Digital Commons Network^™

Ranked Choice Voting In Mayoral Elections, Bryan Mccannon

Faculty & Staff Scholarship

Numerous cities across the U.S. have recently switched to ranked choice voting in their local mayoral elections. Proponents argue that, by allowing voters to fully express their preferences over the candidates, voter satisfaction and, ultimately, turnout will improve. Opponents are concerned over the number of candidates who enter the race, as it increases the chances of someone only supported by a minority taking office. To date, there has not been an empirical analysis of ranked choice voting’s effects. First, using the Synthetic Control Method on three large U.S. cities who switched relatively recently, I explore the voting rule’s causal impact. …

Expert Witnesses And Arbitration Outcomes: Insights From Public Procurement Contracts, Bryan Mccannon, Claudio Detotto, Marco Vannini, Riccardo Marselli

Faculty & Staff Scholarship

We explore the use of expert witnesses in arbitration proceedings by analyzing public procurement contract disputes in Italy. Balancing cost with accuracy, participants to a contract select arbitration when speedy dispute resolution is valued highly. Arbitration mechanisms tend to give arbitrators discretion in how to proceed. Consequently, principal-agent problems can arise. Using an IV approach, we show that the use of an expert witness causes a slowing down of the case resolution, without having an effect on the outcome of the dispute nor resolving uncertainty as measured by unanimous decisions by the panel of arbitrators.

Do Elections Encourage Public Actors To Be More Responsive?, Bryan Mccannon, Corey Williams

Faculty & Staff Scholarship

In the U.S. many public services are provided by individuals who are selected in local elections. We ask whether elections encourage public actors to be responsive to citizens. We design a novel field experiment where we send an information request to a random sample of prosecutor offices. Whether someone replies to the request is our measurement of responsiveness. We show that offices whose head is up for re-election are more likely to respond. We also show that offices in states that appoint their local prosecutors are substantially less likely to respond than a matched set of offices with elected leadership.

The Right To Counsel: Criminal Prosecution In 19th Century London, Bryan Mccannon, Zachary Porreca

Faculty & Staff Scholarship

Exploiting a novel data set of criminal trials in 19th century London, we evaluate the impact of an accused’s right to counsel on convictions. While lower-level crimes had an established history of professional representation prior to 1836, individuals accused of committing a felony did not, even though the prosecution was conducted by professional attorneys. The Prisoners’ Counsel At of 1836 remedied this and first introduced the right to counsel in common law systems. Using a difference-in-difference estimation strategy we identify the causal effect of defense counsel. We find the surprising result that the professionalization of the courtroom lead to an …

Sexual Assault On Campus: The Impact Of The Women's Gymnastics Scandal On Michigan State, Bryan Mccannon, Kaleigh Strohl

Faculty & Staff Scholarship

In 2017 Larry Nassar was sentenced to 60 years for assaulting over 300 women during his career as team doctor for the U.S. women’s national gymnastics team and as an osteopathic doctor and professor at Michigan State University. The university received a stream of negative publicity for their role in the scandal. We identify the impact of the sexual assault scandal on the university. Using a synthetic control method approach, we estimate the differences between the real and “synthetic” Michigan State in several university outcomes. We find significant reductions in the number of applications, changes in gender ratio of incoming …

Aacsb Accreditation And Student Demand, Bryan Mccannon, Katherine Starr, Marisa Cameron

Faculty & Staff Scholarship

We ask whether AACSB accreditation has a meaningful impact on university admissions. To do this, we explore 16 U.S. institutions which first achieved this certification recently. We, first, document a modest, but nonzero, impact on university-wide undergraduate applications, without any changes in first-year enrollment, price, or quality of the incoming student body. Restricting attention to business schools, while initial evidence suggests that the accreditation is associated with a decrease in enrollments, we show that this is complicated by non-parallel trends prior to accreditation. Compared to their comparison institutions, universities who seek out accreditation were experiencing flatter business enrollments. Correcting for …

Three Golden Balls: Pawn Shops And Crime, Bryan Mccannon, Zachary Rodriguez, Zachary Porreca

Faculty & Staff Scholarship

We ask what the relationship is between pawn shops and crime. The dominant narrative is that pawn shops reduce the transaction costs of crime and, consequently, promote it. We explore the alternative where pawn shops address the financial distress of those in need, which reduces the incentive to engage in crime. We exploit two distinct policies affecting access to pawn shops − severe licensing fees implemented in London in the early 1800s and state variation in the classification of pawn shops as essential businesses during the Covid-19 pandemic in spring 2020. For each, employing a difference-in-difference identification strategy, we provide …

Comparison Of Crop Yield Estimates Obtained From An Historic Expert System To The Physical Characteristics Of The Soil Components, Edward Barrow Rayburn, Tom Basden

Faculty & Staff Scholarship

No abstract provided.

Point Count System For Measuring Ground Cover From Digital Photos, Edward Barrow Rayburn

Faculty & Staff Scholarship

WVU-Extension fact sheet

Random Misalignment And Anisotropic Deformation Of The Nested Cladding Elements In Hollow-Core Anti-Resonant Fibers, Michael Petry, Rodrigo Amezcua-Correa, Md Selim Habib

Electrical Engineering and Computer Science Faculty Publications

Hollow-core anti-resonant fibers (HC-ARFs) are en route to compete with and surpass the transmission performance of standard single-mode fibers (SSMFs). Recently, nested cladding elements emerged as a key enabler in reaching ultra-low transmission losses over a wide bandwidth. However, implementing nested geometry features poses a great challenge even in the current state-of-the-art fiber fabrication technology, often leading to structural imperfections, which ultimately worsen overall fiber performance. This article provides insights into the impact of fabrication-based perturbations of the cladding elements on the transmission performance and identifies areas of highest susceptibility. The impact of random outer and nested cladding tube misalignments …

Evaluating The Influence Of Twitter Bots Via Agent-Based Social Simulation, Aldo Averza, Khaled Slhoub, Siddhartha Bhattacharyya

Electrical Engineering and Computer Science Faculty Publications

Social Media is used by many as a source of information for current world events, followed by publicly sharing their sentiment about these events. However, when the shared information is not trustworthy and receives a large number of interactions, it alters the public's perception of authentic and false information, particularly when the origin of these stories comes from malicious sources. Over the past decade, there has been an influx of users on the Twitter social network, many of them automated bot accounts with the objective of participating in misinformation campaigns that heavily influence user susceptibility to fake information. This can …

Enhancing Cybersecurity By Generating User-Specific Security Policy Through The Formal Modeling Of User Behavior, Arwa Alqadheeb, Siddhartha Bhattacharyya, Samuel Perl

Electrical Engineering and Computer Science Faculty Publications

Organizations today are faced with the difficult challenge of balancing the embrace of new and emerging technology, and securing their systems and data that support critical business functions. Although there have been significant advances in security enforcement technology, attackers are still able to compromise organizations and access. The impacts of computer intrusions have become so untenable that many organizations are looking at a drastic rethinking of their approach to the security of internal networks. This approach is called Zero Trust and it seeks to remove all notion of a trusted internal network boundary. The benefits of Zero Trust include significantly …

A Machine Learning Approach To Predicting Sep Events Using Properties Of Coronal Mass Ejections, Jesse Torres, Lulu Zhao, Philip K. Chan

Electrical Engineering and Computer Science Faculty Publications

Solar energetic particles (SEPs) can cause severe damage to astronauts and their equipment, and can disrupt communications on Earth. A lack of thorough understanding the eruption processes of solar activities and the subsequent acceleration and transport processes of energetic particles makes it difficult to forecast the occurrence of an SEP event and its intensity using conventional modeling with physics-based parameters. Therefore, in order to provide an advance warning for astronauts to seek shelter in a timely manner, we apply neural networks to forecast the occurrence of SEP events. We use the properties of coronal mass ejections (CMEs) archived in the …

Automatic Verification Of Multi-Agent Systems Security Properties Specified With Ltl, Kholud Alghamdi, Marius Silaghi

Electrical Engineering and Computer Science Faculty Publications

We propose a way to verify security requirements of critical multi-agent system processes by using logic representations and automatic reasoning. The typical multi-agent system considered in our work would be an election system with agents representing their users and aiming to ensure security. Relevant processes are authentication, voting, re-voting, and election verification. The security requirements commonly addressed in such a voting system are: no user can vote unless it got authenticated, no invalid vote should be counted, no vote should be counted twice, and each valid vote should be eventually counted. We show a model of such security requirements by …

Exploring Factors That Predict Marketing Of E-Cigarette Products On Twitter: Infodemiology Approach Using Time Series, Nnamdi C. Ezike, Allison Ames Boykin, Page D. Dobbs, Huy Mai, Brian A. Primack

Health, Human Performance and Recreation Faculty Publications and Presentations

Background:

Electronic nicotine delivery systems (known as electronic cigarettes or e-cigarettes) increase risk for adverse health outcomes among naïve tobacco users, particularly youth and young adults. This vulnerable population is also at risk for exposed brand marketing and advertisement of e-cigarettes on social media. Understanding predictors of how e-cigarette manufacturers conduct social media advertising and marketing could benefit public health approaches to addressing e-cigarette use.

Objective:

This study documents factors that predict changes in daily frequency of commercial tweets about e-cigarettes using time series modeling techniques.

Methods:

We analyzed data on the daily frequency of commercial tweets about e-cigarettes collected …

Cradle-To-Grave Life Cycle Assessment Of Production And Consumption Of Pulses In The United States, Prathamesh A. Bandekar, Ben Putman, Greg Thoma, Marty Matlock

Biological and Agricultural Engineering Faculty Publications and Presentations

Environmental impact associated with production and consumption of pulses in the United States was evaluated using life cycle assessment (LCA). The system boundary was set to cradle-to-grave with a functional unit of 60 g (dry basis) of pulses consumed in a US household. Varieties of pulses modeled in the study included field pea (Pisum sativum), lentil (Lens culinaris), chickpea (Cicer arietinum), and dry bean. Three methods of cooking pulses at the consumer stage tested in the study were cooking in open vessel on electric cooking range (OVC), cooking in stovetop pressure cooker on electric cooking range (SPC), and cooking in …

Sieve Or Shield? High Tech Firms And Entrepreneurs And The Impacts Of Covid 19 On North American Border Regions, Kathrine Eileen Richardson, Francesco Cappellano

Faculty Research, Scholarly, and Creative Activity

This study examines the role of international borders in the era of the Covid-19 pandemic, which led to unprecedented national decisions to close borders in order to contain the domestic contagion. The idea that borders act as shields conflicts with the needs of cross-border regions, as they rely on networks straddling the borders for goods and services’ provisions. This paper explores different approaches at individual, local, and regional policy levels used to counterbalance such impacts. As evidenced by North American border closures to most non-citizens seeking entry (shield effects), it is important to understand how professionals, firms, and their networks …

Markov Decision Process For Modeling Social Engineering Attacks And Finding Optimal Attack Strategies, Faranak Abri, Jianjun Zheng, Akbar Siami Namin, Keith S. Jones

Faculty Research, Scholarly, and Creative Activity

It is important to comprehend the attacker's behavior and capacity in order to build a stronger fortress and thus be able to protect valuable assets more effectively. Prior to launching technical and physical attacks, an attacker may enter the reconnaissance stage and gather sensitive information. To collect such valuable data, one of the most effective approaches is through conducting social engineering attacks, borrowing techniques from deception theory. As a result, it is of utmost importance to understand when an attacker behaves truthfully and when the attacker opts to be deceitful. This paper models attacker's states using the Markov Decision Process …

Reproductive Regrets Among A Population-Based Sample Of U.S. Women, Arthur L. Greil, Michele H. Lowry, Andrea R. Burch, Kathleen Slauson-Blevins, Nicholas Park, Julia Mcquillan

Sociology & Criminal Justice Faculty Publications

Women have many reproductive options, but little is known about their regrets regarding prior reproductive choices and outcomes. Guided by the life-course and stratified reproduction perspectives, this study draws on an open-ended question about reproductive regrets from wave I of the National Survey of Fertility Barriers, a representative telephone survey of reproductive aged U.S. women conducted from 2004 to 2006. The authors classified regrets into five broad categories: (1) none, (2) problematic fertility, (3) unfulfilled fertility desires, (4) family, and (5) pregnancy experiences. The authors conducted the analyses separately by motherhood status. Logistic regression analysis revealed that regardless of parental …

Covid-19 Vaccination In Palestine/Israel: Citizenship, Capitalism, And The Logic Of Elimination, Nicolas Howard, Emily Schneider

Sociology & Criminal Justice Faculty Publications

Despite Israel’s responsibility under international law to combat the spread of contagious diseases and epidemics in its occupied territories, Israeli officials have refused to distribute COVID-19 vaccines to Palestinians in the West Bank and Gaza Strip. Through a critical discourse analysis of Israeli officials’ statements regarding Israel’s COVID-19 vaccination campaign, this paper explores how Israel evades this responsibility while presenting itself as committed to public health and human rights. We find that Israeli officials strategically present Palestinians as an autonomous nation when discussing COVID-19 vaccinations, despite Israel’s ongoing attempts to prevent the creation of a Palestinian state. Relatedly, Israel justifies …

Induction Immunotherapy Followed By Thoracic Radiation Without Chemotherapy In Unresectable Stage Iii Non-Small Cell Lung Cancer: A Case Series., Srikiran Dasari, Takefumi Komiya Md

PCI Publications and Projects

OBJECTIVE: Although concurrent chemoradiation has been the standard of care for unresectable stage III non-small cell lung cancer (NSCLC) due to increased survival and decreased disease progression, patients with poor performance status cannot tolerate chemotherapy toxicity well. Durvalumab, an immune checkpoint inhibitor targeting the programmed death receptor-1 (PD-1) / programmed death-ligand 1 (PD-L1) axis, demonstrated efficacy as maintenance therapy after definitive chemoradiation. However, the role of immunotherapy in those who cannot tolerate chemoradiation is unclear.

METHODS: This retrospective case series reports adult patients with PD-L1-expressing stage III NSCLC diagnosed at Parkview Cancer Institute from 2019-2021 and treated initially with pembrolizumab …

This Is Not A Drill: The War Against Antiracist Teaching In America, Kimberlé W. Crenshaw

Faculty Scholarship

On January 5, 2022, Professor Kimberlé Williams Crenshaw received the 2021 Triennial Award for Lifetime Service to Legal Education and the Legal Profession from the Association of American Law Schools (AALS). In this modified acceptance speech delivered at the 2022 AALS Awards Ceremony, she reflects on the path that brought her to this moment and the crisis over antiracist and social justice education that is unfolding today. Arguing that the legal academy bears a collective responsibility to fight back against the silencing of antiracist frameworks, she calls on legal educational institutions to confront their historical agnosticism toward racial subordination and …

The Short- And Long-Term Effects On The Microbiome Of Infants Who Are Exposed To Opioids In Utero, Dawson Brown-Ezell

Undergraduate Honors Theses

Introduction: The gut microbiome is believed to have a significant impact on health throughout the lifespan, and the influence of infant nutrition and other environmental factors are of particular interest in its development. The aim of this research project was to learn more about the microbiome and short chain fatty acid (SCFA) composition of toddlers of differing weights, considering birth history, environment, and diet. In East Tennessee, opioid misuse is a growing issue, and a number of participants in this study were exposed in utero. We also hoped to identify related effects on infant’s SCFA composition. Finally, it is known …

Loss Of Mmr And Tgfbr2 Increases The Susceptibility To Microbiota-Dependent Inflammation-Associated Colon Cancer, Elena Tosti, Ana S Almeida, Tam T T Tran, Mariel Barbachan E Silva, Pilib Ó Broin, Robert Dubin, Ken Chen, Amanda P Beck, Andrew S Mclellan, Eduardo Vilar, Aaron Golden, Paul W O'Toole, Winfried Edelmann

Faculty, Staff and Student Publications

Background and aims: Mutations in DNA mismatch repair (MMR) genes are causative in Lynch syndrome and a significant proportion of sporadic colorectal cancers (CRCs). MMR-deficient (dMMR) CRCs display increased mutation rates, with mutations frequently accumulating at short repetitive DNA sequences throughout the genome (microsatellite instability). The TGFBR2 gene is one of the most frequently mutated genes in dMMR CRCs. Therefore, we generated an animal model to study how the loss of both TGFBR2 signaling impacts dMMR-driven intestinal tumorigenesis in vivo and explore the impact of the gut microbiota.

Methods: We generated VCMsh2/Tgfbr2 mice in which Msh2loxP and Tgfbr2loxP alleles are …

Recent Advances On Dna Base Flipping: A General Mechanism For Writing, Reading, And Erasing Dna Modifications, Ren Ren, John R Horton, Samuel Hong, Xiaodong Cheng

Faculty, Staff and Student Publications

The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier. Each modified base can be considered a distinct epigenetic signal with broader biological implications beyond simple chemical changes. Since 1994, several crystal structures of proteins and enzymes involved in writing, reading, and erasing modified bases have become available. Here, we present a structural synopsis of writers, readers, and erasers of the modified …

A Phase I, Open-Label, Dose-Escalation Study Of The Ox40 Agonist Ivuxolimab In Patients With Locally Advanced Or Metastatic Cancers, Adi Diab, Omid Hamid, John A Thompson, Willeke Ros, Ferry A L M Eskens, Toshihiko Doi, Siwen Hu-Lieskovan, Samuel J Klempner, Bishu Ganguly, Catherine Fleener, Xiao Wang, Tenshang Joh, Ken Liao, Shahram Salek-Ardakani, Carrie Turich Taylor, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

PURPOSE: Stimulation of effector T cells is an appealing immunotherapeutic approach in oncology. OX40 (CD134) is a costimulatory receptor expressed on activated CD4

PATIENTS AND METHODS: Adult patients (

RESULTS: The most common all-causality adverse events were fatigue (46.2%), nausea (28.8%), and decreased appetite (25.0%). Of 31 treatment-related adverse events, 30 (96.8%) were grade ≤2. No dose-limiting toxicities occurred. Ivuxolimab exposure increased in a dose-proportionate manner from 0.3 to 10 mg/kg. Full peripheral blood target engagement occurred at ≥0.3 mg/kg. Three (5.8%) patients achieved a partial response, and disease control was achieved in 56% of patients. Increased CD4

CONCLUSIONS: Ivuxolimab …

Inhibition Of The Cd47-Sirpα Axis For Cancer Therapy: A Systematic Review And Meta-Analysis Of Emerging Clinical Data, Ji Son, Rodney Cheng-En Hsieh, Heather Y Lin, Kate J Krause, Ying Yuan, Amadeo B Biter, James Welsh, Michael A Curran, David S Hong

Faculty, Staff and Student Publications

CD47-SIRPα interaction acts as a "don't eat me" signal and is exploited by cancer to downregulate innate and adaptive immune surveillance. There has been intense interest to develop a mechanism of blockade, and we aimed to analyze the emerging data from early clinical trials. We performed a systematic review and meta-analysis of relevant databases and conference abstracts including clinical trials using CD47 and/or SIRPα inhibitors in cancer treatment. Nonlinear mixed models were applied for comparison of response and toxicity. We retrieved 317 articles, 24 of which were eligible. These included 771 response-evaluable patients with hematologic (47.1%) and solid tumors (52.9%). …

Cell-Directed Aptamer Therapeutic Targeting For Cancers Including Those Within The Central Nervous System, Jun Wei, Renduo Song, Aria Sabbagh, Anantha Marisetty, Neal Shukla, Dexing Fang, Hinda Najem, Martina Ott, James Long, Lijie Zhai, Maciej S Lesniak, Charles David James, Leonidas Platanias, Michael Curran, Amy B Heimberger

Faculty, Staff and Student Publications

Osteopontin (OPN) is produced by tumor cells as well as by myeloid cells and is enriched in the tumor microenvironment (TME) of many cancers. Given the roles of OPN in tumor progression and immune suppression, we hypothesized that targeting OPN with aptamers that have high affinity and specificity could be a promising therapeutic strategy. Bi-specific aptamers targeting ligands for cellular internalization were conjugated to siRNAs to suppress OPN were created, and therapeutic leads were selected based on target engagement and

Comparison Of Psma-Based 18f-Dcfpyl Pet/Ct And Pelvic Multiparametric Mri For Lesion Detection In The Pelvis In Patients With Prostate Cancer, Trinh T Nguyen, Priya R Bhosale, Guofan Xu, Tinsu Pan, Peng Wei, Yang Lu

Faculty, Staff and Student Publications

Purpose: To directly compare the performance of pelvic mpMRI versus recently approved and increasingly used PSMA-based 18F-DCFPyL PET/CT in intermediate-high risk and biochemical recurrent prostate cancer patient cohort while exploring their potential differing applications in specific clinical scenarios.

Methods: A retrospective analysis was performed on patients who had 18F-DCFPyL PET/CT and pelvic mpMRI done from September 2021 to January 2022 at a single institution. The inclusion criteria were paired exams within a 3-month interval. Exclusion criteria were intervening treatment between exams, a change in PSA by more than 50% and absolute difference more than 1 ng/mL, or concurrent history of …

Checkpoint Inhibitors As Immunotherapy For Fungal Infections: Promises, Challenges, And Unanswered Questions, Sebastian Wurster, Stephanie S Watowich, Dimitrios P Kontoyiannis

Faculty, Staff and Student Publications

Opportunistic fungal infections have high mortality in patients with severe immune dysfunction. Growing evidence suggests that the immune environment of invasive fungal infections and cancers share common features of immune cell exhaustion through activation of immune checkpoint pathways. This observation gave rise to several preclinical studies and clinical case reports describing blockade of the Programmed Cell Death Protein 1 and Cytotoxic T-Lymphocyte Antigen 4 immune checkpoint pathways as an adjunct immune enhancement strategy to treat opportunistic fungal infections. The first part of this review summarizes the emerging evidence for contributions of checkpoint pathways to the immunopathology of fungal sepsis, opportunistic …