defined competencies for employees in Extension can help express what to expect in this job day-to-day. McClelland (1973) described …