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Perspectives On Gender Stereotypes And Glass Ceiling Beliefs Of Male And Female Corporate Professionals, Shellie Cecelia Jones

Walden Dissertations and Doctoral Studies

In the United States, as of 2021, women comprise almost half of the entire workforce (46.8%), yet only represent 24% of top earning officers and 6% of CEO positions. A phenomenon known as the glass ceiling is recognized as an unofficial barrier to advancement within a profession or a company that specifically affects minority populations, including women in business. The purpose of this study is to examine the relationship between the glass ceiling barriers to career advancement for professional women and gender stereotypes. The framework used for this study was based on the role congruity theory that proposes prejudice towards …

Jitim Front Cover Vol 31 1 2022

Journal of International Technology and Information Management

Table of Content JITIM Vol 31. issue 1, 2022

Intrinsic Motivation Is Not Enough: Exploring The Decision To Pursue Promotion To Full Professor, Margaret Roberts

University of the Pacific Theses and Dissertations

The academic career path for tenure track faculty in most four-year universities in the United States allows those who earn tenure to make an individual choice about whether to pursue promotion to the rank of full professor. Limited research exists on the intrinsic motivators that individuals possess and draw upon to push past obstacles or challenges they encounter along their academic career journey. This study explored the role of intrinsic motivation in the decision of tenured associate professors to pursue promotion to full professor. Using a basic qualitative research design, this inquiry involved two in-depth interviews each with seven participants. …

Effects Of Peer Relationships On The Relationship Between Avoidant Attachment And Romantic Intimacy Among Adolescents, Selina Johnson

University of the Pacific Theses and Dissertations

Adolescence is a time when interacting with the opposite sex tends to increase and become more serious, and romantic relationships start to form. However, for some adolescents, specifically adolescents who have an avoidant state of mind in regards to attachment, romantic relationships and particularly intimacy is an experience they may find challenging. Given the importance of intimacy in an adolescent’s life, this study proposes to investigate whether the quality of peer relationships can influence romantic intimacy among adolescents with an avoidant attachment. Friendship quality was chosen as a mediating variable in the present study to examine if the quality of …

Gas-Phase Acid-Base Properties And Conformations Of Oligopeptides Through Mass Spectrometry And Computational Studies, Yuntao Zhang

University of the Pacific Theses and Dissertations

This dissertation presents a comprehensive study of the peptides of interest to deeper understand the gas-phase acid-base properties in relation to their conformations and chirality. In the first part of the study, two pairs of alanine (A)-based isomeric peptides consisting of a basic probe, lysine (Lys) or 2,3-diaminopropionic acid (Dap), were investigated to understand the nature of the enhanced basicity when the basic probe was moved from the N-terminus to the C-terminus. In the second part of the study, alanine-based peptides containing a cysteine (C) as the acidic probe were investigated to understand the chirality effects on the gas-phase acidity …

Where Are All The African-American Women Superintendents In California, Oregon, And Washington State?, Toniesha D. Webb

University of the Pacific Theses and Dissertations

There are many African American women in leadership positions such as Assistant Superintendents, Network Superintendents, Directors, Principals, Assistant Principals, and Coaches. There is a disconnect for African American women in leadership and the highest position of authority in a school district. This leads to the question, what are the barriers, if any, that are limiting the amount of African American Women in the far western states to transition into Superintendent positions? In the reverse, what supports did the women who are superintendents have in their leadership ascension? Finally, what structures need to be developed and formalized in order to facilitate …

Investigation Of Cdk8 Inhibitor Q-12 Effects On Cdk8 And Cdk8 Substrates In Triple Negative Breast Cancer Cell Line Mda-Mb-468, Shengxi Li

University of the Pacific Theses and Dissertations

Cyclin-dependent kinases (CDKs) and cyclins (Cyclins) are the core molecules in the regulation mechanism of the entire cell cycle. Cell cycle dysregulation is a common feature of human cancers, and inhibitors of cyclin-dependent kinases (CDKs) play a crucial role in cell cycle control and are one of the most promising areas of cancer therapy. We aspired to use our cyclin-dependent kinase 8 (CDK8) inhibitor, Q-12, as a probe for biomarker discovery for CDK8 inhibitor sensitive tumor types. Q-12 shows potent inhibition of cell viability and induction of apoptosis process in some triple-negative breast cancer (TNBC) and colorectal cancer cell lines …

Optimization Of The Structure Of Ttr Ligands For Half-Life Extension (Tlhe), Guanming Jiang

University of the Pacific Theses and Dissertations

Many potential therapeutic agents face challenges for their clinical development due to short circulation half-life. As a result, prolonging the half-life of therapeutic drugs in circulation while preserving their hydrophilicity and small size will be a key step toward more effective and safe pharmacological molecules. Our lab developed a new approach for enhancing the safety and efficacy of therapeutic agents. By endowing therapeutic agents with a hydrophilic small molecule (a derivative of the clinical candidate, AG10) which reversibly binds to the serum protein transthyretin (TTR), the half-life of the therapeutic agent should be extended by binding to the TTR in …

Popularity And Internalizing Symptoms: The Possible Mediational Role Of Friendship Quality, Jocelyn Camargo

University of the Pacific Theses and Dissertations

Adolescence is an important developmental period where friendships become important for social emotional adjustment. Given the importance of friendships in adolescence, the current study explored the relation between popularity and internalizing problems and whether friendship qualities mediated this relation. The present study aimed to answer the following research question: What is the mediating role of friendship qualities in the relationship between perceived popularity and internalizing symptoms? Data from the National Institute of Child Health and Development – Study of Early Child Care and Youth Development were analyzed. Data were analyzed using structural equation modeling. Results indicate that adolescents who rated …

Self-Authorship And The Effects Of Reverse Culture Shock In Post-Study Abroad U.S. College Students: Strangers In Their Own Land, Tarianne G. Cotton

University of the Pacific Theses and Dissertations

Traditionally, in our globally diverse and intertwined society, study abroad has served as a valuable, enriching, and life-changing aspect of college and university offerings and opportunities for students. Today, the lives of post-study abroad students will be defined by the ways they make sense of unexpected major events surrounding the history-changing COVID-19 pandemic and the contemporary protests against racism and social injustice. A large body of research exists on study abroad, culture shock, self-authorship, provocative moments, cross-cultural reentry, and reverse culture shock. A lack of research exists on what ways post-study abroad U.S. students make meaning of their experiences in …

Empowerment By Design: Classroom Innovation And Inquiry Through Design Thinking And Action Research, Cory Rayala

University of the Pacific Theses and Dissertations

Increasingly standardized and assessment-driven educational systems are failing to meet the needs of many students, replacing their love of learning with a fear of failure. Importantly, the fear of failure is a common mindset of not only students but also teachers, administrators, and policymakers. This qualitative, action research study is situated in a design thinking/growth mindset conceptual theory that posits that the design thinking process can serve as a meaningful growth mindset opportunity for teachers and students. The prototyping mindset inherent in design thinking may mitigate the fear of failure by focusing on rapid iteration rather than striving for perfection. …

Expression Of Mouse Full-Length Aryl Hydrocarbon Receptor And Human Aryl Hydrocarbon Receptor Ligand Binding Domain In Pichia Pastoris, Yiyuan Wang

University of the Pacific Theses and Dissertations

Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates biological responses to planar aromatic hydrocarbon. AHR activates gene transcription by binding to its corresponding enhancer with its partner-aryl hydrocarbon receptor nuclear translocator (ARNT). In addition, this receptor has been shown to regulate xenobiotic-metabolizing enzymes such as cytochrome P450. AHR exists widely in body tissues and affects bioactivation of carcinogenic compounds, T cell differentiation, fatty acid synthesis, cell proliferation, hematopoietic stem cell differentiation, respiratory reactivity, and insulin sensitivity. Although the precise mechanism illustrating the endogenous AHR function remains unclear, there has been intense interest in exploring AHR as a …

A Cultural Perspective Of The Adult Attachment Projective Picture System With Latino Youth, Erika J. Leacox

University of the Pacific Theses and Dissertations

This study investigated the usefulness of administering the Adult Attachment Projective Picture system (AAP) through a cultural lens with two Latino youth receiving mental health treatment. The AAP is a measure developed from the Bowlby-Ainsworth developmental attachment theory that is used to assess an attachment state of mind for individuals. These case studies facilitated an understanding of how the attachment perspective may be combined with knowledge of cultural themes represented in the AAP results to inform mental health treatment. Each of the participants of this single-subject study design are youth who have experienced symptoms of trauma. We observe from this …

Social Movement Splintering: An Examination Of Stockton Stands With Minneapolis And News Media Representation, Kevin Ozomaro

University of the Pacific Theses and Dissertations

The phenomenon surrounding news media’s power to alter group identity and group cohesion is something that rarely a point of focus in communication studies. In this study I worked with a local social movement group called Stockton Stands with Minneapolis. This group illustrated the importance of maintaining shared values. Utilizing relational Interviewing, SSWM members provided evidence showing the connection between news media and group success. News media has had a role in shaping group members’ understanding of SSWM and activism. SSWM has faced internal conflict as a result of negative news representation. SSWM is a relatively small and young (2 …

Optimizing The Human Aryl Hydrocarbon Receptor (Hahr) Expression In Pichia Pastoris, Junyu Qian

University of the Pacific Theses and Dissertations

The aryl hydrocarbon receptor (AHR) is a transcription factor which heterodimerizes with the aryl hydrocarbon receptor nuclear translocator (Arnt) to regulate downstream gene transcription. For the purpose of studying the crystal structure of human aryl hydrocarbon receptor (hAHR), it is essential to obtain abundant amount of pure recombinant protein.Basing on the benefits of using P. pastoris system to produce recombinant protein, including appropriate folding, secretion of interest proteins to the external environment of the cell, and easier purification process of protein due to the its limited production of endogenous secretory proteins [1], our lab chose P. pastoris yeast as the …

Student Engagement, Experience, & Support Among Pre-Pharmacy Students, James J. Stack

University of the Pacific Theses and Dissertations

This study was guided by Astin’s Student Involvement theory which explored student’s needs in a demanding program amongst 12 pre-pharmacy students at the University of the Pacific. This qualitative study looked to uncover the engagement, experiences, and support of pre-pharmacy students in order to learn what students want from their learning experiences; to aid in student success and retention. Qualitative interviews provided detailed stories to their pre-pharmacy experiences. Through a thorough analysis of the data seven themes emerged: (a) peer support (b) time management (c) exam structure (d) increased faculty support (e) housing placement (f) coping with stress (g) core …

Regulation Of Ppp1r15a (Gadd34) And Ppp1r15b (Crep) Mrna Expression And Localization In The Unfolded Protein Response, Krithika Giresh

University of the Pacific Theses and Dissertations

The failure to balance protein synthesis, folding, and degradation in the endoplasmic reticulum (ER) leads to the accumulation of unfolded proteins, leading to ER stress. Cells respond to this stress by activating a response signaling pathway known as the Unfolded Protein Response (UPR). One of the branches of the UPR induces the phosphorylation of eIF2α (Eukaryotic Initiation Factor 2) to attenuate global protein synthesis, allowing for a chance to clear misfolded and unfolded proteins. This phosphorylation of eIF2α is opposed by a phosphatase, containing a catalytic subunit, Protein Phosphatase 1, and a scaffolding protein, either GADD34 or CReP. Inhibition of …

Developmental Plasticity Of Stress Tolerance And Life-History Strategy To Artificial Light At Night, Alyssa M. Bonfoey

University of the Pacific Theses and Dissertations

Artificial light at night (ALAN), or ecological light pollution, is increasingly prevalent worldwide. Exposure to ALAN tends to negatively impact animals—particularly, nocturnal animals—but life-history strategies may mitigate these costs. Animals in many regions are also increasingly exposed to climate-related stressors, such as heat and drought. Yet, interactions among ALAN, life-history strategy, and stress tolerance are unknown. Therefore, I determined if developmental ALAN exposure (1) affects development, (2) affects adult phenotype, including heat and desiccation tolerance, and (3) affects and/or interacts with life-history strategy. To address my aims, I used the variable field cricket (Gryllus lineaticeps) because its geographic range is …

How Do They Do It? Using Omics Approaches To Explore Metabolic Responses Associated With Hypoxia And Exercise Tolerance In The Deepest Diving Pinniped, Elizabeth R. Piotrowski

University of the Pacific Theses and Dissertations

Marine mammals such as northern elephant seals (NES) routinely experience hypoxemia and ischemia-reperfusion events to many tissues during deep dives with no apparent adverse effects. Adaptations to diving include increased antioxidants and elevated oxygen storage capacity associated with high hemoprotein content in blood and muscle. Despite experiencing decreased oxygen tensions during diving, NES likely rely on the mobilization of large lipids stores and catabolism of fatty acids to provide energy to exercising muscle while diving. To identify potential regulatory mechanisms that may underly hypoxia and exercise tolerance in diving mammals, this study used system-wide approaches to characterize changes in genes …

Beyond Cortisol: Indicators Of Stress And Negative Feedback In Plasma And Blubber Of Marine Mammals, Jessica Avalos

University of the Pacific Theses and Dissertations

Marine mammals play an important role in ecosystem stability. However, anthropogenic activity is compounding pressure on many already vulnerable populations. A potential consequence of anthropogenic disturbance is physiological stress, which can impact metabolism, immunity, and reproduction, especially if it occurs repeatedly. Previous studies on marine mammals have focused on acute stress, but the impacts of repeated stress are poorly understood. Due to its accessibility on land during haul-outs, the northern elephant seal (Mirounga angustirostris) is a good system in which to study the effects of stress in marine mammals. Stress stimulates the release of glucocorticoid hormones, primarily cortisol. Elevated cortisol …

Peripherally Restricted Delivery System Provides Insights On The Role Of Cns In Precipitating Opioid-Induced Constipation, Dengpan Liang

University of the Pacific Theses and Dissertations

A serious opioid crisis is affecting public health and economics, eroding people’s quality of life. 80% of patients who receive opioids suffer from adverse effects such as Opioid-induced constipation (OIC). However, there is no efficient medicine for these adverse effects. Notably, mainstream theory supports that analgesia effects are mainly controlled by CNS while OIC is predominately controlled by peripheral. In addition, the sites of action of opioid was based on the assumption that mu-opioid receptor antagonists (PAMORAs), did not cross the blood-brain barrier (BBB). Unfortunately, the BBB crossing of PAMORAs mislead the understanding of the role of the central nervous …

Evaluating The Effects Of Client-Set Versus Coach-Set Goals In The Context Of A Health-Coaching Intervention For Physical Activity, J. Logan Gibson

University of the Pacific Theses and Dissertations

Health coaching is a relatively new integrated health role in which practitioners use a combination of behavioral interventions to evoke health-related behavior changes; however, there is a lack of valid evidence to support health-based claims. We investigated the effect of an approximation of a health coaching intervention on three college students' number of steps per day. We provided participants with weekly telehealth coaching sessions focused on goal-setting and feedback and used Fitbits to track the results. We used a multiple baseline across participants design to compare daily steps across four phases; self-monitoring, self-monitoring with experimenter-set goals and feedback, self-monitoring with …

The Interrelationship Between Treatment, Ethnicity, And Structured Exercise In Clinical Populations, Amanda M. F. Lopez

University of the Pacific Theses and Dissertations

Cancer is the second leading cause of death, with about approximately 1.9 million Americans being diagnosed each year. Yet, it has high survival rates with the help of advancing treatments like radiation therapy. Cancer patients and survivors are contingent on experiencing a decline in physical functioning, quality of life, and physiological parameters. Treatment is effective and can prolong life expectancy but can be deleterious to a patient’s health. Parallel with cancer's impact on Americans is cardiovascular disease. Cardiovascular disease is responsible for 1 in 4 deaths. The development of cardiovascular disease is not spread accordantly among all ethnicities. Hispanics are …

Continuous Improvement In Practice: One K–12 District’S Leadership Journey, Orquidea Largo

University of the Pacific Theses and Dissertations

K–12 leaders’ compliance mandates, challenges of adopting a continuous improvement approach to student success, and competing priorities often leave leaders feeling vulnerable and unprepared for the task. This basic qualitative study applied the continuous improvement framework (CIF) to research how improvement science penetrated an educational system. This basic qualitative study explored and described leaders’ commitment to employing the principles of improvement science at one California K–12 school district. An in-depth analysis of the interviewees’ transcriptions, persona, and experiences unveiled the following themes for continuous improvement: (a) transformational governance, (b) capacity building, (c) accountability, (d) limitations of transactional governance, and (e) …

Microbial Community Analysis: Biofilm Inhibition & Algae Associated Community Structure, Michelle V. Fong

University of the Pacific Theses and Dissertations

Natural products chemistry is the pursuit of bioactive small molecules from living organisms. These can be classified as primary metabolites if they are essential to survival, and secondary metabolites if they are accessory, playing a role in communication, defense, recruitment, etc.. Natural products have made a significant contribution to society – of 1,881 FDA-approved drugs from 1981 to 2019, 4% were pure natural products, 19% were natural products derived, and 3% were synthetic drugs with a natural products pharmacophore targeting a wide range of diseases and infections (Newman & Cragg, 2020). Pharmacophores are structural components of drugs that are responsible …

Utilization Of Virtual Reality For General Education Purposes, Amit Lal

University of the Pacific Theses and Dissertations

The use of Virtual Reality (VR) in a variety of professional, military, governmental, and educational fields has continued to expand over the past several decades, and the recent Covid-19 pandemic has brought attention to this field. This study surveys 154 college students over 23 questions that include various demographics that can be used to look for discriminators, multiple-choice VR-related questions, as well as a few free-form questions about use of VR in learning environments. The students’ experience with, interest in, and thoughts on how to best use VR vary considerably. The Covid-19 pandemic is found to have limited impact thus …

An Examination Of The Social Emotional Skills Necessary To Promote College And Career Readiness For A Rural California High School, Anna Austin Whitesides

University of the Pacific Theses and Dissertations

Data from the National Center for Education Statistics suggest that as academic standards continue to rise, students' mental health continues to decline (Carr, 2022). Public schools today have a unique opportunity to support the ongoing learning of students, while also encouraging the development of social and emotional skills that will benefit students’ academic performance, as well as their general wellbeing. While schools today follow rigorous state standards and support academic learning, many students attending rural high schools are graduating without the skills necessary to be successful in college or career (Farrington et al., 2012).

This mixed-methods case study examines the …

Self-Care Practices And Burnout Experiences Of Music Therapists In A Metropolitan City, Sylvester Sroka

University of the Pacific Theses and Dissertations

This thesis examined a phenomenological inquiry into the lived experiences of music therapists in a metropolitan city in the United States. During the study, five music therapists were interviewed about their self-care practices and experiences with burnout. Data included a recorded Zoom transcription of the 30–45-minute open-ended interview. The data was analyzed through Moustakas’ (1994) cluster of themes approach. Four themes emerged from the data analyses of the interviews: living/working in a metropolitan city, self-care practices, advice for entry level music therapists, and knowledge of and experience with burnout symptoms. Respondents associated living and working in a metropolitan city with …

Thermodynamic Mechanisms Of Helix Stabilization In A Model Peptide And Protein, Ryan Murray

University of the Pacific Theses and Dissertations

Biologics are large, complex therapeutic agents generally produced from living organisms. One group of biologics is peptide/protein based. Biological agents offer unique advantages over traditional therapeutics including longer half-lives, higher specificity, greater efficacy, and reduced off-target effects. However, protein/peptide based drugs suffer from both delivery and stability issues. The higher order of protein structures (secondary, tertiary, etc.) derive ~80% of their conformational stability from paltry hydrophobic effects, with net stabilization of 5-15 kcal/mole observed for many proteins. Loss of conformational stability can lead to increased aggregation, precipitation, and degradation; and reduced activity and side effects. To increase stability and improve …

Aac Camp As A Pre- And Post- Service Training Model, Joanne Kim

University of the Pacific Theses and Dissertations

The purpose of this study was to determine the effectiveness of participation in an AAC-based day camp as a pre-service training opportunity for students of speech-language pathology and a post-training opportunity for practicing speech-language pathologists (SLPs). Following the conclusion for the most recent iteration of the AAC Academy hosted by the Diagnostic Center of Central California, students and SLPs who volunteered within the past ten years were recruited via email to participate in semi-structured interviews. Upon thematic analysis of the interview transcripts, the following themes were conceptualized: (1) Many volunteers had some interest, if not experience, with AAC prior to …