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2022

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Brown Bag Webinar At The Tmc Library, Beatriz Varman Jan 2022

Brown Bag Webinar At The Tmc Library, Beatriz Varman

TMC Library Newsletter (2015-)

The TMC Library is Offering the Following "Brown Bag" Webinar. The McGovern Historical Center & Me: Thinking about Archives and Legacies. If you only have 30 minutes to spare, join us for this virtual webinar. Everyone who registers, will receive a Zoom link to join the webinar.


Letter To An Unknown Hero Of Kiev, Mustafa Ceric Jan 2022

Letter To An Unknown Hero Of Kiev, Mustafa Ceric

Occasional Papers on Religion in Eastern Europe

A letter of solidarity to the besieged in Kiev, from Mustafa Ceric, Ph.D. Grand Mufti Emeritus of Bosnia.


The Level Of Accessibility Of Inclusive Design Of Christian Temples And Churches In Ukraine, Olga Polumysna, Oktyabrina Chemakina, Valeriy Bulatov Jan 2022

The Level Of Accessibility Of Inclusive Design Of Christian Temples And Churches In Ukraine, Olga Polumysna, Oktyabrina Chemakina, Valeriy Bulatov

Occasional Papers on Religion in Eastern Europe

The article explores the issues of accessibility of inclusive design of Christian churches in Ukraine. The principle of accessibility as the main element of inclusive design often causes a conflict of interests in modern Ukrainian society, as it requires changes in the existing state of affairs. To make the subject-spatial environment accessible not only in everyday life, production, but also in the Christian sacred environment is one of the primary tasks of inclusive design. Many Christian churches in Ukraine are not ready to accept people with inclusion since the conditions of accessibility are not met. One of the reasons is …


Training Of Military Chaplains For The Armed Forces Of Ukraine In Conditions Of The Invasion By The Russian Federation, Bogdan Synchak, Petro Livak, Mykhailo Fedorenko Jan 2022

Training Of Military Chaplains For The Armed Forces Of Ukraine In Conditions Of The Invasion By The Russian Federation, Bogdan Synchak, Petro Livak, Mykhailo Fedorenko

Occasional Papers on Religion in Eastern Europe

The article analyzes the comprehensive training of military chaplains for the Armed Forces of Ukraine. The legislative basis of chaplaincy, and the methods and state of its implementation are characterized. The problems that can befall a military chaplain are identified, in particular the contradiction in the combination of military service and pacifism. The development of chaplaincy in Ukraine is outlined. Active assistance to the chaplaincy began only after the Orange Revolution (2004-2005). The following year, a legislative act was made through the directive “On streamlining issues of meeting the religious needs of the military personnel of the Armed Forces of …


Reconciliation Attempts And The Return To Conflict In The Balkans, 2010-2022 (And Parallels To The Russian War On Ukraine), Vjekoslav Perica Jan 2022

Reconciliation Attempts And The Return To Conflict In The Balkans, 2010-2022 (And Parallels To The Russian War On Ukraine), Vjekoslav Perica

Occasional Papers on Religion in Eastern Europe

"Hopefully there will be soon peace in Ukraine, and another attempt at reconciliation in Western Balkans. Even as mostly symbolic and commemorative practices, these endeavors proved that they improve social trust and reduce interethnic tensions. There still remains the question about the purpose and long-term goals of such reconciliation efforts. In my 2021 book, Reconciliation and Last Days, published in Belgrade, Serbia, I argue that postwar reconciliation projects make sense, provided there is a new beginning for wartime enemies, that is, the peoples, faiths, and states in the region. In other words, the purpose of a longer period of peace …


Development Of The Ukrainian Orthodoxy In The Conditions Of The Revanchist Policy Of The Russian Federation Against Ukraine, Yuriy Figurnyi, Oksana Semenova, Liubov Otroshko, Оlнa Shakurova Jan 2022

Development Of The Ukrainian Orthodoxy In The Conditions Of The Revanchist Policy Of The Russian Federation Against Ukraine, Yuriy Figurnyi, Oksana Semenova, Liubov Otroshko, Оlнa Shakurova

Occasional Papers on Religion in Eastern Europe

The article analyzes the development of Ukrainian Orthodoxy in the context of the revenge policy of Russia against Ukraine at the turn of the 21st century. It is discovered that almost a quarter of a century of inactivity of the Ukrainian authorities and active anti-Ukrainian and anti-state actions of the Russian Orthodox Church and its Little-Russian branch the Ukrainian Orthodox Church of the Moscow Patriarchate contributed to their introduction into the Ukrainian humanitarian space of fundamental ideas, dogmas, and postulates of the “Russian World,” which subsequently led to the occupation by Russia of Crimea and parts of Donbas and the …


Memory, Trauma, And Religious Identity, Petro Kotliarov, Valentyna Kuryliak, Stefaniia Demchuk Jan 2022

Memory, Trauma, And Religious Identity, Petro Kotliarov, Valentyna Kuryliak, Stefaniia Demchuk

Occasional Papers on Religion in Eastern Europe

The so-called ‘memorial turn’ triggered a huge shift in historical studies of the late 20th century. It brought into focus stories of the ‘small people’ previously left out from the ‘grand narrative.’ For post-Soviet countries, the memorial turn can be perceived as an indicator of changes in society associated with the opportunity and interest of previously oppressed social groups and religious movements in finding their "roots," when the reconstruction of personal history becomes the history of the church and strengthens collective identity. In this essay, we attempted at reconstructing the traumatic history of the "little" people in the context of …


Soft, Sharp, And Evil Power: The Russian Orthodox Church In The Russian Invasion Of Ukraine, Alar Kilp, Jerry G. Pankhurst Jan 2022

Soft, Sharp, And Evil Power: The Russian Orthodox Church In The Russian Invasion Of Ukraine, Alar Kilp, Jerry G. Pankhurst

Occasional Papers on Religion in Eastern Europe

This paper examines the enactment of soft/sharp/evil power by the Russian Orthodox Church and its leaders during a month before the major exertion of hard power by the Russian military and one month after the invasion of Ukraine. In the period from January 25 until March 25, 2022, 27 messages of the leading actors in the Church–Patriarch Kirill and Metropolitan Hilarion, head of the Department of External Church Relations (DECR)–are closely examined. The results are presented and discussed in four thematic sections: 1) soft power: the religious approach to the Russian World; 2) Sharp power: the territorial expansion of the …


Frontmatter (Volume 42, Issue 6), Paul B. Mojzes Jan 2022

Frontmatter (Volume 42, Issue 6), Paul B. Mojzes

Occasional Papers on Religion in Eastern Europe

No abstract provided.


Highlights From International Conference On Cancer Health Disparities 2021, Murali M. Yallapu, Jorge L. Teniente, Andrew Tsin, Subhash C. Chauhan Jan 2022

Highlights From International Conference On Cancer Health Disparities 2021, Murali M. Yallapu, Jorge L. Teniente, Andrew Tsin, Subhash C. Chauhan

School of Medicine Publications

The first International Conference on Cancer Health Disparities (ICCHD) was held on August 13-14, 2021, in Harlingen, TX, USA. This two-day ICCHD-2021 was organized by the University of Texas Rio Grande Valley, School of Medicine (UTRGV-SOM). About 200 national and international delegates from 10 countries attended this hybrid meeting in person and through online digital platforms. The event delegates were representatives from National Institutes of Health (NIH), Cancer Prevention and Research Institute of Texas (CPRIT), and the City of Harlingen, in addition to clinicians, faculty, researchers, scientists, bioinformaticians, geneticists, bioethicists, and others. Under the theme of Cancer Health Disparities, this …


The Enhancing Neuroimaging Genetics Through Meta-Analysis Consortium: 10 Years Of Global Collaborations In Human Brain Mapping, Paul M. Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A. Turner, Anderson M. Winkler, Sophia I. Thomopoulos, Gary F. Egan, Peter Kochunov Jan 2022

The Enhancing Neuroimaging Genetics Through Meta-Analysis Consortium: 10 Years Of Global Collaborations In Human Brain Mapping, Paul M. Thompson, Neda Jahanshad, Lianne Schmaal, Jessica A. Turner, Anderson M. Winkler, Sophia I. Thomopoulos, Gary F. Egan, Peter Kochunov

School of Medicine Publications

This Special Issue of Human Brain Mapping is dedicated to a 10-year anniversary of the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Consortium. It reports updates from a broad range of international neuroimaging projects that pool data from around the world to answer fundamental questions in neuroscience. Since ENIGMA was formed in December 2009, the initiative grew into a worldwide effort with over 2,000 participating scientists from 45 countries, and over 50 working groups leading large-scale studies of human brain disorders. Over the last decade, many lessons were learned on how best to pool brain data from diverse sources. Working groups …


Mega‐Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Anderson M. Winkler Jan 2022

Mega‐Analysis Methods In Enigma: The Experience Of The Generalized Anxiety Disorder Working Group, André Zugman, Anita Harrewijn, Elise M. Cardinale, Hannah Zwiebel, Gabrielle F. Freitag, Katy E. Werwath, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Anderson M. Winkler

School of Medicine Publications

The ENIGMA group on Generalized Anxiety Disorder (ENIGMA-Anxiety/GAD) is part of a broader effort to investigate anxiety disorders using imaging and genetic data across multiple sites worldwide. The group is actively conducting a mega-analysis of a large number of brain structural scans. In this process, the group was confronted with many methodological challenges related to study planning and implementation, between-country transfer of subject-level data, quality control of a considerable amount of imaging data, and choices related to statistical methods and efficient use of resources. This report summarizes the background information and rationale for the various methodological decisions, as well as …


Enigma-Anxiety Working Group: Rationale For And Organization Of Large-Scale Neuroimaging Studies Of Anxiety Disorders, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Gabrielle F. Freitag, Anita Harrewijn, Kevin Hilbert, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Anderson M. Winkler Jan 2022

Enigma-Anxiety Working Group: Rationale For And Organization Of Large-Scale Neuroimaging Studies Of Anxiety Disorders, Janna Marie Bas-Hoogendam, Nynke A. Groenewold, Moji Aghajani, Gabrielle F. Freitag, Anita Harrewijn, Kevin Hilbert, Neda Jahanshad, Sophia I. Thomopoulos, Paul M. Thompson, Anderson M. Winkler

School of Medicine Publications

Anxiety disorders are highly prevalent and disabling but seem particularly tractable to investigation with translational neuroscience methodologies. Neuroimaging has informed our understanding of the neurobiology of anxiety disorders, but research has been limited by small sample sizes and low statistical power, as well as heterogenous imaging methodology. The ENIGMA-Anxiety Working Group has brought together researchers from around the world, in a harmonized and coordinated effort to address these challenges and generate more robust and reproducible findings. This paper elaborates on the concepts and methods informing the work of the working group to date, and describes the initial approach of the …


Medication Errors: Causes, Theories And Interventions, Tuyba Karim Jan 2022

Medication Errors: Causes, Theories And Interventions, Tuyba Karim

Master of Science in Nursing Family Nurse Practitioner

Rationale, aims and objectives: Following heart disease and cancer, medication errors rank third as the leading cause of death in the United States. For the primary care provider, the root causes of medication errors stem from multiple factors. To improve positive learning outcomes for primary care providers in reducing medication errors, this project sets out to examine the utility of educational interventions in improving the present standard of care as it relates to medication error safety and patient outcomes.

Methods: A literature review was conducted analyzing recent studies that examined the use of educational interventions in promoting positive learning outcomes …


Multimodal Medicine: Pain Control Potential, Tyler Ostlund Jan 2022

Multimodal Medicine: Pain Control Potential, Tyler Ostlund

Master of Science in Nursing Family Nurse Practitioner

Due to the continual problem with overuse of, overdose on, and abuse of opioid medications for the past three decades it is paramount that effective, cheap, and above all safe forms of pain control are studied and applied. Multimodal pain management utilizes a combination of pharmacological and non pharmacological therapies in synergy to control pain and reduce dependence on strictly opioids. Combining the effects of medications or therapies that focus on treating different types or sources of pain such as inflammatory pain, neurological pain, etc. With the adoption of this method of pain management, the longstanding effects of the opioid …


The Use Of Distraction Techniques During Painful Procedures In Pediatric Patients, Bethany Hayward Jan 2022

The Use Of Distraction Techniques During Painful Procedures In Pediatric Patients, Bethany Hayward

Master of Science in Nursing Family Nurse Practitioner

No abstract provided.


Prediction Of Formation Conditions Of Gas Hydrates Using Machine Learning And Genetic Programming, Anupama Kumari, Mukund Madhaw, Vishnu S. Pendyala Jan 2022

Prediction Of Formation Conditions Of Gas Hydrates Using Machine Learning And Genetic Programming, Anupama Kumari, Mukund Madhaw, Vishnu S. Pendyala

Faculty Research, Scholarly, and Creative Activity

The formation of gas hydrates in the pipelines of oil, gas, chemical, and other industries has been a significant problem for many years because the formation of gas hydrates may block the pipelines. Hence, the knowledge of the phase equilibrium conditions of gas hydrate became necessary for the economic and safe working of oil, gas, chemical industries. Various thermodynamic approaches with various mathematical techniques are available for the prediction of formation conditions of gas hydrates. In this chapter, the authors have discussed the least square support vector machine and artificial neural network models for the prediction of stability conditions of …


An Overview Of Carbon Footprint Mitigation Strategies. Machine Learning For Societal Improvement, Modernization, And Progress, Vishnu S. Pendyala, Saritha Podali Jan 2022

An Overview Of Carbon Footprint Mitigation Strategies. Machine Learning For Societal Improvement, Modernization, And Progress, Vishnu S. Pendyala, Saritha Podali

Faculty Research, Scholarly, and Creative Activity

Among the most pressing issues in the world today is the impact of globalization and energy consumption on the environment. Despite the growing regulatory framework to prevent ecological degradation, sustainability continues to be a problem. Machine learning can help with the transition toward a net-zero carbon society. Substantial work has been done in this direction. Changing electrical systems, transportation, buildings, industry, and land use are all necessary to reduce greenhouse gas emissions. Considering the carbon footprint aspect of sustainability, this chapter provides a detailed overview of how machine learning can be applied to forge a path to ecological sustainability in …


Von Willebrand Factor Levels In The Diagnosis Of Von Willebrand Disease: A Systematic Review And Meta-Analysis, Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer Jan 2022

Von Willebrand Factor Levels In The Diagnosis Of Von Willebrand Disease: A Systematic Review And Meta-Analysis, Mohamad A. Kalot, Nedaa Husainat, Abdallah El Alayli, Omar Abughanimeh, Osama Diab, Sammy Tayiem, Bader Madoukh, Ahmad Bilal Dimassi, Aref Qureini, Barbara Ameer

School of Medicine Publications

Von Willebrand Disease (VWD) is associated with significant morbidity as a result of excessive mucocutaneous bleeding symptoms. Patients with VWD can experience easy bruising, epistaxis, gastrointestinal and oral cavity bleeding, as well as heavy menstrual bleeding and bleeding after dental work, surgical procedures, and childbirth. Early diagnosis and treatment is important to prevent and treat these symptoms. We systematically reviewed the accuracy of diagnostic tests using different cut-off values of VWF:Ag and platelet-dependent VWF activity assays in the diagnosis of VWD. We searched Cochrane Central, MEDLINE, and EMBASE for eligible studies. Two investigators screened and abstracted data. Risk of bias …


Clergy Social Activity During War Conditions: The Case Of Western Regions Of Ukraine, Ihor Lutsan, Iryna Horokholinska Jan 2022

Clergy Social Activity During War Conditions: The Case Of Western Regions Of Ukraine, Ihor Lutsan, Iryna Horokholinska

Occasional Papers on Religion in Eastern Europe

In this article, the authors analyze the impact of Russia-Ukraine war on church-religious life and the state of public consciousness in Ukraine and identify the main trends and contradictions in public reactions to threats to their lives and spirituality. The research focuses on religious communities of the western regions of Ukraine and their socially significant activities. The primary empirical source of the article was the study (by questionnaire survey) of the opinions of the clergy of this religious organization on the characteristics of parish life and the role of the pastor in the conditions of war. Three defining vectors that …


Appeal To The World Council Of Churches On Russian Terroristic Attacks On Ukrainian Civilians: Statement Of Ukrainian Council Of Churches And Religious Organizations, - Ukrainian Council Of Churches And Religious Organizations Jan 2022

Appeal To The World Council Of Churches On Russian Terroristic Attacks On Ukrainian Civilians: Statement Of Ukrainian Council Of Churches And Religious Organizations, - Ukrainian Council Of Churches And Religious Organizations

Occasional Papers on Religion in Eastern Europe

No abstract provided.


Agricultural Ecosystem Services: Exploring Models And Methods For Scenario Development Along The Wasatch Front, Utah, Daniella Hirschfeld Jan 2022

Agricultural Ecosystem Services: Exploring Models And Methods For Scenario Development Along The Wasatch Front, Utah, Daniella Hirschfeld

Funded Research Records

No abstract provided.


Phylogenetic And Geographic Relationships Of Cheilostome Bryozoans In The Eastern Pacific, Hannah E. Lee Jan 2022

Phylogenetic And Geographic Relationships Of Cheilostome Bryozoans In The Eastern Pacific, Hannah E. Lee

Cal Poly Humboldt theses and projects

The phylum Bryozoa is an incredibly diverse group of marine invertebrates with a widespread global distribution that is well suited for evolutionary studies but whose phylogenetic relationships are still poorly understood. Although recent studies on bryozoan taxonomies and phylogenies have increased, there is still a lack of assessment of species found at shallow water (<1 m) to intertidal depths. In this study, I aimed to expand the taxonomic sampling and assessment of the phylogenetic diversity of cheilostome bryozoans along the California coastline by utilizing mitochondrial DNA as well as inferring potential correlations between species presence and dispersal range both within and between rocky outer coast and sheltered harbor habitats. Illumina high-throughput sequencing was used to produce mitogenomes for cheilostome bryozoan samples collected off rocks from two rocky intertidal sites and off settlement panels from two harbor sites. Phylogenetic analyses generated evolutionary hypotheses of species relationships alongside geographic mapping of their distribution. This study identified 15 distinct species that represent 10 different families to form the first comprehensive phylogeny for multiple bryozoan families in California across a total range of approximately 973 km of coastline. Three genetically distinct species were found at multiple sites that are separated by a combination of rocky shores and sandy beaches, which indicates that the dispersal range of these species are not limited by geographic barriers along the coast of California. These results provide a future opportunity for further integration of this data with the phylogenies generated in this study to examine more robust evolutionary hypotheses for the phylogenetic and geographic relationships of Californian bryozoan species.


The Slater Fire Was The Product Of Settler Colonialism, William Joseph Curtis Jan 2022

The Slater Fire Was The Product Of Settler Colonialism, William Joseph Curtis

Cal Poly Humboldt theses and projects

The Slater Fire of 2020 burned in Karuk aboriginal territory overseen by the Klamath National Forest. It burned over 200 homes to the ground and ravage over 100,000 acres of forest. This thesis argues that state-enforced fire suppression policies and methods are tools of settler-colonial erasure and the continuation of genocidal violence towards Karuk people. It analyzes the conflict between interests of the colonial state on one side and Indigenous resistance and survival on the other. Fire is an essential tool for the survival of Indigenous cultural identities, the material security of said populations, and the health of the environs …


Assessing The Potential And Pathways For Renewable Energy Transformations In Orleans, California, Malcolm Prescott Moncheur De Rieudotte Jan 2022

Assessing The Potential And Pathways For Renewable Energy Transformations In Orleans, California, Malcolm Prescott Moncheur De Rieudotte

Cal Poly Humboldt theses and projects

In what is now known as the state of California in the United States, the Karuk Tribe is interested in deploying a renewable-powered microgrid in the rural community of Orleans to improve electricity system reliability and resilience to address a wide range of challenges, including extreme events such as wildfires. This study assesses the potential of local distributed renewable energy and battery storage to meet Orleans' energy needs today and in the increasingly electrified future using an energy model. It also identifies existing cultural and social priorities for energy technology along with structural barriers to renewable energy adoption and the …


Evaluating Relative Abundance, Fish Length, And Marine Protected Area Effectiveness For Four Key Rocky Reef Species Along The Northern Californian Coast, Leon Davis Jan 2022

Evaluating Relative Abundance, Fish Length, And Marine Protected Area Effectiveness For Four Key Rocky Reef Species Along The Northern Californian Coast, Leon Davis

Cal Poly Humboldt theses and projects

Marine protected areas (MPAs) were created with the purpose of helping conserve and restore diminished populations of marine organisms. Measuring the effectiveness of MPAs requires long-term monitoring, investigating the abundance and size distributions of the species that utilize the conservation areas, and comparing the results to neighboring reference sites that are not currently protected. In this study, observations from long-term MPA monitoring in northern California (2010-2019) were modeled with substrate, oceanographic, spatial, temporal, and body size variables to describe the variability in abundance and size of three fish groups: Black rockfish (Sebastes melanops), the Blue rockfish group (comprised …


From The Edge Of A Rib: Pro-Ana Edgeworking Narratives, Casey Dobbins Jan 2022

From The Edge Of A Rib: Pro-Ana Edgeworking Narratives, Casey Dobbins

Cal Poly Humboldt theses and projects

People who deliberately practice eating disordered behaviors as a lifestyle form digital communities known as pro-ana. Pro-ana identity is constructed through the medicalized frameworks of anorexia nervosa that attempt to maximize weight loss and also manage other eating disorder behaviors such as binging and purging. This thesis examines pro-ana materials requested and produced on websites, Whisper, and Reddit, assembling these discursive and image exchanges into discourses that identify and describe eating disorder pathology and recovery. My ethnographic collection consists of screenshots of written materials and images from websites, Whisper posts, Reddit threads, and a Discord. This thesis examines discursive strategies …


Envisioning A Grassroots Framework For Community-Based Mental Health Crisis Intervention, Xandra C. Gradine Jan 2022

Envisioning A Grassroots Framework For Community-Based Mental Health Crisis Intervention, Xandra C. Gradine

Cal Poly Humboldt theses and projects

The mental health and well-being of both individuals and communities are going to be best served by community-based services and care completely unreliant on traditional top-down models that often include inaccessible services and/or coercive methods. This is especially prevalent in the case of mental health crisis intervention; where most state-based interventions involve coercive agents who often are not given any specific training on mental health crisis response. As mental health crisis and suicide rates continue to rise in the U.S., and even the most well-respected model of crisis intervention has done little to resolve the issues of prisons serving as …


Does Bisphenol-A, An Estrogen-Like Environmental Toxin, Disrupt Expression Of The Neuronal Chloride Exporter Protein During Early Brain Development?, Mayra S. Mendez Jan 2022

Does Bisphenol-A, An Estrogen-Like Environmental Toxin, Disrupt Expression Of The Neuronal Chloride Exporter Protein During Early Brain Development?, Mayra S. Mendez

Cal Poly Humboldt theses and projects

Bisphenol A (BPA), a manufactured compound found in consumer products, is known to adversely affect early brain development by disrupting normal estrogen signaling. Recently, BPA was reported to suppress expression of a gene encoding the neuron-specific chloride ion transporter, KCC2. Human and animal studies show suppressing KCC2 can cause neuronal and behavioral hyperactivity. Therefore, some adverse effects of BPA may be due to KCC2 suppression and consequent neuronal hyperactivity. This study aimed to determine whether BPA exposure during brain development alters KCC2 expression. A secondary purpose was to evaluate whether a new transgenic zebrafish line, KCC2:mCitrine,could be used to track …


Modulation Of Polyamines To Elucidate Function Within Osteogenesis Of Mesenchymal Stromal Cells, Amin S. Cressman Jan 2022

Modulation Of Polyamines To Elucidate Function Within Osteogenesis Of Mesenchymal Stromal Cells, Amin S. Cressman

Cal Poly Humboldt theses and projects

Snyder-Robinson Syndrome (SRS), an X-linked intellectual disability that arises in children, exhibits debilitating phenotypes like severe osteoporosis. These patients demonstrate an inability to produce mineralized new bone in comparison to the rate at which bone is resorbed, thus leading to weaker skeletal structure and atraumatic fractures. The known cause of SRS is due to loss-of-function mutations within the gene that encodes Spermine Synthase (SMS). Loss of SMS enzymatic activity, which catalyzes the conversion of polyamines spermidine into spermine, demonstrates an increase in the spermidine/spermine ratio in all documented cases of this disorder. The involvement of polyamines in osteogenesis is still …